SCMC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCMC1_MOUSE
• UniProt AC: Q8BMD8
• Protein Name: Calcium-binding mitochondrial carrier protein SCaMC-1
• Gene Name: Slc25a24
• Organism: Mus musculus (Mouse).
• Sequence Length: 475
• Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.
• Protein Description: Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix (By similarity)..
• Protein Sequence: MLRWLRAFVLPTAACHDAEPPTRYETLFRALDRNGDGVVDIGELQQGLQSLGIPLGQDAEEKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEPSEIVQSLQMLGLHISEKQAELILQSIDSDGTMTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGVAGAVSRTSTAPLDRLKVMMQVHGSKSMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKLGTFERFISGSMAGATAQTFIYPMEVLKTRLAVAKTGQYSGIYGCAKKILKHEGFGAFYKGYIPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLSCGALSSTCGQLASYPLALVRTRMQAQATVEGAPQLSMVGLFQRIVSKEGVSGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVAQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
227	Phosphorylation	VMMQVHGSKSMNIFG HHHHHHCCCCCEECH	13.48	25338131
278	Phosphorylation	EQYKKLLTEEGQKLG HHHHHHHCHHHHHHH	42.29	22871156
286	Phosphorylation	EEGQKLGTFERFISG HHHHHHHCHHHHHCC	32.53	22871156
294	Phosphorylation	FERFISGSMAGATAQ HHHHHCCCCCCCCCH	9.92	29899451
318	Acetylation	KTRLAVAKTGQYSGI HHHHHHHHHCCCCCH	46.73	23806337
318	Succinylation	KTRLAVAKTGQYSGI HHHHHHHHHCCCCCH	46.73	-
318	Succinylation	KTRLAVAKTGQYSGI HHHHHHHHHCCCCCH	46.73	23806337
334	Acetylation	GCAKKILKHEGFGAF HHHHHHHHHCCCCHH	42.98	22826441
435	Acetylation	LFQRIVSKEGVSGLY HHHHHHCCCCCCHHH	47.82	23806337
435	Succinylation	LFQRIVSKEGVSGLY HHHHHHCCCCCCHHH	47.82	-
435	Succinylation	LFQRIVSKEGVSGLY HHHHHHCCCCCCHHH	47.82	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCMC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCMC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCMC1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SCMC1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.