| UniProt ID | RIPR2_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y4F9 | |
| Protein Name | Rho family-interacting cell polarization regulator 2 | |
| Gene Name | RIPOR2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1068 | |
| Subcellular Localization | Cytoplasm . Cytoplasm, cytoskeleton . Cell projection, filopodium . Cell projection, stereocilium . Cell projection, stereocilium membrane . Apical cell membrane . Localized in the cytoplasm in cells undergoing mitosis (PubMed:17150207). Colocalized | |
| Protein Description | Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. [PubMed: 17150207] | |
| Protein Sequence | MLVGSQSFSPGGPNGIIRSQSFAGFSGLQERRSRCNSFIENSSALKKPQAKLKKMHNLGHKNNNPPKEPQPKRVEEVYRALKNGLDEYLEVHQTELDKLTAQLKDMKRNSRLGVLYDLDKQIKTIERYMRRLEFHISKVDELYEAYCIQRRLQDGASKMKQAFATSPASKAARESLTEINRSFKEYTENMCTIEVELENLLGEFSIKMKGLAGFARLCPGDQYEIFMKYGRQRWKLKGKIEVNGKQSWDGEETVFLPLIVGFISIKVTELKGLATHILVGSVTCETKELFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDMTASSGAGNKAAALQRRMSMYSQGTPETPTFKDHSFFRWLHPSPDKPRRLSVLSALQDTFFAKLHRSRSFSDLPSLRPSPKAVLELYSNLPDDIFENGKAAEEKMPLSLSFSDLPNGDCALTSHSTGSPSNSTNPEITITPAEFNLSSLASQNEGMDDTSSASSRNSLGEGQEPKSHLKEEDPEEPRKPASAPSEACRRQSSGAGAEHLFLENDVAEALLQESEEASELKPVELDTSEGNITKQLVKRLTSAEVPMATDRLLSEGSVGGESEGCRSFLDGSLEDAFNGLLLALEPHKEQYKEFQDLNQEVMNLDDILKCKPAVSRSRSSSLSLTVESALESFDFLNTSDFDEEEDGDEVCNVGGGADSVFSDTETEKHSYRSVHPEARGHLSEALTEDTGVGTSVAGSPLPLTTGNESLDITIVRHLQYCTQLVQQIVFSSKTPFVARSLLEKLSRQIQVMEKLAAVSDENIGNISSVVEAIPEFHKKLSLLSFWTKCCSPVGVYHSPADRVMKQLEASFARTVNKEYPGLADPVFRTLVSQILDRAEPLLSSSLSSEVVTVFQYYSYFTSHGVSDLESYLSQLARQVSMVQTLQSLRDEKLLQTMSDLAPSNLLAQQEVLRTLALLLTREDNEVSEAVTLYLAAASKNQHFREKALLYYCEALTKTNLQLQKAACLALKILEATESIKMLVTLCQSDTEEIRNVASETLLSLGEDGRLAYEQLDKFPRDCVKVGGRHGTEVATAF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MLVGSQSFSPGG ---CCCCCCCCCCCC | 26552605 | ||
| 7 | Phosphorylation | -MLVGSQSFSPGGPN -CCCCCCCCCCCCCC | 26552605 | ||
| 9 | Phosphorylation | LVGSQSFSPGGPNGI CCCCCCCCCCCCCCE | 26552605 | ||
| 19 | Phosphorylation | GPNGIIRSQSFAGFS CCCCEEECCCCCCCC | 23401153 | ||
| 21 | Phosphorylation | NGIIRSQSFAGFSGL CCEEECCCCCCCCCH | 23927012 | ||
| 26 | Phosphorylation | SQSFAGFSGLQERRS CCCCCCCCCHHHHHH | 23927012 | ||
| 33 | Phosphorylation | SGLQERRSRCNSFIE CCHHHHHHHHHHHHH | 23401153 | ||
| 37 | Phosphorylation | ERRSRCNSFIENSSA HHHHHHHHHHHCCHH | 23401153 | ||
| 42 | Phosphorylation | CNSFIENSSALKKPQ HHHHHHCCHHCCCHH | 26552605 | ||
| 43 | Phosphorylation | NSFIENSSALKKPQA HHHHHCCHHCCCHHH | 26552605 | ||
| 98 | Ubiquitination | VHQTELDKLTAQLKD HHHHHHHHHHHHHHH | - | ||
| 104 | Ubiquitination | DKLTAQLKDMKRNSR HHHHHHHHHHHHHCC | - | ||
| 170 | Ubiquitination | FATSPASKAARESLT HHCCHHHHHHHHHHH | - | ||
| 175 | Phosphorylation | ASKAARESLTEINRS HHHHHHHHHHHHHHH | 29978859 | ||
| 177 | Phosphorylation | KAARESLTEINRSFK HHHHHHHHHHHHHHH | 23312004 | ||
| 205 | Phosphorylation | ENLLGEFSIKMKGLA HHHHHHHHHHHCCCC | 24719451 | ||
| 223 | Phosphorylation | RLCPGDQYEIFMKYG HCCCCCHHHHHHHHC | - | ||
| 229 | Phosphorylation | QYEIFMKYGRQRWKL HHHHHHHHCCCCEEE | - | ||
| 306 | Phosphorylation | VDINDLGTIKLNLEI EECCCCCEEEEEEEE | - | ||
| 314 | Phosphorylation | IKLNLEITWYPFDVE EEEEEEEEEEECCHH | 24275569 | ||
| 316 | Phosphorylation | LNLEITWYPFDVEDM EEEEEEEEECCHHHC | 24275569 | ||
| 324 | Phosphorylation | PFDVEDMTASSGAGN ECCHHHCCCCCCCCH | 24275569 | ||
| 341 | Phosphorylation | AALQRRMSMYSQGTP HHHHHHHHHHCCCCC | 23401153 | ||
| 343 | Phosphorylation | LQRRMSMYSQGTPET HHHHHHHHCCCCCCC | 25219547 | ||
| 344 | Phosphorylation | QRRMSMYSQGTPETP HHHHHHHCCCCCCCC | 25219547 | ||
| 347 | Phosphorylation | MSMYSQGTPETPTFK HHHHCCCCCCCCCCC | 25219547 | ||
| 350 | Phosphorylation | YSQGTPETPTFKDHS HCCCCCCCCCCCCCC | 25219547 | ||
| 352 | Phosphorylation | QGTPETPTFKDHSFF CCCCCCCCCCCCCCH | 29978859 | ||
| 357 (in isoform 2) | Phosphorylation | - | 24275569 | ||
| 357 | Phosphorylation | TPTFKDHSFFRWLHP CCCCCCCCCHHCCCC | 24719451 | ||
| 373 | Phosphorylation | PDKPRRLSVLSALQD CCCCHHHHHHHHHHH | 26503514 | ||
| 389 | Phosphorylation | FFAKLHRSRSFSDLP HHHHHHCCCCHHHCC | - | ||
| 391 | Phosphorylation | AKLHRSRSFSDLPSL HHHHCCCCHHHCCCC | - | ||
| 397 | Phosphorylation | RSFSDLPSLRPSPKA CCHHHCCCCCCCHHH | 24719451 | ||
| 430 | Phosphorylation | AEEKMPLSLSFSDLP HHHHCCCEEECCCCC | 26074081 | ||
| 432 | Phosphorylation | EKMPLSLSFSDLPNG HHCCCEEECCCCCCC | 26074081 | ||
| 434 | Phosphorylation | MPLSLSFSDLPNGDC CCCEEECCCCCCCCE | 26074081 | ||
| 444 | Phosphorylation | PNGDCALTSHSTGSP CCCCEEEEECCCCCC | 26074081 | ||
| 445 | Phosphorylation | NGDCALTSHSTGSPS CCCEEEEECCCCCCC | 26074081 | ||
| 447 | Phosphorylation | DCALTSHSTGSPSNS CEEEEECCCCCCCCC | 26074081 | ||
| 448 | Phosphorylation | CALTSHSTGSPSNST EEEEECCCCCCCCCC | 26074081 | ||
| 450 | Phosphorylation | LTSHSTGSPSNSTNP EEECCCCCCCCCCCC | 26074081 | ||
| 452 | Phosphorylation | SHSTGSPSNSTNPEI ECCCCCCCCCCCCCE | 26074081 | ||
| 454 | Phosphorylation | STGSPSNSTNPEITI CCCCCCCCCCCCEEE | 26074081 | ||
| 455 | Phosphorylation | TGSPSNSTNPEITIT CCCCCCCCCCCEEEE | 26074081 | ||
| 489 | Phosphorylation | SSASSRNSLGEGQEP CCCHHHCCCCCCCCC | 23401153 | ||
| 523 | Phosphorylation | SEACRRQSSGAGAEH HHHHHHHCCCCCCHH | 23684312 | ||
| 524 | Phosphorylation | EACRRQSSGAGAEHL HHHHHHCCCCCCHHH | 28464451 | ||
| 564 | Phosphorylation | DTSEGNITKQLVKRL CCCCCCHHHHHHHHH | 23532336 | ||
| 572 | Phosphorylation | KQLVKRLTSAEVPMA HHHHHHHHHCCCCCC | 28787133 | ||
| 573 | Phosphorylation | QLVKRLTSAEVPMAT HHHHHHHHCCCCCCH | 23401153 | ||
| 580 | Phosphorylation | SAEVPMATDRLLSEG HCCCCCCHHHHHHCC | 30108239 | ||
| 585 | Phosphorylation | MATDRLLSEGSVGGE CCHHHHHHCCCCCCC | 23401153 | ||
| 588 | Phosphorylation | DRLLSEGSVGGESEG HHHHHCCCCCCCCHH | 23401153 | ||
| 593 | Phosphorylation | EGSVGGESEGCRSFL CCCCCCCCHHHHHHC | 26552605 | ||
| 603 | Phosphorylation | CRSFLDGSLEDAFNG HHHHCCCCHHHHHHH | 22617229 | ||
| 623 | Acetylation | EPHKEQYKEFQDLNQ CCCHHHHHHHHHHCH | 19814999 | ||
| 714 | Phosphorylation | PEARGHLSEALTEDT HHHHCCHHHHHHCCC | 27080861 | ||
| 718 | Phosphorylation | GHLSEALTEDTGVGT CCHHHHHHCCCCCCC | 27080861 | ||
| 721 | Phosphorylation | SEALTEDTGVGTSVA HHHHHCCCCCCCCCC | 27080861 | ||
| 725 | Phosphorylation | TEDTGVGTSVAGSPL HCCCCCCCCCCCCCC | 27080861 | ||
| 726 | Phosphorylation | EDTGVGTSVAGSPLP CCCCCCCCCCCCCCC | 27080861 | ||
| 730 | Phosphorylation | VGTSVAGSPLPLTTG CCCCCCCCCCCCCCC | 27080861 | ||
| 735 | Phosphorylation | AGSPLPLTTGNESLD CCCCCCCCCCCCCCC | 27080861 | ||
| 762 | Phosphorylation | LVQQIVFSSKTPFVA HHHHHHHCCCCHHHH | 30631047 | ||
| 763 | Phosphorylation | VQQIVFSSKTPFVAR HHHHHHCCCCHHHHH | 30631047 | ||
| 771 | Phosphorylation | KTPFVARSLLEKLSR CCHHHHHHHHHHHHH | 24719451 | ||
| 809 | Ubiquitination | EAIPEFHKKLSLLSF HHCHHHHHHHHHHHH | - | ||
| 848 | Ubiquitination | SFARTVNKEYPGLAD HHHHHHCCCCCCCCC | - | ||
| 860 | Phosphorylation | LADPVFRTLVSQILD CCCHHHHHHHHHHHH | 23090842 | ||
| 863 | Phosphorylation | PVFRTLVSQILDRAE HHHHHHHHHHHHHHH | 23090842 | ||
| 874 | Phosphorylation | DRAEPLLSSSLSSEV HHHHHHHCCCCCCCC | 29759185 | ||
| 911 | Phosphorylation | SQLARQVSMVQTLQS HHHHHHHHHHHHHHH | 22817900 | ||
| 915 | Phosphorylation | RQVSMVQTLQSLRDE HHHHHHHHHHHHCHH | 22817900 | ||
| 918 | Phosphorylation | SMVQTLQSLRDEKLL HHHHHHHHHCHHHHH | 30622161 | ||
| 945 | Phosphorylation | AQQEVLRTLALLLTR HHHHHHHHHHHHHHC | - | ||
| 951 | O-linked_Glycosylation | RTLALLLTREDNEVS HHHHHHHHCCCCHHH | 30379171 | ||
| 1043 | Phosphorylation | GEDGRLAYEQLDKFP CCCCCHHHHHHHCCC | 28796482 | ||
| 1048 | Ubiquitination | LAYEQLDKFPRDCVK HHHHHHHCCCHHHHE | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RIPR2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RIPR2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RIPR2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RHOA_HUMAN | RHOA | physical | 21988832 | |
| PER1_HUMAN | PER1 | physical | 21988832 | |
| MP2K2_HUMAN | MAP2K2 | physical | 21988832 | |
| 1433Z_HUMAN | YWHAZ | physical | 24687993 | |
| HDAC6_HUMAN | HDAC6 | physical | 24687993 | |
| DYSF_HUMAN | DYSF | physical | 24687993 | |
| MYOF_HUMAN | MYOF | physical | 24687993 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
