CCD22_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCD22_MOUSE
• UniProt AC: Q9JIG7
• Protein Name: Coiled-coil domain-containing protein 22
• Gene Name: Ccdc22
• Organism: Mus musculus (Mouse).
• Sequence Length: 627
• Subcellular Localization: Endosome .
• Protein Description: Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes..
• Protein Sequence: MEEADRILIHSLRQAGTAVPPEVQTLRAFTTELVVEAVVRCLRVINPDVGSGLSHLLPPAMSARFRLAMSLAQACMDLGYPLELGYQNFLYPSEPDLRDLLLFLAERLPSDASEDADQPAGDSAIFLRAIGSQIRDQLALPWVPPLLRTPKVQRLQGSALQQPFHSSRLVLPELNSSGELWEFQASPLLLPAPTQVPQLQGRAASLLEHHASQLCQHVNRDCPGDEDRVRWASRVPSQEDSRAPQQRLHKQLIEHLRQSWGPLGAPTQVRDLGEMLQTWGARAMTGVPKGSRFTHSEKFTFHLEPQVQAAQVADVPATSQRLEQDTRAAQEQELESLREQLASVNHNIEEVEADMKTLGINLVQVETECRQSELSVAEQEQALRLKSRTVELLPDGAANLAKLQLVVESSAQRLIHLASQWEKHRVPLLAEYRHLRRLQDCRELESSRRLAEIQELHHSVRAAAEEARRKEEVYKQLVSELETLPKDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETEMGKKTLSNLEKICEDYRALRQENAGLLGRVREA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	Phosphorylation	FLAERLPSDASEDAD HHHHHCCCCCCCCCC	50.86	28066266
113	Phosphorylation	ERLPSDASEDADQPA HHCCCCCCCCCCCCC	40.79	27180971
123	Phosphorylation	ADQPAGDSAIFLRAI CCCCCCCHHHHHHHH	23.50	28285833
237	Phosphorylation	RWASRVPSQEDSRAP HHHHCCCCHHCCCCH	43.26	23684622
410	Phosphorylation	LQLVVESSAQRLIHL HHHHHHHHHHHHHHH	18.21	-
474	Phosphorylation	ARRKEEVYKQLVSEL HHHHHHHHHHHHHHH	9.04	-
573	Phosphorylation	NCSQLIQTIEDTGTI HHHHHHHHHHHHCHH	21.24	-
601	Phosphorylation	EMGKKTLSNLEKICE HHHHHHHHHHHHHHH	44.60	22006019

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCD22_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCD22_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCD22_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPNE1_HUMAN	CPNE1	physical	12522145
CPNE4_HUMAN	CPNE4	physical	12522145

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.