UFO_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UFO_MOUSE
• UniProt AC: Q00993
• Protein Name: Tyrosine-protein kinase receptor UFO
• Gene Name: Axl
• Organism: Mus musculus (Mouse).
• Sequence Length: 888
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response..
• Protein Sequence: MGRVPLAWWLALCCWGCAAHKDTQTEAGSPFVGNPGNITGARGLTGTLRCELQVQGEPPEVVWLRDGQILELADNTQTQVPLGEDWQDEWKVVSQLRISALQLSDAGEYQCMVHLEGRTFVSQPGFVGLEGLPYFLEEPEDKAVPANTPFNLSCQAQGPPEPVTLLWLQDAVPLAPVTGHSSQHSLQTPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQRPHHLHVVSRQPTELEVAWTPGLSGIYPLTHCNLQAVLSDDGVGIWLGKSDPPEDPLTLQVSVPPHQLRLEKLLPHTPYHIRISCSSSQGPSPWTHWLPVETTEGVPLGPPENVSAMRNGSQVLVRWQEPRVPLQGTLLGYRLAYRGQDTPEVLMDIGLTREVTLELRGDRPVANLTVSVTAYTSAGDGPWSLPVPLEPWRPGQGQPLHHLVSEPPPRAFSWPWWYVLLGALVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILPFMKHGDLHSFLLYSRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPVDCLDGLYALMSRCWELNPRDRPSFAELREDLENTLKALPPAQEPDEILYVNMDEGGSHLEPRGAAGGADPPTQPDPKDSCSCLTAADVHSAGRYVLCPSTAPGPTLSADRGCPAPPGQEDGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	GCAAHKDTQTEAGSP HHHHCCCCCCCCCCC	42.04	25777480
25	Phosphorylation	AAHKDTQTEAGSPFV HHCCCCCCCCCCCCC	29.87	25777480
29	Phosphorylation	DTQTEAGSPFVGNPG CCCCCCCCCCCCCCC	23.39	25777480
37	N-linked_Glycosylation	PFVGNPGNITGARGL CCCCCCCCCCCCCCC	29.88	-
39	Phosphorylation	VGNPGNITGARGLTG CCCCCCCCCCCCCCE	28.87	25777480
104	Phosphorylation	RISALQLSDAGEYQC EEEEEECCCCCCEEE	16.68	-
109	Phosphorylation	QLSDAGEYQCMVHLE ECCCCCCEEEEEEEC	13.19	-
151	N-linked_Glycosylation	VPANTPFNLSCQAQG CCCCCCCCEEEECCC	32.04	-
192	N-linked_Glycosylation	SLQTPGLNKTSSFSC CCCCCCCCCCCCCCC	52.02	-
250	Phosphorylation	LSGIYPLTHCNLQAV CCCEEECCCCCEEEE	21.63	-
259	Phosphorylation	CNLQAVLSDDGVGIW CCEEEEECCCCCEEE	27.36	-
333	N-linked_Glycosylation	VPLGPPENVSAMRNG CCCCCCCCHHCCCCC	38.53	-
339	N-linked_Glycosylation	ENVSAMRNGSQVLVR CCHHCCCCCCEEEEE	41.19	-
395	N-linked_Glycosylation	RGDRPVANLTVSVTA CCCCCEEEEEEEEEE	36.16	-
475	Phosphorylation	RRKKETRYGEVFEPT HHCCCCCCCEEECCE	25.67	22817900
502	Phosphorylation	RKSYSRRTTEATLNS ECCCCCCCCHHHHHH	28.07	-
503	Phosphorylation	KSYSRRTTEATLNSL CCCCCCCCHHHHHHC	23.08	25521595
506	Phosphorylation	SRRTTEATLNSLGIS CCCCCHHHHHHCCCC	21.90	25338131
509	Phosphorylation	TTEATLNSLGISEEL CCHHHHHHCCCCHHH	30.96	26824392
517	Ubiquitination	LGISEELKEKLRDVM CCCCHHHHHHHHHHH	56.96	22790023
534	Ubiquitination	RHKVALGKTLGEGEF HHHHHHCCCCCCCCC	41.23	22790023
564	Ubiquitination	KVAVKTMKIAICTRS HHHHHHCEEEEECHH	33.93	-
629	Phosphorylation	LHSFLLYSRLGDQPV HHHHHHHHHHCCCCE	22.46	-
640	Phosphorylation	DQPVFLPTQMLVKFM CCCEEEEHHHHHHHH	28.85	24719451
688	Phosphorylation	CVADFGLSKKIYNGD EEEEECCCCCCCCCC	32.08	23984901
692	Phosphorylation	FGLSKKIYNGDYYRQ ECCCCCCCCCCCCCC	23.21	29514104
696	Phosphorylation	KKIYNGDYYRQGRIA CCCCCCCCCCCCCCC	11.27	18515860
697	Phosphorylation	KIYNGDYYRQGRIAK CCCCCCCCCCCCCCC	10.95	20116462
753	Phosphorylation	GVENSEIYDYLRQGN CCCCHHHHHHHHCCC	8.42	25338131
755	Phosphorylation	ENSEIYDYLRQGNRL CCHHHHHHHHCCCCC	6.19	22817900
763	Ubiquitination	LRQGNRLKQPVDCLD HHCCCCCCCCHHHHH	49.68	22790023
773	Phosphorylation	VDCLDGLYALMSRCW HHHHHHHHHHHHHHH	11.83	-
815	Phosphorylation	QEPDEILYVNMDEGG CCCCCEEEEECCCCC	8.74	28507225
860	Phosphorylation	DVHSAGRYVLCPSTA HHHCCCCEEECCCCC	9.24	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UFO_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UFO_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UFO_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TYRO3_MOUSE	Tyro3	physical	18787040
GRB2_MOUSE	Grb2	physical	18346204
P85A_MOUSE	Pik3r1	physical	18346204

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.