COTL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COTL1_MOUSE
• UniProt AC: Q9CQI6
• Protein Name: Coactosin-like protein
• Gene Name: Cotl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 142
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Nucleus .
• Protein Description: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis (By similarity)..
• Protein Sequence: MATKIDKEACRAAYNLVRDDGSAVIWVTFRYDGATIVPGDQGADYQHFIQQCTDDVRLFAFVRFTTGDAMSKRSKFALITWIGEDVSGLQRAKTGTDKTLVKEVVQNFAKEFVISDRKELEEDFIRSELKKAGGANYDAQSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATKIDKEA ------CCCHHCHHH	20.01	-
7	Ubiquitination	-MATKIDKEACRAAY -CCCHHCHHHHHHHH	51.16	-
7	Acetylation	-MATKIDKEACRAAY -CCCHHCHHHHHHHH	51.16	22826441
45	Phosphorylation	PGDQGADYQHFIQQC CCCCCCCHHHHHHHC	11.89	26026062
52	S-palmitoylation	YQHFIQQCTDDVRLF HHHHHHHCCCCCEEE	2.30	28680068
71	Phosphorylation	FTTGDAMSKRSKFAL EECCCHHCHHHCEEE	27.00	29176673
75	Acetylation	DAMSKRSKFALITWI CHHCHHHCEEEEEEC	38.39	22826441
102	Acetylation	GTDKTLVKEVVQNFA CCCHHHHHHHHHHHH	48.15	22826441
102	Ubiquitination	GTDKTLVKEVVQNFA CCCHHHHHHHHHHHH	48.15	-
110	Acetylation	EVVQNFAKEFVISDR HHHHHHHHHHHCCCH	47.77	22826441
118	Ubiquitination	EFVISDRKELEEDFI HHHCCCHHHHHHHHH	72.19	-
137	Phosphorylation	KKAGGANYDAQSE-- HHHCCCCCCCCCC--	16.48	19854140
141	Phosphorylation	GANYDAQSE------ CCCCCCCCC------	47.17	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COTL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COTL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COTL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LOX5_HUMAN	ALOX5	physical	11785969
ACTG_MOUSE	Actg1	physical	11785969
ACTB_MOUSE	Actb	physical	11785969

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141, AND MASSSPECTROMETRY.
PubMed: 19367708