FBXL7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBXL7_HUMAN
• UniProt AC: Q9UJT9
• Protein Name: F-box/LRR-repeat protein 7
• Gene Name: FBXL7
• Organism: Homo sapiens (Human).
• Sequence Length: 491
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes to the centrosome during spindle formation..
• Protein Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest..
• Protein Sequence: MGANNGKQYGSEGKGSSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	GANNGKQYGSEGKGS CCCCCCCCCCCCCCC	26.55	30622161
11	Phosphorylation	NNGKQYGSEGKGSSS CCCCCCCCCCCCCCC	37.94	30622161
18	Phosphorylation	SEGKGSSSISSDVSS CCCCCCCCCCCCCCC	28.34	24719451
24	Phosphorylation	SSISSDVSSSTDHTP CCCCCCCCCCCCCCC	24.46	23312004
25	Phosphorylation	SISSDVSSSTDHTPT CCCCCCCCCCCCCCC	36.79	24719451
26	Phosphorylation	ISSDVSSSTDHTPTK CCCCCCCCCCCCCCH	30.28	23312004
27	Phosphorylation	SSDVSSSTDHTPTKA CCCCCCCCCCCCCHH	33.47	23312004
30	Phosphorylation	VSSSTDHTPTKAQKN CCCCCCCCCCHHHHC	35.15	25159151
32	Phosphorylation	SSTDHTPTKAQKNVA CCCCCCCCHHHHCCC	39.92	27732954
43	Phosphorylation	KNVATSEDSDLSMRT HCCCCCCCCCCCCCC	47.41	32142685
73	Phosphorylation	GFQNGRGSSTSSSSI CCCCCCCCCCCCCCC	29.14	27251275
74	Phosphorylation	FQNGRGSSTSSSSIT CCCCCCCCCCCCCCC	34.82	27251275
75	Phosphorylation	QNGRGSSTSSSSITG CCCCCCCCCCCCCCC	34.03	27251275
76	Phosphorylation	NGRGSSTSSSSITGE CCCCCCCCCCCCCCC	30.12	27251275
77	Phosphorylation	GRGSSTSSSSITGET CCCCCCCCCCCCCCE	28.35	27251275
78	Phosphorylation	RGSSTSSSSITGETV CCCCCCCCCCCCCEE	26.06	27251275
79	Phosphorylation	GSSTSSSSITGETVA CCCCCCCCCCCCEEE	26.56	27732954
81	Phosphorylation	STSSSSITGETVAMV CCCCCCCCCCEEEEE	30.80	27732954
84	Phosphorylation	SSSITGETVAMVHSP CCCCCCCEEEEEECC	18.21	27732954
90	Phosphorylation	ETVAMVHSPPPTRLT CEEEEEECCCCCCCC	27.91	27732954
94	Phosphorylation	MVHSPPPTRLTHPLI EEECCCCCCCCCHHH	44.05	27732954
105	Phosphorylation	HPLIRLASRPQKEQA CHHHHHHCCCHHHHC	49.43	22798277
109	Ubiquitination	RLASRPQKEQASIDR HHHCCCHHHHCCCCC	55.25	-
163	Phosphorylation	TIRLTGETINVDRAL HEEECCCCCCHHHHH	21.13	27762562
174	Phosphorylation	DRALKVLTRRLCQDT HHHHHHHHHHHCCCC	19.41	27762562
181	Phosphorylation	TRRLCQDTPNVCLML HHHHCCCCCCEEEEE	7.29	22210691
190	Phosphorylation	NVCLMLETVTVSGCR CEEEEEEEEEECCHH	19.95	22210691
194	Phosphorylation	MLETVTVSGCRRLTD EEEEEEECCHHHCCC	23.86	21082442
200	Phosphorylation	VSGCRRLTDRGLYTI ECCHHHCCCCCCHHH	23.10	27259358
205	Phosphorylation	RLTDRGLYTIAQCCP HCCCCCCHHHHHHCH	10.02	27259358
255	Phosphorylation	CSKVTCISLTREASI CCEEEEEEEECEEEE	26.32	24719451
261	Phosphorylation	ISLTREASIKLSPLH EEEECEEEEEECCCC	18.59	-
263	Acetylation	LTREASIKLSPLHGK EECEEEEEECCCCCC	40.18	21339330
273	Phosphorylation	PLHGKQISIRYLDMT CCCCCEEEEEEEECC	9.87	24719451
338	O-linked_Glycosylation	VSDCRFVSDFGLREI HHHCCEECCCCHHHH	25.22	30379171
356	Phosphorylation	ESRLRYLSIAHCGRV HHHHHHHHHHCCCCC	14.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	FBXL18	Q96ME1	PMID:25654763

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBXL7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBXL7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SKP1_HUMAN	SKP1	physical	17704768
SKP1_HUMAN	SKP1	physical	15070733
A4_HUMAN	APP	physical	21832049
WDR48_HUMAN	WDR48	physical	24035498
ZRAB2_HUMAN	ZRANB2	physical	24035498
SAHH2_HUMAN	AHCYL1	physical	24035498
FXL18_HUMAN	FBXL18	physical	25654763
CUL1_HUMAN	CUL1	physical	25654763
SKP1_HUMAN	SKP1	physical	25654763
BIRC5_HUMAN	BIRC5	physical	25778398
BIRC5_HUMAN	BIRC5	physical	28218735
SKP1_HUMAN	SKP1	physical	28614300

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.