SL9A3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SL9A3_HUMAN
• UniProt AC: P48764
• Protein Name: Sodium/hydrogen exchanger 3 {ECO:0000305}
• Gene Name: SLC9A3 {ECO:0000312|HGNC:HGNC:11073}
• Organism: Homo sapiens (Human).
• Sequence Length: 834
• Subcellular Localization: Apical cell membrane ; Multi-pass membrane protein . In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical ex
• Protein Description: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. [PubMed: 26358773 Plays an important role in signal transduction.]
• Protein Sequence: MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQVVTFEWAHVQDPYVIALWILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQSLEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKRLESFKSTKLGLNQNKKAAKLYKRERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDTEEPPNYDEEMSGGIEFLASVTKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGETVVPSQRARTQIPYSPGTFCRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
241	N-linked_Glycosylation	FVALGGDNVTGVDCV HHHCCCCCCCCHHHH	36.20	UniProtKB CARBOHYD
326	N-linked_Glycosylation	CQKYVKANISEQSAT HHHHHHHCCCHHCCH	32.38	UniProtKB CARBOHYD
396	Phosphorylation	QTWLLNRYRMVQLEP HHHHHHCCCCCCCCC	11.29	-
502	Phosphorylation	SGQIGHNYLRDKWSH HCCCCCHHHHHCCCH	9.46	22817900
545	Phosphorylation	LNLKDAISYVAEGER CCHHHHHHHHHCCCC	18.44	28857561
546	Phosphorylation	NLKDAISYVAEGERR CHHHHHHHHHCCCCC	9.51	23312004
555	Phosphorylation	AEGERRGSLAFIRSP HCCCCCCCEEEEECC	18.08	26657352
561	Phosphorylation	GSLAFIRSPSTDNVV CCEEEEECCCCCCEE	20.56	28857561
563	Phosphorylation	LAFIRSPSTDNVVNV EEEEECCCCCCEEEE	50.03	26657352
564	Phosphorylation	AFIRSPSTDNVVNVD EEEECCCCCCEEEEE	34.67	28857561
576	Phosphorylation	NVDFTPRSSTVEASV EEEECCCCCCHHHHH	31.40	28857561
577	Phosphorylation	VDFTPRSSTVEASVS EEECCCCCCHHHHHH	37.44	26657352
578	Phosphorylation	DFTPRSSTVEASVSY EECCCCCCHHHHHHH	24.50	28857561
592	Phosphorylation	YLLRENVSAVCLDMQ HHHHCCCCHHEECHH	26.94	24719451
600	Phosphorylation	AVCLDMQSLEQRRRS HHEECHHHHHHHHHH	27.51	24719451
607	Phosphorylation	SLEQRRRSIRDAEDM HHHHHHHHHHHHHHH	21.84	-
636	Phosphorylation	QEYKHLYSRHELTPT HHHHHHHHCCCCCCC	33.26	24719451
641	Phosphorylation	LYSRHELTPTEDEKQ HHHCCCCCCCCCHHH	25.77	23312004
643	Phosphorylation	SRHELTPTEDEKQDR HCCCCCCCCCHHHHH	51.32	23312004
663	Phosphorylation	TMRKRLESFKSTKLG HHHHHHHHHHHCCCC	42.43	28674151
682	Acetylation	KKAAKLYKRERAQKR HHHHHHHHHHHHHHH	59.21	7338343
693	Phosphorylation	AQKRRNSSIPNGKLP HHHHHCCCCCCCCCC	45.68	30576142
748	Phosphorylation	TKDTASDSPAGIDNP CCCCCCCCCCCCCCC	17.72	26657352
793	Phosphorylation	RARTQIPYSPGTFCR CCCCCCCCCCCCCEE	29.18	23312004
794	Phosphorylation	ARTQIPYSPGTFCRL CCCCCCCCCCCCEEE	16.11	23312004
797	Phosphorylation	QIPYSPGTFCRLMPF CCCCCCCCCEEEECE	23.97	23312004
807	Phosphorylation	RLMPFRLSSKSVDSF EEECEECCCCCHHHH	31.31	28857561
808	Phosphorylation	LMPFRLSSKSVDSFL EECEECCCCCHHHHH	33.28	28857561
810	Phosphorylation	PFRLSSKSVDSFLQA CEECCCCCHHHHHHC	32.86	23312004
813	Phosphorylation	LSSKSVDSFLQADGP CCCCCHHHHHHCCCC	26.21	23312004
831	Phosphorylation	PPAALPESTHM---- CCCCCCCCCCC----	22.98	23312004
832	Phosphorylation	PAALPESTHM----- CCCCCCCCCC-----	21.94	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
663	S	Phosphorylation	Kinase	RPS6KA3	P51812	GPS
663	S	Phosphorylation	Kinase	SGK1	O00141	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
663	S	Phosphorylation	Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SL9A3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHP2_HUMAN	CHP2	physical	12576672
CHP1_HUMAN	CHP1	physical	12576672
NHRF2_HUMAN	SLC9A3R2	physical	9748260
DRD3_HUMAN	DRD3	physical	24308971
NED4L_HUMAN	NEDD4L	physical	24831004

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.