PITM2_MOUSE - dbPTM
PITM2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PITM2_MOUSE
UniProt AC Q6ZPQ6
Protein Name Membrane-associated phosphatidylinositol transfer protein 2
Gene Name Pitpnm2
Organism Mus musculus (Mouse).
Sequence Length 1335
Subcellular Localization Endomembrane system
Peripheral membrane protein. Cytoplasm, cytoskeleton . May associate with the cytoskeleton.
Protein Description Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions (By similarity)..
Protein Sequence MIIKEYRIPLPMTVDEYRIAQLYMIQKKSRNETHGQGSGVEILENRPYTDGPGGSGQYTHKVYHVGMHIPGWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDTGENNNVFNLSPVEKSQLITDIIDIVKDPVPPSEYKTEEDPKLFQSVKTCRGPLSENWIQEYKKRLLPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLTMEKIRELEREVQLMLSRKMAQFSEEGPSELSKDSATKDQASGTTSDPGSKNGEPLGRGLKKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDSDEGSEEEFFDAHENLYCTEEKQAKDMTKWNSNDLMDKMESPEPEESQDEIYQQSGSEFRVASSVEQLNIIEDEVSQPLAAPPSKIHVLLLVLHGGTILDTGAGDPSSKQGDTNTITNVFDTVMRVHYPSALGHLAIRLVPCPPICADAFALVSNLSPYGHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVIQRANLAYGDFIKSQEGVTFNGQVCLIGDCVGGILAFDALCYSGQPVSESQSSSRRGSVVSMQDADLLSPGTLANAAHCSGGSGGGGSGGSSLESSRHLSRSNIDIPRSNGTEDSRRQLPRKRSDSSTYELDTIQQHQAFLSSLHASVLRNEPSSRRSSSSTMLDGAGALGKFDFEIADLFLFGCPLGLVLALRKTVIPSLDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHSLPPFSIPRYQRYPLGDGCSTLLADVLQTHNTVFQEHAAPSSPGTAPAGRGFRRASEISIASQVSGMAESYTASSIAQKGPSSLNHTPSIRRLSLLALPPPSPTTQGPRARARQVSPNLERAPCLPDLDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDSSSILELDGKEVSVFTPSQPRERWQRKRTHVKLRNVAANHRINDAVANEDGPQVVTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLHLDTLVTNSSGRVSYTIPETHRLGVGVYPIKMVVRGDHTFADSYITVLPRGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRAHAAYGSTKDVAVYNSISLSPMHIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYNHRARPARNTATRMALRKGSFGLPGQSDFLRSRNHLLRTISAQPSGPSHRHDRTQTQMDSEQRGQRSMSVAASCWGRAMAGRLEPGAATGPK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
129PhosphorylationNNNVFNLSPVEKSQL
CCCEEECCHHCHHHH		28.1825521595
151PhosphorylationVKDPVPPSEYKTEED
HHCCCCHHHCCCCCC		47.70-
153PhosphorylationDPVPPSEYKTEEDPK
CCCCHHHCCCCCCHH		27.78-
256UbiquitinationVQLMLSRKMAQFSEE
HHHHHHHHHHHHCCC		34.9022790023
283PhosphorylationDQASGTTSDPGSKNG
CCCCCCCCCCCCCCC		41.4627841257
303PhosphorylationGLKKQWSTSSKSSRS
CHHHHCCCCCCCCCC		33.7825521595
316PhosphorylationRSSKRGASPSRHSIS
CCCCCCCCCCCCCCC		26.6526824392
318PhosphorylationSKRGASPSRHSISEW
CCCCCCCCCCCCCHH		39.8823684622
321PhosphorylationGASPSRHSISEWRMQ
CCCCCCCCCCHHHHH		27.0526824392
323PhosphorylationSPSRHSISEWRMQSI
CCCCCCCCHHHHHHH		33.8423737553
329PhosphorylationISEWRMQSIARDSDE
CCHHHHHHHHCCCCC		14.6319060867
334PhosphorylationMQSIARDSDEGSEEE
HHHHHCCCCCCCHHH		31.8225521595
338PhosphorylationARDSDEGSEEEFFDA
HCCCCCCCHHHHHHH		39.5225521595
365PhosphorylationKDMTKWNSNDLMDKM
HCCCCCCHHHHHHHH		30.5225521595
374PhosphorylationDLMDKMESPEPEESQ
HHHHHHCCCCCCHHH		30.9429899451
380PhosphorylationESPEPEESQDEIYQQ
CCCCCCHHHHHHHHH		41.0722807455
396PhosphorylationGSEFRVASSVEQLNI
CCCEEECCCHHHHCC		31.8727180971
397PhosphorylationSEFRVASSVEQLNII
CCEEECCCHHHHCCC		21.6725521595
409PhosphorylationNIIEDEVSQPLAAPP
CCCCCCCCCCCCCCH		24.8425293948
441PhosphorylationTGAGDPSSKQGDTNT
CCCCCCCCCCCCCCH		34.09-
586PhosphorylationQSSSRRGSVVSMQDA
CCCCCCCCEEECCCC		19.9621183079
589PhosphorylationSRRGSVVSMQDADLL
CCCCCEEECCCCCCC		14.4725293948
597PhosphorylationMQDADLLSPGTLANA
CCCCCCCCCCCCCCC		28.6925293948
608PhosphorylationLANAAHCSGGSGGGG
CCCCCCCCCCCCCCC		36.0021183079
628PhosphorylationLESSRHLSRSNIDIP
HHHHCCCCCCCCCCC		27.7726824392
630PhosphorylationSSRHLSRSNIDIPRS
HHCCCCCCCCCCCCC		34.4626824392
630 (in isoform 2)Phosphorylation-34.4624719451
652PhosphorylationRQLPRKRSDSSTYEL
HCCCCCCCCCCCCCH		44.9026643407
654PhosphorylationLPRKRSDSSTYELDT
CCCCCCCCCCCCHHH		26.3126643407
655PhosphorylationPRKRSDSSTYELDTI
CCCCCCCCCCCHHHH		39.7426643407
656PhosphorylationRKRSDSSTYELDTIQ
CCCCCCCCCCHHHHH		25.6026643407
657PhosphorylationKRSDSSTYELDTIQQ
CCCCCCCCCHHHHHH		19.2225293948
661PhosphorylationSSTYELDTIQQHQAF
CCCCCHHHHHHHHHH		33.0526643407
686PhosphorylationNEPSSRRSSSSTMLD
CCCCCCCCCCCCCCC		33.2027742792
687PhosphorylationEPSSRRSSSSTMLDG
CCCCCCCCCCCCCCC		26.8825521595
688PhosphorylationPSSRRSSSSTMLDGA
CCCCCCCCCCCCCCC		30.9525521595
689PhosphorylationSSRRSSSSTMLDGAG
CCCCCCCCCCCCCCC		21.5625521595
690PhosphorylationSRRSSSSTMLDGAGA
CCCCCCCCCCCCCCH		24.5728833060
805PhosphorylationFQEHAAPSSPGTAPA
CHHCCCCCCCCCCCC		44.4229899451
806PhosphorylationQEHAAPSSPGTAPAG
HHCCCCCCCCCCCCC		26.7029899451
814MethylationPGTAPAGRGFRRASE
CCCCCCCCCCHHHHH		43.0924129315
820PhosphorylationGRGFRRASEISIASQ
CCCCHHHHHHHHHHH		33.3819060867
820 (in isoform 2)Phosphorylation-33.3827600695
823PhosphorylationFRRASEISIASQVSG
CHHHHHHHHHHHHHC		14.1921082442
823 (in isoform 2)Phosphorylation-14.1929899451
826 (in isoform 2)Phosphorylation-29.4629899451
847PhosphorylationIAQKGPSSLNHTPSI
HHHHCCCCCCCCCCC		36.0020469934
851PhosphorylationGPSSLNHTPSIRRLS
CCCCCCCCCCCCEEE		20.0521183079
853PhosphorylationSSLNHTPSIRRLSLL
CCCCCCCCCCEEEEE		29.8630352176
858PhosphorylationTPSIRRLSLLALPPP
CCCCCEEEEEECCCC		21.3726824392
866PhosphorylationLLALPPPSPTTQGPR
EEECCCCCCCCCCHH		40.4230352176
868PhosphorylationALPPPSPTTQGPRAR
ECCCCCCCCCCHHHH		35.7725338131
880PhosphorylationRARARQVSPNLERAP
HHHHHHCCCCCCCCC		10.3426060331
1083PhosphorylationDHTFADSYITVLPRG
CCCCCCCEEEEECCC		10.9327180971
1209 (in isoform 2)Phosphorylation-17.2424719451
1263PhosphorylationRMALRKGSFGLPGQS
HHHHHHCCCCCCCCC		21.1225521595
1275PhosphorylationGQSDFLRSRNHLLRT
CCCHHHHHCCHHHHH		39.3129514104
1282PhosphorylationSRNHLLRTISAQPSG
HCCHHHHHHCCCCCC		21.1829899451
1284PhosphorylationNHLLRTISAQPSGPS
CHHHHHHCCCCCCCC		21.9029899451
1312PhosphorylationQRGQRSMSVAASCWG
HHHHHHHHHHHHHHH		15.1719060867
1320MethylationVAASCWGRAMAGRLE
HHHHHHHHHHCCCCC		9.1858858967
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PITM2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PITM2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PITM2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CPNE1_HUMANCPNE1physical
12522145
CPNE4_HUMANCPNE4physical
12522145
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PITM2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1263, AND MASSSPECTROMETRY.

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