ZMAT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZMAT3_HUMAN
• UniProt AC: Q9HA38
• Protein Name: Zinc finger matrin-type protein 3
• Gene Name: ZMAT3 {ECO:0000312|EMBL:AAH02896.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 289
• Subcellular Localization: Nucleus . Nucleus, nucleolus .
• Protein Description: Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus..
• Protein Sequence: MILLQHAVLPPPKQPSPSPPMSVATRSTGTLQLPPQKPFGQEASLPLAGEEELSKGGEQDCALEELCKPLYCKLCNVTLNSAQQAQAHYQGKNHGKKLRNYYAANSCPPPARMSNVVEPAATPVVPVPPQMGSFKPGGRVILATENDYCKLCDASFSSPAVAQAHYQGKNHAKRLRLAEAQSNSFSESSELGQRRARKEGNEFKMMPNRRNMYTVQNNSAGPYFNPRSRQRIPRDLAMCVTPSGQFYCSMCNVGAGEEMEFRQHLESKQHKSKVSEQRYRNEMENLGYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	LPPPKQPSPSPPMSV CCCCCCCCCCCCCCE	35.20	30108239
18	Phosphorylation	PPKQPSPSPPMSVAT CCCCCCCCCCCCEEE	46.07	30108239
22	Phosphorylation	PSPSPPMSVATRSTG CCCCCCCCEEECCCC	17.86	30108239
25	Phosphorylation	SPPMSVATRSTGTLQ CCCCCEEECCCCCCC	24.01	25954137
27	Phosphorylation	PMSVATRSTGTLQLP CCCEEECCCCCCCCC	27.17	25954137
28	Phosphorylation	MSVATRSTGTLQLPP CCEEECCCCCCCCCC	30.78	25954137
30	Phosphorylation	VATRSTGTLQLPPQK EEECCCCCCCCCCCC	16.06	25954137
44	Phosphorylation	KPFGQEASLPLAGEE CCCCCCCCCCCCCHH	29.75	25954137
89	Phosphorylation	AQQAQAHYQGKNHGK HHHHHHHHCCCCHHH	23.21	-
155	Phosphorylation	YCKLCDASFSSPAVA CHHHCCCCCCCHHHH	16.65	22199227
157	Phosphorylation	KLCDASFSSPAVAQA HHCCCCCCCHHHHHH	32.68	22199227
158	Phosphorylation	LCDASFSSPAVAQAH HCCCCCCCHHHHHHH	18.18	22199227
166	Phosphorylation	PAVAQAHYQGKNHAK HHHHHHHHCCCCHHH	23.21	22199227
182	Phosphorylation	LRLAEAQSNSFSESS HHHHHHHHCCCCCHH	41.30	-
184	Phosphorylation	LAEAQSNSFSESSEL HHHHHHCCCCCHHHH	35.08	29507054
198	Ubiquitination	LGQRRARKEGNEFKM HHHHHHHHCCCCCCC	69.83	-
214	Phosphorylation	PNRRNMYTVQNNSAG CCCCCCCEEECCCCC	12.59	25954137
219	Phosphorylation	MYTVQNNSAGPYFNP CCEEECCCCCCCCCH	42.00	25954137
219 (in isoform 2)	Phosphorylation	-	42.00	29083192
222 (in isoform 2)	Phosphorylation	-	30.20	29083192
227 (in isoform 2)	Phosphorylation	-	45.64	29083192
228	Phosphorylation	GPYFNPRSRQRIPRD CCCCCHHHHCCCCCC	33.74	25954137
267	Ubiquitination	EFRQHLESKQHKSKV HHHHHHHHHHHHHHH	43.93	29967540
268	Ubiquitination	FRQHLESKQHKSKVS HHHHHHHHHHHHHHH	47.23	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZMAT3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZMAT3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZMAT3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DHX9_HUMAN	DHX9	physical	18519039
ROA2_HUMAN	HNRNPA2B1	physical	18519039
A4_HUMAN	APP	physical	21832049
CNOT6_HUMAN	CNOT6	physical	24469038
ACTA_HUMAN	ACTA2	physical	26186194
DICER_HUMAN	DICER1	physical	26186194
SF3A1_HUMAN	SF3A1	physical	26186194
SUV3_HUMAN	SUPV3L1	physical	26186194
DCA17_HUMAN	DCAF17	physical	26186194
ISCA1_HUMAN	ISCA1	physical	26186194
TRBP2_HUMAN	TARBP2	physical	26186194
FTO_HUMAN	FTO	physical	26186194
DCA17_HUMAN	DCAF17	physical	28514442
ISCA1_HUMAN	ISCA1	physical	28514442
SUV3_HUMAN	SUPV3L1	physical	28514442
FTO_HUMAN	FTO	physical	28514442
ACTA_HUMAN	ACTA2	physical	28514442
TRBP2_HUMAN	TARBP2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.