EFNA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFNA3_HUMAN
• UniProt AC: P52797
• Protein Name: Ephrin-A3
• Gene Name: EFNA3
• Organism: Homo sapiens (Human).
• Sequence Length: 238
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor.
• Protein Description: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity)..
• Protein Sequence: MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNASQGFKRWECNRPHAPHSPIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	N-linked_Glycosylation	NRHAVYWNSSNQHLR CCCEEEECCCCCCHH	20.20	UniProtKB CARBOHYD
67	N-linked_Glycosylation	DIYCPHYNSSGVGPG EEECCCCCCCCCCCC	27.02	UniProtKB CARBOHYD
100	N-linked_Glycosylation	RNGYRTCNASQGFKR CCCEECCCCCCCCCC	41.85	UniProtKB CARBOHYD
123	Phosphorylation	PHSPIKFSEKFQRYS CCCCCCCCHHHHHHE	34.57	24719451
170	O-linked_Glycosylation	VFVCCASTSHSGEKP EEEEECCCCCCCCCC	16.37	OGP
180	Phosphorylation	SGEKPVPTLPQFTMG CCCCCCCCCCCCCCC	51.83	24043423
185	Phosphorylation	VPTLPQFTMGPNVKI CCCCCCCCCCCCCEE	18.90	24043423
213	Phosphorylation	PKLEKSISGTSPKRE CCCCCCCCCCCCCHH	43.01	28348404
214	GPI-anchor	KLEKSISGTSPKREH CCCCCCCCCCCCHHH	28.66	-
215	Phosphorylation	LEKSISGTSPKREHL CCCCCCCCCCCHHHH	34.76	28348404
216	Phosphorylation	EKSISGTSPKREHLP CCCCCCCCCCHHHHH	31.76	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFNA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFNA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFNA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EPHA7_HUMAN	EPHA7	physical	10366629
MEOX2_HUMAN	MEOX2	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.