KANK2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KANK2_MOUSE
• UniProt AC: Q8BX02
• Protein Name: KN motif and ankyrin repeat domain-containing protein 2
• Gene Name: Kank2
• Organism: Mus musculus (Mouse).
• Sequence Length: 843
• Subcellular Localization: Cytoplasm. Mitochondrion.
• Protein Description: Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). May be involved in the control of cytoskeleton formation by regulating actin polymerization (By similarity). Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (By similarity). May be involved in promotion of cell proliferation. [PubMed: 16024821]
• Protein Sequence: MAQVLHVPAPFPGTPGQASPAAFPSKEPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPRLGSLPRGPGSWWTSTESLCSDASGDSRHSAYSYCGRGFYPQYGALETRIGSNPRVERTLLDARRRLEDQAAAPSSGGLGSLTPSAAGSTSSLAGVGLLPPTPRSSGLSTPVAPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPSGTRSRSELCLDLPEAPDDPAALETRSVGTWVRERDLGIPDGEAALVAKVAVLETQLKKALQELRAAQTQQVDLQPQAWPPPDTQVRVDTVRVVEGPREVEVAASTAAGALAQRAQSLEPYGTGLKALTTSGGPENTLVFRSHEVVETMCPLPTATTGNVHTAKKISITERSCTGAPRMTEPSSVNPRPAAASVVQPENPVPAAQDTTDKKPTRPAAASQDSQAADGAGRASLATKRKEDPADPEVNQRNLQFVGVNGGYESPSEDSSTAENSEHESTENEGPEPPARVLSPAECPQLRPPGAAVATTSLEGPQLSQESQRVPAPEVASGPDPEEEIRMDLSPDLISACLALEKYLENPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVCHVDKLNRAGYSPIMLTALATLKTQDDIETILQLFRLGNVNAKASQAGQTALMLAVSHGRVDVVRALLACEADVNIQDEDGSTALMCACEHGHKEITGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDYESPASSSAEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	VPAPFPGTPGQASPA CCCCCCCCCCCCCCC	25.20	26824392
19	Phosphorylation	PGTPGQASPAAFPSK CCCCCCCCCCCCCCC	13.74	26824392
25	Phosphorylation	ASPAAFPSKEPDPPY CCCCCCCCCCCCCCC	43.10	23649490
32	Phosphorylation	SKEPDPPYSVETPYG CCCCCCCCCCCCCCC	30.64	8502899
33	Phosphorylation	KEPDPPYSVETPYGY CCCCCCCCCCCCCCE	21.17	26160508
48	Ubiquitination	RLDLDFLKYVDDIEK EEECHHHHHHHHHHH	43.13	-
49	Phosphorylation	LDLDFLKYVDDIEKG EECHHHHHHHHHHHC	15.97	21183079
58	Phosphorylation	DDIEKGHTLRRVAVQ HHHHHCCEEEEHHHH	30.54	21082442
72	Phosphorylation	QRRPRLGSLPRGPGS HCCCCCCCCCCCCCC	39.53	26160508
79	Phosphorylation	SLPRGPGSWWTSTES CCCCCCCCCCCCHHH	23.67	23737553
82	Phosphorylation	RGPGSWWTSTESLCS CCCCCCCCCHHHHCC	21.36	26160508
83	Phosphorylation	GPGSWWTSTESLCSD CCCCCCCCHHHHCCC	19.22	27149854
84	Phosphorylation	PGSWWTSTESLCSDA CCCCCCCHHHHCCCC	23.40	27149854
86	Phosphorylation	SWWTSTESLCSDASG CCCCCHHHHCCCCCC	34.46	21659605
89	Phosphorylation	TSTESLCSDASGDSR CCHHHHCCCCCCCCC	41.32	26643407
92	Phosphorylation	ESLCSDASGDSRHSA HHHCCCCCCCCCCCC	48.39	22817900
95	Phosphorylation	CSDASGDSRHSAYSY CCCCCCCCCCCCHHH	35.10	22817900
100	Phosphorylation	GDSRHSAYSYCGRGF CCCCCCCHHHCCCCC	11.82	22499769
101	Phosphorylation	DSRHSAYSYCGRGFY CCCCCCHHHCCCCCC	17.42	18521727
105	Methylation	SAYSYCGRGFYPQYG CCHHHCCCCCCCCCC	28.61	24129315
111	Phosphorylation	GRGFYPQYGALETRI CCCCCCCCCCHHCCC	10.40	7474183
120	Phosphorylation	ALETRIGSNPRVERT CHHCCCCCCHHHHHH	41.09	24719451
143	Phosphorylation	EDQAAAPSSGGLGSL HHHCCCCCCCCCCCC	36.57	25293948
144	Phosphorylation	DQAAAPSSGGLGSLT HHCCCCCCCCCCCCC	35.50	23737553
149	Phosphorylation	PSSGGLGSLTPSAAG CCCCCCCCCCCCCCC	33.83	23737553
151	Phosphorylation	SGGLGSLTPSAAGST CCCCCCCCCCCCCCC	19.52	23737553
153	Phosphorylation	GLGSLTPSAAGSTSS CCCCCCCCCCCCCCC	26.05	23737553
157	Phosphorylation	LTPSAAGSTSSLAGV CCCCCCCCCCCCCCC	22.01	23737553
158	Phosphorylation	TPSAAGSTSSLAGVG CCCCCCCCCCCCCCC	22.78	23737553
159	Phosphorylation	PSAAGSTSSLAGVGL CCCCCCCCCCCCCCC	25.67	23737553
160	Phosphorylation	SAAGSTSSLAGVGLL CCCCCCCCCCCCCCC	23.48	23737553
170	Phosphorylation	GVGLLPPTPRSSGLS CCCCCCCCCCCCCCC	29.42	26824392
173	Phosphorylation	LLPPTPRSSGLSTPV CCCCCCCCCCCCCCC	29.93	26824392
174	Phosphorylation	LPPTPRSSGLSTPVA CCCCCCCCCCCCCCC	45.06	22942356
177	Phosphorylation	TPRSSGLSTPVAPSA CCCCCCCCCCCCCCC	33.90	26824392
178	Phosphorylation	PRSSGLSTPVAPSAG CCCCCCCCCCCCCCH	27.16	26824392
183	Phosphorylation	LSTPVAPSAGHLAHV CCCCCCCCCHHHHHH	36.83	25619855
242	Phosphorylation	QKFLGHPSGTRSRSE HHHCCCCCCCCCHHH	47.31	29514104
244	Phosphorylation	FLGHPSGTRSRSELC HCCCCCCCCCHHHEE	29.79	25338131
246	Phosphorylation	GHPSGTRSRSELCLD CCCCCCCCHHHEECC	39.74	25521595
248	Phosphorylation	PSGTRSRSELCLDLP CCCCCCHHHEECCCC	35.85	25521595
331	Phosphorylation	DTQVRVDTVRVVEGP CCEEEEEEEEEEECC	13.83	-
346	O-linked_Glycosylation	REVEVAASTAAGALA CEEHHHHHHHHHHHH	14.61	28528544
358	Phosphorylation	ALAQRAQSLEPYGTG HHHHHHHHCCCCCCC	33.44	25521595
362	Phosphorylation	RAQSLEPYGTGLKAL HHHHCCCCCCCHHHH	20.25	25521595
364	Phosphorylation	QSLEPYGTGLKALTT HHCCCCCCCHHHHHC	33.23	22324799
371	Phosphorylation	TGLKALTTSGGPENT CCHHHHHCCCCCCCE	26.65	29514104
372	Phosphorylation	GLKALTTSGGPENTL CHHHHHCCCCCCCEE	36.20	26824392
378	Phosphorylation	TSGGPENTLVFRSHE CCCCCCCEEEECCCC	23.72	29514104
408	Phosphorylation	VHTAKKISITERSCT CEECEEEEEECCCCC	32.13	22817900
410	Phosphorylation	TAKKISITERSCTGA ECEEEEEECCCCCCC	20.68	22324799
460	Phosphorylation	PTRPAAASQDSQAAD CCCCCCHHCCCHHHC	29.78	25338131
463	Phosphorylation	PAAASQDSQAADGAG CCCHHCCCHHHCCCC	17.68	26824392
501	Phosphorylation	FVGVNGGYESPSEDS EEEECCCCCCCCCCC	18.03	25619855
503	Phosphorylation	GVNGGYESPSEDSST EECCCCCCCCCCCCC	25.83	25619855
505	Phosphorylation	NGGYESPSEDSSTAE CCCCCCCCCCCCCCC	64.41	25619855
508	Phosphorylation	YESPSEDSSTAENSE CCCCCCCCCCCCCCC	26.07	25619855
509	Phosphorylation	ESPSEDSSTAENSEH CCCCCCCCCCCCCCC	43.91	25619855
510	Phosphorylation	SPSEDSSTAENSEHE CCCCCCCCCCCCCCC	41.78	25619855
514	Phosphorylation	DSSTAENSEHESTEN CCCCCCCCCCCCCCC	31.66	25619855
518	Phosphorylation	AENSEHESTENEGPE CCCCCCCCCCCCCCC	42.82	25619855
519	Phosphorylation	ENSEHESTENEGPEP CCCCCCCCCCCCCCC	39.58	25619855
532	Phosphorylation	EPPARVLSPAECPQL CCCCCCCCHHHCCCC	21.14	26824392
548	Phosphorylation	PPGAAVATTSLEGPQ CCCCEEEEECCCCCC	15.43	25367039
549	Phosphorylation	PGAAVATTSLEGPQL CCCEEEEECCCCCCC	22.90	25777480
550	Phosphorylation	GAAVATTSLEGPQLS CCEEEEECCCCCCCC	21.77	63815565
557	Phosphorylation	SLEGPQLSQESQRVP CCCCCCCCHHHCCCC	27.01	25367039
560	Phosphorylation	GPQLSQESQRVPAPE CCCCCHHHCCCCCCH	18.69	25777480
570	Phosphorylation	VPAPEVASGPDPEEE CCCCHHHCCCCHHHH	56.91	26824392
728	Phosphorylation	GNVNAKASQAGQTAL CCCCCCHHHHHHHHH	21.61	28059163
740	Phosphorylation	TALMLAVSHGRVDVV HHHHHHHHCCCHHHH	18.02	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KANK2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KANK2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KANK2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KANK2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246 AND SER-248, ANDMASS SPECTROMETRY.
PubMed: 17242355