dbPTM

OXR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	OXR1_HUMAN
UniProt AC	Q8N573
Protein Name	Oxidation resistance protein 1
Gene Name	OXR1
Organism	Homo sapiens (Human).
Sequence Length	874
Subcellular Localization	Mitochondrion .
Protein Description	May be involved in protection from oxidative damage..
Protein Sequence	MTKDKNSPGLKKKSQSVDINAPGFNPLAGAGKQTPQASKPPAPKTPIIEEEQNNAANTQKHPSRRSELKRFYTIDTGQKKTLDKKDGRRMSFQKPKGTIEYTVESRDSLNSIALKFDTTPNELVQLNKLFSRAVVTGQVLYVPDPEYVSSVESSPSLSPVSPLSPTSSEAEFDKTTNPDVHPTEATPSSTFTGIRPARVVSSTSEEEEAFTEKFLKINCKYITSGKGTVSGVLLVTPNNIMFDPHKNDPLVQENGCEEYGIMCPMEEVMSAAMYKEILDSKIKESLPIDIDQLSGRDFCHSKKMTGSNTEEIDSRIRDAGNDSASTAPRSTEESLSEDVFTESELSPIREELVSSDELRQDKSSGASSESVQTVNQAEVESLTVKSESTGTPGHLRSDTEHSTNEVGTLCHKTDLNNLEMAIKEDQIADNFQGISGPKEDSTSIKGNSDQDSFLHENSLHQEESQKENMPCGETAEFKQKQSVNKGKQGKEQNQDSQTEAEELRKLWKTHTMQQTKQQRENIQQVSQKEAKHKITSADGHIESSALLKEKQRHRLHKFLCLRVGKPMRKTFVSQASATMQQYAQRDKKHEYWFAVPQERTDHLYAFFIQWSPEIYAEDTGEYTREPGFIVVKKIEESETIEDSSNQAAAREWEVVSVAEYHRRIDALNTEELRTLCRRLQITTREDINSKQVATVKADLESESFRPNLSDPSELLLPDQIEKLTKHLPPRTIGYPWTLVYGTGKHGTSLKTLYRTMTGLDTPVLMVIKDSDGQVFGALASEPLKVSDGFYGTGETFVFTFCPEFEVFKWTGDNMFFIKGDMDSLAFGGGGGEFALWLDGDLYHGRSHSCKTFGNRTLSKKEDFFIQDIEIWAFE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTKDKNSPG ------CCCCCCCCC	48.20	29759185
2 (in isoform 5)	Phosphorylation	-	48.20	27251275
2 (in isoform 8)	Phosphorylation	-	48.20	27251275
3 (in isoform 2)	Phosphorylation	-	66.46	27642862
3 (in isoform 4)	Methylation	-	66.46	-
6 (in isoform 4)	Phosphorylation	-	64.67	27762562
6 (in isoform 7)	Phosphorylation	-	64.67	27762562
7	Phosphorylation	-MTKDKNSPGLKKKS -CCCCCCCCCCCCCC	26.53	24719451
13 (in isoform 5)	Phosphorylation	-	52.74	29507054
13 (in isoform 8)	Phosphorylation	-	52.74	29507054
14	Phosphorylation	SPGLKKKSQSVDINA CCCCCCCCCCCCCCC	36.25	28857561
15 (in isoform 5)	Phosphorylation	-	57.25	29507054
15 (in isoform 8)	Phosphorylation	-	57.25	29507054
16	Phosphorylation	GLKKKSQSVDINAPG CCCCCCCCCCCCCCC	28.93	28857561
16 (in isoform 2)	Methylation	-	28.93	-
19	Ubiquitination	KKSQSVDINAPGFNP CCCCCCCCCCCCCCC	4.43	29967540
20 (in isoform 7)	Phosphorylation	-	35.30	27642862
34	Phosphorylation	LAGAGKQTPQASKPP CCCCCCCCCCCCCCC	22.36	29083192
38	Phosphorylation	GKQTPQASKPPAPKT CCCCCCCCCCCCCCC	40.21	29083192
52 (in isoform 2)	Phosphorylation	-	52.32	23663014
61 (in isoform 2)	Phosphorylation	-	18.75	25849741
62 (in isoform 2)	Phosphorylation	-	36.24	23663014
68 (in isoform 2)	Phosphorylation	-	5.20	23663014
72	Phosphorylation	RSELKRFYTIDTGQK HHHHHEEEECCCCCC	13.56	28060719
73	Phosphorylation	SELKRFYTIDTGQKK HHHHEEEECCCCCCC	15.06	28060719
76	Phosphorylation	KRFYTIDTGQKKTLD HEEEECCCCCCCEEC	37.35	28270605
81	Phosphorylation	IDTGQKKTLDKKDGR CCCCCCCEECCCCCC	47.42	28270605
83 (in isoform 2)	Phosphorylation	-	62.28	-
91	Phosphorylation	KKDGRRMSFQKPKGT CCCCCCCEEECCCCE	23.78	23401153
92	Ubiquitination	KDGRRMSFQKPKGTI CCCCCCEEECCCCEE	8.71	29967540
102	Phosphorylation	PKGTIEYTVESRDSL CCCEEEEEECCHHHC	12.66	27251275
105	Phosphorylation	TIEYTVESRDSLNSI EEEEEECCHHHCCEE	36.73	27251275
108	Phosphorylation	YTVESRDSLNSIALK EEECCHHHCCEEEEE	28.48	27251275
111	Phosphorylation	ESRDSLNSIALKFDT CCHHHCCEEEEEECC	17.96	27251275
112	Phosphorylation	SRDSLNSIALKFDTT CHHHCCEEEEEECCC	5.18	18669648
113	Phosphorylation	RDSLNSIALKFDTTP HHHCCEEEEEECCCH	12.43	18669648
114	Phosphorylation	DSLNSIALKFDTTPN HHCCEEEEEECCCHH	5.60	18669648
115	Phosphorylation	SLNSIALKFDTTPNE HCCEEEEEECCCHHH	31.97	18669648
118	Phosphorylation	SIALKFDTTPNELVQ EEEEEECCCHHHHHH	47.49	27251275
119	Phosphorylation	IALKFDTTPNELVQL EEEEECCCHHHHHHH	26.43	21815630
119	Ubiquitination	IALKFDTTPNELVQL EEEEECCCHHHHHHH	26.43	29967540
149	Phosphorylation	VPDPEYVSSVESSPS ECCHHHHCCCCCCCC	27.97	27251275
150	Phosphorylation	PDPEYVSSVESSPSL CCHHHHCCCCCCCCC	21.62	27251275
153	Phosphorylation	EYVSSVESSPSLSPV HHHCCCCCCCCCCCC	45.45	27251275
154	Phosphorylation	YVSSVESSPSLSPVS HHCCCCCCCCCCCCC	12.66	27251275
156	Phosphorylation	SSVESSPSLSPVSPL CCCCCCCCCCCCCCC	43.35	27251275
158	Phosphorylation	VESSPSLSPVSPLSP CCCCCCCCCCCCCCC	27.82	27251275
161	Phosphorylation	SPSLSPVSPLSPTSS CCCCCCCCCCCCCCC	24.41	27251275
164	Phosphorylation	LSPVSPLSPTSSEAE CCCCCCCCCCCCHHH	29.52	27251275
166	Phosphorylation	PVSPLSPTSSEAEFD CCCCCCCCCCHHHCC	41.32	28348404
167	Phosphorylation	VSPLSPTSSEAEFDK CCCCCCCCCHHHCCC	29.57	28348404
168	Phosphorylation	SPLSPTSSEAEFDKT CCCCCCCCHHHCCCC	43.22	28348404
176	Phosphorylation	EAEFDKTTNPDVHPT HHHCCCCCCCCCCCC	50.96	-
183	Phosphorylation	TNPDVHPTEATPSST CCCCCCCCCCCCCCC	24.31	28348404
186	Phosphorylation	DVHPTEATPSSTFTG CCCCCCCCCCCCCCC	19.92	25159151
190	Phosphorylation	TEATPSSTFTGIRPA CCCCCCCCCCCCEEE	29.56	-
192	Phosphorylation	ATPSSTFTGIRPARV CCCCCCCCCCEEEEE	31.61	-
193 (in isoform 2)	Phosphorylation	-	15.09	-
194	Phosphorylation	PSSTFTGIRPARVVS CCCCCCCCEEEEEEC	4.30	33259812
194 (in isoform 2)	Phosphorylation	-	4.30	-
195 (in isoform 2)	Phosphorylation	-	21.85	-
196	Phosphorylation	STFTGIRPARVVSST CCCCCCEEEEEECCC	23.61	32645325
196 (in isoform 2)	Phosphorylation	-	23.61	-
201	Phosphorylation	IRPARVVSSTSEEEE CEEEEEECCCCHHHH	25.66	29255136
202	Phosphorylation	RPARVVSSTSEEEEA EEEEEECCCCHHHHH	25.09	29255136
203	Phosphorylation	PARVVSSTSEEEEAF EEEEECCCCHHHHHH	32.43	29255136
204	Phosphorylation	ARVVSSTSEEEEAFT EEEECCCCHHHHHHH	44.98	29255136
205	Ubiquitination	RVVSSTSEEEEAFTE EEECCCCHHHHHHHH	70.30	29967540
211	Phosphorylation	SEEEEAFTEKFLKIN CHHHHHHHHHHHEEE	45.36	23927012
212	Ubiquitination	EEEEAFTEKFLKINC HHHHHHHHHHHEEEC	35.04	29967540
213	Ubiquitination	EEEAFTEKFLKINCK HHHHHHHHHHEEECE	53.60	29967540
285	Phosphorylation	LDSKIKESLPIDIDQ HCHHHHHCCCCCHHH	34.15	23312004
294	Phosphorylation	PIDIDQLSGRDFCHS CCCHHHCCCCCCCCC	26.58	23312004
301	Phosphorylation	SGRDFCHSKKMTGSN CCCCCCCCCCCCCCC	34.84	23312004
305	Phosphorylation	FCHSKKMTGSNTEEI CCCCCCCCCCCHHHH	46.46	28450419
307	Phosphorylation	HSKKMTGSNTEEIDS CCCCCCCCCHHHHHH	31.26	25159151
309	Phosphorylation	KKMTGSNTEEIDSRI CCCCCCCHHHHHHHH	36.37	28450419
314	Phosphorylation	SNTEEIDSRIRDAGN CCHHHHHHHHHHCCC	34.96	23090842
323	Phosphorylation	IRDAGNDSASTAPRS HHHCCCCCCCCCCCC	28.28	29496963
330	Phosphorylation	SASTAPRSTEESLSE CCCCCCCCCCHHHCC	38.83	28102081
331	Phosphorylation	ASTAPRSTEESLSED CCCCCCCCCHHHCCC	45.08	28102081
334	Phosphorylation	APRSTEESLSEDVFT CCCCCCHHHCCCCCC	30.85	26055452
336	Phosphorylation	RSTEESLSEDVFTES CCCCHHHCCCCCCHH	40.82	28348404
341	Phosphorylation	SLSEDVFTESELSPI HHCCCCCCHHHCHHH	38.15	28102081
343	Phosphorylation	SEDVFTESELSPIRE CCCCCCHHHCHHHHH	40.56	26657352
346	Phosphorylation	VFTESELSPIREELV CCCHHHCHHHHHHHC	17.77	18510355
346 (in isoform 2)	Phosphorylation	-	17.77	-
354	Phosphorylation	PIREELVSSDELRQD HHHHHHCCCHHHHCC	44.70	18510355
355	Phosphorylation	IREELVSSDELRQDK HHHHHCCCHHHHCCC	27.85	29255136
363	Phosphorylation	DELRQDKSSGASSES HHHHCCCCCCCCCHH	42.15	24076635
364	Phosphorylation	ELRQDKSSGASSESV HHHCCCCCCCCCHHC	44.08	24076635
367	Phosphorylation	QDKSSGASSESVQTV CCCCCCCCCHHCEEC	37.86	28348404
368	Phosphorylation	DKSSGASSESVQTVN CCCCCCCCHHCEECC	33.10	28348404
370	Phosphorylation	SSGASSESVQTVNQA CCCCCCHHCEECCHH	22.82	25307156
373	Phosphorylation	ASSESVQTVNQAEVE CCCHHCEECCHHHEE	21.19	24076635
381	Phosphorylation	VNQAEVESLTVKSES CCHHHEEEEEEEECC	34.22	27251275
386	Phosphorylation	VESLTVKSESTGTPG EEEEEEEECCCCCCC	32.23	27251275
388	Phosphorylation	SLTVKSESTGTPGHL EEEEEECCCCCCCCC	38.95	25159151
389	Phosphorylation	LTVKSESTGTPGHLR EEEEECCCCCCCCCC	40.81	25849741
391	Phosphorylation	VKSESTGTPGHLRSD EEECCCCCCCCCCCC	26.62	25159151
397	Phosphorylation	GTPGHLRSDTEHSTN CCCCCCCCCCCCCCC	56.07	23312004
399	Phosphorylation	PGHLRSDTEHSTNEV CCCCCCCCCCCCCCH	36.52	28348404
402	Phosphorylation	LRSDTEHSTNEVGTL CCCCCCCCCCCHHHH	27.05	28348404
403	Phosphorylation	RSDTEHSTNEVGTLC CCCCCCCCCCHHHHC	36.99	28348404
435	Phosphorylation	ADNFQGISGPKEDST HHCCCCCCCCCCCCC	56.73	23898821
437	Phosphorylation	NFQGISGPKEDSTSI CCCCCCCCCCCCCCC	30.03	17525332
440 (in isoform 2)	Phosphorylation	-	64.44	-
441	Phosphorylation	ISGPKEDSTSIKGNS CCCCCCCCCCCCCCC	25.75	22496350
442	Phosphorylation	SGPKEDSTSIKGNSD CCCCCCCCCCCCCCC	46.95	26657352
443	Phosphorylation	GPKEDSTSIKGNSDQ CCCCCCCCCCCCCCH	26.67	23917254
448	Phosphorylation	STSIKGNSDQDSFLH CCCCCCCCCHHHHHC	45.37	20068231
450 (in isoform 2)	Phosphorylation	-	48.33	-
452	Phosphorylation	KGNSDQDSFLHENSL CCCCCHHHHHCCCCC	24.87	25849741
458	Phosphorylation	DSFLHENSLHQEESQ HHHHCCCCCCHHHHH	25.01	25849741
464	Phosphorylation	NSLHQEESQKENMPC CCCCHHHHHHHCCCC	45.88	20068231
474	Phosphorylation	ENMPCGETAEFKQKQ HCCCCCCHHHHHHHH	19.44	30631047
482	Phosphorylation	AEFKQKQSVNKGKQG HHHHHHHHHCCCCCC	34.39	-
496	Phosphorylation	GKEQNQDSQTEAEEL CCCCCCCHHHHHHHH	29.27	28348404
498	Phosphorylation	EQNQDSQTEAEELRK CCCCCHHHHHHHHHH	40.91	23312004
518 (in isoform 2)	Phosphorylation	-	57.10	-
523	Ubiquitination	KQQRENIQQVSQKEA HHHHHHHHHHHHHHH	49.56	30230243
526	Phosphorylation	RENIQQVSQKEAKHK HHHHHHHHHHHHHHH	31.06	25262027
530	Ubiquitination	QQVSQKEAKHKITSA HHHHHHHHHHHCCCC	26.70	30230243
531	Ubiquitination	QVSQKEAKHKITSAD HHHHHHHHHHCCCCC	46.66	30230243
535	Phosphorylation	KEAKHKITSADGHIE HHHHHHCCCCCCCHH	23.75	23312004
536	Phosphorylation	EAKHKITSADGHIES HHHHHCCCCCCCHHH	28.03	23312004
544	Phosphorylation	ADGHIESSALLKEKQ CCCCHHHHHHHHHHH	15.33	28555341
573	Phosphorylation	PMRKTFVSQASATMQ CCHHHHHHHHHHHHH	18.81	28555341
576	Phosphorylation	KTFVSQASATMQQYA HHHHHHHHHHHHHHH	19.35	28857561
622	Phosphorylation	YAEDTGEYTREPGFI EECCCCCCCCCCCEE	16.67	20736484
669	Phosphorylation	RRIDALNTEELRTLC HHHHCCCHHHHHHHH	31.52	-
690	Ubiquitination	TREDINSKQVATVKA CHHHCCCCEEEEEEE	44.28	-
715	Ubiquitination	LSDPSELLLPDQIEK CCCHHHHCCHHHHHH	5.99	29967540
722	Ubiquitination	LLPDQIEKLTKHLPP CCHHHHHHHHCCCCC	64.19	29967540
749	Ubiquitination	TGKHGTSLKTLYRTM CCCCCCCHHHHHHHH	5.02	29967540
750	Ubiquitination	GKHGTSLKTLYRTMT CCCCCCHHHHHHHHC	35.93	29967540
751	Phosphorylation	KHGTSLKTLYRTMTG CCCCCHHHHHHHHCC	34.02	25599653
753	Phosphorylation	GTSLKTLYRTMTGLD CCCHHHHHHHHCCCC	14.85	25599653
755	Phosphorylation	SLKTLYRTMTGLDTP CHHHHHHHHCCCCCC	12.91	22210691
757	Phosphorylation	KTLYRTMTGLDTPVL HHHHHHHCCCCCCEE	33.70	25599653
761	Phosphorylation	RTMTGLDTPVLMVIK HHHCCCCCCEEEEEE	21.97	22210691
851	Phosphorylation	GRSHSCKTFGNRTLS CCCCCCCCCCCCCCC	40.89	21406692
856	Phosphorylation	CKTFGNRTLSKKEDF CCCCCCCCCCCCCCE	39.11	21406692
858	Phosphorylation	TFGNRTLSKKEDFFI CCCCCCCCCCCCEEE	40.86	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of OXR1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of OXR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of OXR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
VPS35_HUMAN	VPS35	physical	22863883

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of OXR1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201; SER-202 ANDSER-204, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-526, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201 AND SER-202, ANDMASS SPECTROMETRY.	17081983 [Abstract]