PXK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PXK_HUMAN
• UniProt AC: Q7Z7A4
• Protein Name: PX domain-containing protein kinase-like protein
• Gene Name: PXK {ECO:0000312|HGNC:HGNC:23326}
• Organism: Homo sapiens (Human).
• Sequence Length: 578
• Subcellular Localization: Cytoplasm . Cell membrane ; Peripheral membrane protein . Also associates with the plasma membrane. Isoform 3 is present throughout the cell.
• Protein Description: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity..
• Protein Sequence: MAFMEKPPAGKVLLDDTVPLTAAIEASQSLQSHTEYIIRVQRGISVENSWQIVRRYSDFDLLNNSLQIAGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFLDPNNYSANYTEIALQQVSMFFRSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVTFATANESSALLIRMFNEKGTLKDLIYKAKPKDPFLKKYCNPKKIQGLELQQIKTYGRQILEVLKFLHDKGFPYGHLHASNVMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTLESVDVHCFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEACKNGMPTISRLLQMPLFSDVLLTTSEKPQFKIPTKLKEALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKKRKILARKKSKRSALENSEEHSAKYSNSNNSAGSGASSPLTSPSSPTPPSTSGISALPPPPPPPPPPAAPLPPASTEAPAQLSSQAVNGMSRGALLSSIQNFQKGTLRKAKTCDHSAPKIG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MAFMEKPPAGKVL --CCCCCCCCCCCEE	44.51	-
50 (in isoform 5)	Ubiquitination	-	11.96	21890473
56	Phosphorylation	SWQIVRRYSDFDLLN CHHHHHHCCCHHHCC	11.30	-
57	Phosphorylation	WQIVRRYSDFDLLNN HHHHHHCCCHHHCCC	29.95	-
104 (in isoform 7)	Ubiquitination	-	19.77	21890473
117	Ubiquitination	SNCELVKKFLDPNNY HCCHHHHHHCCCCCC	43.62	-
142	Phosphorylation	QVSMFFRSEPKWEVV HHHHHHHCCCCCEEE	53.76	22985185
153	Ubiquitination	WEVVEPLKDIGWRIR CEEEECHHHHCHHHH	59.00	-
154 (in isoform 6)	Ubiquitination	-	52.93	21890473
163	Phosphorylation	GWRIRKKYFLMKIKN CHHHHHHEEEEEECC	12.65	22817900
170 (in isoform 4)	Ubiquitination	-	67.85	21890473
187	Ubiquitination	WADLGPDKYLSDKDF HHHHCCCCCCCCHHH	51.75	21890473
187 (in isoform 2)	Ubiquitination	-	51.75	21890473
187 (in isoform 1)	Ubiquitination	-	51.75	21890473
192	Malonylation	PDKYLSDKDFQCLIK CCCCCCCHHHHHHHH	58.00	26320211
192	Acetylation	PDKYLSDKDFQCLIK CCCCCCCHHHHHHHH	58.00	25953088
231	Ubiquitination	LIRMFNEKGTLKDLI HHHHHCCCCCHHHHH	59.30	-
235	Ubiquitination	FNEKGTLKDLIYKAK HCCCCCHHHHHHHCC	50.77	-
386	Phosphorylation	ACKNGMPTISRLLQM HHHCCCCCHHHHHCC	23.77	26074081
388	Phosphorylation	KNGMPTISRLLQMPL HCCCCCHHHHHCCHH	21.25	26074081
406	Ubiquitination	VLLTTSEKPQFKIPT EEECCCCCCCCCCCH	43.84	-
435	Ubiquitination	KRLIEEQKQIHQHRR HHHHHHHHHHHHHHH	55.27	-
444	Phosphorylation	IHQHRRLTRAQSHHG HHHHHHHHHHHHHCC	23.34	-
448	Phosphorylation	RRLTRAQSHHGSEEE HHHHHHHHHCCCHHH	19.23	30576142
452	Phosphorylation	RAQSHHGSEEERKKR HHHHHCCCHHHHHHH	37.16	26546556
467	Phosphorylation	KILARKKSKRSALEN HHHHHHHHHHHHHHC	36.01	26074081
470	Phosphorylation	ARKKSKRSALENSEE HHHHHHHHHHHCCHH	40.73	25850435
475	Phosphorylation	KRSALENSEEHSAKY HHHHHHCCHHHHHHC	34.68	25850435
479	Phosphorylation	LENSEEHSAKYSNSN HHCCHHHHHHCCCCC	29.72	25850435
482 (in isoform 2)	Phosphorylation	-	16.89	22115753
483	Phosphorylation	EEHSAKYSNSNNSAG HHHHHHCCCCCCCCC	32.83	20071362
483 (in isoform 2)	Phosphorylation	-	32.83	22115753
485 (in isoform 2)	Phosphorylation	-	31.29	22115753
488 (in isoform 2)	Phosphorylation	-	37.95	22115753
491	Phosphorylation	NSNNSAGSGASSPLT CCCCCCCCCCCCCCC	30.79	22115753
491 (in isoform 2)	Phosphorylation	-	30.79	22115753
494 (in isoform 2)	Phosphorylation	-	35.69	22115753
494	Phosphorylation	NSAGSGASSPLTSPS CCCCCCCCCCCCCCC	35.69	22115753
495 (in isoform 2)	Phosphorylation	-	24.32	22115753
495	Phosphorylation	SAGSGASSPLTSPSS CCCCCCCCCCCCCCC	24.32	-
498 (in isoform 2)	Phosphorylation	-	41.81	22115753
499 (in isoform 2)	Phosphorylation	-	30.39	22115753
502 (in isoform 2)	Phosphorylation	-	35.86	19690332
555	Phosphorylation	SRGALLSSIQNFQKG CHHHHHHHHHHHHCC	28.32	20071362
563	Phosphorylation	IQNFQKGTLRKAKTC HHHHHCCCCCCCCCC	30.35	-
568	Methylation	KGTLRKAKTCDHSAP CCCCCCCCCCCCCCC	53.36	-
569	Phosphorylation	GTLRKAKTCDHSAPK CCCCCCCCCCCCCCC	28.20	22210691
576	Methylation	TCDHSAPKIG----- CCCCCCCCCC-----	60.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PXK_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PXK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PXK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P85A_HUMAN	PIK3R1	physical	20086096
EEA1_HUMAN	EEA1	physical	20086096
TFR1_HUMAN	TFRC	physical	20086096
LAMP2_HUMAN	LAMP2	physical	20086096
ACTBL_HUMAN	ACTBL2	physical	20086096
YBOX3_HUMAN	YBX3	physical	25852190
FBRL_HUMAN	FBL	physical	25852190
ROA0_HUMAN	HNRNPA0	physical	25852190
THOC4_HUMAN	ALYREF	physical	25852190

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.