PRS23_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRS23_HUMAN
• UniProt AC: O95084
• Protein Name: Serine protease 23
• Gene Name: PRSS23
• Organism: Homo sapiens (Human).
• Sequence Length: 383
• Subcellular Localization: Secreted .
• Protein Sequence: MAGIPGLLFLLFFLLCAVGQVSPYSAPWKPTWPAYRLPVVLPQSTLNLAKPDFGAEAKLEVSSSCGPQCHKGTPLPTYEEAKQYLSYETLYANGSRTETQVGIYILSSSGDGAQHRDSGSSGKSRRKRQIYGYDSRFSIFGKDFLLNYPFSTSVKLSTGCTGTLVAEKHVLTAAHCIHDGKTYVKGTQKLRVGFLKPKFKDGGRGANDSTSAMPEQMKFQWIRVKRTHVPKGWIKGNANDIGMDYDYALLELKKPHKRKFMKIGVSPPAKQLPGGRIHFSGYDNDRPGNLVYRFCDVKDETYDLLYQQCDAQPGASGSGVYVRMWKRQQQKWERKIIGIFSGHQWVDMNGSPQDFNVAVRITPLKYAQICYWIKGNYLDCREG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Ubiquitination	QSTLNLAKPDFGAEA HHHCCCCCCCCCCEE	48.57	22817900
73	O-linked_Glycosylation	GPQCHKGTPLPTYEE CCCCCCCCCCCCHHH	26.84	OGP
84	Phosphorylation	TYEEAKQYLSYETLY CHHHHHHHCCEEEEE	9.26	29083192
86	Phosphorylation	EEAKQYLSYETLYAN HHHHHHCCEEEEECC	18.91	29083192
87	Phosphorylation	EAKQYLSYETLYANG HHHHHCCEEEEECCC	15.44	29083192
89	Phosphorylation	KQYLSYETLYANGSR HHHCCEEEEECCCCC	19.48	29083192
91	Phosphorylation	YLSYETLYANGSRTE HCCEEEEECCCCCCE	12.87	29083192
93	N-linked_Glycosylation	SYETLYANGSRTETQ CEEEEECCCCCCEEE	35.10	UniProtKB CARBOHYD
95	Phosphorylation	ETLYANGSRTETQVG EEEECCCCCCEEEEE	35.52	29083192
107	Phosphorylation	QVGIYILSSSGDGAQ EEEEEEECCCCCCCC	16.95	26091039
109	Phosphorylation	GIYILSSSGDGAQHR EEEEECCCCCCCCCC	37.21	26091039
131	Ubiquitination	SRRKRQIYGYDSRFS CHHHHEECCCCCCCE	10.99	21890473
131	Phosphorylation	SRRKRQIYGYDSRFS CHHHHEECCCCCCCE	10.99	-
138	Phosphorylation	YGYDSRFSIFGKDFL CCCCCCCEECCCCEE	18.85	22210691
154	O-linked_Glycosylation	NYPFSTSVKLSTGCT CCCCCCEEEECCCCC	7.97	-
161	Phosphorylation	VKLSTGCTGTLVAEK EEECCCCCCCEEEEE	34.25	-
190	Phosphorylation	YVKGTQKLRVGFLKP EEECCCEEEEEEECC	3.74	26091039
207	N-linked_Glycosylation	KDGGRGANDSTSAMP CCCCCCCCCCCCCCC	46.73	UniProtKB CARBOHYD
219	Phosphorylation	AMPEQMKFQWIRVKR CCCHHHCEEEEEEEC	6.46	-
247	Phosphorylation	DIGMDYDYALLELKK HCCCCHHHHHHCCCC	7.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
109	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRS23_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRS23_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
B2MG_HUMAN	B2M	physical	16169070
CHP1_HUMAN	CHP1	physical	16169070
TM222_HUMAN	TMEM222	physical	16169070
EFNA3_HUMAN	EFNA3	physical	16169070
GALD1_HUMAN	PDDC1	physical	16169070
GRK6_HUMAN	GRK6	physical	16169070
HSP74_HUMAN	HSPA4	physical	16169070
NIPBL_HUMAN	NIPBL	physical	16169070
CNDD3_HUMAN	NCAPD3	physical	16169070
JIP2_HUMAN	MAPK8IP2	physical	16169070
PHF23_HUMAN	PHF23	physical	16169070
RECQ4_HUMAN	RECQL4	physical	16169070
GLYC_HUMAN	SHMT1	physical	16169070
HTF4_HUMAN	TCF12	physical	16169070
TPPC4_HUMAN	TRAPPC4	physical	16169070
ODF2L_HUMAN	ODF2L	physical	16169070
NOC4L_HUMAN	NOC4L	physical	16169070
PDPK1_HUMAN	PDPK1	physical	16169070
RGAP1_HUMAN	RACGAP1	physical	16169070
ADT3_HUMAN	SLC25A6	physical	16169070
FXR1_HUMAN	FXR1	physical	16169070
ACTG_HUMAN	ACTG1	physical	16169070
PPIA_HUMAN	PPIA	physical	16169070
A4_HUMAN	APP	physical	21832049
ACTB_HUMAN	ACTB	physical	26186194
LRP2_HUMAN	LRP2	physical	26186194
ACTB_HUMAN	ACTB	physical	28514442
CO5A1_HUMAN	COL5A1	physical	28514442
UBR1_HUMAN	UBR1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.