FXL16_HUMAN - dbPTM
FXL16_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FXL16_HUMAN
UniProt AC Q8N461
Protein Name F-box/LRR-repeat protein 16
Gene Name FBXL16
Organism Homo sapiens (Human).
Sequence Length 479
Subcellular Localization
Protein Description Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
Protein Sequence MSSPGIDGDPKPPCLPRNGLVKLPGQPNGLGAASITKGTPATKNRPCQPPPPPTLPPPSLAAPLSRAALAGGPCTPAGGPASALAPGHPAERPPLATDEKILNGLFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYALSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLALGSLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSPGIDGD
------CCCCCCCCC
45.2825627689
3Phosphorylation-----MSSPGIDGDP
-----CCCCCCCCCC
26.3325159151
92MethylationAPGHPAERPPLATDE
CCCCCCCCCCCCCCH
40.00-
155UbiquitinationNVLPGGEKEFVNLQG
HCCCCCCEEEECCHH
60.7830230243
196AcetylationALSKKGVKAMSLKRS
HHCCCCCCEEECCCC
47.2218604523
248PhosphorylationSARITSLSVSDCINV
HHHHHCCCHHHHCCH
21.24-
250PhosphorylationRITSLSVSDCINVAD
HHHCCCHHHHCCHHH
24.32-
350PhosphorylationENLRKLRSLDLSWCP
HHHHHHHCCCCCCCC
36.3522817900
388PhosphorylationRCVRITDTGLSYLST
HCEECCCCCHHHHHH
31.2226503514
391PhosphorylationRITDTGLSYLSTMSS
ECCCCCHHHHHHHHH
25.9326503514
392PhosphorylationITDTGLSYLSTMSSL
CCCCCHHHHHHHHHH
15.0926503514
394PhosphorylationDTGLSYLSTMSSLRS
CCCHHHHHHHHHHHH
17.5226503514
423PhosphorylationKHLLALGSLRLLSLA
HHHHHHHHHHHHHHC
15.9224719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FXL16_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FXL16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FXL16_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HPCL4_HUMANHPCAL4physical
24035498
DAAM1_HUMANDAAM1physical
28514442
UBB_HUMANUBBphysical
28514442
FXL18_HUMANFBXL18physical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FXL16_HUMAN

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Related Literatures of Post-Translational Modification

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