dbPTM

TARA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TARA_HUMAN
UniProt AC	Q9H2D6
Protein Name	TRIO and F-actin-binding protein
Gene Name	TRIOBP
Organism	Homo sapiens (Human).
Sequence Length	2365
Subcellular Localization	Nucleus . Cytoplasm, cytoskeleton . Localized to F-actin in a periodic pattern. Isoform 1: Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Centrosomal localization occurs upon phosphorylation by PLK1 at
Protein Description	May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover..
Protein Sequence	MEEVPGDALCEHFEANILTQNRCQNCFHPEEAHGARYQELRSPSGAEVPYCDLPRCPPAPEDPLSASTSGCQSVVDPGLRPGPKRGPSPSAGLPEEGPTAAPRSRSRELEAVPYLEGLTTSLCGSCNEDPGSDPTSSPDSATPDDTSNSSSVDWDTVERQEEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGRSAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRITQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGAFQAQDEGRSQQPSQGQSQLLRRQSSPAPSRQVTMLPAKQAELTRRSQAEPPHPWSPEKRPEGDRQLQGSPLPPRTSARTPERELRTQRPLESGQAGPRQPLGVWQSQEEPPGSQGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQPEAWEEKPTHELPRELGKRSPLTSPPENWGGPAESSQSWHSGTPTAVGWGAEGACPYPRGSERRPELDWRDLLGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARALGPELGPPGTNDVPEQESHSQPEGWAEATPVNGHSPALQSQSPVQLPSPACTSTQWPKIKVTRGPATATLAGLEQTGPLGSRSTAKGPSLPELQFQPEEPEESEPSRGQDPLTDQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39 (in isoform 6)	Phosphorylation	-	36.90	28674419
39 (in isoform 7)	Phosphorylation	-	36.90	28674419
42	Phosphorylation	ARYQELRSPSGAEVP CCHHCCCCCCCCCCC	35.72	27732954
44	Phosphorylation	YQELRSPSGAEVPYC HHCCCCCCCCCCCCC	52.46	27732954
88	Phosphorylation	PGPKRGPSPSAGLPE CCCCCCCCCCCCCCC	34.02	28450419
90	Phosphorylation	PKRGPSPSAGLPEEG CCCCCCCCCCCCCCC	39.03	28450419
99	Phosphorylation	GLPEEGPTAAPRSRS CCCCCCCCCCCCHHC	46.43	29888752
189	Ubiquitination	PRADSSQRAPSLLTR CCCCCCCCCCCHHHC	50.87	29967540
192	Phosphorylation	DSSQRAPSLLTRSPV CCCCCCCCHHHCCCC	34.72	24719451
200	Ubiquitination	LLTRSPVGGDAAGQK HHHCCCCCCCCCCCC	31.48	27667366
238	Phosphorylation	LSLERHRSTLTQASS CCHHHHHHHHHHHHC	22.95	20068231
239	Phosphorylation	SLERHRSTLTQASSM CHHHHHHHHHHHHCC	33.51	20068231
241	Phosphorylation	ERHRSTLTQASSMTP HHHHHHHHHHHCCCC	23.37	20068231
244	Phosphorylation	RSTLTQASSMTPHSG HHHHHHHHCCCCCCC	15.72	20068231
245	Phosphorylation	STLTQASSMTPHSGP HHHHHHHCCCCCCCC	29.68	20068231
247	Phosphorylation	LTQASSMTPHSGPRS HHHHHCCCCCCCCCC	21.57	20068231
250	Phosphorylation	ASSMTPHSGPRSTTS HHCCCCCCCCCCCCC	52.26	20068231
257	Phosphorylation	SGPRSTTSQASPAQR CCCCCCCCCCCHHHH	24.68	25599653
279	Phosphorylation	TREIPRASSPHRITQ CCCCCCCCCCCCCCH	45.76	24719451
280	Phosphorylation	REIPRASSPHRITQR CCCCCCCCCCCCCHH	24.60	21406692
285	Phosphorylation	ASSPHRITQRDTSRA CCCCCCCCHHHCCCC	19.94	21406692
293	Phosphorylation	QRDTSRASSTQQEIS HHHCCCCCHHHHHHH	32.57	21118733
294	Phosphorylation	RDTSRASSTQQEISR HHCCCCCHHHHHHHH	29.29	21118733
295	Phosphorylation	DTSRASSTQQEISRA HCCCCCHHHHHHHHH	31.60	21118733
300	Phosphorylation	SSTQQEISRASSTQQ CHHHHHHHHHHHCHH	22.50	21118733
303	Phosphorylation	QQEISRASSTQQETS HHHHHHHHHCHHHHH	32.57	21118733
304	Phosphorylation	QEISRASSTQQETSR HHHHHHHHCHHHHHH	29.29	21118733
305	Phosphorylation	EISRASSTQQETSRA HHHHHHHCHHHHHHC	31.60	21118733
309	Phosphorylation	ASSTQQETSRASSTQ HHHCHHHHHHCCCCC	21.12	21118733
310	Phosphorylation	SSTQQETSRASSTQE HHCHHHHHHCCCCCC	25.70	21118733
324	Phosphorylation	EDTPRASSTQEDTPR CCCCCCCCCCCCCCC	32.88	30576142
325	Phosphorylation	DTPRASSTQEDTPRA CCCCCCCCCCCCCCC	33.22	30576142
333	Phosphorylation	QEDTPRASSTQWNTP CCCCCCCCCCCCCCC	34.89	30576142
339	Phosphorylation	ASSTQWNTPRASSPS CCCCCCCCCCCCCCC	15.93	30576142
380	Phosphorylation	PQRENPRTPCVQQDD CCCCCCCCCCCCCCC	23.46	-
391	Phosphorylation	QQDDPRASSPNRTTQ CCCCCCCCCCCCCCC	47.83	-
392	Phosphorylation	QDDPRASSPNRTTQR CCCCCCCCCCCCCCH	25.80	-
430	Phosphorylation	ATRDNPRTSCAQRDN CCCCCCCCCHHHCCC	29.43	28258704
431	Phosphorylation	TRDNPRTSCAQRDNP CCCCCCCCHHHCCCC	14.56	28258704
464	O-linked_Glycosylation	QRDNPRASRTSSPNR HCCCCCCCCCCCCCC	37.05	30379171
476	Methylation	PNRATRDNPRTSCAQ CCCCCCCCCCCCHHH	25.35	-
476	Ubiquitination	PNRATRDNPRTSCAQ CCCCCCCCCCCCHHH	25.35	29967540
479	Phosphorylation	ATRDNPRTSCAQRDN CCCCCCCCCHHHCCC	29.43	28258704
480	Phosphorylation	TRDNPRTSCAQRDNP CCCCCCCCHHHCCCC	14.56	28258704
486	Ubiquitination	TSCAQRDNPRASSPS CCHHHCCCCCCCCCC	30.10	29967540
585	Ubiquitination	SCAQRDNPRASSPNR CHHHCCCCCCCCCCC	37.19	29967540
588	Phosphorylation	QRDNPRASSPNRATR HCCCCCCCCCCCCCC	47.83	23403867
589	Phosphorylation	RDNPRASSPNRATRD CCCCCCCCCCCCCCC	25.80	23403867
594	Phosphorylation	ASSPNRATRDNPTTS CCCCCCCCCCCCCCC	35.01	23403867
630	Ubiquitination	NPRTSCAQRDNPRAS CCCCCHHHCCCCCCC	58.55	29967540
637	Phosphorylation	QRDNPRASSPNRTTQ HCCCCCCCCCCCCCC	47.83	22817900
638	Phosphorylation	RDNPRASSPNRTTQQ CCCCCCCCCCCCCCC	25.80	28450419
642	Phosphorylation	RASSPNRTTQQDSPR CCCCCCCCCCCCCCC	35.28	28450419
666	Phosphorylation	RASSPNRTIQQENPR CCCCCCCCCCCCCCC	29.76	22817900
698	Phosphorylation	IQQENPRTSCAQRDD CCCCCCCCCHHHCCC	29.43	22210691
709	Phosphorylation	QRDDPRASSPNRTTQ HCCCCCCCCCCCCCC	47.83	22210691
710	Phosphorylation	RDDPRASSPNRTTQQ CCCCCCCCCCCCCCC	25.80	21406692
714	Phosphorylation	RASSPNRTTQQENPR CCCCCCCCCCCCCCC	35.28	21406692
715	Phosphorylation	ASSPNRTTQQENPRT CCCCCCCCCCCCCCC	25.64	21406692
757	Phosphorylation	QRDNPRASSPNRTIQ HCCCCCCCCCCCCCC	47.83	21406692
758	Phosphorylation	RDNPRASSPNRTIQQ CCCCCCCCCCCCCCH	25.80	21406692
762	Phosphorylation	RASSPNRTIQQENLR CCCCCCCCCCHHHHH	29.76	21406692
804	Phosphorylation	QRDNLRASSPIRATQ HHHCCCCCCCCCCCC	30.16	24719451
805	Phosphorylation	RDNLRASSPIRATQQ HHCCCCCCCCCCCCC	24.30	28450419
810	Phosphorylation	ASSPIRATQQDNPRT CCCCCCCCCCCCCCC	19.53	28450419
817	Phosphorylation	TQQDNPRTCIQQNIP CCCCCCCCHHHHCCC	18.41	28258704
826	Phosphorylation	IQQNIPRSSSTQQDN HHHCCCCCCCCCCCC	24.24	30576142
827	Phosphorylation	QQNIPRSSSTQQDNP HHCCCCCCCCCCCCC	38.39	30576142
828	Phosphorylation	QNIPRSSSTQQDNPK HCCCCCCCCCCCCCC	31.33	-
829	Phosphorylation	NIPRSSSTQQDNPKT CCCCCCCCCCCCCCC	32.00	28258704
847	Phosphorylation	KRDNLRPTCTQRDRT CCCCCCCCCCCCCCC	23.04	30576142
849	Phosphorylation	DNLRPTCTQRDRTQS CCCCCCCCCCCCCCC	29.17	30576142
856	Phosphorylation	TQRDRTQSFSFQRDN CCCCCCCCEEEECCC	23.42	24719451
867	Phosphorylation	QRDNPGTSSSQCCTQ ECCCCCCCHHHCCCC	33.63	-
869	Phosphorylation	DNPGTSSSQCCTQKE CCCCCCHHHCCCCHH	27.31	-
873	Phosphorylation	TSSSQCCTQKENLRP CCHHHCCCCHHCCCC	50.75	24719451
881	Phosphorylation	QKENLRPSSPHRSTQ CHHCCCCCCCCCCCC	50.49	21406692
882	Phosphorylation	KENLRPSSPHRSTQW HHCCCCCCCCCCCCC	27.66	28985074
886	Phosphorylation	RPSSPHRSTQWNNPR CCCCCCCCCCCCCCC	23.16	21406692
887	Phosphorylation	PSSPHRSTQWNNPRN CCCCCCCCCCCCCCC	37.24	21406692
895	Phosphorylation	QWNNPRNSSPHRTNK CCCCCCCCCCCCCCC	46.67	24719451
908	Phosphorylation	NKDIPWASFPLRPTQ CCCCCCCCCCCCCCC	24.43	27794612
921	Phosphorylation	TQSDGPRTSSPSRSK CCCCCCCCCCCCCCC	36.37	28348404
922	Phosphorylation	QSDGPRTSSPSRSKQ CCCCCCCCCCCCCCC	41.34	28348404
923	Phosphorylation	SDGPRTSSPSRSKQS CCCCCCCCCCCCCCC	26.70	28348404
925	Phosphorylation	GPRTSSPSRSKQSEV CCCCCCCCCCCCCCC	51.65	28348404
1027	Phosphorylation	HRDAPRASSPPRYLQ CCCCCCCCCCCCHHC	44.66	24719451
1032	Phosphorylation	RASSPPRYLQHDPFP CCCCCCCHHCCCCCC	19.25	27642862
1123	Phosphorylation	YRDAPRASSPPRQAP CCCCCCCCCCCCCCC	44.66	28450419
1124	Phosphorylation	RDAPRASSPPRQAPE CCCCCCCCCCCCCCC	37.63	24173317
1133	Phosphorylation	PRQAPEPSLLFQDLP CCCCCCCCCCCCCCC	35.72	28450419
1173	Phosphorylation	IGHRDAPSFSSPPRQ ECCCCCCCCCCCCCC	39.21	27732954
1175	Phosphorylation	HRDAPSFSSPPRQAP CCCCCCCCCCCCCCC	46.39	27732954
1176	Phosphorylation	RDAPSFSSPPRQAPE CCCCCCCCCCCCCCC	36.59	27732954
1227	Phosphorylation	HRDAPRASSPPRHPP CCCCCCCCCCCCCCC	44.66	22210691
1228	Phosphorylation	RDAPRASSPPRHPPS CCCCCCCCCCCCCCC	37.63	21406692
1235	Phosphorylation	SPPRHPPSDLAFLAP CCCCCCCCCCEEEEC	50.10	21406692
1243	Phosphorylation	DLAFLAPSPSPGSSG CCEEEECCCCCCCCC	32.19	22210691
1245	Phosphorylation	AFLAPSPSPGSSGGS EEEECCCCCCCCCCC	46.35	22210691
1248	Phosphorylation	APSPSPGSSGGSRGS ECCCCCCCCCCCCCC	29.24	21406692
1249	Phosphorylation	PSPSPGSSGGSRGSA CCCCCCCCCCCCCCC	53.76	21406692
1252	Phosphorylation	SPGSSGGSRGSAPPG CCCCCCCCCCCCCCC	36.67	21406692
1301	Phosphorylation	SSGGRTHSPGRAEVE CCCCCCCCCCHHHHH	28.56	24719451
1348	Phosphorylation	QLLRRQSSPAPSRQV HHHHHCCCCCCCCCE	19.42	-
1356	Phosphorylation	PAPSRQVTMLPAKQA CCCCCCEEEEEHHHH	12.49	29083192
1399	Phosphorylation	SPLPPRTSARTPERE CCCCCCCCCCCCCHH	19.62	-
1402	Phosphorylation	PPRTSARTPERELRT CCCCCCCCCCHHHHC	29.26	26546556
1429	Phosphorylation	QPLGVWQSQEEPPGS CCCCEEECCCCCCCC	24.69	28122231
1446	Phosphorylation	PHRHLERSWSSQEGG CCCCCHHCCCCCCCC	23.18	24719451
1684	Phosphorylation	TLAGLEQTGPLGSRS EECCHHHCCCCCCCC	31.24	-
1689	Phosphorylation	EQTGPLGSRSTAKGP HHCCCCCCCCCCCCC	30.64	-
1691	Phosphorylation	TGPLGSRSTAKGPSL CCCCCCCCCCCCCCC	34.12	-
1786	Phosphorylation	NFKKGWMSILDEPGE CCCCCHHHHCCCCCC	17.31	23090842
1796	Phosphorylation	DEPGEPPSPSLTTTS CCCCCCCCCCCCCCC	37.52	22617229
1798	Phosphorylation	PGEPPSPSLTTTSTS CCCCCCCCCCCCCCH	42.56	26657352
1800	Phosphorylation	EPPSPSLTTTSTSQW CCCCCCCCCCCCHHC	32.16	28450419
1801	Phosphorylation	PPSPSLTTTSTSQWK CCCCCCCCCCCHHCE	24.84	22199227
1802	Phosphorylation	PSPSLTTTSTSQWKK CCCCCCCCCCHHCEE	25.44	22199227
1803	Phosphorylation	SPSLTTTSTSQWKKH CCCCCCCCCHHCEEE	24.78	28857561
1804	Phosphorylation	PSLTTTSTSQWKKHW CCCCCCCCHHCEEEE	23.89	28857561
1805	Phosphorylation	SLTTTSTSQWKKHWF CCCCCCCHHCEEEEE	33.54	28857561
1809	Malonylation	TSTSQWKKHWFVLTD CCCHHCEEEEEEEEH	43.01	26320211
1843	Phosphorylation	EIDLRSCTDVTEYAV CEEEECCCCHHHHHH	34.45	28152594
1846	Phosphorylation	LRSCTDVTEYAVQRN EECCCCHHHHHHHHH	26.53	28152594
1848	Phosphorylation	SCTDVTEYAVQRNYG CCCCHHHHHHHHHCC	11.60	28152594
1854	Phosphorylation	EYAVQRNYGFQIHTK HHHHHHHCCCEEEEC	22.85	28152594
1865	Phosphorylation	IHTKDAVYTLSAMTS EEECCEEHHHHHHCH	12.04	25072903
1866	Phosphorylation	HTKDAVYTLSAMTSG EECCEEHHHHHHCHH	13.98	25072903
1868	Phosphorylation	KDAVYTLSAMTSGIR CCEEHHHHHHCHHHH	14.27	25072903
1871	Phosphorylation	VYTLSAMTSGIRRNW EHHHHHHCHHHHHHH	24.42	25072903
1872	Phosphorylation	YTLSAMTSGIRRNWI HHHHHHCHHHHHHHH	21.09	25072903
1889	Phosphorylation	LRKTVRPTSAPDVTK HHHHCCCCCCCCCHH	27.27	28857561
1890	Phosphorylation	RKTVRPTSAPDVTKL HHHCCCCCCCCCHHC	40.25	28857561
1895	Phosphorylation	PTSAPDVTKLSDSNK CCCCCCCHHCCCCCH	33.38	-
1898	Phosphorylation	APDVTKLSDSNKENA CCCCHHCCCCCHHHH	40.32	26074081
1900	Phosphorylation	DVTKLSDSNKENALH CCHHCCCCCHHHHCH	46.56	26074081
1902	Ubiquitination	TKLSDSNKENALHSY HHCCCCCHHHHCHHC	57.19	29967540
1908	Phosphorylation	NKENALHSYSTQKGP CHHHHCHHCCCCCCC	22.94	26074081
1909	Phosphorylation	KENALHSYSTQKGPL HHHHCHHCCCCCCCC	12.65	26074081
1910	Phosphorylation	ENALHSYSTQKGPLK HHHCHHCCCCCCCCC	27.63	26074081
1911	Phosphorylation	NALHSYSTQKGPLKA HHCHHCCCCCCCCCC	26.52	26074081
1913	Ubiquitination	LHSYSTQKGPLKAGE CHHCCCCCCCCCCCH	63.69	27667366
1925	Phosphorylation	AGEQRAGSEVISRGG CCHHHCCCCCHHCCC	27.92	28857561
1930	Methylation	AGSEVISRGGPRKAD CCCCCHHCCCCCCCC	42.85	16186591
1945	Phosphorylation	GQRQALDYVELSPLT CCCCCCCEEECCCCC	9.18	21082442
1949	Phosphorylation	ALDYVELSPLTQASP CCCEEECCCCCCCCH	12.35	30266825
1952	Phosphorylation	YVELSPLTQASPQRA EEECCCCCCCCHHHC	26.02	30266825
1955	Phosphorylation	LSPLTQASPQRARTP CCCCCCCCHHHCCCC	16.26	29255136
1961	Phosphorylation	ASPQRARTPARTPDR CCHHHCCCCCCCHHH	21.95	26055452
1965	Phosphorylation	RARTPARTPDRLAKQ HCCCCCCCHHHHHHH	31.48	23403867
1983	Phosphorylation	ERDLAQRSEERRKWF HHHHHHHHHHHHHHH	31.56	25159151
1993	Phosphorylation	RRKWFEATDSRTPEV HHHHHHHCCCCCCCC	27.58	22199227
1995	Phosphorylation	KWFEATDSRTPEVPA HHHHHCCCCCCCCCC	33.43	22199227
1997	Phosphorylation	FEATDSRTPEVPAGE HHHCCCCCCCCCCCC	27.96	29496963
2015	Phosphorylation	RGLGAPLTEDQQNRL CCCCCCCCHHHHHHH	36.13	24719451
2023	Phosphorylation	EDQQNRLSEEIEKKW HHHHHHHHHHHHHHH	29.91	24719451
2053	Phosphorylation	LTALLNQSRGERRGP HHHHHCCCCCCCCCC	40.97	29255136
2062	Phosphorylation	GERRGPPSDGHEALE CCCCCCCCCHHHHHH	60.40	28985074
2091	Phosphorylation	LQGEAPQSALRSQED HCCCCCHHHHHCCCC	28.36	28857561
2175	Phosphorylation	EELSRELSKTRSLQQ HHHHHHHHHHHHHHC	27.51	28450419
2189	Methylation	QGPDGLRKQHQSDVE CCCCHHHHHHHHHHH	58.12	23644510
2189	Ubiquitination	QGPDGLRKQHQSDVE CCCCHHHHHHHHHHH	58.12	29967540
2199	Ubiquitination	QSDVEALKRELQVLS HHHHHHHHHHHHHHH	51.37	29967540
2229	Phosphorylation	QAEEREHTLRRCQQE HHHHHHHHHHHHHHH	19.73	-
2274	Phosphorylation	MGNGCGRSNERSSCE CCCCCCCCCCCCCEE	28.46	27251275
2278	Phosphorylation	CGRSNERSSCELEVL CCCCCCCCCEEEEEE	32.91	27794612
2279	Phosphorylation	GRSNERSSCELEVLL CCCCCCCCEEEEEEE	20.17	27794612
2295	Phosphorylation	VKENELQYLKKEVQC HHHHHHHHHHHHHHH	32.87	26074081
2298	Ubiquitination	NELQYLKKEVQCLRD HHHHHHHHHHHHHHH	61.60	29967540
2317	Phosphorylation	MQKDKRFTSGKYQDV HHHCCCCCCCCCCHH	40.37	25072903
2318	Phosphorylation	QKDKRFTSGKYQDVY HHCCCCCCCCCCHHE	30.49	28857561
2321	Phosphorylation	KRFTSGKYQDVYVEL CCCCCCCCCHHEEEH	17.30	21945579
2325	Phosphorylation	SGKYQDVYVELSHIK CCCCCHHEEEHHHCC	9.12	21945579
2329	Phosphorylation	QDVYVELSHIKTRSE CHHEEEHHHCCCCCH	15.06	21945579
2343	Ubiquitination	EREIEQLKEHLRLAM HHHHHHHHHHHHHHH	42.66	29967540
2358	Phosphorylation	AALQEKESMRNSLAE HHHHHHHHHHHHHCC	33.82	25850435
2362	Phosphorylation	EKESMRNSLAE---- HHHHHHHHHCC----	20.70	25394399

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	HECTD3	Q5T447	PMID:18194665

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
457	T	Phosphorylation		22820163
[Isoform 1]: Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TARA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
VIME_HUMAN	VIM	physical	16169070
HECD3_HUMAN	HECTD3	physical	18194665

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
609823	Deafness, autosomal recessive, 28 (DFNB28)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TARA_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1955 AND SER-1983, ANDMASS SPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1949 AND SER-1955, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-810, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks."; Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.; Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1945, AND MASSSPECTROMETRY.	17389395 [Abstract]

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