PTPRA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTPRA_MOUSE
• UniProt AC: P18052
• Protein Name: Receptor-type tyrosine-protein phosphatase alpha
• Gene Name: Ptpra
• Organism: Mus musculus (Mouse).
• Sequence Length: 829
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Sequence: MDSWFILVLFGSGLIHVSANNATTVSPSLGTTRLIKTSTTELAKEENKTSNSTSSVISLSVAPTFSPNLTLEPTYVTTVNSSHSDNGTRRAASTESGGTTISPNGSWLIENQFTDAITEPWEGNSSTAATTPETFPPADETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPFLSLAVSKDAVKALNKTTPLLERRFIGKSNSRGCLSDDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNVRVSVEDVTVLVDYTVRKFCIQQVGDVTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHSERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMINIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	N-linked_Glycosylation	LIHVSANNATTVSPS EEEEECCCCCCCCCC	38.08	-
47	N-linked_Glycosylation	TELAKEENKTSNSTS HHHHHHHCCCCCCCC	54.73	-
51	N-linked_Glycosylation	KEENKTSNSTSSVIS HHHCCCCCCCCCEEE	55.31	-
68	N-linked_Glycosylation	VAPTFSPNLTLEPTY ECCCCCCCCEEECEE	44.45	-
80	N-linked_Glycosylation	PTYVTTVNSSHSDNG CEEEEEECCCCCCCC	35.38	-
86	N-linked_Glycosylation	VNSSHSDNGTRRAAS ECCCCCCCCCEEEEE	57.67	-
104	N-linked_Glycosylation	GGTTISPNGSWLIEN CCEEECCCCCEEEEE	50.79	-
124	N-linked_Glycosylation	ITEPWEGNSSTAATT CCCCCCCCCCCCCCC	22.67	-
176	Phosphorylation	KKYKQAGSHSNSFRL HHHHHCCCCCCCEEC	27.10	25521595
178	Phosphorylation	YKQAGSHSNSFRLSN HHHCCCCCCCEECCC	35.55	25159016
180	Phosphorylation	QAGSHSNSFRLSNGR HCCCCCCCEECCCCC	18.11	25521595
184	Phosphorylation	HSNSFRLSNGRTEDV CCCCEECCCCCCCCC	32.74	20531401
188	Phosphorylation	FRLSNGRTEDVEPQS EECCCCCCCCCCCCC	37.63	25777480
195	Phosphorylation	TEDVEPQSVPLLARS CCCCCCCCCCEEECC	36.10	26026062
202	Phosphorylation	SVPLLARSPSTNRKY CCCEEECCCCCCCCC	20.00	25521595
204	Phosphorylation	PLLARSPSTNRKYPP CEEECCCCCCCCCCC	39.29	7537734
205	Phosphorylation	LLARSPSTNRKYPPL EEECCCCCCCCCCCC	42.29	19060867
262 (in isoform 2)	Phosphorylation	-	13.77	25195567
279	Acetylation	AVSKDAVKALNKTTP HCCHHHHHHHCCCCH	49.21	22902405
334	Ubiquitination	FINGYQEKNKFIAAQ HCCCHHHCCCEEEEC	50.33	22790023
409	Acetylation	LVDYTVRKFCIQQVG EEEHHHHHHHHHHHC	40.01	22826441
476	Phosphorylation	CSAGVGRTGTFVVID CCCCCCCCCEEEEEH	34.34	-
478	Phosphorylation	AGVGRTGTFVVIDAM CCCCCCCEEEEEHHH	16.79	-
549	Phosphorylation	ETHLQKIYNKIPGTS HHHHHHHHHCCCCCC	19.89	25367039
818	Phosphorylation	CYKVVQEYIDAFSDY HHHHHHHHHHHHHHH	6.24	25619855
823	Phosphorylation	QEYIDAFSDYANFK- HHHHHHHHHHHCCC-	31.28	22942356
825	Phosphorylation	YIDAFSDYANFK--- HHHHHHHHHCCC---	11.40	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
180	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
180	S	Phosphorylation	Kinase	CAMK2A	P11798	PSP
180	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
180	S	Phosphorylation	Kinase	KPCA	P20444	PhosphoELM
180	S	Phosphorylation	Kinase	PKCA	P05696	PSP
180	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
204	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
204	S	Phosphorylation	Kinase	CAMK2A	P11798	PSP
204	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
204	S	Phosphorylation	Kinase	KPCA	P20444	PhosphoELM
204	S	Phosphorylation	Kinase	PKCA	P05696	PSP
204	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
825	Y	Phosphorylation	Kinase	SRC	P05480	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTPRA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTPRA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
2AAA_MOUSE	Ppp2r1a	physical	12952889

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180; SER-204 ANDTYR-825, AND MASS SPECTROMETRY.
PubMed: 19144319

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-825, AND MASSSPECTROMETRY.
PubMed: 18034455

"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling.";
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.;
J. Immunol. 179:5864-5876(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-825, AND MASSSPECTROMETRY.
PubMed: 17947660