TBCC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBCC1_HUMAN
• UniProt AC: Q9NVR7
• Protein Name: TBCC domain-containing protein 1
• Gene Name: TBCCD1
• Organism: Homo sapiens (Human).
• Sequence Length: 557
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Localizes at the spindle midzone, midbody and basal bodies of primary and motile cilia.
• Protein Description: Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration..
• Protein Sequence: MDQSRVLLWVKAEPFIVGALQVPPPSKFSLHYLRKISTYVQIRATEGAYPRLYWSTWRHIACGKLQLAKDLAWLYFEIFDSLSMKTPEERLEWSEVLSNCMSEEEVEKQRNQLSVDTLQFLLFLYIQQLNKVSLRTSLIGEEWPSPRNKSQSPDLTEKSNCHNKNWNDYSHQAFVYDHLSDLLELLLDPKQLTASFHSTHSSLVSREAVVALSFLIEGTISRARKIYPLHELALWQPLHADSGFSKISKTFSFYKLETWLRSCLTGNPFGTSACLKSGKKLAWAHQVEGTTKRAKIACNTHVAPRMHRLVVMSQVYKQTLAKSSDTLAGAHVKIHRCNESFIYLLSPLRSVTIEKCRNSIFVLGPVGTTLHLHSCDNVKVIAVCHRLSISSTTGCIFHVLTPTRPLILSGNQTVTFAPFHTHYPMLEDHMARTGLATVPNYWDNPMVVCRENSDTRVFQLLPPCEFYVFIIPFEMEGDTTEIPGGLPSVYQKALGQREQKIQIWQKTVKEAHLTKDQRKQFQVLVENKFYEWLINTGHRQQLDSLVPPAAGSKQAAG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Acetylation	FSLHYLRKISTYVQI CCHHHHHHHCEEEEE	38.11	20167786
53	Ubiquitination	EGAYPRLYWSTWRHI CCCCCCHHHEECCHH	9.90	27667366
62	Ubiquitination	STWRHIACGKLQLAK EECCHHHHCHHHHHH	4.96	29967540
83	Phosphorylation	FEIFDSLSMKTPEER HHHHHHHCCCCHHHH	23.37	24719451
133	Phosphorylation	IQQLNKVSLRTSLIG HHHHCCCCCCHHCCC	17.47	-
145	Phosphorylation	LIGEEWPSPRNKSQS CCCCCCCCCCCCCCC	37.25	21815630
149	Ubiquitination	EWPSPRNKSQSPDLT CCCCCCCCCCCCCCC	51.67	27667366
150	Phosphorylation	WPSPRNKSQSPDLTE CCCCCCCCCCCCCCH	39.17	26471730
152	Phosphorylation	SPRNKSQSPDLTEKS CCCCCCCCCCCCHHC	27.72	26471730
158	Ubiquitination	QSPDLTEKSNCHNKN CCCCCCHHCCCCCCC	41.56	29967540
184	Ubiquitination	DHLSDLLELLLDPKQ HHHHHHHHHHCCHHH	44.67	29967540
193	Phosphorylation	LLDPKQLTASFHSTH HCCHHHHHHCCCCCC	20.12	-
202	Phosphorylation	SFHSTHSSLVSREAV CCCCCCHHHCCHHHH	25.78	-
213	Phosphorylation	REAVVALSFLIEGTI HHHHHHHHHHHHCHH	14.31	-
219	Phosphorylation	LSFLIEGTISRARKI HHHHHHCHHHHHHHH	11.73	-
221	Phosphorylation	FLIEGTISRARKIYP HHHHCHHHHHHHHEE	21.52	-
280	Ubiquitination	ACLKSGKKLAWAHQV HHHHHCCEEEEEEEC	47.14	29967540
280	Acetylation	ACLKSGKKLAWAHQV HHHHHCCEEEEEEEC	47.14	30592855
300	Phosphorylation	RAKIACNTHVAPRMH CCHHHCCCCCCHHHH	20.01	27499020
340	Phosphorylation	KIHRCNESFIYLLSP EEEECCCCHHHHHCC	11.71	22817900
343	Phosphorylation	RCNESFIYLLSPLRS ECCCCHHHHHCCCCC	10.28	22817900
346	Phosphorylation	ESFIYLLSPLRSVTI CCHHHHHCCCCCCCH	21.20	24719451
401	Phosphorylation	GCIFHVLTPTRPLIL CCEEEEECCCCCEEE	22.86	24719451
410	Ubiquitination	TRPLILSGNQTVTFA CCCEEECCCCEEEEC	27.16	-
410	Ubiquitination	TRPLILSGNQTVTFA CCCEEECCCCEEEEC	27.16	29967540
457	Ubiquitination	RENSDTRVFQLLPPC ECCCCCCEEEECCCE	3.78	27667366
506	Ubiquitination	QKIQIWQKTVKEAHL HHHHHHHHHHHHHHC	40.04	29967540
553	Ubiquitination	VPPAAGSKQAAG--- CCCCCCCCCCCC---	42.93	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBCC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBCC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBCC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P2R3B_HUMAN	PPP2R3B	physical	28514442
UBP47_HUMAN	USP47	physical	28514442
FA13A_HUMAN	FAM13A	physical	28514442
PP2AA_HUMAN	PPP2CA	physical	28514442
2AAB_HUMAN	PPP2R1B	physical	28514442
HIC2_HUMAN	HIC2	physical	28514442
2AAA_HUMAN	PPP2R1A	physical	28514442
SIR1_HUMAN	SIRT1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-340 AND TYR-343, ANDMASS SPECTROMETRY.
PubMed: 19690332