dbPTM

RAB5C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RAB5C_HUMAN
UniProt AC	P51148
Protein Name	Ras-related protein Rab-5C
Gene Name	RAB5C
Organism	Homo sapiens (Human).
Sequence Length	216
Subcellular Localization	Cell membrane Lipid-anchor Cytoplasmic side. Early endosome membrane Lipid-anchor. Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Description	Protein transport. Probably involved in vesicular traffic (By similarity)..
Protein Sequence	MAGRGGAARPNGPAAGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNTDTFARAKNWVKELQRQASPNIVIALAGNKADLASKRAVEFQEAQAYADDNSLLFMETSAKTAMNVNEIFMAIAKKLPKNEPQNATGAPGRNRGVDLQENNPASRSQCCSN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGRGGAAR ------CCCCCCCCC	19.18	-
4	Methylation	----MAGRGGAARPN ----CCCCCCCCCCC	30.73	115367883
9	Methylation	AGRGGAARPNGPAAG CCCCCCCCCCCCCCC	25.36	115385817
18	Ubiquitination	NGPAAGNKICQFKLV CCCCCCCCCCEEEEE	43.89	-
18	Acetylation	NGPAAGNKICQFKLV CCCCCCCCCCEEEEE	43.89	26822725
23	Acetylation	GNKICQFKLVLLGES CCCCCEEEEEEECCC	16.29	129523
30	Phosphorylation	KLVLLGESAVGKSSL EEEEECCCCCCCCHH	26.84	23911959
34	Ubiquitination	LGESAVGKSSLVLRF ECCCCCCCCHHHHHH	30.21	-
36	Phosphorylation	ESAVGKSSLVLRFVK CCCCCCCHHHHHHHC	26.44	24719451
83	Phosphorylation	DTAGQERYHSLAPMY CCCCCCCCHHCCCCH	8.60	25106551
85	Phosphorylation	AGQERYHSLAPMYYR CCCCCCHHCCCCHHC	19.79	28857561
89	Sulfoxidation	RYHSLAPMYYRGAQA CCHHCCCCHHCCCCE	3.69	28183972
116	Phosphorylation	FARAKNWVKELQRQA HHHHHHHHHHHHHHC	4.89	27642862
117	Ubiquitination	ARAKNWVKELQRQAS HHHHHHHHHHHHHCC	44.30	21906983
118	Phosphorylation	RAKNWVKELQRQASP HHHHHHHHHHHHCCC	40.28	27251275
123	Phosphorylation	VKELQRQASPNIVIA HHHHHHHCCCCEEEE	29.19	27642862
124	Phosphorylation	KELQRQASPNIVIAL HHHHHHCCCCEEEEE	15.33	25159151
135	Ubiquitination	VIALAGNKADLASKR EEEECCCHHHHHHHH	42.22	21906983
140	Phosphorylation	GNKADLASKRAVEFQ CCHHHHHHHHHHHHH	29.94	17137347
141	Ubiquitination	NKADLASKRAVEFQE CHHHHHHHHHHHHHH	38.48	-
141	Acetylation	NKADLASKRAVEFQE CHHHHHHHHHHHHHH	38.48	25953088
152	Phosphorylation	EFQEAQAYADDNSLL HHHHHHHHCCCCCEE	9.85	21406692
157	Phosphorylation	QAYADDNSLLFMETS HHHCCCCCEEEEECC	33.18	21406692
161	Sulfoxidation	DDNSLLFMETSAKTA CCCCEEEEECCCCCC	5.76	30846556
163	Phosphorylation	NSLLFMETSAKTAMN CCEEEEECCCCCCCC	23.38	21406692
164	Phosphorylation	SLLFMETSAKTAMNV CEEEEECCCCCCCCH	17.92	21406692
167	Phosphorylation	FMETSAKTAMNVNEI EEECCCCCCCCHHHH	30.75	22210691
173	Phosphorylation	KTAMNVNEIFMAIAK CCCCCHHHHHHHHHH	33.06	27251275
180	Ubiquitination	EIFMAIAKKLPKNEP HHHHHHHHHCCCCCC	49.05	21906983
180	Acetylation	EIFMAIAKKLPKNEP HHHHHHHHHCCCCCC	49.05	25953088
184	Acetylation	AIAKKLPKNEPQNAT HHHHHCCCCCCCCCC	81.84	23236377
191	Phosphorylation	KNEPQNATGAPGRNR CCCCCCCCCCCCCCC	41.23	24173317
191	O-linked_Glycosylation	KNEPQNATGAPGRNR CCCCCCCCCCCCCCC	41.23	OGP
209	O-linked_Glycosylation	LQENNPASRSQCCSN CCCCCCCCHHHHCCC	33.45	23301498
209	Phosphorylation	LQENNPASRSQCCSN CCCCCCCCHHHHCCC	33.45	21712546
213	Geranylgeranylation	NPASRSQCCSN---- CCCCHHHHCCC----	2.64	-
214	Geranylgeranylation	PASRSQCCSN----- CCCHHHHCCC-----	3.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
85	S	Phosphorylation	Kinase	LRRK2	Q5S007	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
85	S	Phosphorylation		29125462
Phosphorylation of Ser-85 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RAB5C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUN2_HUMAN	SUN2	physical	17353931
EEA1_HUMAN	EEA1	physical	12493736
RBNS5_HUMAN	RBSN	physical	12493736
A4_HUMAN	APP	physical	21832049
DP13B_HUMAN	APPL2	physical	25416956
ARF1_HUMAN	ARF1	physical	26344197
ARL8A_HUMAN	ARL8A	physical	26344197
ETFA_HUMAN	ETFA	physical	26344197
LDHA_HUMAN	LDHA	physical	26344197
LDH6A_HUMAN	LDHAL6A	physical	26344197
LDH6B_HUMAN	LDHAL6B	physical	26344197
LDHB_HUMAN	LDHB	physical	26344197
PRS7_HUMAN	PSMC2	physical	26344197
RAB1A_HUMAN	RAB1A	physical	26344197
RAB1B_HUMAN	RAB1B	physical	26344197
RAB2A_HUMAN	RAB2A	physical	26344197
RAB8A_HUMAN	RAB8A	physical	26344197
RAB8B_HUMAN	RAB8B	physical	26344197
RPN1_HUMAN	RPN1	physical	26344197
QCR2_HUMAN	UQCRC2	physical	26344197
VATA_HUMAN	ATP6V1A	physical	26496610
VATB2_HUMAN	ATP6V1B2	physical	26496610
VPP1_HUMAN	ATP6V0A1	physical	26496610
CAV1_HUMAN	CAV1	physical	26496610
CLCN7_HUMAN	CLCN7	physical	26496610
COX5B_HUMAN	COX5B	physical	26496610
CX6B1_HUMAN	COX6B1	physical	26496610
FLOT2_HUMAN	FLOT2	physical	26496610
H33_HUMAN	H3F3A	physical	26496610
MPRI_HUMAN	IGF2R	physical	26496610
NDUA7_HUMAN	NDUFA7	physical	26496610
NDUB7_HUMAN	NDUFB7	physical	26496610
NDUS1_HUMAN	NDUFS1	physical	26496610
NDUS5_HUMAN	NDUFS5	physical	26496610
CHM1A_HUMAN	CHMP1A	physical	26496610
PHB_HUMAN	PHB	physical	26496610
PPIA_HUMAN	PPIA	physical	26496610
RAD51_HUMAN	RAD51	physical	26496610
SMCA4_HUMAN	SMARCA4	physical	26496610
SMRC1_HUMAN	SMARCC1	physical	26496610
SOAT1_HUMAN	SOAT1	physical	26496610
SSXT_HUMAN	SS18	physical	26496610
TFR1_HUMAN	TFRC	physical	26496610
TTC3_HUMAN	TTC3	physical	26496610
VDAC1_HUMAN	VDAC1	physical	26496610
VDAC2_HUMAN	VDAC2	physical	26496610
STX7_HUMAN	STX7	physical	26496610
RAI3_HUMAN	GPRC5A	physical	26496610
VA0D1_HUMAN	ATP6V0D1	physical	26496610
XPR1_HUMAN	XPR1	physical	26496610
CSN2_HUMAN	COPS2	physical	26496610
GOSR1_HUMAN	GOSR1	physical	26496610
EPN4_HUMAN	CLINT1	physical	26496610
CAPON_HUMAN	NOS1AP	physical	26496610
PIEZ1_HUMAN	PIEZO1	physical	26496610
IST1_HUMAN	IST1	physical	26496610
C2CD5_HUMAN	C2CD5	physical	26496610
FLOT1_HUMAN	FLOT1	physical	26496610
CKAP4_HUMAN	CKAP4	physical	26496610
TMEDA_HUMAN	TMED10	physical	26496610
MIC60_HUMAN	IMMT	physical	26496610
RASF8_HUMAN	RASSF8	physical	26496610
PHB2_HUMAN	PHB2	physical	26496610
KDM2A_HUMAN	KDM2A	physical	26496610
WDFY3_HUMAN	WDFY3	physical	26496610
FAF2_HUMAN	FAF2	physical	26496610
SCFD1_HUMAN	SCFD1	physical	26496610
HAUS5_HUMAN	HAUS5	physical	26496610
BICRL_HUMAN	GLTSCR1L	physical	26496610
SUN2_HUMAN	SUN2	physical	26496610
GRAN_HUMAN	GCA	physical	26496610
LTMD1_HUMAN	LETMD1	physical	26496610
CHM2B_HUMAN	CHMP2B	physical	26496610
MYOF_HUMAN	MYOF	physical	26496610
AT2C1_HUMAN	ATP2C1	physical	26496610
CHM2A_HUMAN	CHMP2A	physical	26496610
SGSM3_HUMAN	SGSM3	physical	26496610
ABT1_HUMAN	ABT1	physical	26496610
STML2_HUMAN	STOML2	physical	26496610
NDUBB_HUMAN	NDUFB11	physical	26496610
MIC19_HUMAN	CHCHD3	physical	26496610
OCAD1_HUMAN	OCIAD1	physical	26496610
RMD3_HUMAN	RMDN3	physical	26496610
IMPCT_HUMAN	IMPACT	physical	26496610
TTC17_HUMAN	TTC17	physical	26496610
MUC13_HUMAN	MUC13	physical	26496610
BBX_HUMAN	BBX	physical	26496610
KDIS_HUMAN	KIDINS220	physical	26496610
SUGP1_HUMAN	SUGP1	physical	26496610
RT14_HUMAN	MRPS14	physical	26496610
S35E1_HUMAN	SLC35E1	physical	26496610
YIPF5_HUMAN	YIPF5	physical	26496610
ZCRB1_HUMAN	ZCRB1	physical	26496610
G45IP_HUMAN	GADD45GIP1	physical	26496610
ACBD5_HUMAN	ACBD5	physical	26496610
S38A5_HUMAN	SLC38A5	physical	26496610
CAVN3_HUMAN	PRKCDBP	physical	26496610
LLR1_HUMAN	LRR1	physical	26496610
RM55_HUMAN	MRPL55	physical	26496610
CHM4B_HUMAN	CHMP4B	physical	26496610
MITD1_HUMAN	MITD1	physical	26496610
CAVN1_HUMAN	PTRF	physical	26496610
RAB43_HUMAN	RAB43	physical	26496610
RAE1_HUMAN	CHM	physical	28514442
GDIA_HUMAN	GDI1	physical	28514442
GNAT3_HUMAN	GNAT3	physical	28514442
RAE2_HUMAN	CHML	physical	28514442
GDIB_HUMAN	GDI2	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RAB5C_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]

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