SL9A5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SL9A5_HUMAN
• UniProt AC: Q14940
• Protein Name: Sodium/hydrogen exchanger 5
• Gene Name: SLC9A5
• Organism: Homo sapiens (Human).
• Sequence Length: 896
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity)..
• Protein Sequence: MLRAALSLLALPLAGAAEEPTQKPESPGEPPPGLELFRWQWHEVEAPYLVALWILVASLAKIVFHLSRKVTSLVPESCLLILLGLVLGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAVDSSKWAWDSGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVKRSEHHKPTLNQELHEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMRRSAYRIRDQIWDVYYRLNIRDAISFVDQGGHVLSSTGLTLPSMPSRNSVAETSVTNLLRESGSGACLDLQVIDTVRSGRDREDAVMHHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRRLESFKSTKHNICFTKSKPRPRKTGRRKKDGVANAEATNGKHRGLGFQDTAAVILTVESEEEEEESDSSETEKEDDEGIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKELPWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSISSLESLASPPCNQAPILTCLPPHPRGTEEPQVPLHLPSDPRSSFAFPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGTATSHWCIQFNRGSRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
199	N-linked_Glycosylation	VFEEVHVNETLFIIV HEEEEECCCEEEEEE	22.97	UniProtKB CARBOHYD
319	N-linked_Glycosylation	CKKYVEANISHKSRT CHHHHHHHCCCCCCC	23.84	UniProtKB CARBOHYD
321	Phosphorylation	KYVEANISHKSRTTV HHHHHHCCCCCCCHH	25.35	22964224
459	Ubiquitination	LVKWLKVKRSEHHKP HHHHHHHCCCCCCCC	48.93	-
538	Phosphorylation	LNIRDAISFVDQGGH CCHHHHHHEEECCCC	22.42	-
559	Phosphorylation	LTLPSMPSRNSVAET CCCCCCCCCCCCCHH	35.14	-
566	Phosphorylation	SRNSVAETSVTNLLR CCCCCCHHHHHHHHH	20.82	27732954
567	Phosphorylation	RNSVAETSVTNLLRE CCCCCHHHHHHHHHH	20.60	27732954
569	Phosphorylation	SVAETSVTNLLRESG CCCHHHHHHHHHHHC	21.66	27732954
575	Phosphorylation	VTNLLRESGSGACLD HHHHHHHHCCCCEEE	31.65	30266825
577	Phosphorylation	NLLRESGSGACLDLQ HHHHHHCCCCEEEEE	32.28	30266825
618	Phosphorylation	PRRRYKASCSRHFIS CCHHHHCCHHHHCCC	14.42	-
620	Phosphorylation	RRYKASCSRHFISED HHHHCCHHHHCCCHH	26.71	-
647	Phosphorylation	NMKRRLESFKSTKHN HHHHHHHHHHCCCCC	42.43	23312004
681	Phosphorylation	GVANAEATNGKHRGL CCCCCHHCCCCCCCC	35.69	30576142
702	Phosphorylation	AVILTVESEEEEEES EEEEEECCHHHHHCC	46.07	21296876
709	Phosphorylation	SEEEEEESDSSETEK CHHHHHCCCCCCCCC	46.18	21296876
711	Phosphorylation	EEEEESDSSETEKED HHHHCCCCCCCCCCC	39.08	21296876
712	Phosphorylation	EEEESDSSETEKEDD HHHCCCCCCCCCCCC	54.23	21296876
714	Phosphorylation	EESDSSETEKEDDEG HCCCCCCCCCCCCCC	55.06	21296876
729	Phosphorylation	IIFVARATSEVLQEG EEEEEEEHHHHHHCC	21.62	-
739	Phosphorylation	VLQEGKVSGSLEVCP HHHCCCCCCCCEECC	26.59	22210691
741	Phosphorylation	QEGKVSGSLEVCPSP HCCCCCCCCEECCCC	17.53	22210691
747	Phosphorylation	GSLEVCPSPRIIPPS CCCEECCCCCCCCCC	22.99	29978859
851	Phosphorylation	SLAKAGRSRSESSAD HHHHCCCCCCCCCCC	38.96	-
853	Phosphorylation	AKAGRSRSESSADLP HHCCCCCCCCCCCCC	42.97	-
855	Phosphorylation	AGRSRSESSADLPQQ CCCCCCCCCCCCCCH	31.88	-
856	Phosphorylation	GRSRSESSADLPQQQ CCCCCCCCCCCCCHH	23.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
575	S	Phosphorylation	Kinase	AMPKA2	Q09137	PSP
577	S	Phosphorylation	Kinase	AMPKA2	Q09137	PSP
618	S	Phosphorylation	Kinase	AMPKA2	Q09137	PSP
620	S	Phosphorylation	Kinase	AMPKA2	Q09137	PSP
702	S	Phosphorylation	Kinase	GRK2	P25098	PSP
702	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
709	S	Phosphorylation	Kinase	GRK2	P25098	PSP
709	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
711	S	Phosphorylation	Kinase	GRK2	P25098	PSP
711	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
712	S	Phosphorylation	Kinase	GRK2	P25098	PSP
712	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
714	T	Phosphorylation	Kinase	GRK2	P25098	PSP
714	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
851	S	Phosphorylation	Kinase	AMPKA2	Q09137	PSP
853	S	Phosphorylation	Kinase	AMPKA2	Q09137	PSP
855	S	Phosphorylation	Kinase	AMPKA2	Q09137	PSP
856	S	Phosphorylation	Kinase	AMPKA2	Q09137	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SL9A5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SL9A5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARRB2_HUMAN	ARRB2	physical	15699339
ARRB1_HUMAN	ARRB1	physical	15699339

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.