| UniProt ID | ACTB_MOUSE | |
|---|---|---|
| UniProt AC | P60710 | |
| Protein Name | Actin, cytoplasmic 1 | |
| Gene Name | Actb | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 375 | |
| Subcellular Localization | Cytoplasm, cytoskeleton. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.. | |
| Protein Description | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.. | |
| Protein Sequence | MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MDDDIAAL -------CCCCCEEE | 13.23 | - | |
| 2 | Acetylation | ------MDDDIAALV ------CCCCCEEEE | 63.39 | 213279 | |
| 14 | Phosphorylation | ALVVDNGSGMCKAGF EEEEECCCCCEECCC | 29.61 | 26239621 | |
| 33 | Phosphorylation | APRAVFPSIVGRPRH CCCCCCHHHCCCCCC | 20.59 | 26824392 | |
| 44 | Oxidation | RPRHQGVMVGMGQKD CCCCCCEEEECCCCC | 2.49 | 23911929 | |
| 47 | Oxidation | HQGVMVGMGQKDSYV CCCEEEECCCCCCCC | 3.32 | 23911929 | |
| 50 | Acetylation | VMVGMGQKDSYVGDE EEEECCCCCCCCCCH | 42.80 | 21728379 | |
| 50 | Ubiquitination | VMVGMGQKDSYVGDE EEEECCCCCCCCCCH | 42.80 | - | |
| 50 | Malonylation | VMVGMGQKDSYVGDE EEEECCCCCCCCCCH | 42.80 | 25418362 | |
| 50 | Succinylation | VMVGMGQKDSYVGDE EEEECCCCCCCCCCH | 42.80 | 23954790 | |
| 52 | Phosphorylation | VGMGQKDSYVGDEAQ EECCCCCCCCCCHHH | 28.84 | 25521595 | |
| 53 | Phosphorylation | GMGQKDSYVGDEAQS ECCCCCCCCCCHHHC | 20.70 | 26824392 | |
| 60 | Phosphorylation | YVGDEAQSKRGILTL CCCCHHHCCCCEEEE | 31.22 | 27087446 | |
| 61 | Acetylation | VGDEAQSKRGILTLK CCCHHHCCCCEEEEE | 42.43 | 21728379 | |
| 61 | Ubiquitination | VGDEAQSKRGILTLK CCCHHHCCCCEEEEE | 42.43 | - | |
| 61 | Malonylation | VGDEAQSKRGILTLK CCCHHHCCCCEEEEE | 42.43 | 26073543 | |
| 61 | Succinylation | VGDEAQSKRGILTLK CCCHHHCCCCEEEEE | 42.43 | 23954790 | |
| 66 | Phosphorylation | QSKRGILTLKYPIEH HCCCCEEEEECEECC | 21.20 | 22817900 | |
| 68 | Acetylation | KRGILTLKYPIEHGI CCCEEEEECEECCCC | 43.69 | 23806337 | |
| 69 | Phosphorylation | RGILTLKYPIEHGIV CCEEEEECEECCCCC | 16.74 | 26239621 | |
| 73 | Methylation | TLKYPIEHGIVTNWD EEECEECCCCCCCHH | 31.81 | 213279 | |
| 84 | Methylation | TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH | 44.45 | - | |
| 84 | Acetylation | TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH | 44.45 | 23236377 | |
| 89 | Phosphorylation | MEKIWHHTFYNELRV HHHHHHHHHHCCCCC | 18.22 | 22499769 | |
| 89 | O-linked_Glycosylation | MEKIWHHTFYNELRV HHHHHHHHHHCCCCC | 18.22 | 9423825 | |
| 91 | Phosphorylation | KIWHHTFYNELRVAP HHHHHHHHCCCCCCC | 14.64 | 27742792 | |
| 106 | Phosphorylation | EEHPVLLTEAPLNPK CCCCEEEEECCCCCC | 26.41 | 26824392 | |
| 106 | O-linked_Glycosylation | EEHPVLLTEAPLNPK CCCCEEEEECCCCCC | 26.41 | 57405011 | |
| 113 | Ubiquitination | TEAPLNPKANREKMT EECCCCCCCCHHHHH | 58.16 | - | |
| 113 | Acetylation | TEAPLNPKANREKMT EECCCCCCCCHHHHH | 58.16 | 23806337 | |
| 113 | Succinylation | TEAPLNPKANREKMT EECCCCCCCCHHHHH | 58.16 | 23806337 | |
| 141 | Phosphorylation | VAIQAVLSLYASGRT HHHHHHHHHHHCCCC | 16.85 | 21082442 | |
| 143 | Phosphorylation | IQAVLSLYASGRTTG HHHHHHHHHCCCCEE | 8.71 | 30803941 | |
| 145 | Phosphorylation | AVLSLYASGRTTGIV HHHHHHHCCCCEEEE | 18.43 | - | |
| 148 | Phosphorylation | SLYASGRTTGIVMDS HHHHCCCCEEEEEEC | 32.66 | 19060867 | |
| 149 | Phosphorylation | LYASGRTTGIVMDSG HHHCCCCEEEEEECC | 24.45 | 23984901 | |
| 155 | Phosphorylation | TTGIVMDSGDGVTHT CEEEEEECCCCCEEE | 22.23 | 23984901 | |
| 160 | Phosphorylation | MDSGDGVTHTVPIYE EECCCCCEEEEEEEC | 19.84 | 21183079 | |
| 162 | Phosphorylation | SGDGVTHTVPIYEGY CCCCCEEEEEEECCC | 20.72 | 21183079 | |
| 166 | Phosphorylation | VTHTVPIYEGYALPH CEEEEEEECCCCCCH | 9.38 | 25177544 | |
| 169 | Phosphorylation | TVPIYEGYALPHAIL EEEEECCCCCCHHHH | 7.94 | 40701 | |
| 169 | Nitration | TVPIYEGYALPHAIL EEEEECCCCCCHHHH | 7.94 | - | |
| 186 | Phosphorylation | DLAGRDLTDYLMKIL HHCCCCHHHHHHHHH | 27.21 | 24899341 | |
| 188 | Phosphorylation | AGRDLTDYLMKILTE CCCCHHHHHHHHHHH | 11.94 | 2001175 | |
| 188 | Nitration | AGRDLTDYLMKILTE CCCCHHHHHHHHHHH | 11.94 | - | |
| 191 | Acetylation | DLTDYLMKILTERGY CHHHHHHHHHHHCCC | 31.78 | 21728379 | |
| 191 | Ubiquitination | DLTDYLMKILTERGY CHHHHHHHHHHHCCC | 31.78 | - | |
| 194 | Phosphorylation | DYLMKILTERGYSFT HHHHHHHHHCCCCCC | 27.40 | 25367039 | |
| 198 | Phosphorylation | KILTERGYSFTTTAE HHHHHCCCCCCCCHH | 13.56 | 25177544 | |
| 199 | Phosphorylation | ILTERGYSFTTTAER HHHHCCCCCCCCHHH | 20.95 | 22499769 | |
| 201 | Phosphorylation | TERGYSFTTTAEREI HHCCCCCCCCHHHHH | 19.80 | 30635358 | |
| 201 | O-linked_Glycosylation | TERGYSFTTTAEREI HHCCCCCCCCHHHHH | 19.80 | 22645316 | |
| 202 | Phosphorylation | ERGYSFTTTAEREIV HCCCCCCCCHHHHHH | 23.23 | 30635358 | |
| 203 | Phosphorylation | RGYSFTTTAEREIVR CCCCCCCCHHHHHHH | 24.38 | 26824392 | |
| 213 | Acetylation | REIVRDIKEKLCYVA HHHHHHHHHHHHEEE | 53.75 | 8275699 | |
| 213 | Succinylation | REIVRDIKEKLCYVA HHHHHHHHHHHHEEE | 53.75 | 23954790 | |
| 215 | Ubiquitination | IVRDIKEKLCYVALD HHHHHHHHHHEEECC | 38.56 | - | |
| 217 | S-nitrosocysteine | RDIKEKLCYVALDFE HHHHHHHHEEECCHH | 3.68 | - | |
| 217 | Glutathionylation | RDIKEKLCYVALDFE HHHHHHHHEEECCHH | 3.68 | 24333276 | |
| 217 | S-nitrosylation | RDIKEKLCYVALDFE HHHHHHHHEEECCHH | 3.68 | 22178444 | |
| 217 | S-palmitoylation | RDIKEKLCYVALDFE HHHHHHHHEEECCHH | 3.68 | 28526873 | |
| 218 | Nitrated tyrosine | DIKEKLCYVALDFEQ HHHHHHHEEECCHHH | 10.13 | - | |
| 218 | Phosphorylation | DIKEKLCYVALDFEQ HHHHHHHEEECCHHH | 10.13 | 23527152 | |
| 229 | Phosphorylation | DFEQEMATAASSSSL CHHHHHHHHHCCCCC | 22.80 | 55241617 | |
| 232 | Phosphorylation | QEMATAASSSSLEKS HHHHHHHCCCCCCCC | 28.43 | 26745281 | |
| 233 | Phosphorylation | EMATAASSSSLEKSY HHHHHHCCCCCCCCE | 21.15 | 27087446 | |
| 234 | Phosphorylation | MATAASSSSLEKSYE HHHHHCCCCCCCCEE | 36.13 | 27087446 | |
| 235 | Phosphorylation | ATAASSSSLEKSYEL HHHHCCCCCCCCEEC | 42.36 | 63716397 | |
| 239 | Phosphorylation | SSSSLEKSYELPDGQ CCCCCCCCEECCCCC | 17.92 | 25521595 | |
| 239 | O-linked_Glycosylation | SSSSLEKSYELPDGQ CCCCCCCCEECCCCC | 17.92 | 6372519 | |
| 240 | Phosphorylation | SSSLEKSYELPDGQV CCCCCCCEECCCCCE | 32.33 | 24925903 | |
| 249 | Phosphorylation | LPDGQVITIGNERFR CCCCCEEEECCCEEC | 24.79 | 46158343 | |
| 257 | S-nitrosocysteine | IGNERFRCPEALFQP ECCCEECCCHHHHCC | 3.08 | - | |
| 257 | Glutathionylation | IGNERFRCPEALFQP ECCCEECCCHHHHCC | 3.08 | 24333276 | |
| 257 | S-nitrosylation | IGNERFRCPEALFQP ECCCEECCCHHHHCC | 3.08 | 22178444 | |
| 265 | Phosphorylation | PEALFQPSFLGMESC CHHHHCCHHHCCCCC | 23.48 | 30814625 | |
| 271 | Phosphorylation | PSFLGMESCGIHETT CHHHCCCCCCCCCCC | 14.57 | 26239621 | |
| 272 | S-nitrosocysteine | SFLGMESCGIHETTF HHHCCCCCCCCCCCH | 3.65 | - | |
| 272 | Glutathionylation | SFLGMESCGIHETTF HHHCCCCCCCCCCCH | 3.65 | 24333276 | |
| 272 | S-nitrosylation | SFLGMESCGIHETTF HHHCCCCCCCCCCCH | 3.65 | 22178444 | |
| 272 | S-palmitoylation | SFLGMESCGIHETTF HHHCCCCCCCCCCCH | 3.65 | 28526873 | |
| 277 | Phosphorylation | ESCGIHETTFNSIMK CCCCCCCCCHHHHHC | 23.64 | 23984901 | |
| 278 | Phosphorylation | SCGIHETTFNSIMKC CCCCCCCCHHHHHCC | 20.17 | 23984901 | |
| 281 | Phosphorylation | IHETTFNSIMKCDVD CCCCCHHHHHCCCCC | 21.62 | 23984901 | |
| 285 | S-nitrosocysteine | TFNSIMKCDVDIRKD CHHHHHCCCCCCCCH | 3.22 | - | |
| 285 | Glutathionylation | TFNSIMKCDVDIRKD CHHHHHCCCCCCCCH | 3.22 | 24333276 | |
| 285 | S-nitrosylation | TFNSIMKCDVDIRKD CHHHHHCCCCCCCCH | 3.22 | 22178444 | |
| 291 | Ubiquitination | KCDVDIRKDLYANTV CCCCCCCCHHHCCCE | 53.04 | - | |
| 291 | Malonylation | KCDVDIRKDLYANTV CCCCCCCCHHHCCCE | 53.04 | 25418362 | |
| 294 | Phosphorylation | VDIRKDLYANTVLSG CCCCCHHHCCCEECC | 14.13 | 26824392 | |
| 294 | Nitration | VDIRKDLYANTVLSG CCCCCHHHCCCEECC | 14.13 | - | |
| 297 | Phosphorylation | RKDLYANTVLSGGTT CCHHHCCCEECCCCC | 18.04 | 9567085 | |
| 300 | Phosphorylation | LYANTVLSGGTTMYP HHCCCEECCCCCCCC | 30.73 | 28833060 | |
| 303 | Phosphorylation | NTVLSGGTTMYPGIA CCEECCCCCCCCCHH | 16.35 | 23984901 | |
| 304 | Phosphorylation | TVLSGGTTMYPGIAD CEECCCCCCCCCHHH | 20.27 | 28833060 | |
| 306 | Phosphorylation | LSGGTTMYPGIADRM ECCCCCCCCCHHHHH | 9.01 | 28833060 | |
| 315 | Acetylation | GIADRMQKEITALAP CHHHHHHHHHHHHCC | 41.56 | 21728379 | |
| 315 | Ubiquitination | GIADRMQKEITALAP CHHHHHHHHHHHHCC | 41.56 | - | |
| 318 | Phosphorylation | DRMQKEITALAPSTM HHHHHHHHHHCCCCE | 19.40 | 25521595 | |
| 323 | Phosphorylation | EITALAPSTMKIKII HHHHHCCCCEEEEEE | 35.21 | 25521595 | |
| 324 | Phosphorylation | ITALAPSTMKIKIIA HHHHCCCCEEEEEEC | 22.79 | 46158475 | |
| 326 | Acetylation | ALAPSTMKIKIIAPP HHCCCCEEEEEECCC | 40.72 | 23864654 | |
| 326 | Ubiquitination | ALAPSTMKIKIIAPP HHCCCCEEEEEECCC | 40.72 | - | |
| 326 | Malonylation | ALAPSTMKIKIIAPP HHCCCCEEEEEECCC | 40.72 | 25418362 | |
| 328 | Acetylation | APSTMKIKIIAPPER CCCCEEEEEECCCCC | 23.65 | 23864654 | |
| 328 | Ubiquitination | APSTMKIKIIAPPER CCCCEEEEEECCCCC | 23.65 | - | |
| 328 | Malonylation | APSTMKIKIIAPPER CCCCEEEEEECCCCC | 23.65 | 25418362 | |
| 362 | Phosphorylation | MWISKQEYDESGPSI HHHHCCCCCCCCCCC | 23.63 | 26026062 | |
| 365 | Phosphorylation | SKQEYDESGPSIVHR HCCCCCCCCCCCCCC | 53.78 | 20139300 | |
| 365 | O-linked_Glycosylation | SKQEYDESGPSIVHR HCCCCCCCCCCCCCC | 53.78 | 29471825 | |
| 368 | Phosphorylation | EYDESGPSIVHRKCF CCCCCCCCCCCCCCC | 40.54 | 27180971 | |
| 373 | Acetylation | GPSIVHRKCF----- CCCCCCCCCC----- | 25.72 | 129769 | |
| 374 | S-nitrosocysteine | PSIVHRKCF------ CCCCCCCCC------ | 5.02 | - | |
| 374 | S-nitrosylation | PSIVHRKCF------ CCCCCCCCC------ | 5.02 | 22178444 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ACTB_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACTB_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Nitration | |
| Reference | PubMed |
| "Endogenously nitrated proteins in mouse brain: links toneurodegenerative disease."; Sacksteder C.A., Qian W.-J., Knyushko T.V., Wang H., Chin M.H.,Lacan G., Melega W.P., Camp D.G. II, Smith R.D., Smith D.J.,Squier T.C., Bigelow D.J.; Biochemistry 45:8009-8022(2006). Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-218, AND MASS SPECTROMETRY. | |
