DYSF_HUMAN - dbPTM
DYSF_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DYSF_HUMAN
UniProt AC O75923
Protein Name Dysferlin
Gene Name DYSF
Organism Homo sapiens (Human).
Sequence Length 2080
Subcellular Localization Cell membrane, sarcolemma
Single-pass type II membrane protein. Cytoplasmic vesicle membrane
Single-pass type II membrane protein. Cell membrane. Colocalizes, during muscle differentiation, with BIN1 in the T-tubule system of myotubules and at the
Protein Description Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity)..
Protein Sequence MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLDQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEEEPAGAVKPSKASDLDDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVMDDKSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLVKPFS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10 (in isoform 10)Phosphorylation-46.3520068231
10 (in isoform 11)Phosphorylation-46.3520068231
10 (in isoform 12)Phosphorylation-46.3520068231
10 (in isoform 13)Phosphorylation-46.3520068231
10 (in isoform 14)Phosphorylation-46.3520068231
10 (in isoform 8)Phosphorylation-46.3520068231
10 (in isoform 9)Phosphorylation-46.3520068231
14 (in isoform 10)Phosphorylation-20.6920068231
14 (in isoform 11)Phosphorylation-20.6920068231
14 (in isoform 12)Phosphorylation-20.6920068231
14 (in isoform 13)Phosphorylation-20.6920068231
14 (in isoform 14)Phosphorylation-20.6920068231
14 (in isoform 8)Phosphorylation-20.6920068231
14 (in isoform 9)Phosphorylation-20.6920068231
23PhosphorylationDTDISDAYCSAVFAG
CCCHHHHHHHHHHCC		7.60-
25PhosphorylationDISDAYCSAVFAGVK
CHHHHHHHHHHCCCH		18.13-
79MethylationHETMGRNRFLGEAKV
CCCCCCCCCCCCCCC		27.14-
94PhosphorylationPLREVLATPSLSASF
CHHHHCCCCCCCCCC		14.8427732954
96PhosphorylationREVLATPSLSASFNA
HHHCCCCCCCCCCCC		30.5127732954
98PhosphorylationVLATPSLSASFNAPL
HCCCCCCCCCCCCCC		26.6327732954
100PhosphorylationATPSLSASFNAPLLD
CCCCCCCCCCCCCCC		18.6927732954
142 (in isoform 2)Phosphorylation-22.5726657352
142 (in isoform 5)Phosphorylation-22.5726657352
142 (in isoform 7)Phosphorylation-22.5726657352
143 (in isoform 11)Phosphorylation-48.9826657352
143 (in isoform 13)Phosphorylation-48.9826657352
143 (in isoform 8)Phosphorylation-48.9826657352
160PhosphorylationDTGGEEDTEDQGLTG
CCCCCCCCCCCCCCC		44.7524275569
161 (in isoform 2)Phosphorylation-61.7430266825
161 (in isoform 5)Phosphorylation-61.7430266825
161 (in isoform 7)Phosphorylation-61.7430266825
162 (in isoform 11)Phosphorylation-50.3630266825
162 (in isoform 13)Phosphorylation-50.3630266825
162 (in isoform 8)Phosphorylation-50.3630266825
163 (in isoform 2)Phosphorylation-42.4330266825
163 (in isoform 5)Phosphorylation-42.4330266825
163 (in isoform 7)Phosphorylation-42.4330266825
164 (in isoform 11)Phosphorylation-37.2130266825
164 (in isoform 13)Phosphorylation-37.2130266825
164 (in isoform 8)Phosphorylation-37.2130266825
166PhosphorylationDTEDQGLTGDEAEPF
CCCCCCCCCCCCCCC		49.7810196377
166 (in isoform 2)Phosphorylation-49.7830266825
166 (in isoform 5)Phosphorylation-49.7830266825
166 (in isoform 7)Phosphorylation-49.7830266825
167 (in isoform 11)Phosphorylation-35.4930266825
167 (in isoform 13)Phosphorylation-35.4930266825
167 (in isoform 8)Phosphorylation-35.4930266825
168 (in isoform 2)Phosphorylation-46.8530266825
168 (in isoform 5)Phosphorylation-46.8530266825
168 (in isoform 7)Phosphorylation-46.8530266825
169 (in isoform 11)Phosphorylation-57.1730266825
169 (in isoform 13)Phosphorylation-57.1730266825
169 (in isoform 2)Phosphorylation-57.1730266825
169 (in isoform 5)Phosphorylation-57.1730266825
169 (in isoform 7)Phosphorylation-57.1730266825
169 (in isoform 8)Phosphorylation-57.1730266825
170 (in isoform 11)Phosphorylation-34.2130266825
170 (in isoform 13)Phosphorylation-34.2130266825
170 (in isoform 8)Phosphorylation-34.2130266825
172 (in isoform 2)Phosphorylation-41.9922673903
172 (in isoform 5)Phosphorylation-41.9922673903
172 (in isoform 7)Phosphorylation-41.9922673903
173 (in isoform 11)Phosphorylation-9.8822673903
173 (in isoform 13)Phosphorylation-9.8822673903
173 (in isoform 8)Phosphorylation-9.8822673903
174 (in isoform 2)Phosphorylation-9.5428450419
174 (in isoform 5)Phosphorylation-9.5428450419
174 (in isoform 7)Phosphorylation-9.5428450419
175 (in isoform 11)Phosphorylation-40.7628450419
175 (in isoform 13)Phosphorylation-40.7628450419
175 (in isoform 2)Phosphorylation-40.7622617229
175 (in isoform 5)Phosphorylation-40.7622617229
175 (in isoform 7)Phosphorylation-40.7622617229
175 (in isoform 8)Phosphorylation-40.7628450419
176 (in isoform 11)Phosphorylation-46.2322617229
176 (in isoform 13)Phosphorylation-46.2322617229
176 (in isoform 8)Phosphorylation-46.2322617229
177PhosphorylationAEPFLDQSGGPGAPT
CCCCCCCCCCCCCCC		45.4426657352
183 (in isoform 2)Phosphorylation-42.6028450419
183 (in isoform 5)Phosphorylation-42.6028450419
183 (in isoform 7)Phosphorylation-42.6028450419
184PhosphorylationSGGPGAPTTPRKLPS
CCCCCCCCCCCCCCC		49.2321552520
184 (in isoform 11)Phosphorylation-49.2328450419
184 (in isoform 13)Phosphorylation-49.2328450419
184 (in isoform 8)Phosphorylation-49.2328450419
185PhosphorylationGGPGAPTTPRKLPSR
CCCCCCCCCCCCCCC		21.7521552520
185 (in isoform 2)Phosphorylation-21.7528450419
185 (in isoform 5)Phosphorylation-21.7528450419
185 (in isoform 7)Phosphorylation-21.7528450419
186 (in isoform 11)Phosphorylation-33.6128450419
186 (in isoform 13)Phosphorylation-33.6128450419
186 (in isoform 8)Phosphorylation-33.6128450419
191PhosphorylationTTPRKLPSRPPPHYP
CCCCCCCCCCCCCCC		68.7828348404
191 (in isoform 2)Phosphorylation-68.7828450419
191 (in isoform 5)Phosphorylation-68.7828450419
191 (in isoform 7)Phosphorylation-68.7828450419
192 (in isoform 11)Phosphorylation-45.8928450419
192 (in isoform 13)Phosphorylation-45.8928450419
192 (in isoform 8)Phosphorylation-45.8928450419
197PhosphorylationPSRPPPHYPGIKRKR
CCCCCCCCCCCCCCC		14.6621214269
197 (in isoform 2)Phosphorylation-14.6626657352
197 (in isoform 5)Phosphorylation-14.6626657352
197 (in isoform 7)Phosphorylation-14.6626657352
198 (in isoform 11)Phosphorylation-34.6926657352
198 (in isoform 13)Phosphorylation-34.6926657352
198 (in isoform 8)Phosphorylation-34.6926657352
208 (in isoform 2)Phosphorylation-40.6628450419
208 (in isoform 5)Phosphorylation-40.6628450419
208 (in isoform 7)Phosphorylation-40.6628450419
209PhosphorylationRKRSAPTSRKLLSDK
CCCCCCCCCHHHCCC		26.76-
209 (in isoform 11)Phosphorylation-26.7628450419
209 (in isoform 13)Phosphorylation-26.7628450419
209 (in isoform 8)Phosphorylation-26.7628450419
215 (in isoform 2)Phosphorylation-67.6328450419
215 (in isoform 5)Phosphorylation-67.6328450419
215 (in isoform 7)Phosphorylation-67.6328450419
216 (in isoform 11)Phosphorylation-41.0028450419
216 (in isoform 13)Phosphorylation-41.0028450419
216 (in isoform 2)Phosphorylation-41.0028450419
216 (in isoform 5)Phosphorylation-41.0028450419
216 (in isoform 7)Phosphorylation-41.0028450419
216 (in isoform 8)Phosphorylation-41.0028450419
217 (in isoform 11)Phosphorylation-43.9228450419
217 (in isoform 13)Phosphorylation-43.9228450419
217 (in isoform 8)Phosphorylation-43.9228450419
250AcetylationVTAAGQTKRTRIHKG
EEECCCCCCCCCCCC		43.837669665
324PhosphorylationLRKWLLLSDPDDFSA
HHHHHHHCCCCCCCC		47.25-
330PhosphorylationLSDPDDFSAGARGYL
HCCCCCCCCCHHHCC		32.56-
413UbiquitinationFGFESNKKNLVDPFV
HCCCCCCCCCCCCCE		60.8229967540
414UbiquitinationGFESNKKNLVDPFVE
CCCCCCCCCCCCCEE		47.0829967540
423PhosphorylationVDPFVEVSFAGKMLC
CCCCEEEHHHHHHHH		8.8929978859
431PhosphorylationFAGKMLCSKILEKTA
HHHHHHHHHHHHHHC		20.8329978859
437PhosphorylationCSKILEKTANPQWNQ
HHHHHHHHCCCCCCC		23.4518187866
444UbiquitinationTANPQWNQNITLPAM
HCCCCCCCCCCCCCC		39.4829967540
445UbiquitinationANPQWNQNITLPAMF
CCCCCCCCCCCCCCC		26.4629967540
454PhosphorylationTLPAMFPSMCEKMRI
CCCCCCHHHHHHCCE		25.46-
470PhosphorylationIIDWDRLTHNDIVAT
EEEHHCCCCCCEEEE		21.3725072903
477PhosphorylationTHNDIVATTYLSMSK
CCCCEEEEEEEEHHH		12.7025072903
478PhosphorylationHNDIVATTYLSMSKI
CCCEEEEEEEEHHHC		16.8425072903
479PhosphorylationNDIVATTYLSMSKIS
CCEEEEEEEEHHHCC		7.7625072903
481PhosphorylationIVATTYLSMSKISAP
EEEEEEEEHHHCCCC		15.5925072903
483PhosphorylationATTYLSMSKISAPGG
EEEEEEHHHCCCCCC		24.3825072903
486PhosphorylationYLSMSKISAPGGEIE
EEEHHHCCCCCCCCC		31.9523898821
503PhosphorylationPAGAVKPSKASDLDD
CCCCCCCCCCCCHHH		34.8323898821
508 (in isoform 15)Phosphorylation-5.1022210691
508 (in isoform 3)Phosphorylation-5.1022210691
508 (in isoform 6)Phosphorylation-5.1022210691
509 (in isoform 12)Phosphorylation-47.7222210691
509 (in isoform 9)Phosphorylation-47.7222210691
512 (in isoform 15)Phosphorylation-5.1422210691
512 (in isoform 3)Phosphorylation-5.1422210691
512 (in isoform 6)Phosphorylation-5.1422210691
513 (in isoform 12)Phosphorylation-18.8022210691
513 (in isoform 9)Phosphorylation-18.8022210691
514 (in isoform 15)Phosphorylation-7.3422210691
514 (in isoform 3)Phosphorylation-7.3422210691
514 (in isoform 6)Phosphorylation-7.3422210691
515 (in isoform 12)Phosphorylation-3.5622210691
515 (in isoform 9)Phosphorylation-3.5622210691
539 (in isoform 5)Phosphorylation-21.8922210691
539 (in isoform 7)Phosphorylation-21.8922210691
540 (in isoform 11)Phosphorylation-39.1122210691
540 (in isoform 13)Phosphorylation-39.1122210691
543 (in isoform 5)Phosphorylation-40.3222210691
543 (in isoform 7)Phosphorylation-40.3222210691
544 (in isoform 11)Phosphorylation-53.5522210691
544 (in isoform 13)Phosphorylation-53.5522210691
545 (in isoform 5)Phosphorylation-34.5922210691
545 (in isoform 7)Phosphorylation-34.5922210691
546 (in isoform 11)Phosphorylation-52.3122210691
546 (in isoform 13)Phosphorylation-52.3122210691
634PhosphorylationTCLPLASTTQYSRAV
EEEECCCCCHHHHHH		16.5923911959
637PhosphorylationPLASTTQYSRAVFDG
ECCCCCHHHHHHCCC		9.68-
638PhosphorylationLASTTQYSRAVFDGC
CCCCCHHHHHHCCCC		12.1623911959
741PhosphorylationTHLDQYLYQLRTHHL
HHHHHHHHHHHHHCH		10.68-
806PhosphorylationQGDKRVAYQRVPAHQ
ECCCCEEEEECCHHH		8.2627282143
817PhosphorylationPAHQVLFSRRGANYC
CHHHHHHCCCCCCCC		19.5327282143
823UbiquitinationFSRRGANYCGKNCGK
HCCCCCCCCCCCCCC		11.3129967540
824UbiquitinationSRRGANYCGKNCGKL
CCCCCCCCCCCCCCC		6.6729967540
837UbiquitinationKLQTIFLKYPMEKVP
CCEEEEEECCHHHCC		36.2429967540
838UbiquitinationLQTIFLKYPMEKVPG
CEEEEEECCHHHCCC		15.2329967540
854UbiquitinationRMPVQIRVKLWFGLS
CCCEEEEEEEEEECC		6.8029967540
855UbiquitinationMPVQIRVKLWFGLSV
CCEEEEEEEEEECCC		30.1029967540
861PhosphorylationVKLWFGLSVDEKEFN
EEEEEECCCCHHHHH		28.09-
868UbiquitinationSVDEKEFNQFAEGKL
CCCHHHHHHHHHCCE		36.8329967540
869UbiquitinationVDEKEFNQFAEGKLS
CCHHHHHHHHHCCEE		44.2229967540
896UbiquitinationALVGNWGTTGLTYPK
EEEECCCCCCCCCCC		14.8733845483
897UbiquitinationLVGNWGTTGLTYPKF
EEECCCCCCCCCCCH		26.6833845483
905PhosphorylationGLTYPKFSDVTGKIK
CCCCCCHHCCCCCEE		36.98-
910UbiquitinationKFSDVTGKIKLPKDS
CHHCCCCCEECCCCC		27.5733845483
911UbiquitinationFSDVTGKIKLPKDSF
HHCCCCCEECCCCCC		6.1533845483
927UbiquitinationPSAGWTWAGDWFVCP
CCCCCEECCCEEECC		9.9333845483
928UbiquitinationSAGWTWAGDWFVCPE
CCCCEECCCEEECCC		25.0133845483
941UbiquitinationPEKTLLHDMDAGHLS
CCCCEEEECCCCCHH		36.3033845483
942UbiquitinationEKTLLHDMDAGHLSF
CCCEEEECCCCCHHH		2.3733845483
969UbiquitinationGGQWIYMSDNYTDVN
CCCEEEECCCEECCC		13.0129967540
970UbiquitinationGQWIYMSDNYTDVNG
CCEEEECCCEECCCC		35.3129967540
983UbiquitinationNGEKVLPKDDIECPL
CCCEECCCCCCCCCC		64.9629967540
984UbiquitinationGEKVLPKDDIECPLG
CCEECCCCCCCCCCC		61.2529967540
1000UbiquitinationKWEDEEWSTDLNRAV
CCCCCCCCCCHHHHH		18.4729967540
1001UbiquitinationWEDEEWSTDLNRAVD
CCCCCCCCCHHHHHH		45.6529967540
1014UbiquitinationVDEQGWEYSITIPPE
HHHCCCEEEEECCCC		10.0029967540
1015UbiquitinationDEQGWEYSITIPPER
HHCCCEEEEECCCCC		11.1829967540
1267PhosphorylationLTRGSQPSGELLASF
CCCCCCCCCHHHHHH		36.94-
1302PhosphorylationTSRILDESEDTDLPY
CCCCCCCCCCCCCCC		40.2028857561
1305PhosphorylationILDESEDTDLPYPPP
CCCCCCCCCCCCCCC		35.0728857561
1309PhosphorylationSEDTDLPYPPPQREA
CCCCCCCCCCCCCCC		35.3523312004
1319PhosphorylationPQREANIYMVPQNIK
CCCCCCEEEECCCCH		7.5927259358
1384PhosphorylationNPNFDICTLFMEVML
CCCCCHHHHHHHHHC		24.30-
1532PhosphorylationFKLYRGKTQEETEDP
HHHHCCCCCCCCCCC		44.0026437602
1540PhosphorylationQEETEDPSVIGEFKG
CCCCCCCCHHHEEEC		38.3926437602
1552PhosphorylationFKGLFKIYPLPEDPA
EECCEEEEECCCCCC		10.1729759185
1595UbiquitinationFGLQPKDPNGKCDPY
CCCCCCCCCCCCCCC		58.5632015554
1596UbiquitinationGLQPKDPNGKCDPYI
CCCCCCCCCCCCCCE		73.0932015554
1597UbiquitinationLQPKDPNGKCDPYIK
CCCCCCCCCCCCCEE		37.0425015289
1602PhosphorylationPNGKCDPYIKISIGK
CCCCCCCCEEEEECC		11.1223663014
1606PhosphorylationCDPYIKISIGKKSVS
CCCCEEEEECCCCCC		21.9326437602
1609UbiquitinationYIKISIGKKSVSDQD
CEEEEECCCCCCCCC		39.9632015554
1610UbiquitinationIKISIGKKSVSDQDN
EEEEECCCCCCCCCC		51.3732015554
1611UbiquitinationKISIGKKSVSDQDNY
EEEECCCCCCCCCCC		30.2725015289
1616UbiquitinationKKSVSDQDNYIPCTL
CCCCCCCCCCEECEE		55.6932015554
1617UbiquitinationKSVSDQDNYIPCTLE
CCCCCCCCCEECEEE		30.8832015554
1618UbiquitinationSVSDQDNYIPCTLEP
CCCCCCCCEECEEEC		17.9625015289
1626UbiquitinationIPCTLEPVFGKMFEL
EECEEECCCCEEEEE		7.8332015554
1627UbiquitinationPCTLEPVFGKMFELT
ECEEECCCCEEEEEE		13.0832015554
1628UbiquitinationCTLEPVFGKMFELTC
CEEECCCCEEEEEEE		22.2825015289
1630UbiquitinationLEPVFGKMFELTCTL
EECCCCEEEEEEEEC		3.0232015554
1631UbiquitinationEPVFGKMFELTCTLP
ECCCCEEEEEEEECC		8.7332015554
1632UbiquitinationPVFGKMFELTCTLPL
CCCCEEEEEEEECCC		39.4025015289
1640UbiquitinationLTCTLPLEKDLKITL
EEEECCCCCCCEEEE		42.4532015554
1641UbiquitinationTCTLPLEKDLKITLY
EEECCCCCCCEEEEE		75.8532015554
1642UbiquitinationCTLPLEKDLKITLYD
EECCCCCCCEEEEEE		43.7625015289
1646PhosphorylationLEKDLKITLYDYDLL
CCCCCEEEEEEHHCC		20.06-
1647UbiquitinationEKDLKITLYDYDLLS
CCCCEEEEEEHHCCC		3.3132015554
1648PhosphorylationKDLKITLYDYDLLSK
CCCEEEEEEHHCCCC		12.10-
1648UbiquitinationKDLKITLYDYDLLSK
CCCEEEEEEHHCCCC		12.1032015554
1649UbiquitinationDLKITLYDYDLLSKD
CCEEEEEEHHCCCCC		33.3225015289
1650PhosphorylationLKITLYDYDLLSKDE
CEEEEEEHHCCCCCC		8.57-
1661UbiquitinationSKDEKIGETVVDLEN
CCCCCCCCEEHHHHH		41.7325015289
1662UbiquitinationKDEKIGETVVDLENR
CCCCCCCEEHHHHHH		22.1825015289
1663UbiquitinationDEKIGETVVDLENRL
CCCCCCEEHHHHHHH		2.4725015289
1683PhosphorylationARCGLPQTYCVSGPN
CCCCCCCEEEECCCC		19.56-
1684PhosphorylationRCGLPQTYCVSGPNQ
CCCCCCEEEECCCCH		5.89-
1687PhosphorylationLPQTYCVSGPNQWRD
CCCEEEECCCCHHHH		45.00-
1729PhosphorylationMFQDKEYSIEEIEAG
EECCCCEEHHHHHCC		25.3126437602
1804PhosphorylationPGPPFNITPRRARRF
CCCCCCCCHHHHHHH		16.3124719451
1829PhosphorylationDVILDDLSLTGEKMS
CEEHHHHCCCCCCHH		30.7730266825
1831PhosphorylationILDDLSLTGEKMSDI
EHHHHCCCCCCHHHE		39.6630266825
1858PhosphorylationKQKTDVHYRSLGGEG
HCCCCEEEHHHCCCC		11.1826356563
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DYSF_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DYSF_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DYSF_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CAV3_HUMANCAV3physical
11532985
HDAC6_HUMANHDAC6physical
22174839
RIPR2_HUMANFAM65Bphysical
24687993
Drug and Disease Associations
Kegg Disease
H00566 Dysferlinopathies, including: Miyoshi myopathy (MM); Limb-girdle muscular dystrophy (LGMD) 2B; Dista
H00593 Limb-girdle muscular dystrophy (LGMD)
H00594 Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (T
OMIM Disease
253601Limb-girdle muscular dystrophy 2B (LGMD2B)
254130Miyoshi muscular dystrophy 1 (MMD1)
606768Distal myopathy with anterior tibial onset (DMAT)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DYSF_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-437, AND MASSSPECTROMETRY.

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