| UniProt ID | DRD3_HUMAN | |
|---|---|---|
| UniProt AC | P35462 | |
| Protein Name | D(3) dopamine receptor | |
| Gene Name | DRD3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 400 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 m |
|
| Protein Description | Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.. | |
| Protein Sequence | MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | N-linked_Glycosylation | SQLSSHLNYTCGAEN HHHHHHHCCCCCCCC | 25.33 | UniProtKB CARBOHYD | |
| 19 | N-linked_Glycosylation | NYTCGAENSTGASQA CCCCCCCCCCCCCCC | 44.32 | UniProtKB CARBOHYD | |
| 97 | N-linked_Glycosylation | EVTGGVWNFSRICCD EECCCCCCHHHHHHC | 23.70 | UniProtKB CARBOHYD | |
| 142 | Phosphorylation | PVHYQHGTGQSSCRR ECCCCCCCCCCHHHH | 29.89 | - | |
| 173 | N-linked_Glycosylation | CPLLFGFNTTGDPTV CHHHCCCCCCCCCCE | 36.79 | UniProtKB CARBOHYD | |
| 225 | Phosphorylation | RRRKRILTRQNSQCN HHHHHHHHHCCCCCC | 28.04 | 17536008 | |
| 229 | Phosphorylation | RILTRQNSQCNSVRP HHHHHCCCCCCCCCC | 27.98 | 17536008 | |
| 233 | Phosphorylation | RQNSQCNSVRPGFPQ HCCCCCCCCCCCCCC | 27.42 | 17536008 | |
| 257 | Phosphorylation | LELKRYYSICQDTAL HHHHHHHHHHHHHHC | 14.14 | 17536008 | |
| 282 (in isoform 3) | Phosphorylation | - | 38.06 | 27251275 | |
| 282 | Phosphorylation | ELKREEKTRNSLSPT CCCHHHHHHCCCCCC | 38.06 | 27251275 | |
| 285 | Phosphorylation | REEKTRNSLSPTIAP HHHHHHCCCCCCCHH | 27.25 | 20068231 | |
| 285 (in isoform 3) | Phosphorylation | - | 27.25 | 22210691 | |
| 287 | Phosphorylation | EKTRNSLSPTIAPKL HHHHCCCCCCCHHHH | 21.59 | 20068231 | |
| 289 | Phosphorylation | TRNSLSPTIAPKLSL HHCCCCCCCHHHHCE | 26.79 | 20068231 | |
| 295 | Phosphorylation | PTIAPKLSLEVRKLS CCCHHHHCEEEEECC | 28.72 | 20068231 | |
| 302 | Phosphorylation | SLEVRKLSNGRLSTS CEEEEECCCCCCCCE | 40.03 | 20068231 | |
| 309 | Phosphorylation | SNGRLSTSLKLGPLQ CCCCCCCEEECCCCC | 21.82 | - | |
| 400 | S-palmitoylation | AFLKILSC------- HHHHHHCC------- | 6.07 | 27349735 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DRD3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DRD3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DRD3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CLIC6_HUMAN | CLIC6 | physical | 14499480 | |
| MPDZ_HUMAN | MPDZ | physical | 14499480 | |
| GIPC1_HUMAN | GIPC1 | physical | 14499480 | |
| RADI_HUMAN | RDX | physical | 14499480 | |
| E41L1_HUMAN | EPB41L1 | physical | 12181426 | |
| SL9A3_HUMAN | SLC9A3 | physical | 24308971 | |
| UBP48_HUMAN | USP48 | physical | 24308971 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 190300 | Tremor, hereditary essential 1 (ETM1) | |||||
| Kegg Drug | ||||||
| D00059 | Levodopa (JP16/USP/INN); Dopar (TN) | |||||
| D00454 | Olanzapine (JAN/USAN/INN); Zyprexa (TN) | |||||
| D00458 | Quetiapine fumarate (JP16/USAN); Seroquel (TN) | |||||
| D00559 | Pramipexole hydrochloride hydrate (JAN); Pramipexole hydrochloride (USAN); Mirapex (TN) | |||||
| D00560 | Pimozide (JP16/USP/INN); Orap (TN) | |||||
| D00633 | Dopamine hydrochloride (JP16/USP); Actopamin (TN); Intropin (TN) | |||||
| D01226 | Sulpiride (JP16/USAN/INN); Dogmatyl (TN) | |||||
| D01468 | Nemonapride (JAN/INN); Emilace (TN) | |||||
| D02676 | Oxiperomide (USAN/INN) | |||||
| D03891 | Dopexamine (USAN/INN) | |||||
| D05575 | Pramipexole (USAN/INN) | |||||
| D05682 | Quinpirole hydrochloride (USAN) | |||||
| D06623 | Olanzapine pamoate (USAN); Olanzapine pamoate monohydrate | |||||
| D07305 | Piribedil (INN); Trivastal (TN) | |||||
| D07312 | Levosulpiride (INN); Levopraid (TN) | |||||
| D07870 | Dopamine (INN); Medopa (TN) | |||||
| D08456 | Quetiapine (INN); Norsic (TN) | |||||
| D09366 | Pardoprunox hydrochloride (USAN) | |||||
| D09397 | Pardoprunox (USAN/INN) | |||||
| D09876 | Cariprazine hydrochloride (JAN/USAN) | |||||
| D09997 | Cariprazine (USAN/INN) | |||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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