ZGRF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZGRF1_HUMAN
• UniProt AC: Q86YA3
• Protein Name: Protein ZGRF1
• Gene Name: ZGRF1
• Organism: Homo sapiens (Human).
• Sequence Length: 2104
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Sequence: MESQEFIVLYTHQKMKKSKVWQDGILKITHLGNKAILYDDKGACLESLFLKCLEVKPGDDLESDRYLITVEEVKVAGAIGIVKQNVNKEAPELNSRTFISSGRSLGCQPSGLKRKFTGFQGPRQVPKKMVIMESGESAASHEAKKTGPTIFSPFCSMPPLFPTVGKKDVNNILADPENIVTYKNRERNAMDFSSVFSPSFQINPEVLCEENYFCSPVNSGNKLSDSLLTNEPVKRDSLASHYSGVSQNIRSKAQILALLKSESSSSCEELNSEMTEHFPQKQPQGSLKIATKPKYLIQQEECAEMKSTENLYYQHQSENTMRNKSRWAMYLSSQSSPIHSSTVDGNDTERKPKAQEDDVNSNLKDLSLQKIIQFVETYAEERKKYNVDQSVGNNDPSWNQEVKLEIPSFNESSSLQVTCSSAENDGILSESDIQEDNKIPFNQNDKGCIKGSVLIKENAQEVNTCGTLEKEYEQSESSLPELKHLQIESSNNSRISDDITDMISESKMDNESLNSIHESLSNVTQPFLEVTFNLNNFETSDTEEESQESNKISQDSESWVKDILVNDGNSCFQKRSENTNCEEIEGEHLPFLTSVSDKPTVTFPVKETLPSQFCDKTYVGFDMGICKTENTGKEIEEYSDTLSNFESFKWTDAVYGDNKEDANKPIQEVRINYDFALPPNKSKGINMNLHIPHIQNQIAENSNLFSEDAQPQPFILGSDLDKNDEHVLPSTSSSDNSVQLLNTNQNHYECIALDKSNTHISNSLFYPLGKKHLISKDTEAHISEPEDLGKIRSPPPDHVEVETAREGKQYWNPRNSSELSGLVNTISILKSLCEHSTALDSLEILKKKNTVFQQGTQQTYEPDSPPEVRKPFITVVSPKSPHLHKDSQQILKEDEVELSEPLQSVQFSSSGSKEETAFQAVIPKQIERKTCDPKPVEFQGHQVKGSATSGVMVRGHSSQLGCSQFPDSTEYENFMTETPELPSTCMQIDFLQVTSPEENISTLSPVSTFSLNSRDEDFMVEFSETSLKARTLPDDLHFLNLEGMKKSRSLENENLQRLSLLSRTQVPLITLPRTDGPPDLDSHSYMINSNTYESSGSPMLNLCEKSAVLSFSIEPEDQNETFFSEESREVNPGDVSLNNISTQSKWLKYQNTSQCNVATPNRVDKRITDGFFAEAVSGMHFRDTSERQSDAVNESSLDSVHLQMIKGMLYQQRQDFSSQDSVSRKKVLSLNLKQTSKTEEIKNVLGGSTCYNYSVKDLQEISGSELCFPSGQKIKSAYLPQRQIHIPAVFQSPAHYKQTFTSCLIEHLNILLFGLAQNLQKALSKVDISFYTSLKGEKLKNAENNVPSCHHSQPAKLVMVKKEGPNKGRLFYTCDGPKADRCKFFKWLEDVTPGYSTQEGARPGMVLSDIKSIGLYLRSQKIPLYEECQLLVRKGFDFQRKQYGKLKKFTTVNPEFYNEPKTKLYLKLSRKERSSAYSKNDLWVVSKTLDFELDTFIACSAFFGPSSINEIEILPLKGYFPSNWPTNMVVHALLVCNASTELTTLKNIQDYFNPATLPLTQYLLTTSSPTIVSNKRVSKRKFIPPAFTNVSTKFELLSLGATLKLASELIQVHKLNKDQATALIQIAQMMASHESIEEVKELQTHTFPITIIHGVFGAGKSYLLAVVILFFVQLFEKSEAPTIGNARPWKLLISSSTNVAVDRVLLGLLSLGFENFIRVGSVRKIAKPILPYSLHAGSENESEQLKELHALMKEDLTPTERVYVRKSIEQHKLGTNRTLLKQVRVVGVTCAACPFPCMNDLKFPVVVLDECSQITEPASLLPIARFECEKLILVGDPKQLPPTIQGSDAAHENGLEQTLFDRLCLMGHKPILLRTQYRCHPAISAIANDLFYKGALMNGVTEIERSPLLEWLPTLCFYNVKGLEQIERDNSFHNVAEATFTLKLIQSLIASGIAGSMIGVITLYKSQMYKLCHLLSAVDFHHPDIKTVQVSTVDAFQGAEKEIIILSCVRTRQVGFIDSEKRMNVALTRGKRHLLIVGNLACLRKNQLWGRVIQHCEGREDGLQHANQYEPQLNHLLKDYFEKQVEEKQKKKSEKEKSKDKSHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Ubiquitination	KITHLGNKAILYDDK EEEEECCEEEEECCC		29967540
38	Phosphorylation	LGNKAILYDDKGACL ECCEEEEECCCCHHH		-
41	Ubiquitination	KAILYDDKGACLESL EEEEECCCCHHHHHH		29967540
51	Ubiquitination	CLESLFLKCLEVKPG HHHHHHHHHHCCCCC		29967540
83	Ubiquitination	AGAIGIVKQNVNKEA HHHHHHEECCCCCCC		29967540
88	Ubiquitination	IVKQNVNKEAPELNS HEECCCCCCCCCCCC		29967540
110	Phosphorylation	RSLGCQPSGLKRKFT CCCCCCCCCCCCCCC		19413330
113	Ubiquitination	GCQPSGLKRKFTGFQ CCCCCCCCCCCCCCC		29967540
117	Phosphorylation	SGLKRKFTGFQGPRQ CCCCCCCCCCCCCCC		27174698
134	Phosphorylation	KKMVIMESGESAASH CEEEEEECCCCHHHH		25072903
137	Phosphorylation	VIMESGESAASHEAK EEEECCCCHHHHHHH		25072903
140	Phosphorylation	ESGESAASHEAKKTG ECCCCHHHHHHHHHC		25072903
152	Ubiquitination	KTGPTIFSPFCSMPP HHCCCCCCCCCCCCC		-
167	Ubiquitination	LFPTVGKKDVNNILA CCCCCCCCCHHHHCC		29967540
183	Ubiquitination	PENIVTYKNRERNAM HHHCEEECCCCCCCC		29967540
203	Ubiquitination	FSPSFQINPEVLCEE CCCCCCCCHHHHCCC		-
224	Phosphorylation	VNSGNKLSDSLLTNE CCCCCCCCCCCCCCC		23403867
226	Phosphorylation	SGNKLSDSLLTNEPV CCCCCCCCCCCCCCC		23403867
229	Phosphorylation	KLSDSLLTNEPVKRD CCCCCCCCCCCCCHH		23403867
234	Ubiquitination	LLTNEPVKRDSLASH CCCCCCCCHHHHHHH		29967540
237	Phosphorylation	NEPVKRDSLASHYSG CCCCCHHHHHHHHCC		28555341
240	Phosphorylation	VKRDSLASHYSGVSQ CCHHHHHHHHCCCCH		28555341
243	Phosphorylation	DSLASHYSGVSQNIR HHHHHHHCCCCHHHH		28555341
252	Ubiquitination	VSQNIRSKAQILALL CCHHHHHHHHHHHHH		29967540
281	Ubiquitination	MTEHFPQKQPQGSLK HHHHCCCCCCCCCCE		29967540
317	Phosphorylation	NLYYQHQSENTMRNK CCHHHHCCCCCCCCH		28555341
325	Phosphorylation	ENTMRNKSRWAMYLS CCCCCCHHHHHHHHH		-
333	Ubiquitination	RWAMYLSSQSSPIHS HHHHHHHCCCCCCCC		-
336	Phosphorylation	MYLSSQSSPIHSSTV HHHHCCCCCCCCCCC		-
344	Ubiquitination	PIHSSTVDGNDTERK CCCCCCCCCCCCCCC		22817900
364	Ubiquitination	DDVNSNLKDLSLQKI CCCCCCHHHHHHHHH		22817900
364 (in isoform 1)	Ubiquitination	-		21906983
364 (in isoform 2)	Ubiquitination	-		21906983
367	Phosphorylation	NSNLKDLSLQKIIQF CCCHHHHHHHHHHHH		24719451
384	Ubiquitination	TYAEERKKYNVDQSV HHHHHHHHCCCCCCC		29967540
483	Ubiquitination	ESSLPELKHLQIESS CCCCCCCCCCEECCC		29967540
489	Phosphorylation	LKHLQIESSNNSRIS CCCCEECCCCCCCCC		27732954
490	Phosphorylation	KHLQIESSNNSRISD CCCEECCCCCCCCCH		27732954
493	Phosphorylation	QIESSNNSRISDDIT EECCCCCCCCCHHHH		27732954
496	Phosphorylation	SSNNSRISDDITDMI CCCCCCCCHHHHHHH		27732954
561	Ubiquitination	QDSESWVKDILVNDG CCCHHHHHHHHCCCC		29967540
574	Ubiquitination	DGNSCFQKRSENTNC CCCCCCHHCCCCCCH		29967540
655	Phosphorylation	FKWTDAVYGDNKEDA CCCCHHCCCCCHHHC		29978859
659	Ubiquitination	DAVYGDNKEDANKPI HHCCCCCHHHCCCCC		29967540
706	Phosphorylation	AENSNLFSEDAQPQP HHCCCCCCCCCCCCC		17081983
756	Phosphorylation	ECIALDKSNTHISNS EEEEECCCCCCCCCC		25627689
758	Phosphorylation	IALDKSNTHISNSLF EEECCCCCCCCCCCC		25627689
770	Ubiquitination	SLFYPLGKKHLISKD CCCCCCCCCCCCCCC		29967540
776	Ubiquitination	GKKHLISKDTEAHIS CCCCCCCCCCCHHCC		29967540
777	Ubiquitination	KKHLISKDTEAHISE CCCCCCCCCCHHCCC		-
783	Phosphorylation	KDTEAHISEPEDLGK CCCCHHCCCCHHHCC		24961811
793	Phosphorylation	EDLGKIRSPPPDHVE HHHCCCCCCCCCCEE		30266825
808	Ubiquitination	VETAREGKQYWNPRN EEEHHCCCCCCCCCC		29967540
827	Phosphorylation	SGLVNTISILKSLCE HHHHHHHHHHHHHHC		24719451
846	Ubiquitination	LDSLEILKKKNTVFQ HHHHHHHHHCCCEEE		29967540
860	Phosphorylation	QQGTQQTYEPDSPPE ECCCCCCCCCCCCHH		28985074
864 (in isoform 6)	Trimethylation	-		-
864	Phosphorylation	QQTYEPDSPPEVRKP CCCCCCCCCHHHCCC		28348404
864	Methylation	QQTYEPDSPPEVRKP CCCCCCCCCHHHCCC		-
866 (in isoform 6)	Trimethylation	-		-
866 (in isoform 6)	Ubiquitination	-		-
866	Methylation	TYEPDSPPEVRKPFI CCCCCCCHHHCCCEE		-
866	Ubiquitination	TYEPDSPPEVRKPFI CCCCCCCHHHCCCEE		-
870	Ubiquitination	DSPPEVRKPFITVVS CCCHHHCCCEEEEEC		29967540
874	Phosphorylation	EVRKPFITVVSPKSP HHCCCEEEEECCCCC		28152594
877	Phosphorylation	KPFITVVSPKSPHLH CCEEEEECCCCCCCC		25159151
880	Phosphorylation	ITVVSPKSPHLHKDS EEEECCCCCCCCCCH		28464451
885	Ubiquitination	PKSPHLHKDSQQILK CCCCCCCCCHHHHHH		29967540
916	Phosphorylation	SSGSKEETAFQAVIP CCCCCCCHHHHHHCC		28348404
924	Ubiquitination	AFQAVIPKQIERKTC HHHHHCCHHHCCCCC		29967540
1045	Ubiquitination	FLNLEGMKKSRSLEN ECCHHCHHHCCCCCC		29967540
1059	Phosphorylation	NENLQRLSLLSRTQV CHHHHHHHHHHCCCC		24719451
1062	Phosphorylation	LQRLSLLSRTQVPLI HHHHHHHHCCCCCEE		24719451
1145	Ubiquitination	NNISTQSKWLKYQNT CCCCCCCCCCCCCCC		29967540
1148	Ubiquitination	STQSKWLKYQNTSQC CCCCCCCCCCCCCCC		29967540
1177	Phosphorylation	GFFAEAVSGMHFRDT CHHHHHHCCCCCCCC		29255136
1196	Phosphorylation	SDAVNESSLDSVHLQ HHCCCHHHHHHHHHH		22210691
1199	Phosphorylation	VNESSLDSVHLQMIK CCHHHHHHHHHHHHH		22210691
1221	Phosphorylation	QDFSSQDSVSRKKVL CCCCCCCCCCHHHHH		22210691
1235	Phosphorylation	LSLNLKQTSKTEEIK HHHCCCCCCCCHHHH		23403867
1236	Phosphorylation	SLNLKQTSKTEEIKN HHCCCCCCCCHHHHH		23403867
1238	Phosphorylation	NLKQTSKTEEIKNVL CCCCCCCCHHHHHHH		23403867
1251	Phosphorylation	VLGGSTCYNYSVKDL HHCCCCCCCCCCCCH		-
1273	Ubiquitination	LCFPSGQKIKSAYLP CCCCCCCCCHHEECC		29967540
1275	Ubiquitination	FPSGQKIKSAYLPQR CCCCCCCHHEECCCC		-
1275	Ubiquitination	FPSGQKIKSAYLPQR CCCCCCCHHEECCCC		-
1296	Phosphorylation	VFQSPAHYKQTFTSC ECCCCCHHHHHHHHH		-
1331	Phosphorylation	SKVDISFYTSLKGEK HCCCHHHHHCCCCHH		-
1421	Ubiquitination	GLYLRSQKIPLYEEC CHHHHCCCCCHHHHH		-
1421	Ubiquitination	GLYLRSQKIPLYEEC CHHHHCCCCCHHHHH		-
1434	Ubiquitination	ECQLLVRKGFDFQRK HHHHHHHCCCCCCHH		29967540
1448	Ubiquitination	KQYGKLKKFTTVNPE HHHCCCCCCEECCHH		29967540
1450	Phosphorylation	YGKLKKFTTVNPEFY HCCCCCCEECCHHHH		29083192
1451	Phosphorylation	GKLKKFTTVNPEFYN CCCCCCEECCHHHHC		29083192
1457	Phosphorylation	TTVNPEFYNEPKTKL EECCHHHHCCCCCHH		29083192
1461	Acetylation	PEFYNEPKTKLYLKL HHHHCCCCCHHEEEE		7926071
1462	Phosphorylation	EFYNEPKTKLYLKLS HHHCCCCCHHEEEEC		29083192
1463	Acetylation	FYNEPKTKLYLKLSR HHCCCCCHHEEEECH		7926079
1465	Phosphorylation	NEPKTKLYLKLSRKE CCCCCHHEEEECHHH		-
1467	Acetylation	PKTKLYLKLSRKERS CCCHHEEEECHHHHC		7926087
1478	Phosphorylation	KERSSAYSKNDLWVV HHHCCCCCCCCEEEE		-
1727	Ubiquitination	GSVRKIAKPILPYSL CCHHHCCCCCCCCCC		29967540
1753	Ubiquitination	KELHALMKEDLTPTE HHHHHHHHCCCCCCC		29967540
1757	Phosphorylation	ALMKEDLTPTERVYV HHHHCCCCCCCCEEE		23403867
1759	Phosphorylation	MKEDLTPTERVYVRK HHCCCCCCCCEEEHH		23403867
1763	Phosphorylation	LTPTERVYVRKSIEQ CCCCCCEEEHHHHHH		23403867
1772	Ubiquitination	RKSIEQHKLGTNRTL HHHHHHHCCCCCHHH		29967540
1772	Ubiquitination	RKSIEQHKLGTNRTL HHHHHHHCCCCCHHH		-
1781	Ubiquitination	GTNRTLLKQVRVVGV CCCHHHHHHCCEEEE		-
1781	Ubiquitination	GTNRTLLKQVRVVGV CCCHHHHHHCCEEEE		-
1830	Ubiquitination	IARFECEKLILVGDP EEEEEEEEEEEECCH		29967540
1877	Phosphorylation	PILLRTQYRCHPAIS CEEEECCCCCCHHHH		22210691
1884	Phosphorylation	YRCHPAISAIANDLF CCCCHHHHHHHCCHH		22210691
1901	Phosphorylation	GALMNGVTEIERSPL CHHHCCCCEEECCHH		22210691
1956	Phosphorylation	IASGIAGSMIGVITL HHCCCCHHHHHHHHH		24667141
1964	Phosphorylation	MIGVITLYKSQMYKL HHHHHHHHHHHHHHH		24667141
1969	Phosphorylation	TLYKSQMYKLCHLLS HHHHHHHHHHHHHHH		24667141
1987	Phosphorylation	FHHPDIKTVQVSTVD CCCCCCCEEEEEEEC		24667141

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZGRF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZGRF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZGRF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.