BICD2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BICD2_MOUSE
• UniProt AC: Q921C5
• Protein Name: Protein bicaudal D homolog 2
• Gene Name: Bicd2
• Organism: Mus musculus (Mouse).
• Sequence Length: 820
• Subcellular Localization: Golgi apparatus . Cytoplasm, cytoskeleton . Cytoplasm . Nucleus, nuclear pore complex . Nucleus envelope . In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (PubMed:11483508). Localizes t
• Protein Description: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). [PubMed: 11483508]
• Protein Sequence: MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLTSVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNNLRKELSHYMSINDSFYTSHLQVSLDGLKFSDDTVTAEPNNDAEALVNGFEHSGLVKSSLDNKTSTPRKDGLAPPSPSLVSDLLSELHISEIQKLKQQLVQMEREKVGLLATLQDTQKQLEQARGTLSEQHEKVNRLTENLSALRRLQAGKERQTSLDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKISLLEKASHQDRELLAHLEKELKKVSDVAGETQGSLNVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGKAGRTSPEGRGRRSPVLLPKGLLATEVGRADGGTGDNSPSPSSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRSKAASKAKPASPSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSAPSEEEE ------CCCCCHHHH	49.22	-
30	Phosphorylation	RAEVKRLSHELAETT HHHHHHHHHHHHHHH	20.96	29176673
113	Phosphorylation	ESASKEQYYVRKVLE HHHCHHHHHHHHHHH	12.67	28576409
114	Phosphorylation	SASKEQYYVRKVLEL HHCHHHHHHHHHHHH	8.09	28576409
181	Phosphorylation	EARLLQDYSELEEEN HHHHHHCHHHHHHHC	7.35	25338131
182	Phosphorylation	ARLLQDYSELEEENI HHHHHCHHHHHHHCC	43.95	25338131
190	Phosphorylation	ELEEENISLQKQVSV HHHHHCCCHHHHHHH	36.01	-
196	Phosphorylation	ISLQKQVSVLRQNQV CCHHHHHHHHHHCCC	16.97	25338131
224	Phosphorylation	EETEYLNSQLEDAIR HHHHHHHHHHHHHHH	33.28	-
246	Phosphorylation	QLEEALETLKTEREQ HHHHHHHHHHHHHHH	34.11	25266776
249	Phosphorylation	EALETLKTEREQKNN HHHHHHHHHHHHHHH	43.30	25266776
320	Phosphorylation	SSLDNKTSTPRKDGL CCCCCCCCCCCCCCC	37.71	25338131
321	Phosphorylation	SLDNKTSTPRKDGLA CCCCCCCCCCCCCCC	32.14	-
331	Phosphorylation	KDGLAPPSPSLVSDL CCCCCCCCHHHHHHH	26.51	27180971
333	Phosphorylation	GLAPPSPSLVSDLLS CCCCCCHHHHHHHHH	45.82	26745281
336	Phosphorylation	PPSPSLVSDLLSELH CCCHHHHHHHHHHHC	28.03	25777480
340	Phosphorylation	SLVSDLLSELHISEI HHHHHHHHHHCHHHH	45.47	25777480
345	Phosphorylation	LLSELHISEIQKLKQ HHHHHCHHHHHHHHH	20.21	25777480
393	Phosphorylation	HEKVNRLTENLSALR HHHHHHHHHHHHHHH	21.42	28066266
397	Phosphorylation	NRLTENLSALRRLQA HHHHHHHHHHHHHHC	36.52	28066266
410	Phosphorylation	QAGKERQTSLDNEKD HCCCHHCCCCCCCCC	37.16	22324799
411	Phosphorylation	AGKERQTSLDNEKDR CCCHHCCCCCCCCCC	25.95	26824392
420	Phosphorylation	DNEKDRDSHEDGDYY CCCCCCCCCCCCCEE	29.66	26643407
426	Phosphorylation	DSHEDGDYYEVDING CCCCCCCEEEEECCC	13.68	26643407
427	Phosphorylation	SHEDGDYYEVDINGP CCCCCCEEEEECCCH	17.76	26643407
569	Phosphorylation	GQGKAGRTSPEGRGR CCCCCCCCCCCCCCC	47.95	22324799
570	Phosphorylation	QGKAGRTSPEGRGRR CCCCCCCCCCCCCCC	21.42	25266776
578	Phosphorylation	PEGRGRRSPVLLPKG CCCCCCCCCCCCCCC	20.28	26824392
598	Phosphorylation	VGRADGGTGDNSPSP CCCCCCCCCCCCCCC	47.06	-
602	Phosphorylation	DGGTGDNSPSPSSSL CCCCCCCCCCCCCCC	31.34	25619855
604	Phosphorylation	GTGDNSPSPSSSLPS CCCCCCCCCCCCCCC	36.92	25619855
606	Phosphorylation	GDNSPSPSSSLPSPL CCCCCCCCCCCCCCC	36.58	25619855
607	Phosphorylation	DNSPSPSSSLPSPLS CCCCCCCCCCCCCCC	39.00	25619855
608	Phosphorylation	NSPSPSSSLPSPLSD CCCCCCCCCCCCCCC	48.95	25619855
611	Phosphorylation	SPSSSLPSPLSDPRR CCCCCCCCCCCCCCC	43.71	25619855
614	Phosphorylation	SSLPSPLSDPRREPM CCCCCCCCCCCCCCC	49.29	25619855
654	Phosphorylation	LSRQRIASQELGPAV HHHHHHHHCCCCCCC	23.09	25338131
681	Phosphorylation	KLKSLLSTKREQITT HHHHHHCCCHHHHHH	33.81	22418434
699	Phosphorylation	VLKANKQTAEVALAN HHHHCHHHHHHHHHH	26.79	21454597
802	Phosphorylation	LELDHEQTRRGRSKA HHCCHHHHHHHHHHH	21.24	28066266
811	Phosphorylation	RGRSKAASKAKPASP HHHHHHHHHCCCCCC	37.70	28059163
817 (in isoform 2)	Phosphorylation	-	24.45	29899451
817	Phosphorylation	ASKAKPASPSL---- HHHCCCCCCCC----	24.45	26824392
819	Phosphorylation	KAKPASPSL------ HCCCCCCCC------	44.19	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BICD2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BICD2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BICD2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPNE4_HUMAN	CPNE4	physical	12522145
DCTN1_HUMAN	DCTN1	physical	22956769
DC1I1_HUMAN	DYNC1I1	physical	22956769
MTOR_HUMAN	MTOR	physical	22956769
DC1I1_BOVIN	DYNC1I1	physical	22956769

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.