PPBI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPBI_HUMAN
• UniProt AC: P09923
• Protein Name: Intestinal-type alkaline phosphatase
• Gene Name: ALPI
• Organism: Homo sapiens (Human).
• Sequence Length: 528
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor.
• Protein Sequence: MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Ubiquitination	AEALDAAKKLQPIQK HHHHHHHHHCHHHHH	56.59	-
44	Ubiquitination	EALDAAKKLQPIQKV HHHHHHHHCHHHHHH	47.86	-
50	Ubiquitination	KKLQPIQKVAKNLIL HHCHHHHHHHHHHHH	44.90	-
102	Phosphorylation	YLALSKTYNVDRQVP CEEEECCCCCCCCCC	19.54	22210691
111	Phosphorylation	VDRQVPDSAATATAY CCCCCCCHHHHHHHH	17.46	25159151
114	Phosphorylation	QVPDSAATATAYLCG CCCCHHHHHHHHHHC	25.02	23663014
116	Phosphorylation	PDSAATATAYLCGVK CCHHHHHHHHHHCHH	16.10	23663014
118	Phosphorylation	SAATATAYLCGVKAN HHHHHHHHHHCHHHC	9.73	20068231
120	Carbamidation	ATATAYLCGVKANFQ HHHHHHHHCHHHCCE	3.71	17322306
141	N-linked_Glycosylation	AARFNQCNTTRGNEV HHHHHCCCCCCCCHH	34.42	UniProtKB CARBOHYD
150	Phosphorylation	TRGNEVISVMNRAKQ CCCCHHHHHHHHHHH	22.08	113305377
160	Ubiquitination	NRAKQAGKSVGVVTT HHHHHCCCCEEEEEE	45.01	-
174	Phosphorylation	TTRVQHASPAGTYAH EEEEECCCCCCCEEE	17.10	72265383
179	Phosphorylation	HASPAGTYAHTVNRN CCCCCCCEEEECCCC	8.75	110739419
225	Phosphorylation	ILGGGRKYMFPMGTP EECCCCEEECCCCCC	11.57	74103177
241	Phosphorylation	PEYPADASQNGIRLD CCCCCCHHHCCEEEC	25.40	22210691
250	Ubiquitination	NGIRLDGKNLVQEWL CCEEECCHHHHHHHH	46.93	-
268	N-linked_Glycosylation	QGAWYVWNRTELMQA CCCEEEEEHHHHHHH	30.84	UniProtKB CARBOHYD
270	Phosphorylation	AWYVWNRTELMQASL CEEEEEHHHHHHHHH	30.20	-
311	Phosphorylation	DPSLMEMTEAALRLL CHHHHHHHHHHHHHH	14.79	20068231
319	Phosphorylation	EAALRLLSRNPRGFY HHHHHHHHHCCCCEE	34.30	28355574
387	Phosphorylation	VFSFGGYTLRGSSIF EEEECCEEEECCEEC	17.16	24719451
399	Phosphorylation	SIFGLAPSKAQDSKA EECCCCCCCCCCCCC	34.71	26270265
429	N-linked_Glycosylation	SGVRPDVNESESGSP CCCCCCCCCCCCCCC	55.23	UniProtKB CARBOHYD
431	Phosphorylation	VRPDVNESESGSPDY CCCCCCCCCCCCCCH	31.68	22468782
433	Phosphorylation	PDVNESESGSPDYQQ CCCCCCCCCCCCHHH	54.58	22468782
435	Phosphorylation	VNESESGSPDYQQQA CCCCCCCCCCHHHEE	24.71	22468782
438	Phosphorylation	SESGSPDYQQQAAVP CCCCCCCHHHEEECC	16.17	22468782
447	Phosphorylation	QQAAVPLSSETHGGE HEEECCCCCCCCCCC	21.76	22468782
503	GPI-anchor	APPACTTDAAHPVAA CCCCCCCCCCCCHHH	24.49	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPBI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPBI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPBI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IRF5_HUMAN	IRF5	physical	19786094
KR109_HUMAN	KRTAP10-9	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
PPB1_HUMAN	ALPP	physical	28514442
ARL2_HUMAN	ARL2	physical	28514442
TBB1_HUMAN	TUBB1	physical	28514442
ARF5_HUMAN	ARF5	physical	28514442
DD19B_HUMAN	DDX19B	physical	28514442
RB39B_HUMAN	RAB39B	physical	28514442
RDH13_HUMAN	RDH13	physical	28514442
ARL8B_HUMAN	ARL8B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111, AND MASSSPECTROMETRY.
PubMed: 15302935