UBP48_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP48_HUMAN
• UniProt AC: Q86UV5
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 48
• Gene Name: USP48
• Organism: Homo sapiens (Human).
• Sequence Length: 1035
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites..
• Protein Sequence: MAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVCRRNCKGNPNCLVGIGEHIWLGEIDENSFHNIDDPNCERRKKNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDYMLGDGIQEEKDYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALGLDTGQQQDAQEFSKLFMSLLEDTLSKQKNPDVRNIVQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNIQGHKQLTDCISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNTYIGFSEILDMEPYVEHKGGSYVYELSAVLIHRGVSAYSGHYIAHVKDPQSGEWYKFNDEDIEKMEGKKLQLGIEEDLAEPSKSQTRKPKCGKGTHCSRNAYMLVYRLQTQEKPNTTVQVPAFLQELVDRDNSKFEEWCIEMAEMRKQSVDKGKAKHEEVKELYQRLPAGAEPYEFVSLEWLQKWLDESTPTKPIDNHACLCSHDKLHPDKISIMKRISEYAADIFYSRYGGGPRLTVKALCKECVVERCRILRLKNQLNEDYKTVNNLLKAAVKGSDGFWVGKSSLRSWRQLALEQLDEQDGDAEQSNGKMNGSTLNKDESKEERKEEEELNFNEDILCPHGELCISENERRLVSKEAWSKLQQYFPKAPEFPSYKECCSQCKILEREGEENEALHKMIANEQKTSLPNLFQDKNRPCLSNWPEDTDVLYIVSQFFVEEWRKFVRKPTRCSPVSSVGNSALLCPHGGLMFTFASMTKEDSKLIALIWPSEWQMIQKLFVVDHVIKITRIEVGDVNPSETQYISEPKLCPECREGLLCQQQRDLREYTQATIYVHKVVDNKKVMKDSAPELNVSSSETEEDKEEAKPDGEKDPDFNQSNGGTKRQKISHQNYIAYQKQVIRRSMRHRKVRGEKALLVSANQTLKELKIQIMHAFSVAPFDQNLSIDGKILSDDCATLGTLGVIPESVILLKADEPIADYAAMDDVMQVCMPEEGFKGTGLLGH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Ubiquitination	APRLQLEKAAWRWAE CCHHHHHHHHHHHHH	52.58	-
9	Acetylation	APRLQLEKAAWRWAE CCHHHHHHHHHHHHH	52.58	26051181
9	Ubiquitination	APRLQLEKAAWRWAE CCHHHHHHHHHHHHH	52.58	-
11 (in isoform 6)	Phosphorylation	-	13.87	25056879
12 (in isoform 6)	Phosphorylation	-	10.95	25056879
13 (in isoform 6)	Phosphorylation	-	20.28	25056879
43	Ubiquitination	LEPCIRGVCRRNCKG HHHHHHHHHHHHCCC	1.32	21963094
70 (in isoform 6)	Ubiquitination	-	46.34	21890473
71	Phosphorylation	LGEIDENSFHNIDDP EEECCCCCCCCCCCC	26.32	28348404
72	Ubiquitination	GEIDENSFHNIDDPN EECCCCCCCCCCCCC	8.46	22817900
74	Ubiquitination	IDENSFHNIDDPNCE CCCCCCCCCCCCCCC	37.06	22817900
81 (in isoform 6)	Ubiquitination	-	63.26	21890473
90 (in isoform 5)	Ubiquitination	-	25.44	-
94 (in isoform 5)	Ubiquitination	-	4.09	-
103	Ubiquitination	ATCYVNTFLQVWFLN CCCHHHHHHHHHHHC	3.66	21963094
126 (in isoform 5)	Ubiquitination	-	34.70	-
132	Ubiquitination	SDYMLGDGIQEEKDY CHHHCCCCCCCCCCC	22.98	22817900
134	Ubiquitination	YMLGDGIQEEKDYEP HHCCCCCCCCCCCCH	59.32	22817900
137	Ubiquitination	GDGIQEEKDYEPQTI CCCCCCCCCCCHHHH	65.93	23000965
141	Ubiquitination	QEEKDYEPQTICEHL CCCCCCCHHHHHHHH	30.31	23000965
149	Ubiquitination	QTICEHLQYLFALLQ HHHHHHHHHHHHHHH	34.49	21963094
162	Phosphorylation	LQNSNRRYIDPSGFV HHCCCCCCCCCHHHH	13.36	-
169	Ubiquitination	YIDPSGFVKALGLDT CCCCHHHHHHHCCCC	3.96	23000965
170	Ubiquitination	IDPSGFVKALGLDTG CCCHHHHHHHCCCCC	35.32	21890473
170	Ubiquitination	IDPSGFVKALGLDTG CCCHHHHHHHCCCCC	35.32	21963094
170 (in isoform 1)	Ubiquitination	-	35.32	21890473
170 (in isoform 2)	Ubiquitination	-	35.32	21890473
170 (in isoform 3)	Ubiquitination	-	35.32	21890473
170 (in isoform 4)	Ubiquitination	-	35.32	21890473
170 (in isoform 7)	Ubiquitination	-	35.32	21890473
173	Ubiquitination	SGFVKALGLDTGQQQ HHHHHHHCCCCCCHH	26.77	21890473
187	Ubiquitination	QDAQEFSKLFMSLLE HHHHHHHHHHHHHHH	51.57	-
199	Ubiquitination	LLEDTLSKQKNPDVR HHHHHHHHCCCHHHH	69.29	-
199	Ubiquitination	LLEDTLSKQKNPDVR HHHHHHHHCCCHHHH	69.29	21906983
199 (in isoform 1)	Ubiquitination	-	69.29	21890473
199 (in isoform 2)	Ubiquitination	-	69.29	21890473
199 (in isoform 3)	Ubiquitination	-	69.29	21890473
199 (in isoform 4)	Ubiquitination	-	69.29	21890473
199 (in isoform 7)	Ubiquitination	-	69.29	21890473
201	Ubiquitination	EDTLSKQKNPDVRNI HHHHHHCCCHHHHHH	74.34	-
201	Ubiquitination	EDTLSKQKNPDVRNI HHHHHHCCCHHHHHH	74.34	22817900
207 (in isoform 5)	Ubiquitination	-	38.33	-
209	Ubiquitination	NPDVRNIVQQQFCGE CHHHHHHHHHHHCCC	4.86	21963094
212 (in isoform 5)	Ubiquitination	-	20.64	-
219 (in isoform 5)	Ubiquitination	-	8.85	21890473
227 (in isoform 5)	Ubiquitination	-	26.99	-
231	Ubiquitination	NQCGRESKLLSKFYE CCCCCHHHHHHHHHH	49.01	-
234 (in isoform 5)	Ubiquitination	-	31.02	-
241	Ubiquitination	SKFYELELNIQGHKQ HHHHHHHHHCCCHHH	12.22	22817900
254	Phosphorylation	KQLTDCISEFLKEEK HHHHHHHHHHHHHCC	28.73	26846344
255	Ubiquitination	QLTDCISEFLKEEKL HHHHHHHHHHHHCCC	34.78	23000965
258	Ubiquitination	DCISEFLKEEKLEGD HHHHHHHHHCCCCCC	69.97	-
258	Ubiquitination	DCISEFLKEEKLEGD HHHHHHHHHCCCCCC	69.97	29967540
260	Ubiquitination	ISEFLKEEKLEGDNR HHHHHHHCCCCCCCC	62.44	23000965
267	Methylation	EKLEGDNRYFCENCQ CCCCCCCCCCCCCCC	30.55	115919645
267	Ubiquitination	EKLEGDNRYFCENCQ CCCCCCCCCCCCCCC	30.55	21890473
275	Ubiquitination	YFCENCQSKQNATRK CCCCCCCCCCCCCHH	38.11	21963094
276	Ubiquitination	FCENCQSKQNATRKI CCCCCCCCCCCCHHH	22.99	-
276	Ubiquitination	FCENCQSKQNATRKI CCCCCCCCCCCCHHH	22.99	21963094
287	Phosphorylation	TRKIRLLSLPCTLNL CHHHHHHHCCEECHH	34.55	28188228
301	Ubiquitination	LQLMRFVFDRQTGHK HHHHHHHHCCCCCCC	6.19	22817900
326	Phosphorylation	EILDMEPYVEHKGGS HHCCCCCCEEECCCC	12.74	-
368	Ubiquitination	PQSGEWYKFNDEDIE CCCCCEEEECHHHHH	38.47	-
368	Ubiquitination	PQSGEWYKFNDEDIE CCCCCEEEECHHHHH	38.47	21906983
368 (in isoform 1)	Ubiquitination	-	38.47	21890473
368 (in isoform 2)	Ubiquitination	-	38.47	21890473
368 (in isoform 3)	Ubiquitination	-	38.47	21890473
368 (in isoform 7)	Ubiquitination	-	38.47	21890473
376	Ubiquitination	FNDEDIEKMEGKKLQ ECHHHHHHHCCCCCC	42.45	23503661
380	Ubiquitination	DIEKMEGKKLQLGIE HHHHHCCCCCCCCCC	36.68	23503661
381	Ubiquitination	IEKMEGKKLQLGIEE HHHHCCCCCCCCCCC	52.93	29967540
394	Phosphorylation	EEDLAEPSKSQTRKP CCCCCCCCCCCCCCC	36.12	-
395	Ubiquitination	EDLAEPSKSQTRKPK CCCCCCCCCCCCCCC	58.25	32015554
396	Phosphorylation	DLAEPSKSQTRKPKC CCCCCCCCCCCCCCC	40.91	28555341
398	Phosphorylation	AEPSKSQTRKPKCGK CCCCCCCCCCCCCCC	47.99	-
406 (in isoform 5)	Ubiquitination	-	13.13	21890473
412 (in isoform 5)	Ubiquitination	-	21.09	-
424	Ubiquitination	VYRLQTQEKPNTTVQ EEEECCCCCCCCEEE	74.08	23000965
425	Ubiquitination	YRLQTQEKPNTTVQV EEECCCCCCCCEEEC	33.48	29967540
428	Ubiquitination	QTQEKPNTTVQVPAF CCCCCCCCEEECCHH	36.55	23000965
454	Ubiquitination	FEEWCIEMAEMRKQS HHHHHHHHHHHHHHH	1.62	21890473
456	Ubiquitination	EWCIEMAEMRKQSVD HHHHHHHHHHHHHHH	37.90	23000965
460	Ubiquitination	EMAEMRKQSVDKGKA HHHHHHHHHHHHHHH	38.02	21890473
467	Ubiquitination	QSVDKGKAKHEEVKE HHHHHHHHCHHHHHH	27.40	-
468	Ubiquitination	SVDKGKAKHEEVKEL HHHHHHHCHHHHHHH	55.84	29967540
473	Ubiquitination	KAKHEEVKELYQRLP HHCHHHHHHHHHHCC	45.33	29967540
484	Ubiquitination	QRLPAGAEPYEFVSL HHCCCCCCCEEEECH	47.71	23000965
488	Ubiquitination	AGAEPYEFVSLEWLQ CCCCCEEEECHHHHH	3.59	23000965
501	Phosphorylation	LQKWLDESTPTKPID HHHHHCCCCCCCCCC	39.08	25627689
502	Phosphorylation	QKWLDESTPTKPIDN HHHHCCCCCCCCCCC	32.69	25627689
505	Ubiquitination	LDESTPTKPIDNHAC HCCCCCCCCCCCCEE	40.97	29967540
516	Ubiquitination	NHACLCSHDKLHPDK CCEEEECCCCCCHHH	34.92	23000965
517	Ubiquitination	HACLCSHDKLHPDKI CEEEECCCCCCHHHH	38.63	23000965
518	Ubiquitination	ACLCSHDKLHPDKIS EEEECCCCCCHHHHH	43.18	29967540
520	Ubiquitination	LCSHDKLHPDKISIM EECCCCCCHHHHHHH	33.96	21890473
521	Ubiquitination	CSHDKLHPDKISIMK ECCCCCCHHHHHHHH	55.84	21890473
523	Ubiquitination	HDKLHPDKISIMKRI CCCCCHHHHHHHHHH	42.69	29967540
531	Ubiquitination	ISIMKRISEYAADIF HHHHHHHHHHHHHHH	28.70	21890473
542	Ubiquitination	ADIFYSRYGGGPRLT HHHHHHHCCCCCCCH	17.74	21890473
545	Ubiquitination	FYSRYGGGPRLTVKA HHHHCCCCCCCHHHH	10.37	23000965
547	Ubiquitination	SRYGGGPRLTVKALC HHCCCCCCCHHHHHH	46.39	23000965
550	Ubiquitination	GGGPRLTVKALCKEC CCCCCCHHHHHHHHH	3.96	-
550	Ubiquitination	GGGPRLTVKALCKEC CCCCCCHHHHHHHHH	3.96	23000965
551	Ubiquitination	GGPRLTVKALCKECV CCCCCHHHHHHHHHH	30.33	23000965
554	Ubiquitination	RLTVKALCKECVVER CCHHHHHHHHHHHHH	4.10	-
554	Ubiquitination	RLTVKALCKECVVER CCHHHHHHHHHHHHH	4.10	21890473
555	Ubiquitination	LTVKALCKECVVERC CHHHHHHHHHHHHHH	55.81	23000965
562	Ubiquitination	KECVVERCRILRLKN HHHHHHHHHHHHHHH	1.69	21963094
568	Ubiquitination	RCRILRLKNQLNEDY HHHHHHHHHHCCCCH	35.89	29967540
576	Ubiquitination	NQLNEDYKTVNNLLK HHCCCCHHHHHHHHH	59.32	-
582	Ubiquitination	YKTVNNLLKAAVKGS HHHHHHHHHHHHCCC	3.74	23000965
583	Ubiquitination	KTVNNLLKAAVKGSD HHHHHHHHHHHCCCC	37.15	23000965
586	Ubiquitination	NNLLKAAVKGSDGFW HHHHHHHHCCCCCEE	9.60	21890473
586	Ubiquitination	NNLLKAAVKGSDGFW HHHHHHHHCCCCCEE	9.60	21890473
586 (in isoform 1)	Ubiquitination	-	9.60	21890473
587	Ubiquitination	NLLKAAVKGSDGFWV HHHHHHHCCCCCEEE	48.23	23000965
587 (in isoform 2)	Ubiquitination	-	48.23	21890473
587 (in isoform 3)	Ubiquitination	-	48.23	21890473
595	Ubiquitination	GSDGFWVGKSSLRSW CCCCEEECHHHHHHH	18.09	-
596	Ubiquitination	SDGFWVGKSSLRSWR CCCEEECHHHHHHHH	27.53	29967540
602	Ubiquitination	GKSSLRSWRQLALEQ CHHHHHHHHHHHHHH	5.89	23000965
603	Ubiquitination	KSSLRSWRQLALEQL HHHHHHHHHHHHHHH	23.92	23000965
607	Ubiquitination	RSWRQLALEQLDEQD HHHHHHHHHHHHHCC	6.15	23000965
608	Ubiquitination	SWRQLALEQLDEQDG HHHHHHHHHHHHCCC	43.41	23000965
614	Ubiquitination	LEQLDEQDGDAEQSN HHHHHHCCCCHHHCC	55.69	21890473
615	Ubiquitination	EQLDEQDGDAEQSNG HHHHHCCCCHHHCCC	35.40	21890473
620	Phosphorylation	QDGDAEQSNGKMNGS CCCCHHHCCCCCCCC	38.77	28985074
622	Ubiquitination	GDAEQSNGKMNGSTL CCHHHCCCCCCCCCC	35.52	21963094
623	Ubiquitination	DAEQSNGKMNGSTLN CHHHCCCCCCCCCCC	33.18	21963094
627	Phosphorylation	SNGKMNGSTLNKDES CCCCCCCCCCCCCCC	25.39	-
628	Phosphorylation	NGKMNGSTLNKDESK CCCCCCCCCCCCCCH	35.43	-
629	Ubiquitination	GKMNGSTLNKDESKE CCCCCCCCCCCCCHH	8.86	33845483
663	Ubiquitination	ELCISENERRLVSKE CEEECHHHHHHCCHH	34.82	23503661
667	Ubiquitination	SENERRLVSKEAWSK CHHHHHHCCHHHHHH	7.93	23000965
668	Ubiquitination	ENERRLVSKEAWSKL HHHHHHCCHHHHHHH	29.39	23000965
669	Ubiquitination	NERRLVSKEAWSKLQ HHHHHCCHHHHHHHH	43.93	23000965
672	Ubiquitination	RLVSKEAWSKLQQYF HHCCHHHHHHHHHHC	9.33	23000965
673	Ubiquitination	LVSKEAWSKLQQYFP HCCHHHHHHHHHHCC	30.45	23000965
674	Ubiquitination	VSKEAWSKLQQYFPK CCHHHHHHHHHHCCC	39.35	23000965
679	Ubiquitination	WSKLQQYFPKAPEFP HHHHHHHCCCCCCCC	4.32	21890473
680	Ubiquitination	SKLQQYFPKAPEFPS HHHHHHCCCCCCCCC	27.28	21890473
681	Ubiquitination	KLQQYFPKAPEFPSY HHHHHCCCCCCCCCH	67.67	-
681	Sumoylation	KLQQYFPKAPEFPSY HHHHHCCCCCCCCCH	67.67	-
681	Ubiquitination	KLQQYFPKAPEFPSY HHHHHCCCCCCCCCH	67.67	23000965
681 (in isoform 2)	Ubiquitination	-	67.67	21890473
681 (in isoform 3)	Ubiquitination	-	67.67	21890473
686	Ubiquitination	FPKAPEFPSYKECCS CCCCCCCCCHHHHHH	34.78	-
687	Ubiquitination	PKAPEFPSYKECCSQ CCCCCCCCHHHHHHH	54.91	21963094
688	Ubiquitination	KAPEFPSYKECCSQC CCCCCCCHHHHHHHC	15.85	21963094
689	Acetylation	APEFPSYKECCSQCK CCCCCCHHHHHHHCC	48.92	26051181
689	Ubiquitination	APEFPSYKECCSQCK CCCCCCHHHHHHHCC	48.92	21963094
693	Ubiquitination	PSYKECCSQCKILER CCHHHHHHHCCHHHH	50.72	21890473
693 (in isoform 1)	Ubiquitination	-	50.72	21890473
694	Ubiquitination	SYKECCSQCKILERE CHHHHHHHCCHHHHC	20.71	33845483
695	Ubiquitination	YKECCSQCKILEREG HHHHHHHCCHHHHCC	1.38	33845483
696	Acetylation	KECCSQCKILEREGE HHHHHHCCHHHHCCC	42.56	26051181
696	Ubiquitination	KECCSQCKILEREGE HHHHHHCCHHHHCCC	42.56	32015554
701	Ubiquitination	QCKILEREGEENEAL HCCHHHHCCCHHHHH	62.68	-
708	Ubiquitination	EGEENEALHKMIANE CCCHHHHHHHHHHHC	3.04	-
710	Ubiquitination	EENEALHKMIANEQK CHHHHHHHHHHHCHH	32.62	29967540
717	Ubiquitination	KMIANEQKTSLPNLF HHHHHCHHCCCCHHH	33.62	29967540
723	Ubiquitination	QKTSLPNLFQDKNRP HHCCCCHHHCCCCCC	3.73	23503661
724	Ubiquitination	KTSLPNLFQDKNRPC HCCCCHHHCCCCCCC	12.87	23503661
727	Ubiquitination	LPNLFQDKNRPCLSN CCHHHCCCCCCCHHC	44.03	23503661
728	Ubiquitination	PNLFQDKNRPCLSNW CHHHCCCCCCCHHCC	62.51	23503661
741	Ubiquitination	NWPEDTDVLYIVSQF CCCCCCCHHHHHHHH	4.79	21890473
764	Phosphorylation	VRKPTRCSPVSSVGN CCCCCCCCCCCCCCC	25.66	27251275
767	Phosphorylation	PTRCSPVSSVGNSAL CCCCCCCCCCCCCEE	23.77	27251275
768	Phosphorylation	TRCSPVSSVGNSALL CCCCCCCCCCCCEEE	33.99	27251275
772	Phosphorylation	PVSSVGNSALLCPHG CCCCCCCCEEECCCC	17.86	27251275
787	Phosphorylation	GLMFTFASMTKEDSK CEEEEEEECCCCCCC	23.85	27251275
788	Ubiquitination	LMFTFASMTKEDSKL EEEEEEECCCCCCCE	5.79	23503661
789	Phosphorylation	MFTFASMTKEDSKLI EEEEEECCCCCCCEE	28.87	27251275
789	Ubiquitination	MFTFASMTKEDSKLI EEEEEECCCCCCCEE	28.87	23503661
790	Ubiquitination	FTFASMTKEDSKLIA EEEEECCCCCCCEEE	51.38	23503661
790 (in isoform 2)	Ubiquitination	-	51.38	-
792	Ubiquitination	FASMTKEDSKLIALI EEECCCCCCCEEEEE	53.26	23503661
793	Ubiquitination	ASMTKEDSKLIALIW EECCCCCCCEEEEEC	30.38	23503661
794	Ubiquitination	SMTKEDSKLIALIWP ECCCCCCCEEEEECC	57.12	23503661
801	Ubiquitination	KLIALIWPSEWQMIQ CEEEEECCCHHHHHH	18.51	21890473
802	Ubiquitination	LIALIWPSEWQMIQK EEEEECCCHHHHHHH	36.15	-
802	Ubiquitination	LIALIWPSEWQMIQK EEEEECCCHHHHHHH	36.15	21890473
818	Ubiquitination	FVVDHVIKITRIEVG HHHCEEEEEEEEEEC	36.62	21890473
820	Phosphorylation	VDHVIKITRIEVGDV HCEEEEEEEEEECCC	22.16	-
829	Ubiquitination	IEVGDVNPSETQYIS EEECCCCHHHCCCCC	33.13	21890473
832	Ubiquitination	GDVNPSETQYISEPK CCCCHHHCCCCCCCC	30.89	23000965
839	Ubiquitination	TQYISEPKLCPECRE CCCCCCCCCCHHHHC	59.68	29967540
859	Phosphorylation	QQRDLREYTQATIYV HHHHHHHHHHHEEEE	9.56	-
860	Phosphorylation	QRDLREYTQATIYVH HHHHHHHHHHEEEEE	13.63	28555341
865	Phosphorylation	EYTQATIYVHKVVDN HHHHHEEEEEEEECC	7.67	-
866	Ubiquitination	YTQATIYVHKVVDNK HHHHEEEEEEEECCC	2.89	21890473
867	Ubiquitination	TQATIYVHKVVDNKK HHHEEEEEEEECCCC	10.54	21890473
868	Ubiquitination	QATIYVHKVVDNKKV HHEEEEEEEECCCCC	33.63	21890473
868 (in isoform 2)	Ubiquitination	-	33.63	21890473
878	Ubiquitination	DNKKVMKDSAPELNV CCCCCCCCCCCCCCC	31.75	21890473
879	Phosphorylation	NKKVMKDSAPELNVS CCCCCCCCCCCCCCC	39.96	28985074
879	Ubiquitination	NKKVMKDSAPELNVS CCCCCCCCCCCCCCC	39.96	21890473
880	Ubiquitination	KKVMKDSAPELNVSS CCCCCCCCCCCCCCC	16.24	21890473
880 (in isoform 1)	Ubiquitination	-	16.24	21890473
886	Ubiquitination	SAPELNVSSSETEED CCCCCCCCCCCCHHH	27.37	-
886	Phosphorylation	SAPELNVSSSETEED CCCCCCCCCCCCHHH	27.37	28355574
887	Phosphorylation	APELNVSSSETEEDK CCCCCCCCCCCHHHH	28.10	30278072
888	Phosphorylation	PELNVSSSETEEDKE CCCCCCCCCCHHHHH	40.82	28355574
889	Ubiquitination	ELNVSSSETEEDKEE CCCCCCCCCHHHHHH	63.29	21890473
890	Phosphorylation	LNVSSSETEEDKEEA CCCCCCCCHHHHHHC	46.77	25159151
890	Ubiquitination	LNVSSSETEEDKEEA CCCCCCCCHHHHHHC	46.77	21890473
892	Ubiquitination	VSSSETEEDKEEAKP CCCCCCHHHHHHCCC	80.12	23000965
893	Ubiquitination	SSSETEEDKEEAKPD CCCCCHHHHHHCCCC	58.39	23000965
910	Phosphorylation	KDPDFNQSNGGTKRQ CCCCCCCCCCCCCCC	38.25	25159151
914	Phosphorylation	FNQSNGGTKRQKISH CCCCCCCCCCCCCCC	25.18	25627689
918	Ubiquitination	NGGTKRQKISHQNYI CCCCCCCCCCCHHHH	50.65	29967540
920	Phosphorylation	GTKRQKISHQNYIAY CCCCCCCCCHHHHHH	26.51	28555341
924	Phosphorylation	QKISHQNYIAYQKQV CCCCCHHHHHHHHHH	4.75	-
929	Ubiquitination	QNYIAYQKQVIRRSM HHHHHHHHHHHHHHH	33.58	-
935	Phosphorylation	QKQVIRRSMRHRKVR HHHHHHHHHHHHCCC	15.43	-
943	Ubiquitination	MRHRKVRGEKALLVS HHHHCCCCCCEEEEE	43.68	21890473
944	Ubiquitination	RHRKVRGEKALLVSA HHHCCCCCCEEEEEC	25.29	21890473
945	Ubiquitination	HRKVRGEKALLVSAN HHCCCCCCEEEEECC	47.35	29967540
954	Ubiquitination	LLVSANQTLKELKIQ EEEECCHHHHHHHHH	39.34	21890473
955	Ubiquitination	LVSANQTLKELKIQI EEECCHHHHHHHHHH	2.67	21890473
956	Acetylation	VSANQTLKELKIQIM EECCHHHHHHHHHHH	65.47	19608861
956	Ubiquitination	VSANQTLKELKIQIM EECCHHHHHHHHHHH	65.47	23000965
957	Ubiquitination	SANQTLKELKIQIMH ECCHHHHHHHHHHHE	59.41	21890473
957	Ubiquitination	SANQTLKELKIQIMH ECCHHHHHHHHHHHE	59.41	23000965
957 (in isoform 1)	Ubiquitination	-	59.41	21890473
958	Ubiquitination	ANQTLKELKIQIMHA CCHHHHHHHHHHHEE	5.91	23000965
959	Ubiquitination	NQTLKELKIQIMHAF CHHHHHHHHHHHEEE	33.39	23000965
968	Ubiquitination	QIMHAFSVAPFDQNL HHHEEEEECCCCCCC	6.74	21890473
968 (in isoform 1)	Ubiquitination	-	6.74	21890473
976	Ubiquitination	APFDQNLSIDGKILS CCCCCCCCCCCEEEC	26.61	29967540
986	Glutathionylation	GKILSDDCATLGTLG CEEECCCCCCCCCCC	3.60	22555962
1003	Sumoylation	PESVILLKADEPIAD CCCEEEEECCCCCCC	50.80	-
1028	Ubiquitination	CMPEEGFKGTGLLGH HCCCCCCCCCCCCCC	67.43	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP48_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP48_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP48_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
UCHL3_HUMAN	UCHL3	physical	22939629
ZCCHV_HUMAN	ZC3HAV1	physical	22939629
ZFR_HUMAN	ZFR	physical	22939629
VPS35_HUMAN	VPS35	physical	22939629
UBC_HUMAN	UBC	physical	23287719
SAP_HUMAN	PSAP	physical	22863883
SC24D_HUMAN	SEC24D	physical	22863883
SL9A3_HUMAN	SLC9A3	physical	24308971
DC1L1_HUMAN	DYNC1LI1	physical	26344197
NCBP2_HUMAN	NCBP2	physical	26344197
NU188_HUMAN	NUP188	physical	26344197
NDUF7_HUMAN	NDUFAF7	physical	28514442
RN123_HUMAN	RNF123	physical	28514442
UBB_HUMAN	UBB	physical	28514442
PXK_HUMAN	PXK	physical	28514442
UBAC1_HUMAN	UBAC1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-956, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-886, AND MASSSPECTROMETRY.
PubMed: 19413330

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-886; SER-887; SER-888AND THR-890, AND MASS SPECTROMETRY.
PubMed: 17081983