SC24D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC24D_HUMAN
• UniProt AC: O94855
• Protein Name: Protein transport protein Sec24D {ECO:0000305}
• Gene Name: SEC24D {ECO:0000312|HGNC:HGNC:10706}
• Organism: Homo sapiens (Human).
• Sequence Length: 1032
• Subcellular Localization: Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol .
• Protein Description: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. [PubMed: 17499046]
• Protein Sequence: MSQQGYVATPPYSQPQPGIGLSPPHYGHYGDPSHTASPTGMMKPAGPLGATATRGMLPPGPPPPGPHQFGQNGAHATGHPPQRFPGPPPVNNVASSHAPYQPSAQSSYPGPISTSSVTQLGSQLSAMQINSYGSGMAPPSQGPPGPLSATSLQTPPRPPQPSILQPGSQVLPPPPTTLNGPGASPLPLPMYRPDGLSGPPPPNAQYQPPPLPGQTLGAGYPPQQANSGPQMAGAQLSYPGGFPGGPAQMAGPPQPQKKLDPDSIPSPIQVIENDRASRGGQVYATNTRGQIPPLVTTDCMIQDQGNASPRFIRCTTYCFPCTSDMAKQAQIPLAAVIKPFATIPSNESPLYLVNHGESGPVRCNRCKAYMCPFMQFIEGGRRYQCGFCNCVNDVPPFYFQHLDHIGRRLDHYEKPELSLGSYEYVATLDYCRKSKPPNPPAFIFMIDVSYSNIKNGLVKLICEELKTMLEKIPKEEQEETSAIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGEVFVPLLDGFLVNYQESQSVIHNLLDQIPDMFADSNENETVFAPVIQAGMEALKAADCPGKLFIFHSSLPTAEAPGKLKNRDDKKLVNTDKEKILFQPQTNVYDSLAKDCVAHGCSVTLFLFPSQYVDVASLGLVPQLTGGTLYKYNNFQMHLDRQQFLNDLRNDIEKKIGFDAIMRVRTSTGFRATDFFGGILMNNTTDVEMAAIDCDKAVTVEFKHDDKLSEDSGALIQCAVLYTTISGQRRLRIHNLGLNCSSQLADLYKSCETDALINFFAKSAFKAVLHQPLKVIREILVNQTAHMLACYRKNCASPSAASQLILPDSMKVLPVYMNCLLKNCVLLSRPEISTDERAYQRQLVMTMGVADSQLFFYPQLLPIHTLDVKSTMLPAAVRCSESRLSEEGIFLLANGLHMFLWLGVSSPPELIQGIFNVPSFAHINTDMTLLPEVGNPYSQQLRMIMGIIQQKRPYSMKLTIVKQREQPEMVFRQFLVEDKGLYGGSSYVDFLCCVHKEICQLLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQQGYVAT ------CCCCCCCCC	42.38	23401153
6	Phosphorylation	--MSQQGYVATPPYS --CCCCCCCCCCCCC	5.20	26074081
9	Phosphorylation	SQQGYVATPPYSQPQ CCCCCCCCCCCCCCC	18.11	23401153
12	Phosphorylation	GYVATPPYSQPQPGI CCCCCCCCCCCCCCC	22.57	26074081
13	Phosphorylation	YVATPPYSQPQPGIG CCCCCCCCCCCCCCC	40.95	26074081
22	Phosphorylation	PQPGIGLSPPHYGHY CCCCCCCCCCCCCCC	31.04	25159151
26	Phosphorylation	IGLSPPHYGHYGDPS CCCCCCCCCCCCCCC	16.04	26074081
29	Phosphorylation	SPPHYGHYGDPSHTA CCCCCCCCCCCCCCC	20.89	26074081
33	Phosphorylation	YGHYGDPSHTASPTG CCCCCCCCCCCCCCC	37.90	23401153
35	Phosphorylation	HYGDPSHTASPTGMM CCCCCCCCCCCCCCC	32.92	28348404
37	Phosphorylation	GDPSHTASPTGMMKP CCCCCCCCCCCCCCC	24.93	28348404
140	Phosphorylation	GSGMAPPSQGPPGPL CCCCCCCCCCCCCCC	46.86	23879269
148	Phosphorylation	QGPPGPLSATSLQTP CCCCCCCCCCCCCCC	32.41	23879269
154	Phosphorylation	LSATSLQTPPRPPQP CCCCCCCCCCCCCCC	40.32	23879269
258	Ubiquitination	GPPQPQKKLDPDSIP CCCCCCCCCCCCCCC	53.53	-
263	Phosphorylation	QKKLDPDSIPSPIQV CCCCCCCCCCCCEEE	41.61	30266825
266	Phosphorylation	LDPDSIPSPIQVIEN CCCCCCCCCEEEEEC	32.72	30266825
278	Methylation	IENDRASRGGQVYAT EECCCCCCCCCEEEE	52.88	115493563
283	Phosphorylation	ASRGGQVYATNTRGQ CCCCCCEEEECCCCC	10.38	21253578
300	Sulfoxidation	PLVTTDCMIQDQGNA CCEEECCEECCCCCC	3.25	30846556
315	Phosphorylation	SPRFIRCTTYCFPCT CCCEEEEEEEEEECC	15.79	24114839
317	Phosphorylation	RFIRCTTYCFPCTSD CEEEEEEEEEECCHH	3.64	24114839
322	Phosphorylation	TTYCFPCTSDMAKQA EEEEEECCHHHHHHC	28.18	24114839
323	Phosphorylation	TYCFPCTSDMAKQAQ EEEEECCHHHHHHCC	31.91	24114839
338	Ubiquitination	IPLAAVIKPFATIPS CCCEEEECCCCCCCC	27.73	-
339 (in isoform 2)	Ubiquitination	-	17.00	-
466	Ubiquitination	KLICEELKTMLEKIP HHHHHHHHHHHHHCC	34.86	-
471	Ubiquitination	ELKTMLEKIPKEEQE HHHHHHHHCCHHHHH	61.42	-
480	Phosphorylation	PKEEQEETSAIRVGF CHHHHHHHCCEEEEE	23.78	29083192
481	Phosphorylation	KEEQEETSAIRVGFI HHHHHHHCCEEEEEE	25.61	29083192
576	Acetylation	KAADCPGKLFIFHSS HHCCCCCCEEEEECC	25.93	26051181
576	Ubiquitination	KAADCPGKLFIFHSS HHCCCCCCEEEEECC	25.93	-
577 (in isoform 2)	Ubiquitination	-	5.02	-
594	Ubiquitination	AEAPGKLKNRDDKKL CCCCCCCCCCCCCCC	54.12	-
595 (in isoform 2)	Ubiquitination	-	64.15	-
600	Ubiquitination	LKNRDDKKLVNTDKE CCCCCCCCCCCCCHH	65.74	-
608	Ubiquitination	LVNTDKEKILFQPQT CCCCCHHHHCCCCCC	50.91	-
639	Phosphorylation	VTLFLFPSQYVDVAS EEEEECCHHHCCHHH	27.15	22210691
646	Phosphorylation	SQYVDVASLGLVPQL HHHCCHHHHCCCCCC	23.87	22210691
666	Sulfoxidation	YKYNNFQMHLDRQQF EEECCEEEEECHHHH	2.72	30846556
684	Ubiquitination	LRNDIEKKIGFDAIM HHHHHHHHHCHHHEE	34.96	-
685 (in isoform 2)	Ubiquitination	-	11.15	-
702	Phosphorylation	TSTGFRATDFFGGIL CCCCCCCCCCCCCEE	29.14	23532336
728	Phosphorylation	IDCDKAVTVEFKHDD ECCCCCEEEEEECCC	21.12	23532336
770	Phosphorylation	HNLGLNCSSQLADLY ECCCCCCHHHHHHHH	21.75	27732954
771	Phosphorylation	NLGLNCSSQLADLYK CCCCCCHHHHHHHHH	31.26	27732954
779	Phosphorylation	QLADLYKSCETDALI HHHHHHHHHCHHHHH	12.02	21712546
791 (in isoform 1)	Ubiquitination	-	36.84	21890473
791	Ubiquitination	ALINFFAKSAFKAVL HHHHHHHHHHHHHHH	36.84	21906983
792 (in isoform 2)	Ubiquitination	-	35.19	21890473
795	Ubiquitination	FFAKSAFKAVLHQPL HHHHHHHHHHHHCHH	36.98	2189047
795	Acetylation	FFAKSAFKAVLHQPL HHHHHHHHHHHHCHH	36.98	25953088
795 (in isoform 1)	Ubiquitination	-	36.98	21890473
796 (in isoform 2)	Ubiquitination	-	11.58	21890473
803	Malonylation	AVLHQPLKVIREILV HHHHCHHHHHHHHHC	42.15	26320211
803	Ubiquitination	AVLHQPLKVIREILV HHHHCHHHHHHHHHC	42.15	-
804 (in isoform 2)	Ubiquitination	-	7.03	-
816	Sulfoxidation	LVNQTAHMLACYRKN HCHHHHHHHHHHHHC	2.05	30846556
826	Phosphorylation	CYRKNCASPSAASQL HHHHCCCCHHHHHHH	22.91	25850435
828	Phosphorylation	RKNCASPSAASQLIL HHCCCCHHHHHHHHC	33.69	25850435
831	Phosphorylation	CASPSAASQLILPDS CCCHHHHHHHHCCCH	25.82	21712546
851	Ubiquitination	VYMNCLLKNCVLLSR HHHHHHHHCCHHHCC	35.04	-
852 (in isoform 2)	Ubiquitination	-	22.54	-
857	Phosphorylation	LKNCVLLSRPEISTD HHCCHHHCCCCCCCC	41.44	29449344
862	Phosphorylation	LLSRPEISTDERAYQ HHCCCCCCCCHHHHH	28.30	29449344
863	Phosphorylation	LSRPEISTDERAYQR HCCCCCCCCHHHHHH	47.76	29449344
875	Phosphorylation	YQRQLVMTMGVADSQ HHHHHHHHHCCCCHH	11.86	24043423
881	Phosphorylation	MTMGVADSQLFFYPQ HHHCCCCHHEEECCC	21.03	25332170
886	Phosphorylation	ADSQLFFYPQLLPIH CCHHEEECCCCCCCE	5.24	24043423
894	Phosphorylation	PQLLPIHTLDVKSTM CCCCCCEECCCCCCC	25.93	24043423
899	Phosphorylation	IHTLDVKSTMLPAAV CEECCCCCCCCCHHH	20.92	25690035
901	Sulfoxidation	TLDVKSTMLPAAVRC ECCCCCCCCCHHHHC	5.64	21406390
911	Phosphorylation	AAVRCSESRLSEEGI HHHHCCCCCCCHHHE	23.40	-
981 (in isoform 2)	Ubiquitination	-	30.93	-
988	Phosphorylation	RPYSMKLTIVKQREQ CCCCCEEEEEECCCC	20.43	-
991	Ubiquitination	SMKLTIVKQREQPEM CCEEEEEECCCCCCH	39.52	-
992 (in isoform 2)	Ubiquitination	-	43.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SC24D_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC24D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC24D_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SC23B_HUMAN	SEC23B	physical	16189514
RSU1_HUMAN	RSU1	physical	22863883
GLYM_HUMAN	SHMT2	physical	22863883
SF3B4_HUMAN	SF3B4	physical	25416956
SC23B_HUMAN	SEC23B	physical	25416956
ARFP1_HUMAN	ARFIP1	physical	26344197
CD2AP_HUMAN	CD2AP	physical	26344197
SC23A_HUMAN	SEC23A	physical	26344197
SC23B_HUMAN	SEC23B	physical	26344197
SC24A_HUMAN	SEC24A	physical	26344197
SC24C_HUMAN	SEC24C	physical	26344197
SH3K1_HUMAN	SH3KBP1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 616294: Cole-Carpenter syndrome 2 (CLCRP2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.