dbPTM

LBR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LBR_MOUSE
UniProt AC	Q3U9G9
Protein Name	Lamin-B receptor
Gene Name	Lbr
Organism	Mus musculus (Mouse).
Sequence Length	626
Subcellular Localization	Nucleus inner membrane Multi-pass membrane protein.
Protein Description	Anchors the lamina and the heterochromatin to the inner nuclear membrane..
Protein Sequence	MPSRKFVEGEVVRGRWPGSSLYYEVEILSHDNKSQLYTVKYKDGTELELKESDIKPLKSFKQRKSGSISSSPSRRRGSRSRSRSRSRSRSPGRAPKGSRRSVSASHEGDVKEKKEKEMRREILQVKLTPLVLKPFGNSVSVYNGEPEHMEKNATPYKDKQERIILSTEDRYIVTQYSLRPRREEVKAKEIESEEQNLVTKGPAPLGTFQVTTPQRKDLEFGGVPGAVLIMLGLPACVLLLLLQCRQKDPGLLHFPPPLPALHELWEPRVCGVYLLWFFVQALFHLLPVGKVAEGTPLVDGRRLQYRLNGLYAFILTSAALGAAVFWGVELCYLYTHFLQLALAATGFSVLLSAYLYVRSLRAPREELSPASSGNAVYDFFIGRELNPRLGAFDLKFFCELRPGLIGWVVINLVMLLMEMKIQERAAPSLAMILVNSFQLLYVVDALWNEEALLTSMDIMHDGFGFMLAFGDLVWVPFTYSLQAFYLVSHPHDLSWPLASVIIALKLCGYVIFRCANSQKNAFRKNPTDPKLAHLKTIHTSTGKSLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHLLPYFYIIYFTALLIHREARDEHQCRRKYGLAWEKYCQRVPYRIFPYIY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MPSRKFVEGEVV ---CCCCCEEECEEE	59.09	23806337
5	Ubiquitination	---MPSRKFVEGEVV ---CCCCCEEECEEE	59.09	22790023
19	Phosphorylation	VRGRWPGSSLYYEVE ECCCCCCCCEEEEEE	17.06	22871156
34	Phosphorylation	ILSHDNKSQLYTVKY EEECCCCCCEEEEEE	31.50	22871156
42	Ubiquitination	QLYTVKYKDGTELEL CEEEEEECCCCEEEE	43.92	22790023
45	Phosphorylation	TVKYKDGTELELKES EEEECCCCEEEEEHH	47.75	18779572
50	Ubiquitination	DGTELELKESDIKPL CCCEEEEEHHHCCCC	45.88	-
55	Acetylation	ELKESDIKPLKSFKQ EEEHHHCCCCHHHHC	49.65	-
59	Phosphorylation	SDIKPLKSFKQRKSG HHCCCCHHHHCCCCC	45.41	25159016
65	Phosphorylation	KSFKQRKSGSISSSP HHHHCCCCCCCCCCH	39.71	27087446
67	Phosphorylation	FKQRKSGSISSSPSR HHCCCCCCCCCCHHH	26.79	27087446
69	Phosphorylation	QRKSGSISSSPSRRR CCCCCCCCCCHHHCC	26.85	27087446
70	Phosphorylation	RKSGSISSSPSRRRG CCCCCCCCCHHHCCC	44.60	27087446
71	Phosphorylation	KSGSISSSPSRRRGS CCCCCCCCHHHCCCC	21.80	27087446
73	Phosphorylation	GSISSSPSRRRGSRS CCCCCCHHHCCCCCC	40.13	21082442
86	Phosphorylation	RSRSRSRSRSRSPGR CCCCCCCCCCCCCCC	35.54	22817900
88	Phosphorylation	RSRSRSRSRSPGRAP CCCCCCCCCCCCCCC	38.05	25266776
90	Phosphorylation	RSRSRSRSPGRAPKG CCCCCCCCCCCCCCC	32.71	23684622
98	Phosphorylation	PGRAPKGSRRSVSAS CCCCCCCCCCCCCCC	30.55	26824392
98	O-linked_Glycosylation	PGRAPKGSRRSVSAS CCCCCCCCCCCCCCC	30.55	12438562
101	Phosphorylation	APKGSRRSVSASHEG CCCCCCCCCCCCCCC	21.22	27087446
103	Phosphorylation	KGSRRSVSASHEGDV CCCCCCCCCCCCCCH	25.87	27087446
105	Phosphorylation	SRRSVSASHEGDVKE CCCCCCCCCCCCHHH	17.99	27087446
111	Ubiquitination	ASHEGDVKEKKEKEM CCCCCCHHHHHHHHH	69.43	-
113	Ubiquitination	HEGDVKEKKEKEMRR CCCCHHHHHHHHHHH	61.59	-
128	Phosphorylation	EILQVKLTPLVLKPF HHHHHCCCCEEECCC	14.62	25159016
133	Ubiquitination	KLTPLVLKPFGNSVS CCCCEEECCCCCEEE	30.71	22790023
138	Phosphorylation	VLKPFGNSVSVYNGE EECCCCCEEEEECCC	19.02	25159016
140	Phosphorylation	KPFGNSVSVYNGEPE CCCCCEEEEECCCHH	20.78	25159016
142	Phosphorylation	FGNSVSVYNGEPEHM CCCEEEEECCCHHHH	15.22	25159016
151	Ubiquitination	GEPEHMEKNATPYKD CCHHHHCCCCCCCCC	44.29	22790023
154	Phosphorylation	EHMEKNATPYKDKQE HHHCCCCCCCCCHHC	36.22	25266776
157	Ubiquitination	EKNATPYKDKQERII CCCCCCCCCHHCEEE	60.70	-
166	Phosphorylation	KQERIILSTEDRYIV HHCEEEEECCCCEEE	21.24	28066266
167	Phosphorylation	QERIILSTEDRYIVT HCEEEEECCCCEEEE	38.16	28066266
171	Phosphorylation	ILSTEDRYIVTQYSL EEECCCCEEEEECCC	16.44	25159016
174	Phosphorylation	TEDRYIVTQYSLRPR CCCCEEEEECCCCCC	16.54	25159016
176	Phosphorylation	DRYIVTQYSLRPRRE CCEEEEECCCCCCHH	10.58	24224561
177	Phosphorylation	RYIVTQYSLRPRREE CEEEEECCCCCCHHH	14.21	24704852
188	Ubiquitination	RREEVKAKEIESEEQ CHHHHHHHHHCHHHH	54.21	22790023
188	Acetylation	RREEVKAKEIESEEQ CHHHHHHHHHCHHHH	54.21	23806337
192	Phosphorylation	VKAKEIESEEQNLVT HHHHHHCHHHHHCCC	52.69	28833060
200	Ubiquitination	EEQNLVTKGPAPLGT HHHHCCCCCCCCCCE	56.25	-
211	Phosphorylation	PLGTFQVTTPQRKDL CCCEEEECCCCCCCC	23.21	28066266
212	Phosphorylation	LGTFQVTTPQRKDLE CCEEEECCCCCCCCC	20.68	28066266
527	Phosphorylation	NAFRKNPTDPKLAHL CCCCCCCCCHHHHHC	74.46	27180971
605	Acetylation	DEHQCRRKYGLAWEK CHHHHHHHHCCHHHH	25.07	-
612	Acetylation	KYGLAWEKYCQRVPY HHCCHHHHHHHHCCC	40.39	23806337
612	Ubiquitination	KYGLAWEKYCQRVPY HHCCHHHHHHHHCCC	40.39	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
86	S	Phosphorylation	Kinase	CDK1	P11440	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LBR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LBR_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LBR_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101 AND SER-103, ANDMASS SPECTROMETRY.	19367708 [Abstract]