PTPRF_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTPRF_MOUSE
• UniProt AC: A2A8L5
• Protein Name: Receptor-type tyrosine-protein phosphatase F
• Gene Name: Ptprf
• Organism: Mus musculus (Mouse).
• Sequence Length: 1898
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity)..
• Protein Sequence: MAPEPAPGRRMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKGRTATMLCAAGGNPDPEISWFKDFLPVDPAASNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQANAESDTRIQLSWLLPPQERIVKYELVYWAAEDEGQQHKVTFDPTSSYTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSTPSAPPQKVTCVSTGSTTVRVSWVPPPADSRNGIITQYSVAYEAVDGEDRKRHVVDGISREHSSWDLLGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQIRGYQVTYVRLENGEPRGQPIIQDVMLAEAQETTISGLTPETTYSITVAAYTTKGDGARSKPKVVTTTGAVPGRPTMMVSTTAMHTALLQWHPPKELPGELLGYRLQYRRADEARPNTIDFGKDDQHFTVTGLHKGATYVFRLAAKNRAGPGEEFEKEITTPEDVPSGFPQNLRVTGLTTSTTELTWDPPVLAERNGHITNYTVVYRDINSQLELQNVTNDTHLTLLGLKPDTTYDIKVRAHTSKGAGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPQKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWNTPEELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVDVLPDTFTLGDKKSYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPVRGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVLARNLYAHIQKLGQVPPGESVTAMELEFKLLANSKAHTSRFVSANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
117	N-linked_Glycosylation	TNSLGEINTSAKLSV CCCCCCCCCCCEEEE	24.55	-
218	Phosphorylation	NSAGTRYSAPANLYV CCCCCCEECCCEEEE	25.20	28059163
250	N-linked_Glycosylation	VMPGGSVNLTCVAVG CCCCCCEEEEEEEEC	31.18	-
295	N-linked_Glycosylation	SNVMRSANYTCVAIS HHHHHHCCCEEEEEE	33.61	-
298	S-palmitoylation	MRSANYTCVAISSLG HHHCCCEEEEEECCC	1.06	26165157
721	N-linked_Glycosylation	KVEVEPLNSTAVHVS EEEEEECCCCEEEEE	48.29	19349973
879	Phosphorylation	GLHKGATYVFRLAAK EECCCCEEEEHHHHC	9.32	22817900
900	Phosphorylation	EEFEKEITTPEDVPS HHHHCCCCCCCCCCC	37.07	28576409
901	Phosphorylation	EFEKEITTPEDVPSG HHHCCCCCCCCCCCC	30.27	28576409
936	N-linked_Glycosylation	PPVLAERNGHITNYT CCCHHHCCCEECEEE	37.59	19349973
941	N-linked_Glycosylation	ERNGHITNYTVVYRD HCCCEECEEEEEEEC	29.85	19349973
957	N-linked_Glycosylation	NSQLELQNVTNDTHL CCCEEEEECCCCCEE	56.03	-
960	N-linked_Glycosylation	LELQNVTNDTHLTLL EEEEECCCCCEEEEE	48.15	19349973
1290	Phosphorylation	PSSKDEQSIGLKDSL CCCCCHHCCCCCHHH	19.31	27841257
1294	Ubiquitination	DEQSIGLKDSLLAHS CHHCCCCCHHHHHCC	39.81	22790023
1296	Phosphorylation	QSIGLKDSLLAHSSD HCCCCCHHHHHCCCC	24.56	19060867
1301	Phosphorylation	KDSLLAHSSDPVEMR CHHHHHCCCCHHHHH	30.72	22817900
1302	Phosphorylation	DSLLAHSSDPVEMRR HHHHHCCCCHHHHHH	35.75	22324799
1312	Phosphorylation	VEMRRLNYQTPGMRD HHHHHCCCCCCCCCC	20.53	29514104
1342	Ubiquitination	LKANDGLKFSQEYES HHHCCCCCCCCEECC	48.80	22790023
1367	Ubiquitination	NSNSEVNKPKNRYAN CCCCCCCCCCCCCCE	63.65	22790023
1372	Phosphorylation	VNKPKNRYANVIAYD CCCCCCCCCEEEEEC	16.36	29899451
1723	Phosphorylation	RMLWEHNSTIIVMLT HHHHHCCCEEEEEHH	23.92	28576409
1724	Phosphorylation	MLWEHNSTIIVMLTK HHHHCCCEEEEEHHH	21.75	28576409
1730	Phosphorylation	STIIVMLTKLREMGR CEEEEEHHHHHHHCH	15.22	28576409
1801	Ubiquitination	WPEQGVPKTGEGFID CCCCCCCCCCCCHHH	67.75	-
1852	Phosphorylation	IVLERMRYEGVVDMF HHHHHHCCCCHHHHH	14.00	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTPRF_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTPRF_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTPRF_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTNB1_MOUSE	Ctnnb1	physical	8830779
FYN_MOUSE	Fyn	physical	18854310

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-721; ASN-936; ASN-941 ANDASN-960, AND MASS SPECTROMETRY.
PubMed: 19349973