SL9A2_HUMAN - dbPTM
SL9A2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SL9A2_HUMAN
UniProt AC Q9UBY0
Protein Name Sodium/hydrogen exchanger 2
Gene Name SLC9A2
Organism Homo sapiens (Human).
Sequence Length 812
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption..
Protein Sequence MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKPPPRLVWRASEPGSRKARFGSEKP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
45PhosphorylationNAPRAMGTSSSPPSP
HCCHHCCCCCCCCCC		16.6125332170
46PhosphorylationAPRAMGTSSSPPSPA
CCHHCCCCCCCCCCC		24.0825332170
47PhosphorylationPRAMGTSSSPPSPAS
CHHCCCCCCCCCCCC		46.8625332170
54O-linked_GlycosylationSSPPSPASVVAPGTT
CCCCCCCCEECCCCC		22.10OGP
342PhosphorylationAITACAMTMNKYVEE
HHHHHHHHHHHHHHH		10.0825332170
350N-linked_GlycosylationMNKYVEENVSQKSYT
HHHHHHHHCCCCCHH		25.82UniProtKB CARBOHYD
356PhosphorylationENVSQKSYTTIKYFM
HHCCCCCHHHHHHHH		18.22-
360UbiquitinationQKSYTTIKYFMKMLS
CCCHHHHHHHHHHHH		30.2822817900
361PhosphorylationKSYTTIKYFMKMLSS
CCHHHHHHHHHHHHC		12.69-
364UbiquitinationTTIKYFMKMLSSVSE
HHHHHHHHHHHCCCH		27.1322817900
499PhosphorylationNKKQQAVSEEIYCRL
CHHHHHHHHHHHHHH		32.31-
503PhosphorylationQAVSEEIYCRLFDHV
HHHHHHHHHHHHHHH		3.77-
531UbiquitinationNFWRDKFKKFDDKYL
HHHHHHHHHCCHHHH		59.2722817900
532UbiquitinationFWRDKFKKFDDKYLR
HHHHHHHHCCHHHHH		58.1022817900
536UbiquitinationKFKKFDDKYLRKLLI
HHHHCCHHHHHHHHH		48.2921890473
536UbiquitinationKFKKFDDKYLRKLLI
HHHHCCHHHHHHHHH		48.2921890473
540UbiquitinationFDDKYLRKLLIRENQ
CCHHHHHHHHHHCCC		45.0822817900
550PhosphorylationIRENQPKSSIVSLYK
HHCCCCCCCHHHHHH		31.7923312004
551PhosphorylationRENQPKSSIVSLYKK
HCCCCCCCHHHHHHH		32.8923312004
578PhosphorylationGMISTVPTFASLNDC
CCCCCCCCCCCCHHH		27.7423312004
581PhosphorylationSTVPTFASLNDCREE
CCCCCCCCCHHHHHH		24.4223312004
594PhosphorylationEEKIRKVTSSETDEI
HHHHHHHCCCCHHHH		29.5723312004
595PhosphorylationEKIRKVTSSETDEIR
HHHHHHCCCCHHHHH		29.2125690035
596PhosphorylationKIRKVTSSETDEIRE
HHHHHCCCCHHHHHH		34.8421815630
598PhosphorylationRKVTSSETDEIRELL
HHHCCCCHHHHHHHH		40.6623312004
606PhosphorylationDEIRELLSRNLYQIR
HHHHHHHHCCHHHHH		31.5724719451
610PhosphorylationELLSRNLYQIRQRTL
HHHHCCHHHHHHHHH		12.87-
623PhosphorylationTLSYNRHSLTADTSE
HHHCCCCCCCCCCCH		24.9523312004
643PhosphorylationILIRRRHSLRESIRK
HHHHHHHHHHHHHHH		27.58-
647PhosphorylationRRHSLRESIRKDSSL
HHHHHHHHHHHCCCC		22.6623312004
652PhosphorylationRESIRKDSSLNREHR
HHHHHHCCCCCHHHH		39.50-
661PhosphorylationLNREHRASTSTSRYL
CCHHHHCCCCHHHHH		23.8929978859
662PhosphorylationNREHRASTSTSRYLS
CHHHHCCCCHHHHHC		34.7329978859
663PhosphorylationREHRASTSTSRYLSL
HHHHCCCCHHHHHCC		23.1429978859
664PhosphorylationEHRASTSTSRYLSLP
HHHCCCCHHHHHCCC		19.8129978859
665PhosphorylationHRASTSTSRYLSLPK
HHCCCCHHHHHCCCC		20.7829978859
667PhosphorylationASTSTSRYLSLPKNT
CCCCHHHHHCCCCCC		10.6223186163
669PhosphorylationTSTSRYLSLPKNTKL
CCHHHHHCCCCCCCC		33.4224505115
674PhosphorylationYLSLPKNTKLPEKLQ
HHCCCCCCCCCHHHH		39.8329978859
679AcetylationKNTKLPEKLQKRRTI
CCCCCCHHHHHCCCE		55.047975749
685PhosphorylationEKLQKRRTISIADGN
HHHHHCCCEEECCCC		24.1030278072
687PhosphorylationLQKRRTISIADGNSS
HHHCCCEEECCCCCC		15.8830278072
693PhosphorylationISIADGNSSDSDADA
EEECCCCCCCCCCCC		40.8426657352
694PhosphorylationSIADGNSSDSDADAG
EECCCCCCCCCCCCC		45.1726657352
696PhosphorylationADGNSSDSDADAGTT
CCCCCCCCCCCCCCE		36.3230278072
720PhosphorylationRFLPEQFSKKSPQSY
HHCCHHHCCCCCCCC		38.5828348404
739PhosphorylationKNEVDVDSGRDMPST
CCEECCCCCCCCCCC		35.2623909892
745PhosphorylationDSGRDMPSTPPTPHS
CCCCCCCCCCCCCCC		47.0826657352
746PhosphorylationSGRDMPSTPPTPHSR
CCCCCCCCCCCCCCC		27.6722817900
749PhosphorylationDMPSTPPTPHSREKG
CCCCCCCCCCCCCCC		34.5321712546
752PhosphorylationSTPPTPHSREKGTQT
CCCCCCCCCCCCCCC		43.2521712546
757PhosphorylationPHSREKGTQTSGLLQ
CCCCCCCCCCCCCCC		39.4823312004
759PhosphorylationSREKGTQTSGLLQQP
CCCCCCCCCCCCCCC		25.3023312004
760PhosphorylationREKGTQTSGLLQQPL
CCCCCCCCCCCCCCC		20.0223312004
769PhosphorylationLLQQPLLSKDQSGSE
CCCCCCCCCCCCCCC		41.7023312004
780PhosphorylationSGSEREDSLTEGIPP
CCCCCCCCCCCCCCC		32.2230624053
782PhosphorylationSEREDSLTEGIPPKP
CCCCCCCCCCCCCCC		35.8030624053
798PhosphorylationPRLVWRASEPGSRKA
CCEEEECCCCCCCCC		35.4328348404
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SL9A2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SL9A2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SL9A2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SRC_HUMANSRCphysical
10187839
RASA1_HUMANRASA1physical
10187839
SPTA1_HUMANSPTA1physical
10187839
ABL1_HUMANABL1physical
10187839
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SL9A2_HUMAN

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Related Literatures of Post-Translational Modification

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