HIC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HIC2_HUMAN
• UniProt AC: Q96JB3
• Protein Name: Hypermethylated in cancer 2 protein
• Gene Name: HIC2
• Organism: Homo sapiens (Human).
• Sequence Length: 615
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional repressor..
• Protein Sequence: MVSGPLALRWCAWAGRGDMGPDMELPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGKLLPSDQPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGSGRAGSTGMGRPPRSQRLSTASVIQARYQGLVDGRKGAHAPQELPQAKGSDDELFLGGSNQDSVQGLGRAVCPAGGEAGLGGCSSSTNGSSGGCEQELGLDLSKKSPPLPPATPGPHLTPDDAAQLSDSQHGSPPAASAPPVANSASYSELGGTPDEPMDLEGAEDNHLSLLEAPGGQPRKSLRHSTRKKEWGKKEPVAGSPFERREAGPKGPCPGEEGEGVGDRVPNGILASGAGPSGPYGEPPYPCKEEEENGKDASEDSAQSGSEGGSGHASAHYMYRQEGYETVSYGDNLYVCIPCAKGFPSSEQLNAHVETHTEEELFIKEEGAYETGSGGAEEEAEDLSAPSAAYTAEPRPFKCSVCEKTYKDPATLRQHEKTHWLTRPFPCNICGKMFTQRGTMTRHMRSHLGLKPFACDECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTSPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Phosphorylation	HKNVLAASSIYFKSL CCCHHHHHHHHHHHH	16.20	23898821
68	Phosphorylation	KNVLAASSIYFKSLV CCHHHHHHHHHHHHH	19.31	23898821
148	Phosphorylation	RAGKPFGSGRAGSTG HCCCCCCCCCCCCCC	26.03	26434776
153	Phosphorylation	FGSGRAGSTGMGRPP CCCCCCCCCCCCCCC	22.32	26434776
154	Phosphorylation	GSGRAGSTGMGRPPR CCCCCCCCCCCCCCH	30.21	26434776
162	Phosphorylation	GMGRPPRSQRLSTAS CCCCCCHHHHCCHHH	25.98	28450419
166	Phosphorylation	PPRSQRLSTASVIQA CCHHHHCCHHHHHHH	24.90	28450419
167	Phosphorylation	PRSQRLSTASVIQAR CHHHHCCHHHHHHHH	27.78	28450419
169	Phosphorylation	SQRLSTASVIQARYQ HHHCCHHHHHHHHHC	21.60	28450419
197	Phosphorylation	ELPQAKGSDDELFLG CCCCCCCCCCCEECC	40.98	30266825
206	Phosphorylation	DELFLGGSNQDSVQG CCEECCCCCHHHCCC	29.53	30266825
210	Phosphorylation	LGGSNQDSVQGLGRA CCCCCHHHCCCCCCE	13.43	23186163
253	Phosphorylation	GLDLSKKSPPLPPAT CCCCCCCCCCCCCCC	35.17	-
280	Phosphorylation	LSDSQHGSPPAASAP CCCCCCCCCCHHHCC	26.11	-
348	Phosphorylation	KKEPVAGSPFERREA CCCCCCCCCCCCCCC	19.37	30266825
380	Phosphorylation	VPNGILASGAGPSGP CCCCEECCCCCCCCC	26.23	29116813
385	Phosphorylation	LASGAGPSGPYGEPP ECCCCCCCCCCCCCC	52.03	29116813
393	Phosphorylation	GPYGEPPYPCKEEEE CCCCCCCCCCCHHHH	31.79	29116813
409	Phosphorylation	GKDASEDSAQSGSEG CCCCCHHHHHCCCCC	24.93	23917254
412	Phosphorylation	ASEDSAQSGSEGGSG CCHHHHHCCCCCCCC	43.96	23917254
477	Phosphorylation	FIKEEGAYETGSGGA EEEECCCCCCCCCCC	25.53	27732954
479	Phosphorylation	KEEGAYETGSGGAEE EECCCCCCCCCCCHH	24.79	27732954
481	Phosphorylation	EGAYETGSGGAEEEA CCCCCCCCCCCHHHH	41.28	23186163
492	Phosphorylation	EEEAEDLSAPSAAYT HHHHHHCCCCCCCCC	50.91	27732954
584	Phosphorylation	TEHMRVHSGEKPYEC CCCEEECCCCCCEEC	45.87	25262027
589	Phosphorylation	VHSGEKPYECQLCGG ECCCCCCEECCCCCC	40.17	23663014
612	Phosphorylation	ISHLRMHTSPS---- HHHHHHCCCCC----	32.75	-
613	Phosphorylation	SHLRMHTSPS----- HHHHHCCCCC-----	14.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HIC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HIC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HIC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
HIC2_HUMAN	HIC2	physical	11554746

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.