UBR4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBR4_MOUSE
• UniProt AC: A2AN08
• Protein Name: E3 ubiquitin-protein ligase UBR4
• Gene Name: Ubr4
• Organism: Mus musculus (Mouse).
• Sequence Length: 5180
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Concentrates at the leading edge of membrane structures involved in actin motility..
• Protein Description: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation..
• Protein Sequence: MATSGGEEAAAAAPAPGAPATGQDTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVPSPPISPQALVEGENDEQSSPDQVSAAKTKSVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVVANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHFQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLASLFQDLQVEALHKGWETDGPPAVLSIMAQSTSTQRIQRLIDSVPLTNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVKSPNKQASGEKGNILASRKDPELFSGLASNILNFITTSMLNSRNSFIRSYLSASLSEHHMATLASIIKEVDKDGLKGSSDEDFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQGLSVLSRLLLIWQHKAGAQGDPDVPECLKVWDRFLTTMKQNALQGVVPSETEDLNVEHLQLLLLIFHSFSEKGRRAILTMLVQSIQELSVNMEVQMRTAPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSSSRRANTPLYHGFKEVEENWSKHFSSDAAPQPRFYCVLSTEASEEDLNRLDSEACEVLFSKPVKYDELYSSLTTLLAAGSQLDTTRRKEKKNVTALEACALQYYFLILWRILGILPPSKTYMNQLAMNSPEMSECDILHTLRWSSRLRISSYVSWIKDHLIKQGMKPEHAGSLIELAASKCSSVKYDVEIVEEYFARQISSFCSIDCTAVLQLHEIPSLQSIYTLDAAVSKVQVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNLNEEGSTEKPSQEKLHGFAAVLAIGSSRCKANTLGPTLVQNLPSSVQSVCESWNNINTNEFPNIGSWRNAFANDTIPSESYISAVQAAHLGTLCGQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPAQVIRTLLPLLLESSTESAAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEFFSDGGELVQIMMATANEDLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLEVIQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATDMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAAVDWLGRCKKYLSQKNVVEKLNANVMHGKHVMVLECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRVSESLVRHASTSPADKAKVTISDGKVTDEEKPKKSSLCRTVEGCREELQNQANFSFAPLVLDMLSFLMDAIQTNFQQASAVGSSSRAQQALSELHTVDKGVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLSIDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYMYTQLMEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYSQGRSFAATVSRSTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPGTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITARTSSQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNSSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADRKLSLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEDFPSASVSNICPPNLNQSNGTGESDSAAPATTSGTVLERLVVSSLEALESCFAVGPIIEKERNKHAAQELATLLLSLPAPASVQQQSKSLLASLHSSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAVTRPNNLVHFTESKLPQMETEGADEGKEPQKQEGDGCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPDGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTATGHQEGDGSEGEGEGEAEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLAQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQSDEEPVAASQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKIADTSSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASTGSSSVASSSAPPAASSGQATTQSKSSTKKSKKEEKEKEKEGESSGSQEDQLCTALVNQLNRFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSNKAQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTAQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQEDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGAAAIREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYEAWKKCLPIRGVDGNGKSPSKSELHRLYLTEKYVWRWKQFLSRRGKRTTPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATVPSRKQQVLDLLTSYLDELSVAGECAAEYLALYQKLIASCHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVLQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCATNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYRMAGVMAQCGGLQCMLNRLAGVKDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLETNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCSFEKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAMQHPATQVLIGTDSITSLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWTESAFDVDGPHYFTILALHVLPPEQWKAIRVEILRRLLVASHARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDAAGLLSEITDPESFLKDLLNSVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
152	Phosphorylation	RTEIITFTAMMKSAK HHHHHHHHHHHHHCC	12.66	-
157	Phosphorylation	TFTAMMKSAKLPQTV HHHHHHHHCCCCCHH	16.85	-
166	Phosphorylation	KLPQTVKTLSDVEDQ CCCCHHCCCCHHHHH	27.45	26525534
168	Phosphorylation	PQTVKTLSDVEDQKE CCHHCCCCHHHHHHH	44.86	22668510
178	Phosphorylation	EDQKELASPVSPELR HHHHHHCCCCCHHHH	38.16	25521595
181	Phosphorylation	KELASPVSPELRQKE HHHCCCCCHHHHHHH	18.95	25521595
187	Ubiquitination	VSPELRQKEVQMNFL CCHHHHHHHHHHHHH	54.11	22790023
187 (in isoform 5)	Ubiquitination	-	54.11	22790023
205	Phosphorylation	TSVFNPRTVPSPPIS HHCCCCCCCCCCCCC	37.72	27087446
208	Phosphorylation	FNPRTVPSPPISPQA CCCCCCCCCCCCHHH	38.68	27087446
212	Phosphorylation	TVPSPPISPQALVEG CCCCCCCCHHHHHCC	19.41	27087446
225	Phosphorylation	EGENDEQSSPDQVSA CCCCCCCCCHHHHHH	41.62	29899451
260	S-palmitoylation	SEKLLRVCLNLPYFL CHHHHHHHHCHHHHH	1.36	28526873
360	Phosphorylation	GSAQQVRTGSTSSKE CCCCCCCCCCCCCCC	36.31	27087446
362	Phosphorylation	AQQVRTGSTSSKEDD CCCCCCCCCCCCCCC	25.22	27087446
363	Phosphorylation	QQVRTGSTSSKEDDY CCCCCCCCCCCCCCC	38.06	27742792
364	Phosphorylation	QVRTGSTSSKEDDYE CCCCCCCCCCCCCCH	40.90	27087446
365	Phosphorylation	VRTGSTSSKEDDYES CCCCCCCCCCCCCHH	39.90	27087446
370	Phosphorylation	TSSKEDDYESDAATI CCCCCCCCHHHHHHH	29.65	25619855
372	Phosphorylation	SKEDDYESDAATIVQ CCCCCCHHHHHHHHH	26.73	25619855
376	Phosphorylation	DYESDAATIVQKCLE CCHHHHHHHHHHHHH	24.33	25619855
457	Phosphorylation	RTKEGVGSPKLGPGK HCCCCCCCCCCCCCC	19.22	24453211
473	Phosphorylation	HQGFGVLSVILANHA CCCCHHHHHHHHHHH	12.52	25521595
544	Malonylation	LLSTSYRKACVLQRQ HHCHHHHHHHHHHHH	37.59	26320211
619	Phosphorylation	PPPPPLESSPRVKSP CCCCCCCCCCCCCCC	54.01	25521595
620	Phosphorylation	PPPPLESSPRVKSPN CCCCCCCCCCCCCCC	13.83	27087446
625	Phosphorylation	ESSPRVKSPNKQASG CCCCCCCCCCCCCCC	30.74	25266776
631	Phosphorylation	KSPNKQASGEKGNIL CCCCCCCCCCCCCCC	45.02	27566939
634	Ubiquitination	NKQASGEKGNILASR CCCCCCCCCCCCCCC	61.86	22790023
634 (in isoform 5)	Ubiquitination	-	61.86	22790023
648	Phosphorylation	RKDPELFSGLASNIL CCCHHHHHHHHHHHH	45.59	30635358
652	Phosphorylation	ELFSGLASNILNFIT HHHHHHHHHHHHHHH	29.46	30635358
659	Phosphorylation	SNILNFITTSMLNSR HHHHHHHHHHHHCCC	14.53	30635358
660	Phosphorylation	NILNFITTSMLNSRN HHHHHHHHHHHCCCH	13.81	30635358
661	Phosphorylation	ILNFITTSMLNSRNS HHHHHHHHHHCCCHH	16.78	30635358
665	Phosphorylation	ITTSMLNSRNSFIRS HHHHHHCCCHHHHHH	28.95	30635358
668	Phosphorylation	SMLNSRNSFIRSYLS HHHCCCHHHHHHHHH	22.42	30635358
905	Phosphorylation	SSSRRANTPLYHGFK CCCCCCCCCCCCCHH	17.43	24899341
924	Phosphorylation	NWSKHFSSDAAPQPR HHHHHCCCCCCCCCC	30.26	29899451
1083	Acetylation	ASKCSSVKYDVEIVE HHHCCCCCCHHHHHH	37.37	-
1149	Ubiquitination	AAETDPHKSSEITKN HHCCCCCCCCHHHHC	62.15	22790023
1149 (in isoform 5)	Ubiquitination	-	62.15	22790023
1151	Phosphorylation	ETDPHKSSEITKNLL CCCCCCCCHHHHCHH	37.51	28059163
1154	Phosphorylation	PHKSSEITKNLLPAT CCCCCHHHHCHHHHH	15.16	28059163
1155	Ubiquitination	HKSSEITKNLLPATL CCCCHHHHCHHHHHH	51.78	-
1401	Phosphorylation	KAMEEFFSDGGELVQ HHHHHHHCCHHHHHH	40.44	-
1449	S-palmitoylation	NPSLLHLCGSLAQLA CHHHHHHHHHHHHHH	2.12	28680068
1478	Phosphorylation	TTSPPKDSDQLEVIQ CCCCCCCHHHHHHHH	33.12	20469934
1573	Ubiquitination	CKKYLSQKNVVEKLN HHHHHCCCCHHHHHC	48.62	22790023
1573 (in isoform 5)	Ubiquitination	-	48.62	22790023
1633	Phosphorylation	ERAIEVDSDWVEELA CCEEEECCHHHHHHH	38.25	21743459
1646	Phosphorylation	LAVEEEDSQAEDSDE HHCCCCCCCCCCCCH	34.27	21743459
1651	Phosphorylation	EDSQAEDSDEDSLCN CCCCCCCCCHHHHHH	34.11	21743459
1655	Phosphorylation	AEDSDEDSLCNKLCT CCCCCHHHHHHHHHE	32.54	21743459
1732	Phosphorylation	ALVKRTPSSGMSSTM EEEEECCCCCCCCCH	38.62	24759943
1733	Phosphorylation	LVKRTPSSGMSSTMK EEEECCCCCCCCCHH	39.45	24759943
1736	Phosphorylation	RTPSSGMSSTMKESA ECCCCCCCCCHHHHH	26.61	22871156
1737	Phosphorylation	TPSSGMSSTMKESAF CCCCCCCCCHHHHHC	24.51	22871156
1742	Phosphorylation	MSSTMKESAFQSEPR CCCCHHHHHCCCCCC	28.94	24759943
1746	Phosphorylation	MKESAFQSEPRVSES HHHHHCCCCCCCCHH	43.01	-
1753	Phosphorylation	SEPRVSESLVRHAST CCCCCCHHHHHHCCC	25.34	26643407
1759	Phosphorylation	ESLVRHASTSPADKA HHHHHHCCCCHHHHC	24.24	28542873
1760	Phosphorylation	SLVRHASTSPADKAK HHHHHCCCCHHHHCC	39.24	29895711
1761	Phosphorylation	LVRHASTSPADKAKV HHHHCCCCHHHHCCE	18.65	27087446
1860	Phosphorylation	TDQLMVPTLGSQEGA CCCEEECCCCCCCCC	32.13	26239621
1875	Phosphorylation	FENVRMNYSGDQGQT CCCEECCCCCCCHHH	12.51	28066266
1876	Phosphorylation	ENVRMNYSGDQGQTI CCEECCCCCCCHHHH	30.78	28066266
1882	Phosphorylation	YSGDQGQTIRQLISA CCCCCHHHHHHHHHH	25.59	28066266
1902	Phosphorylation	VAMCVLSSPHGRRQH HHHHHHCCCCCCCCE	19.43	-
1937	Ubiquitination	QADSSKRKLTLTRLA HCCCCCCCCCHHHHH	49.95	27667366
1945	Phosphorylation	LTLTRLASAPVPFTV CCHHHHHCCCCCEEE	37.38	23608596
2577	O-linked_Glycosylation	RLVITARSIAVTRPN HHHHEEEEEEECCCC	16.66	55414513
2577	Phosphorylation	RLVITARSIAVTRPN HHHHEEEEEEECCCC	16.66	30387612
2599 (in isoform 5)	Phosphorylation	-	34.08	28066266
2603 (in isoform 5)	Phosphorylation	-	75.85	22324799
2691	Phosphorylation	LCPDPAVSFSCKQAL CCCCHHHCCHHHHHH	17.35	22807455
2693	Phosphorylation	PDPAVSFSCKQALIR CCHHHCCHHHHHHHH	16.95	22807455
2712	Phosphorylation	RNKRRHVTLPSSPRS CCCCCCCCCCCCCCC	27.16	24925903
2715	Phosphorylation	RRHVTLPSSPRSNTP CCCCCCCCCCCCCCC	56.96	24925903
2716	Phosphorylation	RHVTLPSSPRSNTPM CCCCCCCCCCCCCCC	23.53	27087446
2719	Phosphorylation	TLPSSPRSNTPMGDK CCCCCCCCCCCCCCC	48.73	27087446
2721	Phosphorylation	PSSPRSNTPMGDKDD CCCCCCCCCCCCCCC	18.85	25521595
2740	Phosphorylation	DADEKMQSSGIPDGG CHHHHHHHCCCCCCC	27.34	23684622
2741	Phosphorylation	ADEKMQSSGIPDGGH HHHHHHHCCCCCCCC	24.69	29472430
2854	Phosphorylation	SSSLDAGTLSDTTAS CCCCCCCCCCCCCCC	25.47	22807455
2856	Phosphorylation	SLDAGTLSDTTASAP CCCCCCCCCCCCCCC	32.52	-
2858	Phosphorylation	DAGTLSDTTASAPAS CCCCCCCCCCCCCCC	22.38	-
2859	Phosphorylation	AGTLSDTTASAPASD CCCCCCCCCCCCCCC	24.49	-
2881	Phosphorylation	TDGSTLRTSPADHGG CCCCCCCCCCCCCCC	42.02	27742792
2882	Phosphorylation	DGSTLRTSPADHGGS CCCCCCCCCCCCCCC	16.20	27742792
2889	Phosphorylation	SPADHGGSVGSESGG CCCCCCCCCCCCCCC	28.09	27742792
2892	Phosphorylation	DHGGSVGSESGGSAV CCCCCCCCCCCCCCC	26.83	27742792
2894	Phosphorylation	GGSVGSESGGSAVDS CCCCCCCCCCCCCHH	50.59	27742792
2897	Phosphorylation	VGSESGGSAVDSVAG CCCCCCCCCCHHCCC	28.75	25619855
2901	Phosphorylation	SGGSAVDSVAGEHSV CCCCCCHHCCCCCCC	13.78	25619855
2907	Phosphorylation	DSVAGEHSVSGRSSA HHCCCCCCCCCCCCC	17.42	25619855
2909	Phosphorylation	VAGEHSVSGRSSAYG CCCCCCCCCCCCCCC	31.35	25619855
2913	Phosphorylation	HSVSGRSSAYGDATA CCCCCCCCCCCCCCC	24.93	25367039
2929	Phosphorylation	GHPAGPGSVSSSTGA CCCCCCCCCCCCCCC	23.20	25367039
2931	Phosphorylation	PAGPGSVSSSTGAIS CCCCCCCCCCCCCEE	21.92	25367039
2932	Phosphorylation	AGPGSVSSSTGAIST CCCCCCCCCCCCEEE	29.75	25367039
2933	Phosphorylation	GPGSVSSSTGAISTA CCCCCCCCCCCEEEC	24.29	25367039
2934	Phosphorylation	PGSVSSSTGAISTAT CCCCCCCCCCEEECC	32.36	25367039
2938	Phosphorylation	SSSTGAISTATGHQE CCCCCCEEECCCCCC	16.08	25367039
2939	Phosphorylation	SSTGAISTATGHQEG CCCCCEEECCCCCCC	23.33	25367039
2941	Phosphorylation	TGAISTATGHQEGDG CCCEEECCCCCCCCC	34.97	25367039
2949	Phosphorylation	GHQEGDGSEGEGEGE CCCCCCCCCCCCCCC	47.36	25367039
3038	Acetylation	MDKKDVSKKNERSAL CCHHHHCHHHHHHHH	60.51	19858427
3380	Phosphorylation	EKEKEGESSGSQEDQ HHHHCCCCCCCHHHH	51.35	25293948
3381	Phosphorylation	KEKEGESSGSQEDQL HHHCCCCCCCHHHHH	37.86	25293948
3383	Phosphorylation	KEGESSGSQEDQLCT HCCCCCCCHHHHHHH	32.14	25293948
3390	Phosphorylation	SQEDQLCTALVNQLN CHHHHHHHHHHHHHH	31.45	25293948
3731	Ubiquitination	ENEEDRKKAVSNINT CCHHHHHHHHHHHHH	55.72	-
3776	Phosphorylation	PEKPQEDSGTAGGIS CCCCCCCCCCCCCCC	36.97	25338131
3784	Phosphorylation	GTAGGISSTSASVNR CCCCCCCCCHHHHHH	25.18	25338131
3813	Acetylation	NSFDELSKIIQKVFA CCHHHHHHHHHHHHH	57.35	23236377
3838	Acetylation	QQREAATKSSRTSVQ HHHHHHHHCCCCCCC	41.53	23576753
3857	Phosphorylation	ASQYRALSVLGCGHT HHHHHHHHEECCCCC	17.82	25266776
3930	Phosphorylation	RQLMCLLTRDNPEAT HHHHHHHHCCCHHHH	24.03	-
4002	Phosphorylation	LMAVNIKTPVVVENI HHHCCCCCCHHHHHH	19.95	-
4010	Phosphorylation	PVVVENITLMCLRIL CHHHHHHHHHHHHHH	21.74	-
4019	Ubiquitination	MCLRILQKLIKPPAP HHHHHHHHHCCCCCC	49.05	22790023
4019 (in isoform 5)	Ubiquitination	-	49.05	22790023
4047 (in isoform 5)	Ubiquitination	-	45.47	-
4083	Phosphorylation	GVDGNGKSPSKSELH CCCCCCCCCCHHHHH	35.49	24719451
4085	Phosphorylation	DGNGKSPSKSELHRL CCCCCCCCHHHHHHH	56.77	24719451
4087	Phosphorylation	NGKSPSKSELHRLYL CCCCCCHHHHHHHHH	50.13	24719451
4272	Ubiquitination	NGYLCLRKLVLQRTK HHHHHHHHHHHHHHC	29.96	27667366
4429	Phosphorylation	YKKVWCATNEGEPMR HHHHEEECCCCCCCH	30.57	-
4458	Phosphorylation	EFIESLDSTTDEEED HHHHHHCCCCCCCCC	38.20	23649490
4459	Phosphorylation	FIESLDSTTDEEEDE HHHHHCCCCCCCCCH	37.62	29899451
4460	Phosphorylation	IESLDSTTDEEEDEE HHHHCCCCCCCCCHH	45.42	23649490
4510	Phosphorylation	TVLLKLFSYCVKVKV HHHHHHHHHHHHHCC	28.23	29472430
4511	Phosphorylation	VLLKLFSYCVKVKVN HHHHHHHHHHHHCCC	8.23	29472430
4685	Phosphorylation	LILQKGITQNALDYM HHHHCCCCHHHHHHH	25.16	22802335
4691	Phosphorylation	ITQNALDYMKKHIPS CCHHHHHHHHHHCCC	16.22	22802335
4785	Phosphorylation	IDAARRETRAEKKRM HHHHHHHHHHHHHHH	33.11	20139300
4807	Phosphorylation	ALGTLGMTTNEKGQV HHHHCCCCCCCCCCE	25.35	29514104
4847	Phosphorylation	EGYKFQPTKVLGIYT CCCCCCCCEEEEEEE	24.01	-
4944	Phosphorylation	NTYLQECTGQREPTY CCHHHHHCCCCCCEE	35.28	22802335
5079	Acetylation	GATRLTDKAVKDYSA CCCCCCHHHHHCHHH	50.25	19843179

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBR4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBR4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBR4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UBR4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; SER-181; SER-365;THR-2712; SER-2716; SER-2719 AND THR-2721, AND MASS SPECTROMETRY.
PubMed: 17242355