CPNE4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CPNE4_HUMAN
• UniProt AC: Q96A23
• Protein Name: Copine-4 {ECO:0000305}
• Gene Name: CPNE4 {ECO:0000312|HGNC:HGNC:2317}
• Organism: Homo sapiens (Human).
• Sequence Length: 557
• Protein Description: Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes..
• Protein Sequence: MKKMSNIYESAANTLGIFNSPCLTKVELRVACKGISDRDALSKPDPCVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFTVDFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSLLKHGNTAGKSSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVVMNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAMEGKQVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNGDPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAINFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFILLILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVLRDIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKPKCSSEMYESSRTLAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6 (in isoform 2)	Phosphorylation	-	37.05	20068231
7 (in isoform 2)	Phosphorylation	-	2.94	20068231
8 (in isoform 2)	Phosphorylation	-	14.21	20068231
10 (in isoform 2)	Phosphorylation	-	18.73	20068231
75	Phosphorylation	RTCINPVYSKLFTVD HHHHHHHHHHCEEEE	11.01	20736484
126	Acetylation	GQIVSQRKLSKSLLK HHHHHHHHHHHHHHH	49.85	12435537
129	Acetylation	VSQRKLSKSLLKHGN HHHHHHHHHHHHCCC	56.40	12435547
130	Phosphorylation	SQRKLSKSLLKHGNT HHHHHHHHHHHCCCC	35.24	23401153
213	Phosphorylation	AWKSFKVSVNSLCSG HHHHCCEEHHHHCCC	19.03	20860994
216	Phosphorylation	SFKVSVNSLCSGDPD HCCEEHHHHCCCCCC	28.70	20860994
219	Phosphorylation	VSVNSLCSGDPDRRL EEHHHHCCCCCCCCE	52.07	20860994
492	Phosphorylation	GDDGILRSPKGEPVL CCCCCCCCCCCCCCH	27.76	21406692
510 (in isoform 2)	Phosphorylation	-	51.18	21406692
522	Phosphorylation	SPAALAKSVLAEVPN CHHHHHHHHHHCCCC	19.43	24706070

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CPNE4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CPNE4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CPNE4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYCB2_MOUSE	Mycbp2	physical	12522145
SKIL_MOUSE	Skil	physical	12522145
NONO_MOUSE	Nono	physical	12522145
BCOR_MOUSE	Bcor	physical	12522145
CPNE1_MOUSE	Cpne1	physical	12522145
UBE2O_MOUSE	Ube2o	physical	12522145
RADI_MOUSE	Rdx	physical	12522145
ACTB_MOUSE	Actb	physical	12522145
SPTB2_MOUSE	Sptbn1	physical	12522145
BICD2_MOUSE	Bicd2	physical	12522145
MRCKB_MOUSE	Cdc42bpb	physical	12522145
CCD22_MOUSE	Ccdc22	physical	12522145
PITM2_MOUSE	Pitpnm2	physical	12522145
CE162_MOUSE	Cep162	physical	12522145
PDCD6_MOUSE	Pdcd6	physical	12522145
H11_HUMAN	HIST1H1A	physical	28514442
COE3_HUMAN	EBF3	physical	28514442
BAHC1_HUMAN	BAHCC1	physical	28514442
CPNE6_HUMAN	CPNE6	physical	28514442
RABE2_HUMAN	RABEP2	physical	28514442
RS27A_HUMAN	RPS27A	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
RGPD5_HUMAN	RGPD5	physical	28514442
TF3C2_HUMAN	GTF3C2	physical	28514442
UTRO_HUMAN	UTRN	physical	28514442
NSD2_HUMAN	WHSC1	physical	28514442
SPT5H_HUMAN	SUPT5H	physical	28514442
DHX30_HUMAN	DHX30	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
RLP24_HUMAN	RSL24D1	physical	28514442
STAU1_HUMAN	STAU1	physical	28514442
NOP2_HUMAN	NOP2	physical	28514442
SPB1_HUMAN	FTSJ3	physical	28514442
RL18A_HUMAN	RPL18A	physical	28514442
RL3_HUMAN	RPL3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.