CHP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHP1_HUMAN
• UniProt AC: Q99653
• Protein Name: Calcineurin B homologous protein 1
• Gene Name: CHP1
• Organism: Homo sapiens (Human).
• Sequence Length: 195
• Subcellular Localization: Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Endomembrane system . Endoplasmic reticulum-Golgi intermediate compartment . Endoplasmic reticulum . Cell membrane . Membrane ; Lipid-anchor . Localizes in cytoplasmic compartments in dividing cells. Lo
• Protein Description: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner..
• Protein Sequence: MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVLEKVDVEQKMSIRFLH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGSRASTLL ------CCCHHHHHC	26.32	-
2	Myristoylation	------MGSRASTLL ------CCCHHHHHC	26.32	25255805
6	Phosphorylation	--MGSRASTLLRDEE --CCCHHHHHCCHHH	20.62	28348404
7	Phosphorylation	-MGSRASTLLRDEEL -CCCHHHHHCCHHHH	28.91	28355574
10	Methylation	SRASTLLRDEELEEI CHHHHHCCHHHHHHH	53.02	-
19	2-Hydroxyisobutyrylation	EELEEIKKETGFSHS HHHHHHHHHHCCCHH	67.19	-
19	Ubiquitination	EELEEIKKETGFSHS HHHHHHHHHHCCCHH	67.19	-
21	Phosphorylation	LEEIKKETGFSHSQI HHHHHHHHCCCHHHH	53.02	24719451
24	Phosphorylation	IKKETGFSHSQITRL HHHHHCCCHHHHHHH	24.47	23663014
26	Phosphorylation	KETGFSHSQITRLYS HHHCCCHHHHHHHHH	23.29	23663014
29	Phosphorylation	GFSHSQITRLYSRFT CCCHHHHHHHHHHHH	13.64	23663014
32	Phosphorylation	HSQITRLYSRFTSLD HHHHHHHHHHHHCCC	8.43	24719451
33	Phosphorylation	SQITRLYSRFTSLDK HHHHHHHHHHHCCCC	26.05	24719451
37	Phosphorylation	RLYSRFTSLDKGENG HHHHHHHCCCCCCCC	31.68	-
40	Ubiquitination	SRFTSLDKGENGTLS HHHHCCCCCCCCCCC	73.71	21906983
40	2-Hydroxyisobutyrylation	SRFTSLDKGENGTLS HHHHCCCCCCCCCCC	73.71	-
86	Phosphorylation	NFRGFMRTLAHFRPI CHHHHHHHHHHCCCC	19.26	20068231
98	Ubiquitination	RPIEDNEKSKDVNGP CCCCCCCCCCCCCCC	69.89	-
100	Ubiquitination	IEDNEKSKDVNGPEP CCCCCCCCCCCCCCC	76.42	21906983
114	Ubiquitination	PLNSRSNKLHFAFRL CCCCCCCCCEEEEEE	44.58	-
126	Ubiquitination	FRLYDLDKDEKISRD EEECCCCCCCCCCHH	75.08	-
126	2-Hydroxyisobutyrylation	FRLYDLDKDEKISRD EEECCCCCCCCCCHH	75.08	-
129	2-Hydroxyisobutyrylation	YDLDKDEKISRDELL CCCCCCCCCCHHHHH	56.99	-
154	Phosphorylation	ISDEQLGSIADRTIQ CCHHHHHHHHHHHHH	24.16	-
178	Ubiquitination	ISFTEFVKVLEKVDV EEHHHHHHHHHHCCH	46.56	21906983
182	Ubiquitination	EFVKVLEKVDVEQKM HHHHHHHHCCHHHHH	39.30	21906983
182	2-Hydroxyisobutyrylation	EFVKVLEKVDVEQKM HHHHHHHHCCHHHHH	39.30	-
188	Ubiquitination	EKVDVEQKMSIRFLH HHCCHHHHHCCEECC	22.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SL9A1_HUMAN	SLC9A1	physical	12576672
SL9A2_HUMAN	SLC9A2	physical	12576672
SL9A3_HUMAN	SLC9A3	physical	12576672
SL9A4_HUMAN	SLC9A4	physical	12576672
SL9A5_HUMAN	SLC9A5	physical	12576672
SL9A1_HUMAN	SLC9A1	physical	8901634
SL9A1_HUMAN	SLC9A1	physical	11350981

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D00107: Tacrolimus hydrate (JP16); Tacrolimus (USAN/INN); Prograf (TN); Protopic (TN)
• D00184: Ciclosporin (JP16); Cyclosporine (USP); Gengraf (TN); Neoral (TN); Restasis (TN); Sandimmune (TN)
• D05480: Pimecrolimus (JAN/USAN/INN); Elidel (TN)
• D08556: Tacrolimus (INN); Prograf (TN)
• D09033: Voclosporin (USAN/INN)
• DrugBank
• There are no disease associations of PTM sites.