| UniProt ID | FXL18_HUMAN | |
|---|---|---|
| UniProt AC | Q96ME1 | |
| Protein Name | F-box/LRR-repeat protein 18 | |
| Gene Name | FBXL18 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 805 | |
| Subcellular Localization | ||
| Protein Description | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.. | |
| Protein Sequence | MASSGEDISNDDDDMHPAAAGMADGVHLLGFSDEILLHILSHVPSTDLILNVRRTCRKLAALCLDKSLIHTVLLQKDYQASEDKVRQLVKEIGREIQQLSMAGCYWLPGSTVEHVARCRSLVKVNLSGCHLTSLRLSKMLSALQHLRSLAIDVSPGFDASQLSSECKATLSRVRELKQTLFTPSYGVVPCCTSLEKLLLYFEILDRTREGAILSGQLMVGQSNVPHYQNLRVFYARLAPGYINQEVVRLYLAVLSDRTPQNLHAFLISVPGSFAESGATKNLLDSMARNVVLDALQLPKSWLNGSSLLQHMKFNNPFYFSFSRCTLSGGHLIQQVINGGKDLRSLASLNLSGCVHCLSPDSLLRKAEDDIDSSILETLVASCCNLRHLNLSAAHHHSSEGLGRHLCQLLARLRHLRSLSLPVCSVADSAPRADRAPAQPAMHAVPRGFGKKVRVGVQSCPSPFSGQACPQPSSVFWSLLKNLPFLEHLELIGSNFSSAMPRNEPAIRNSLPPCSRAQSVGDSEVAAIGQLAFLRHLTLAQLPSVLTGSGLVNIGLQCQQLRSLSLANLGMMGKVVYMPALSDMLKHCKRLRDLRLEQPYFSANAQFFQALSQCPSLQRLCLVSRSGTLQPDAVLAFMARCLQVVMCHLFTGESLATCKSLQQSLLRRWGEVTGRRPQLFTELREEPSARTSRATGRRQPCLPDSGVVCCPCGRPLAVSGIILVGVSPSLVVKTTCVYRVLFKNLDYASIFFLVCLFETESHSVVQAGVQWRDLSSLQPLLSGLQPQPPEQLENELEIGFSYCFVI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 76 | Ubiquitination | IHTVLLQKDYQASED HHHHHHHCCCCCCHH | 59.37 | 2190698 | |
| 76 (in isoform 4) | Ubiquitination | - | 59.37 | 21906983 | |
| 76 (in isoform 3) | Ubiquitination | - | 59.37 | 21906983 | |
| 76 (in isoform 1) | Ubiquitination | - | 59.37 | 21906983 | |
| 76 (in isoform 2) | Ubiquitination | - | 59.37 | 21906983 | |
| 84 | Ubiquitination | DYQASEDKVRQLVKE CCCCCHHHHHHHHHH | 34.95 | - | |
| 84 (in isoform 4) | Ubiquitination | - | 34.95 | - | |
| 90 (in isoform 4) | Ubiquitination | - | 52.81 | - | |
| 127 | Phosphorylation | SLVKVNLSGCHLTSL HHEEEECCCCCHHHH | 33.88 | 29457462 | |
| 132 | Phosphorylation | NLSGCHLTSLRLSKM ECCCCCHHHHHHHHH | 11.31 | 29457462 | |
| 133 | Phosphorylation | LSGCHLTSLRLSKML CCCCCHHHHHHHHHH | 20.18 | 29457462 | |
| 138 | Malonylation | LTSLRLSKMLSALQH HHHHHHHHHHHHHHH | 48.75 | 32601280 | |
| 138 (in isoform 4) | Ubiquitination | - | 48.75 | - | |
| 138 | Ubiquitination | LTSLRLSKMLSALQH HHHHHHHHHHHHHHH | 48.75 | - | |
| 141 | Phosphorylation | LRLSKMLSALQHLRS HHHHHHHHHHHHHHH | 24.35 | 24043423 | |
| 167 (in isoform 4) | Ubiquitination | - | 40.11 | - | |
| 177 (in isoform 4) | Ubiquitination | - | 36.16 | - | |
| 234 | Phosphorylation | YQNLRVFYARLAPGY HCCCHHHHHHCCCCC | 6.48 | - | |
| 250 | Phosphorylation | NQEVVRLYLAVLSDR CHHHHHHHHHHHCCC | 5.09 | - | |
| 285 | Phosphorylation | ATKNLLDSMARNVVL CCHHHHHHHHHHHHH | 17.82 | 21406692 | |
| 299 | Ubiquitination | LDALQLPKSWLNGSS HHHHHCCHHHHCCCH | 63.96 | - | |
| 340 (in isoform 4) | Ubiquitination | - | 55.79 | - | |
| 361 | Phosphorylation | VHCLSPDSLLRKAED EECCCHHHHHHHHHC | 32.46 | 24719451 | |
| 365 (in isoform 4) | Ubiquitination | - | 56.98 | - | |
| 441 | Sulfoxidation | RAPAQPAMHAVPRGF CCCCCCCCCCCCCCC | 2.37 | 30846556 | |
| 446 | Methylation | PAMHAVPRGFGKKVR CCCCCCCCCCCCEEE | 46.61 | - | |
| 461 | Phosphorylation | VGVQSCPSPFSGQAC EEEECCCCCCCCCCC | 42.79 | 21815630 | |
| 464 | Phosphorylation | QSCPSPFSGQACPQP ECCCCCCCCCCCCCC | 33.12 | 24719451 | |
| 472 | Phosphorylation | GQACPQPSSVFWSLL CCCCCCCHHHHHHHH | 33.61 | - | |
| 477 | Phosphorylation | QPSSVFWSLLKNLPF CCHHHHHHHHHCCCH | 16.62 | 24719451 | |
| 518 | Phosphorylation | PPCSRAQSVGDSEVA CCCCCCCCCCHHHHH | 27.38 | 28348404 | |
| 585 | Acetylation | PALSDMLKHCKRLRD HHHHHHHHHHHHHHH | 40.08 | 25953088 | |
| 615 | Phosphorylation | QALSQCPSLQRLCLV HHHHCCCCHHHHHEE | 44.77 | 26091039 | |
| 650 | Phosphorylation | VVMCHLFTGESLATC HHHHHHHCCCCHHHH | 46.53 | - | |
| 653 | Phosphorylation | CHLFTGESLATCKSL HHHHCCCCHHHHHHH | 25.34 | - | |
| 663 | Phosphorylation | TCKSLQQSLLRRWGE HHHHHHHHHHHHHHH | 19.19 | 24719451 | |
| 706 (in isoform 4) | Ubiquitination | - | 3.27 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FXL18_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FXL18_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FXL18_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KR412_HUMAN | KRTAP4-12 | physical | 16189514 | |
| MDFI_HUMAN | MDFI | physical | 19060904 | |
| ACSF3_HUMAN | ACSF3 | physical | 24035498 | |
| NEDD4_HUMAN | NEDD4 | physical | 24657926 | |
| K1C40_HUMAN | KRT40 | physical | 25416956 | |
| KR103_HUMAN | KRTAP10-3 | physical | 25416956 | |
| NT2NL_HUMAN | NOTCH2NL | physical | 25416956 | |
| GNA11_HUMAN | GNA11 | physical | 26186194 | |
| FBXL7_HUMAN | FBXL7 | physical | 25654763 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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