FA13A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FA13A_HUMAN
• UniProt AC: O94988
• Protein Name: Protein FAM13A
• Gene Name: FAM13A
• Organism: Homo sapiens (Human).
• Sequence Length: 1023
• Protein Sequence: MGAGALAICQSKAAVRLKEDMKKIVAVPLNEQKDFTYQKLFGVSLQELERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILENYNTLFEVEYTENDHLRCENLARLIIVKEVYYKNSLPILLTRGLERDMPKPPPKTKIPKSRSEGSIQAHRVLQPELSDGIPQLSLRLSYRKACLEDMNSAEGAISAKLVPSSQEDERPLSPFYLSAHVPQVSNVSATGELLERTIRSAVEQHLFDVNNSGGQSSEDSESGTLSASSATSARQRRRQSKEQDEVRHGRDKGLINKENTPSGFNHLDDCILNTQEVEKVHKNTFGCAGERSKPKRQKSSTKLSELHDNQDGLVNMESLNSTRSHERTGPDDFEWMSDERKGNEKDGGHTQHFESPTMKIQEHPSLSDTKQQRNQDAGDQEESFVSEVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQAGRLIRQLLDEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPSHSDKAANPEVLKWTNDLAKFRRQLKESKLKISEEDLTPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKLQEKRAESSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVTKNERQVMKPLYDRYRLVKQILSRANTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDSNVKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYSEYKHIKAKLRLLEVLISKRDTDSKSM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10 (in isoform 3)	Phosphorylation	-	41.68	28348404
10 (in isoform 5)	Phosphorylation	-	41.68	24043423
10 (in isoform 1)	Phosphorylation	-	41.68	28348404
11 (in isoform 3)	Phosphorylation	-	21.61	28348404
11 (in isoform 1)	Phosphorylation	-	21.61	28348404
17 (in isoform 5)	Phosphorylation	-	5.99	24043423
19 (in isoform 1)	Phosphorylation	-	68.85	28348404
19 (in isoform 3)	Phosphorylation	-	68.85	28348404
19	Ubiquitination	KAAVRLKEDMKKIVA HHHHHCHHHHHHEEE	68.85	22817900
20 (in isoform 5)	Phosphorylation	-	53.25	24043423
22 (in isoform 5)	Phosphorylation	-	52.23	24043423
33	Ubiquitination	AVPLNEQKDFTYQKL EEECCCCCCCHHHHH	48.94	29967540
39	Ubiquitination	QKDFTYQKLFGVSLQ CCCCHHHHHHCCCHH	35.06	22817900
39 (in isoform 3)	Ubiquitination	-	35.06	21906983
40	Ubiquitination	KDFTYQKLFGVSLQE CCCHHHHHHCCCHHH	2.39	27667366
54	Phosphorylation	ELERQGLTENGIPAV HHHHCCCCCCCCCHH	33.94	22468782
68	Phosphorylation	VVWNIVEYLTQHGLT HHHHHHHHHHHCCCC	12.26	22468782
70	Phosphorylation	WNIVEYLTQHGLTQE HHHHHHHHHCCCCCC	20.02	22468782
75	Phosphorylation	YLTQHGLTQEGLFRV HHHHCCCCCCCEEEE	29.21	22468782
75	Ubiquitination	YLTQHGLTQEGLFRV HHHHCCCCCCCEEEE	29.21	27667366
95	Ubiquitination	VVEQLRLKFESGVPV EEEEEEEEECCCCCC	40.42	27667366
106	Ubiquitination	GVPVELGKDGDVCSA CCCCCCCCCCCCCCH	71.77	29967540
115	Phosphorylation	GDVCSAASLLKLFLR CCCCCHHHHHHHHHH	33.67	24719451
235	Phosphorylation	NTLFEVEYTENDHLR CCCEEEECCCCCCCC	25.24	27642862
285	Phosphorylation	PKTKIPKSRSEGSIQ CCCCCCCCCCCCCCC	35.37	27251275
287	Phosphorylation	TKIPKSRSEGSIQAH CCCCCCCCCCCCCEE	54.09	30242111
290	Phosphorylation	PKSRSEGSIQAHRVL CCCCCCCCCCEEEEC	13.89	30242111
296	Phosphorylation	GSIQAHRVLQPELSD CCCCEEEECCHHHCC	4.12	33259812
309	Phosphorylation	SDGIPQLSLRLSYRK CCCCCHHHHHHHHHH	13.24	24719451
310	Phosphorylation	DGIPQLSLRLSYRKA CCCCHHHHHHHHHHH	9.68	33259812
324	Phosphorylation	ACLEDMNSAEGAISA HHHHHHHHCCCCHHC	22.51	33259812
326	Phosphorylation	LEDMNSAEGAISAKL HHHHHHCCCCHHCEE	49.32	18669648
329	Phosphorylation	MNSAEGAISAKLVPS HHHCCCCHHCEECCC	6.39	15302935
345	Phosphorylation	QEDERPLSPFYLSAH CCCCCCCCHHHHHCC	18.69	22468782
348	Phosphorylation	ERPLSPFYLSAHVPQ CCCCCHHHHHCCCCC	11.79	22468782
406	Phosphorylation	ASSATSARQRRRQSK HHHHHHHHHHHHHHH	30.24	16964243
412	Phosphorylation	ARQRRRQSKEQDEVR HHHHHHHHHHHHHHH	36.03	24719451
471	Phosphorylation	SKPKRQKSSTKLSEL CCCCCCCCCCHHHHH	34.60	-
493	Phosphorylation	VNMESLNSTRSHERT CCHHHHCCCCCCCCC	30.41	28555341
502	Phosphorylation	RSHERTGPDDFEWMS CCCCCCCCCCCCCCC	37.07	32142685
509	Phosphorylation	PDDFEWMSDERKGNE CCCCCCCCCCCCCCC	37.08	25159151
516	Phosphorylation	SDERKGNEKDGGHTQ CCCCCCCCCCCCCCC	62.28	32142685
522	Phosphorylation	NEKDGGHTQHFESPT CCCCCCCCCCCCCCC	27.32	23312004
527	Phosphorylation	GHTQHFESPTMKIQE CCCCCCCCCCCEECC	25.40	20873877
529	Phosphorylation	TQHFESPTMKIQEHP CCCCCCCCCEECCCC	40.14	20873877
530	Phosphorylation	QHFESPTMKIQEHPS CCCCCCCCEECCCCC	4.01	32142685
534 (in isoform 3)	Phosphorylation	-	62.33	28348404
539	Phosphorylation	IQEHPSLSDTKQQRN ECCCCCHHHHHHHHH	47.79	25159151
555	Phosphorylation	DAGDQEESFVSEVPQ CCCCHHHHHHHCCCH	30.14	25159151
589	Phosphorylation	SSWQRENSDSDEAHL CCCCCCCCCCCCHHH	33.47	28857561
591	Phosphorylation	WQRENSDSDEAHLSP CCCCCCCCCCHHHCH	36.85	30242111
597	Phosphorylation	DSDEAHLSPQAGRLI CCCCHHHCHHHHHHH	12.71	25159151
612	Phosphorylation	RQLLDEDSDPMLSPR HHHHCCCCCCCCCHH	41.38	29978859
617	Phosphorylation	EDSDPMLSPRFYAYG CCCCCCCCHHHHHCC	14.05	28857561
621	Phosphorylation	PMLSPRFYAYGQSRQ CCCCHHHHHCCCCCC	10.53	19835603
623	Phosphorylation	LSPRFYAYGQSRQYL CCHHHHHCCCCCCCC	12.34	19835603
626	Phosphorylation	RFYAYGQSRQYLDDT HHHHCCCCCCCCCCC	19.59	19835603
638	Phosphorylation	DDTEVPPSPPNSHSF CCCCCCCCCCCCHHH	47.09	19835603
644	Phosphorylation	PSPPNSHSFMRRRSS CCCCCCHHHCCCCCC	22.13	19835603
650	Phosphorylation	HSFMRRRSSSLGSYD HHHCCCCCCCCCCCC	23.59	23898821
651	Phosphorylation	SFMRRRSSSLGSYDD HHCCCCCCCCCCCCC	27.98	28102081
652	Phosphorylation	FMRRRSSSLGSYDDE HCCCCCCCCCCCCCC	37.69	22617229
655	Phosphorylation	RRSSSLGSYDDEQED CCCCCCCCCCCCCCC	30.59	28102081
656	Phosphorylation	RSSSLGSYDDEQEDL CCCCCCCCCCCCCCC	26.14	23663014
692	Phosphorylation	RFEEEKKYRPSHSDK HHHHHHHHCCCCCCC	38.53	-
727	Phosphorylation	KESKLKISEEDLTPR HHHCCCCCHHHCCHH	33.09	25850435
732	Phosphorylation	KISEEDLTPRMRQRS CCCHHHCCHHHHHHH	22.59	25159151
739	Phosphorylation	TPRMRQRSNTLPKSF CHHHHHHHCCCCHHH	26.31	22210691
741	Phosphorylation	RMRQRSNTLPKSFGS HHHHHHCCCCHHHHH	45.76	22210691
744	Acetylation	QRSNTLPKSFGSQLE HHHCCCCHHHHHHHC	62.62	19828865
752	Acetylation	SFGSQLEKEDEKKQE HHHHHHCHHHHHHHH	78.16	7676307
768	Phosphorylation	VDKAIKPSVEATLES HHHHHHHHHHHHHHH	27.82	30622161
772	Phosphorylation	IKPSVEATLESIQRK HHHHHHHHHHHHHHH	19.97	30622161
775	Phosphorylation	SVEATLESIQRKLQE HHHHHHHHHHHHHHH	27.43	30622161
797	Phosphorylation	PEDIKDMTKDQIANE CHHHHHHCHHHHHHH	41.42	30622161
850	Phosphorylation	QILSRANTIPIIGSP HHHHHCCCCCCCCCC	27.44	23312004
856	Phosphorylation	NTIPIIGSPSSKRRS CCCCCCCCCCCCCCC	15.94	25159151
858	Phosphorylation	IPIIGSPSSKRRSPL CCCCCCCCCCCCCCC	50.63	25159151
859	Phosphorylation	PIIGSPSSKRRSPLL CCCCCCCCCCCCCCC	33.30	25159151
863	Phosphorylation	SPSSKRRSPLLQPII CCCCCCCCCCCHHHH	24.75	20873877
874	Phosphorylation	QPIIEGETASFFKEI HHHHCCCHHHHHHHH	38.16	-
888	Phosphorylation	IKEEEEGSEDDSNVK HHHHHCCCCCCCCCC	40.92	30576142
892	Phosphorylation	EEGSEDDSNVKPDFM HCCCCCCCCCCCCEE	56.71	28348404
901	Phosphorylation	VKPDFMVTLKTDFSA CCCCEEEEEECCCCC	15.68	28102081
932	Phosphorylation	PMDDKIPSKCSQDTG CCCCCCCCCCCCCCC	50.17	24719451
1018	Phosphorylation	VLISKRDTDSKSM-- HHHHCCCCCCCCC--	46.32	-
1020	Phosphorylation	ISKRDTDSKSM---- HHCCCCCCCCC----	28.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FA13A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FA13A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FA13A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
U119A_HUMAN	UNC119	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.