SEP11_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEP11_MOUSE
• UniProt AC: Q8C1B7
• Protein Name: Septin-11
• Gene Name: 11-Sep
• Organism: Mus musculus (Mouse).
• Sequence Length: 431
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Cell junction, synapse . Cell projection, dendritic spine . Cell projection, axon.
• Protein Description: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity)..
• Protein Sequence: MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDEETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEEKKKVEDKKKELEEEVSNFQKKKAAAQLLQSQAQQSGAQQTKKDKDKKNPWLCTE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVAVGRPS ------CCEECCCCC	9.66	-
9	Phosphorylation	AVAVGRPSNEELRNL CEECCCCCHHHHHCC	56.35	26824392
17	Phosphorylation	NEELRNLSLSGHVGF HHHHHCCCCCCCCCC	24.84	26824392
19	Phosphorylation	ELRNLSLSGHVGFDS HHHCCCCCCCCCCCC	24.39	26824392
26	Phosphorylation	SGHVGFDSLPDQLVN CCCCCCCCCCHHHCC	39.27	26643407
84	Phosphorylation	GVRLKARSYELQESN CCEEEEEEEECHHCC	28.02	25338131
85	Phosphorylation	VRLKARSYELQESNV CEEEEEEEECHHCCC	18.33	29899451
175	Ubiquitination	TMKKLDSKVNIIPII EHHHCCCCCCEEEEE	38.68	-
184	Acetylation	NIIPIIAKADTIAKN CEEEEEECCCHHHHH	36.06	22826441
190	Acetylation	AKADTIAKNELHKFK ECCCHHHHHHHHHHH	47.29	22826441
272	Ubiquitination	ENHCDFVKLREMLIR CCCCCHHHHHHHHHH	41.65	-
326	Ubiquitination	LQETYEAKRNEFLGE HHHHHHHHHHHHHHH	43.76	22790023
336	Ubiquitination	EFLGELQKKEEEMRQ HHHHHHHHHHHHHHH	74.83	22790023
366	Acetylation	AEKELHEKFDLLKRT HHHHHHHHHHHHHHH	33.17	23236377
393	Phosphorylation	KELEEEVSNFQKKKA HHHHHHHHHHHHHHH	34.90	26370283
397	Acetylation	EEVSNFQKKKAAAQL HHHHHHHHHHHHHHH	52.70	23236377
397	Ubiquitination	EEVSNFQKKKAAAQL HHHHHHHHHHHHHHH	52.70	22790023
399	Ubiquitination	VSNFQKKKAAAQLLQ HHHHHHHHHHHHHHH	50.74	22790023
407	Phosphorylation	AAAQLLQSQAQQSGA HHHHHHHHHHHHHCC	27.70	29514104
412	Phosphorylation	LQSQAQQSGAQQTKK HHHHHHHHCCCCCCC	24.82	29899451
417	Phosphorylation	QQSGAQQTKKDKDKK HHHCCCCCCCCCCCC	28.16	22324799
418	Ubiquitination	QSGAQQTKKDKDKKN HHCCCCCCCCCCCCC	55.42	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEP11_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEP11_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEP11_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEPT7_HUMAN	SEPT7	physical	26496610
SEPT2_HUMAN	SEPT2	physical	26496610
2A5D_HUMAN	PPP2R5D	physical	26496610
BECN1_HUMAN	BECN1	physical	26496610
SEPT9_HUMAN	SEPT9	physical	26496610
SEPT6_HUMAN	SEPT6	physical	26496610
SEPT8_HUMAN	SEPT8	physical	26496610
BEND3_HUMAN	BEND3	physical	26496610
ZMAT3_HUMAN	ZMAT3	physical	26496610
ENKD1_HUMAN	ENKD1	physical	26496610
SEP10_HUMAN	SEPT10	physical	26496610
E2AK4_HUMAN	EIF2AK4	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.