dbPTM

MICA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MICA3_HUMAN
UniProt AC	Q7RTP6
Protein Name	[F-actin]-monooxygenase MICAL3
Gene Name	MICAL3
Organism	Homo sapiens (Human).
Sequence Length	2002
Subcellular Localization	Cytoplasm . Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Nucleus . Midbody . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, cilium basal body . Mainly localizes in the nucleus.
Protein Description	Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission..
Protein Sequence	MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYWKAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVNVEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINHYGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLRPSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNVTDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQTISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQNKVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAEGKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKEAKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSLRQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGGVPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAGNQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGAPLDENDLEEDVDSEPAEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKLPASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPEPLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPQPPVAASTPPPSPLPICSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRMQQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLWKSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLSSDDVLEKSSQKSRREPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQRRLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELEDRQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLREREEDKDLEAAMLSKGFSLNWS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MEERKHETMNPAHVL CCCHHCCCCCHHHHH	23.20	28555341
26	Ubiquitination	FVQATTCKGTLKAFQ HHHHHCCHHHHHHHH	53.49	29967540
28	Phosphorylation	QATTCKGTLKAFQEL HHHCCHHHHHHHHHH	15.58	20860994
42	Ubiquitination	LCDHLELKPKDYRSF HHHHCCCCCHHHHHH	40.42	29967540
73	Phosphorylation	WAKLDKRGSHKDYKK HHHHHCCCCCCCCCC	39.58	18669648
117	Acetylation	AKVVVIEKRDAFSRN CEEEEEECCCCCCCC	44.44	24468163
158	Phosphorylation	AGAIDHISIRQLQLI HHHCCCCCHHHHHHH	14.32	24719451
208	Phosphorylation	RALVHPKTHPVSEYE EEEECCCCCCCCEEE	35.54	-
212	Phosphorylation	HPKTHPVSEYEFEVI CCCCCCCCEEEEEEE	38.62	-
214	Phosphorylation	KTHPVSEYEFEVIIG CCCCCCEEEEEEEEC	20.57	-
228	Phosphorylation	GGDGRRNTLEGFRRK CCCCCCCCCHHHHHH	25.11	-
254	Phosphorylation	ANFINRNTTAEAKVE HHHHCCCCCCHHHHE	24.93	20068231
255	Phosphorylation	NFINRNTTAEAKVEE HHHCCCCCCHHHHEE	26.50	20068231
296	Phosphorylation	IVYYKDDTHYFVMTA EEEEECCCEEEEEEE	28.71	15302935
332	Phosphorylation	LSRENVDQEALLSYA HCCCCCCHHHHHHHH	33.31	18669648
337	Phosphorylation	VDQEALLSYAREAAD CCHHHHHHHHHHHCC	20.00	23663014
338	Phosphorylation	DQEALLSYAREAADF CHHHHHHHHHHHCCC	15.06	23663014
431	Phosphorylation	MVRSWSLGTSPLEVL HEEECCCCCCHHHHH	20.73	18669648
440	Phosphorylation	SPLEVLAERESIYRL CHHHHHHCHHHHHHH	53.47	18669648
444	Phosphorylation	VLAERESIYRLLPQT HHHCHHHHHHHCCCC	1.67	18669648
450	Phosphorylation	SIYRLLPQTTPENVS HHHHHCCCCCCCHHH	58.96	18669648
457	Phosphorylation	QTTPENVSKNFSQYS CCCCCHHHCCCCCCC	33.20	26657352
458	Ubiquitination	TTPENVSKNFSQYSI CCCCHHHCCCCCCCC	58.70	30230243
461	Phosphorylation	ENVSKNFSQYSIDPV CHHHCCCCCCCCCCC	37.29	20860994
463	Phosphorylation	VSKNFSQYSIDPVTR HHCCCCCCCCCCCCC	13.34	26657352
464	Phosphorylation	SKNFSQYSIDPVTRY HCCCCCCCCCCCCCC	16.93	20860994
469	Phosphorylation	QYSIDPVTRYPNINV CCCCCCCCCCCCCCE	29.85	26657352
477	Phosphorylation	RYPNINVNFLRPSQV CCCCCCEEECCHHHC	26.25	18669648
481	Phosphorylation	INVNFLRPSQVRHLY CCEEECCHHHCEEEE	31.12	18669648
502	Phosphorylation	DIHLEMESLVNSRTT EEEHHHHHHHCCCCC	35.99	28985074
506	Phosphorylation	EMESLVNSRTTPKLT HHHHHHCCCCCCCCC	24.43	30576142
507	Phosphorylation	MESLVNSRTTPKLTR HHHHHCCCCCCCCCC	37.10	18669648
508	Phosphorylation	ESLVNSRTTPKLTRN HHHHCCCCCCCCCCC	47.47	30576142
509	Phosphorylation	SLVNSRTTPKLTRNE HHHCCCCCCCCCCCH	19.81	30576142
511	Phosphorylation	VNSRTTPKLTRNESV HCCCCCCCCCCCHHH	61.47	18669648
513	Phosphorylation	SRTTPKLTRNESVAR CCCCCCCCCCHHHHH	37.26	29052541
517	Phosphorylation	PKLTRNESVARSSKL CCCCCCHHHHHHHHH	25.32	25849741
524	Phosphorylation	SVARSSKLLGWCQRQ HHHHHHHHHHHHHHC	6.05	18669648
532	Phosphorylation	LGWCQRQTDGYAGVN HHHHHHCCCCCCCCC	33.31	23090842
535	Phosphorylation	CQRQTDGYAGVNVTD HHHCCCCCCCCCHHH	11.73	26074081
541	Phosphorylation	GYAGVNVTDLTMSWK CCCCCCHHHCCHHHH	21.78	26074081
544	Phosphorylation	GVNVTDLTMSWKSGL CCCHHHCCHHHHHHH	16.39	26074081
546	Phosphorylation	NVTDLTMSWKSGLAL CHHHCCHHHHHHHHH	26.56	26074081
549	Phosphorylation	DLTMSWKSGLALCAI HCCHHHHHHHHHHHH	32.55	26074081
560	Phosphorylation	LCAIIHRYRPDLIDF HHHHHHHHCCCCCCC	16.60	26074081
593	Phosphorylation	AEKELGISPIMTGKE HHHHHCCCCCCCCCC	13.43	22817900
597	Phosphorylation	LGISPIMTGKEMASV HCCCCCCCCCCHHCC	45.91	22817900
630	Phosphorylation	FKDSLPSSDTLDLNA HHHCCCCCCCCCCCH	32.45	28555341
646	Phosphorylation	EKAVLIASTRSPISF HHEEEEEECCCHHHH	19.84	21712546
647	Phosphorylation	KAVLIASTRSPISFL HEEEEEECCCHHHHH	26.58	24732914
649	Phosphorylation	VLIASTRSPISFLSK EEEEECCCHHHHHHH	27.03	30266825
652	Phosphorylation	ASTRSPISFLSKLGQ EECCCHHHHHHHHHH	24.42	22167270
655	Phosphorylation	RSPISFLSKLGQTIS CCHHHHHHHHHHHHH	24.67	24732914
660	Phosphorylation	FLSKLGQTISRKRSP HHHHHHHHHHCCCCC	21.08	20860994
662	Phosphorylation	SKLGQTISRKRSPKD HHHHHHHHCCCCCCC	34.83	20860994
680	Acetylation	KDLDGAGKRRKTSQS CCCCCCCCCCCCCCC	48.79	25953088
684	Phosphorylation	GAGKRRKTSQSEEEE CCCCCCCCCCCHHHH	30.13	23401153
685	Phosphorylation	AGKRRKTSQSEEEEA CCCCCCCCCCHHHHC	34.44	29255136
687	Phosphorylation	KRRKTSQSEEEEAPR CCCCCCCCHHHHCCC	46.90	29255136
702	O-linked_Glycosylation	GHRGERPTLVSTLTD CCCCCCCCHHHHHCC	46.11	30379171
705	Phosphorylation	GERPTLVSTLTDRRM CCCCCHHHHHCCCCC	22.32	25850435
706	Phosphorylation	ERPTLVSTLTDRRMD CCCCHHHHHCCCCCC	26.63	25850435
708	Phosphorylation	PTLVSTLTDRRMDVA CCHHHHHCCCCCCCC	27.78	25850435
724	Phosphorylation	GNQNKVKYMATQLLA CCCHHHHHHHHHHHH	8.58	28674419
727	Phosphorylation	NKVKYMATQLLAKFE HHHHHHHHHHHHHHH	11.83	-
741	Phosphorylation	EENAPAQSIGIRRQG HHCCCHHHHCCCCCC	25.53	29514088
749	Phosphorylation	IGIRRQGSMKKEFPQ HCCCCCCCCCCCCCC	21.06	25056879
749 (in isoform 3)	Phosphorylation	-	21.06	26437602
763 (in isoform 5)	Phosphorylation	-	15.71	26657352
765 (in isoform 5)	Phosphorylation	-	14.96	26657352
772	Phosphorylation	YFCQKRVYVMERLSA HHHHHHHHHHHHHCC	9.71	26074081
778	Phosphorylation	VYVMERLSAEGKFFH HHHHHHHCCCCCEEC	30.41	26074081
787	Phosphorylation	EGKFFHRSCFKCEYC CCCEECCCHHCCCCH	18.48	26074081
793	Phosphorylation	RSCFKCEYCATTLRL CCHHCCCCHHHEEEE	9.24	-
796	Phosphorylation	FKCEYCATTLRLSAY HCCCCHHHEEEEEEE	23.85	28450419
797	Phosphorylation	KCEYCATTLRLSAYA CCCCHHHEEEEEEEE	7.43	28450419
821 (in isoform 5)	Phosphorylation	-	20.86	26437602
823	Phosphorylation	PHYCYRLSGYAQRKR CCEEEEECCCCCCCC	22.28	28857561
827 (in isoform 5)	Phosphorylation	-	42.83	26437602
837	O-linked_Glycosylation	RPAVAPLSGKEAKGP CCCCCCCCCCCCCCC	46.92	30379171
837	Phosphorylation	RPAVAPLSGKEAKGP CCCCCCCCCCCCCCC	46.92	25159151
862	Phosphorylation	GRANAVASSTERTPG CCCCCCCCCCCCCCC	31.06	22199227
863	Phosphorylation	RANAVASSTERTPGS CCCCCCCCCCCCCCC	25.26	30576142
864	Phosphorylation	ANAVASSTERTPGSG CCCCCCCCCCCCCCC	27.30	22199227
867	Phosphorylation	VASSTERTPGSGVNG CCCCCCCCCCCCCCC	26.26	29255136
870	Phosphorylation	STERTPGSGVNGLEE CCCCCCCCCCCCCCC	40.55	29255136
873 (in isoform 5)	Phosphorylation	-	53.51	26437602
887	Phosphorylation	IAKRLRGTPERIELE HHHHHCCCCCHHHHH	18.62	21712546
895	Phosphorylation	PERIELENYRLSLRQ CCHHHHHHHHHHHHH	39.59	22067460
896	Phosphorylation	ERIELENYRLSLRQA CHHHHHHHHHHHHHH	11.98	22617229
899	Phosphorylation	ELENYRLSLRQAEAL HHHHHHHHHHHHHHH	16.71	30243723
956	Phosphorylation	EEPRLPPSDLGGVPW CCCCCCHHHCCCCCH	43.45	25850435
977	Phosphorylation	HALLKGKSEEELEAS HHHHCCCCHHHHHHH	59.93	23401153
984	Phosphorylation	SEEELEASKSFGPGN CHHHHHHHHHCCCCC	21.32	25159151
1134	Phosphorylation	AELELRVSEDEEKLP EEEEEEECCCHHHCC	32.66	30266825
1143	Phosphorylation	DEEKLPASPKHQERG CHHHCCCCHHHHCCC	32.32	30266825
1152	Phosphorylation	KHQERGPSQATSPIR HHHCCCCCCCCCCCC	34.96	22167270
1155	Phosphorylation	ERGPSQATSPIRSPQ CCCCCCCCCCCCCCC	27.65	30266825
1156	Phosphorylation	RGPSQATSPIRSPQE CCCCCCCCCCCCCCC	22.73	29255136
1160	Phosphorylation	QATSPIRSPQESALL CCCCCCCCCCCEEEE	31.49	25850435
1164	Phosphorylation	PIRSPQESALLFIPV CCCCCCCEEEEEEEC	20.97	25850435
1173	Phosphorylation	LLFIPVHSPSTEGPQ EEEEECCCCCCCCCC	22.30	26657352
1175	Phosphorylation	FIPVHSPSTEGPQLP EEECCCCCCCCCCCC	41.95	25850435
1176	Phosphorylation	IPVHSPSTEGPQLPP EECCCCCCCCCCCCC	48.63	25850435
1188	Phosphorylation	LPPVPAATQEKSPEE CCCCCCCCCCCCHHH	39.09	29116813
1192	Phosphorylation	PAATQEKSPEERLFP CCCCCCCCHHHHCCC	36.47	25159151
1205	Acetylation	FPEPLLPKEKPKADA CCCCCCCCCCCCCCC	77.62	19811477
1214	Phosphorylation	KPKADAPSDLKAVHS CCCCCCCCCHHHCCC	58.24	23312004
1221	Phosphorylation	SDLKAVHSPIRSQPV CCHHHCCCCCCCCCC	18.54	30266825
1225	O-linked_Glycosylation	AVHSPIRSQPVTLPE HCCCCCCCCCCCCCC	39.29	30379171
1225	Phosphorylation	AVHSPIRSQPVTLPE HCCCCCCCCCCCCCC	39.29	25159151
1229	O-linked_Glycosylation	PIRSQPVTLPEARTP CCCCCCCCCCCCCCC	43.19	30379171
1251	Phosphorylation	PQPPVAASTPPPSPL CCCCCCCCCCCCCCC	31.54	28348404
1252	Phosphorylation	QPPVAASTPPPSPLP CCCCCCCCCCCCCCC	34.78	28348404
1256	Phosphorylation	AASTPPPSPLPICSQ CCCCCCCCCCCCCCC	44.86	27251275
1262	Phosphorylation	PSPLPICSQPQPSTE CCCCCCCCCCCCCCC	45.69	24275569
1267	Phosphorylation	ICSQPQPSTEATVPS CCCCCCCCCCCCCCC	33.36	27251275
1268	Phosphorylation	CSQPQPSTEATVPSP CCCCCCCCCCCCCCC	36.00	27251275
1271	Phosphorylation	PQPSTEATVPSPTQS CCCCCCCCCCCCCCC	27.07	28348404
1274	Phosphorylation	STEATVPSPTQSPIR CCCCCCCCCCCCCCC	35.92	27251275
1276	Phosphorylation	EATVPSPTQSPIRFQ CCCCCCCCCCCCCCC	46.12	24275569
1278	Phosphorylation	TVPSPTQSPIRFQPA CCCCCCCCCCCCCCC	25.44	24275569
1289	Phosphorylation	FQPAPAKTSTPLAPL CCCCCCCCCCCCCCC	39.68	25159151
1290	Phosphorylation	QPAPAKTSTPLAPLP CCCCCCCCCCCCCCC	27.59	22199227
1291	Phosphorylation	PAPAKTSTPLAPLPV CCCCCCCCCCCCCCC	27.79	25159151
1300	Phosphorylation	LAPLPVQSQSDTKDR CCCCCCCCCCCCCCC	31.70	25159151
1302	Phosphorylation	PLPVQSQSDTKDRLG CCCCCCCCCCCCCCC	53.12	25159151
1304	Phosphorylation	PVQSQSDTKDRLGSP CCCCCCCCCCCCCCC	39.84	22199227
1310	Phosphorylation	DTKDRLGSPLAVDEA CCCCCCCCCHHHHHH	22.72	19664994
1321	Phosphorylation	VDEALRRSDLVEEFW HHHHHHCCHHHHHHH	28.94	25159151
1330	Ubiquitination	LVEEFWMKSAEIRRS HHHHHHHHHHHHHHH	36.79	32015554
1337	Phosphorylation	KSAEIRRSLGLTPVD HHHHHHHHCCCCCCC	19.55	30266825
1341	Phosphorylation	IRRSLGLTPVDRSKG HHHHCCCCCCCCCCC	21.33	30266825
1346	Phosphorylation	GLTPVDRSKGPEPSF CCCCCCCCCCCCCCC	37.18	25159151
1352	Phosphorylation	RSKGPEPSFPTPAFR CCCCCCCCCCCCCCC	42.04	22199227
1355	Phosphorylation	GPEPSFPTPAFRPVS CCCCCCCCCCCCCCE	25.82	22199227
1362	Phosphorylation	TPAFRPVSLKSYSVE CCCCCCCEECEEECC	32.53	29514088
1364	Ubiquitination	AFRPVSLKSYSVEKS CCCCCEECEEECCCC	39.58	29967540
1365	Phosphorylation	FRPVSLKSYSVEKSP CCCCEECEEECCCCC	28.12	22199227
1366	Phosphorylation	RPVSLKSYSVEKSPQ CCCEECEEECCCCCC	18.36	28060719
1367	Phosphorylation	PVSLKSYSVEKSPQD CCEECEEECCCCCCC	30.78	25159151
1371	Phosphorylation	KSYSVEKSPQDEGLH CEEECCCCCCCCCCH	17.81	28355574
1381	Acetylation	DEGLHLLKPLSIPKR CCCCHHCCCCCCCHH	50.72	26051181
1381	Ubiquitination	DEGLHLLKPLSIPKR CCCCHHCCCCCCCHH	50.72	33845483
1384	Phosphorylation	LHLLKPLSIPKRLGL CHHCCCCCCCHHHCC	45.43	26055452
1400	Phosphorylation	KPEGEPLSLPTPRSP CCCCCCCCCCCCCCC	42.91	25850435
1403	Phosphorylation	GEPLSLPTPRSPSDR CCCCCCCCCCCCCHH	36.31	30576142
1406	Phosphorylation	LSLPTPRSPSDRELR CCCCCCCCCCHHHHH	29.93	21712546
1408	Phosphorylation	LPTPRSPSDRELRSA CCCCCCCCHHHHHHH	51.01	29507054
1423	Phosphorylation	QEERRELSSSSGLGL HHHHHHHHHCCCCCC	24.34	22210691
1424	Phosphorylation	EERRELSSSSGLGLH HHHHHHHHCCCCCCC	40.94	28857561
1425	Phosphorylation	ERRELSSSSGLGLHG HHHHHHHCCCCCCCC	25.67	28857561
1426	Phosphorylation	RRELSSSSGLGLHGS HHHHHHCCCCCCCCC	39.73	27732954
1433	Phosphorylation	SGLGLHGSSSNMKTL CCCCCCCCCCCCCCC	21.61	28857561
1434	Phosphorylation	GLGLHGSSSNMKTLG CCCCCCCCCCCCCCC	30.26	28857561
1435	Phosphorylation	LGLHGSSSNMKTLGS CCCCCCCCCCCCCCC	42.51	28857561
1439	Phosphorylation	GSSSNMKTLGSQSFN CCCCCCCCCCCCCCC	26.11	22199227
1442	Phosphorylation	SNMKTLGSQSFNTSD CCCCCCCCCCCCCCC	26.26	22199227
1444	Phosphorylation	MKTLGSQSFNTSDSA CCCCCCCCCCCCCCC	23.35	22199227
1447	Phosphorylation	LGSQSFNTSDSAMLT CCCCCCCCCCCCCCC	31.72	22199227
1448	Phosphorylation	GSQSFNTSDSAMLTP CCCCCCCCCCCCCCC	30.58	22199227
1450	Phosphorylation	QSFNTSDSAMLTPPS CCCCCCCCCCCCCCC	18.49	25850435
1454	Phosphorylation	TSDSAMLTPPSSPPP CCCCCCCCCCCCCCC	21.77	22617229
1457	Phosphorylation	SAMLTPPSSPPPPPP CCCCCCCCCCCCCCC	57.59	22617229
1458	Phosphorylation	AMLTPPSSPPPPPPP CCCCCCCCCCCCCCC	47.39	22617229
1471	Phosphorylation	PPGEEPATLRRKLRE CCCCCCHHHHHHHHH	31.36	22199227
1512	Phosphorylation	PREEVRKSFVESVEE CHHHHHHHHHHCHHH	24.78	26657352
1516	Phosphorylation	VRKSFVESVEEIPFA HHHHHHHCHHHCCCC	29.53	29507054
1529	Phosphorylation	FADDVEDTYDDKTED CCCCCCCCCCCCCCC	18.49	28102081
1530	Phosphorylation	ADDVEDTYDDKTEDS CCCCCCCCCCCCCCC	34.17	28102081
1538	Phosphorylation	DDKTEDSSLQEKFFT CCCCCCCCHHHHHCC	46.52	21815630
1545	Phosphorylation	SLQEKFFTPPSCWPR CHHHHHCCCHHHCCC	37.11	22199227
1574	Phosphorylation	RLPALEGTLQPQKRG CCCCCCCCCCCHHCC	16.91	29255136
1586	Phosphorylation	KRGLPLVSAEAKELA HCCCCCCCHHHHHHH	28.24	25159151
1603	Phosphorylation	RMRAREKSVKSQALR HHHHHHHHHHHHHHH	29.99	26425664
1606	Phosphorylation	AREKSVKSQALRDAM HHHHHHHHHHHHHHH	20.66	26425664
1618	Phosphorylation	DAMARQLSRMQQMEL HHHHHHHHHHHHHHH	19.85	-
1627	Phosphorylation	MQQMELASGAPRPRK HHHHHHHCCCCCCCC	48.38	21712546
1636	Phosphorylation	APRPRKASSAPSQGK CCCCCCCCCCCCCCC	30.02	27282143
1637	Phosphorylation	PRPRKASSAPSQGKE CCCCCCCCCCCCCCC	49.40	28985074
1640	Phosphorylation	RKASSAPSQGKERRP CCCCCCCCCCCCCCC	51.81	-
1649	Phosphorylation	GKERRPDSPTRPTLR CCCCCCCCCCCCCCC	30.74	29255136
1651	Phosphorylation	ERRPDSPTRPTLRGS CCCCCCCCCCCCCCC	53.91	30266825
1654	Phosphorylation	PDSPTRPTLRGSEEP CCCCCCCCCCCCCCC	26.29	30266825
1658	Phosphorylation	TRPTLRGSEEPTLKH CCCCCCCCCCCCCCC	32.14	30624053
1662	Phosphorylation	LRGSEEPTLKHEATS CCCCCCCCCCCCCCC	52.28	30624053
1668	Phosphorylation	PTLKHEATSEEVLSP CCCCCCCCCCHHCCC	33.42	23663014
1669	Phosphorylation	TLKHEATSEEVLSPP CCCCCCCCCHHCCCC	38.52	23663014
1674	Phosphorylation	ATSEEVLSPPSDSGG CCCCHHCCCCCCCCC	39.68	23663014
1677	Phosphorylation	EEVLSPPSDSGGPDG CHHCCCCCCCCCCCC	48.03	23663014
1679	Phosphorylation	VLSPPSDSGGPDGSF HCCCCCCCCCCCCCC	50.41	23663014
1685	Phosphorylation	DSGGPDGSFTSSEGS CCCCCCCCCCCCCCC	32.50	23663014
1687	Phosphorylation	GGPDGSFTSSEGSSG CCCCCCCCCCCCCCC	32.80	23663014
1688	Phosphorylation	GPDGSFTSSEGSSGK CCCCCCCCCCCCCCC	25.12	27732954
1689	Phosphorylation	PDGSFTSSEGSSGKS CCCCCCCCCCCCCCC	42.81	27732954
1692	Phosphorylation	SFTSSEGSSGKSKKR CCCCCCCCCCCCCCC	31.69	27732954
1693	Phosphorylation	FTSSEGSSGKSKKRS CCCCCCCCCCCCCCC	62.18	27732954
1696	Phosphorylation	SEGSSGKSKKRSSLF CCCCCCCCCCCCCCC	47.11	-
1700	Phosphorylation	SGKSKKRSSLFSPRR CCCCCCCCCCCCCCC	40.03	22199227
1701	Phosphorylation	GKSKKRSSLFSPRRN CCCCCCCCCCCCCCC	37.15	25159151
1704	Phosphorylation	KKRSSLFSPRRNKKE CCCCCCCCCCCCCHH	23.84	23401153
1725	Phosphorylation	GRPPEKPSSNLLEEA CCCCCCCCCCHHHHH	42.81	28555341
1726	Phosphorylation	RPPEKPSSNLLEEAA CCCCCCCCCHHHHHH	39.77	25159151
1742	Phosphorylation	KPKSLWKSVFSGYKK CCHHHHHHHHCCCCC	19.47	25159151
1745	Phosphorylation	SLWKSVFSGYKKDKK HHHHHHHCCCCCCCC	38.77	25159151
1747	Phosphorylation	WKSVFSGYKKDKKKK HHHHHCCCCCCCCCC	17.42	23911959
1748	Ubiquitination	KSVFSGYKKDKKKKA HHHHCCCCCCCCCCC	59.00	29967540
1759	Phosphorylation	KKKADDKSCPSTPSS CCCCCCCCCCCCCCC	37.95	22777824
1762	Phosphorylation	ADDKSCPSTPSSGAT CCCCCCCCCCCCCCE	58.22	30576142
1763	Phosphorylation	DDKSCPSTPSSGATV CCCCCCCCCCCCCEE	16.60	28857561
1765	Phosphorylation	KSCPSTPSSGATVDS CCCCCCCCCCCEECC	41.30	28857561
1766	Phosphorylation	SCPSTPSSGATVDSG CCCCCCCCCCEECCC	33.38	23090842
1769	Phosphorylation	STPSSGATVDSGKHR CCCCCCCEECCCCCC	28.50	23312004
1772	Phosphorylation	SSGATVDSGKHRVLP CCCCEECCCCCCCCH	45.46	27251275
1792	Phosphorylation	LQLRRQLSFSEDSDL HHHHHHCCCCCCCCC	20.56	22617229
1794	Phosphorylation	LRRQLSFSEDSDLSS HHHHCCCCCCCCCCC	36.80	22617229
1797	Phosphorylation	QLSFSEDSDLSSDDV HCCCCCCCCCCCHHH	36.08	22617229
1800	Phosphorylation	FSEDSDLSSDDVLEK CCCCCCCCCHHHHHH	36.39	22617229
1801	Phosphorylation	SEDSDLSSDDVLEKS CCCCCCCCHHHHHHH	45.16	28450419
1809	Phosphorylation	DDVLEKSSQKSRREP HHHHHHHHHHCCCCC	53.33	-
1818	Phosphorylation	KSRREPRTYTEEELN HCCCCCCCCCHHHHH	45.57	29978859
1819	Phosphorylation	SRREPRTYTEEELNA CCCCCCCCCHHHHHH	17.27	29978859
1820	Phosphorylation	RREPRTYTEEELNAK CCCCCCCCHHHHHHH	35.99	29978859
1827	Ubiquitination	TEEELNAKLTRRVQK CHHHHHHHHHHHHHH	49.68	29967540
1841	Acetylation	KAARRQAKQEELKRL HHHHHHHHHHHHHHH	50.32	26051181
1846	Acetylation	QAKQEELKRLHRAQI HHHHHHHHHHHHHHH	57.08	26051181
1899	Ubiquitination	KLMQEWFKLVQEKNA HHHHHHHHHHHHHCC	49.15	29967540
1912	Phosphorylation	NAMVRYESELMIFAR CCCHHHHHHHHHHHH	27.39	28857561
1998	Phosphorylation	AMLSKGFSLNWS--- HHHHCCCCCCCC---	29.48	30576142
2002	Phosphorylation	KGFSLNWS------- CCCCCCCC-------	29.30	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MICA3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MICA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MICA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MICA3_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MICA3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1310 AND THR-1454, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1310 AND SER-1704, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649; THR-887; SER-1310;SER-1337; THR-1341; SER-1367; SER-1371 AND SER-1384, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1310, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-977, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1310; SER-1792;SER-1794; SER-1797; SER-1800 AND SER-1801, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1156, AND MASSSPECTROMETRY.	15302935 [Abstract]