| UniProt ID | SGO1_HUMAN | |
|---|---|---|
| UniProt AC | Q5FBB7 | |
| Protein Name | Shugoshin 1 {ECO:0000312|HGNC:HGNC:25088} | |
| Gene Name | SGO1 {ECO:0000312|HGNC:HGNC:25088} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 561 | |
| Subcellular Localization | Nucleus . Chromosome, centromere . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes to the inner centromere throughout prophase until metaphas | |
| Protein Description | Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.. | |
| Protein Sequence | MAKERCLKKSFQDSLEDIKKRMKEKRNKNLAEIGKRRSFIAAPCQIITNTSTLLKNYQDNNKMLVLALENEKSKVKEAQDIILQLRKECYYLTCQLYALKGKLTSQQTVEPAQNQEICSSGMDPNSDDSSRNLFVKDLPQIPLEETELPGQGESFQIEDQIPTIPQDTLGVDFDSGEAKSTDNVLPRTVSVRSSLKKHCNSICQFDSLDDFETSHLAGKSFEFERVGFLDPLVNMHIPENVQHNACQWSKDQVNLSPKLIQPGTFTKTKEDILESKSEQTKSKQRDTQERKREEKRKANRRKSKRMSKYKENKSENKKTVPQKKMHKSVSSNDAYNFNLEEGVHLTPFRQKVSNDSNREENNESEVSLCESSGSGDDSDDLYLPTCKYIQNPTSNSDRPVTRPLAKRALKYTDEKETEGSKPTKTPTTTPPETQQSPHLSLKDITNVSLYPVVKIRRLSLSPKKNKASPAVALPKRRCTASVNYKEPTLASKLRRGDPFTDLCFLNSPIFKQKKDLRRSKKRALEVSPAKEAIFILYYVREFVSRFPDCRKCKLETHICLR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 | Phosphorylation | LKKSFQDSLEDIKKR HHHHHHHHHHHHHHH | 22817900 | ||
| 19 | Ubiquitination | QDSLEDIKKRMKEKR HHHHHHHHHHHHHHH | - | ||
| 23 | Acetylation | EDIKKRMKEKRNKNL HHHHHHHHHHHHHCH | 24431335 | ||
| 25 | Acetylation | IKKRMKEKRNKNLAE HHHHHHHHHHHCHHH | 24431343 | ||
| 38 | Phosphorylation | AEIGKRRSFIAAPCQ HHHHHHHHHHHHCEE | 22617229 | ||
| 50 | Phosphorylation | PCQIITNTSTLLKNY CEEEEECHHHHHHHH | 22210691 | ||
| 119 | Phosphorylation | AQNQEICSSGMDPNS HHCCHHHHCCCCCCC | 26074081 | ||
| 120 | Phosphorylation | QNQEICSSGMDPNSD HCCHHHHCCCCCCCC | 26074081 | ||
| 126 | Phosphorylation | SSGMDPNSDDSSRNL HCCCCCCCCCHHCCC | 25262027 | ||
| 129 | Phosphorylation | MDPNSDDSSRNLFVK CCCCCCCHHCCCEEC | 25627689 | ||
| 130 | Phosphorylation | DPNSDDSSRNLFVKD CCCCCCHHCCCEECC | 25262027 | ||
| 167 (in isoform 3) | Phosphorylation | - | 28387310 | ||
| 167 (in isoform 5) | Phosphorylation | - | 28387310 | ||
| 185 (in isoform 5) | Ubiquitination | - | 21890473 | ||
| 185 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 190 | Phosphorylation | NVLPRTVSVRSSLKK CCCCCCHHHHHHHHH | 20068231 | ||
| 193 | Phosphorylation | PRTVSVRSSLKKHCN CCCHHHHHHHHHHHC | 25159151 | ||
| 194 | Phosphorylation | RTVSVRSSLKKHCNS CCHHHHHHHHHHHCC | 25159151 | ||
| 201 | Phosphorylation | SLKKHCNSICQFDSL HHHHHHCCCCCCCCC | - | ||
| 202 (in isoform 4) | Ubiquitination | - | 21890473 | ||
| 202 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 207 | Phosphorylation | NSICQFDSLDDFETS CCCCCCCCCCHHHHH | 20068231 | ||
| 220 | Phosphorylation | TSHLAGKSFEFERVG HHHHCCCCEEEEECC | 21815630 | ||
| 256 | Phosphorylation | SKDQVNLSPKLIQPG CHHHCCCCHHHCCCC | 29255136 | ||
| 264 | Phosphorylation | PKLIQPGTFTKTKED HHHCCCCCCCCCHHH | 26074081 | ||
| 266 | Phosphorylation | LIQPGTFTKTKEDIL HCCCCCCCCCHHHHH | 26074081 | ||
| 268 | Phosphorylation | QPGTFTKTKEDILES CCCCCCCCHHHHHHC | 26074081 | ||
| 335 | Phosphorylation | SVSSNDAYNFNLEEG CCCCCCCCCCCCCCC | 28122231 | ||
| 346 | Phosphorylation | LEEGVHLTPFRQKVS CCCCCEECCCCCCCC | 25159151 | ||
| 394 | Phosphorylation | KYIQNPTSNSDRPVT CCCCCCCCCCCCCCC | 28555341 | ||
| 417 | Phosphorylation | KYTDEKETEGSKPTK HHCCCCCCCCCCCCC | 26074081 | ||
| 420 | Phosphorylation | DEKETEGSKPTKTPT CCCCCCCCCCCCCCC | 26074081 | ||
| 423 | Phosphorylation | ETEGSKPTKTPTTTP CCCCCCCCCCCCCCC | 26074081 | ||
| 425 | Phosphorylation | EGSKPTKTPTTTPPE CCCCCCCCCCCCCCC | 25159151 | ||
| 427 | Phosphorylation | SKPTKTPTTTPPETQ CCCCCCCCCCCCCCC | 28450419 | ||
| 428 | Phosphorylation | KPTKTPTTTPPETQQ CCCCCCCCCCCCCCC | 28450419 | ||
| 429 | Phosphorylation | PTKTPTTTPPETQQS CCCCCCCCCCCCCCC | 25159151 | ||
| 433 | Phosphorylation | PTTTPPETQQSPHLS CCCCCCCCCCCCCCC | 30266825 | ||
| 436 | Phosphorylation | TPPETQQSPHLSLKD CCCCCCCCCCCCHHH | 30266825 | ||
| 440 | Phosphorylation | TQQSPHLSLKDITNV CCCCCCCCHHHCCCC | 23663014 | ||
| 445 | Phosphorylation | HLSLKDITNVSLYPV CCCHHHCCCCCEEEE | 28555341 | ||
| 448 | Phosphorylation | LKDITNVSLYPVVKI HHHCCCCCEEEEEEE | 28442448 | ||
| 450 | Phosphorylation | DITNVSLYPVVKIRR HCCCCCEEEEEEEEE | 28152594 | ||
| 454 (in isoform 6) | Ubiquitination | - | 21890473 | ||
| 454 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 454 | Ubiquitination | VSLYPVVKIRRLSLS CCEEEEEEEEEECCC | 21890473 | ||
| 459 | Phosphorylation | VVKIRRLSLSPKKNK EEEEEEECCCCCCCC | 22167270 | ||
| 461 | Phosphorylation | KIRRLSLSPKKNKAS EEEEECCCCCCCCCC | 30266825 | ||
| 463 | Ubiquitination | RRLSLSPKKNKASPA EEECCCCCCCCCCCC | - | ||
| 464 | Ubiquitination | RLSLSPKKNKASPAV EECCCCCCCCCCCCC | - | ||
| 466 | Ubiquitination | SLSPKKNKASPAVAL CCCCCCCCCCCCCCC | - | ||
| 468 | Phosphorylation | SPKKNKASPAVALPK CCCCCCCCCCCCCCC | 25159151 | ||
| 488 | Phosphorylation | SVNYKEPTLASKLRR CCCCCCCCHHHHHCC | 29449344 | ||
| 491 | Phosphorylation | YKEPTLASKLRRGDP CCCCCHHHHHCCCCC | 29449344 | ||
| 500 | Phosphorylation | LRRGDPFTDLCFLNS HCCCCCCCHHHCCCC | 24732914 | ||
| 507 | Phosphorylation | TDLCFLNSPIFKQKK CHHHCCCCHHHHCHH | 25159151 | ||
| 556 | Phosphorylation | CRKCKLETHICLR-- HHHCCCEEEEECC-- | 29457462 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 14 | S | Phosphorylation | Kinase | NEK2 | P51955 | Uniprot |
| 346 | T | Phosphorylation | Kinase | CDK1 | P06493 | PSP |
| 507 | S | Phosphorylation | Kinase | NEK2 | P51955 | Uniprot |
| - | K | Ubiquitination | E3 ubiquitin ligase | FZR1 | Q9UM11 | PMID:19015261 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SGO1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SGO1_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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