| UniProt ID | S38A5_HUMAN | |
|---|---|---|
| UniProt AC | Q8WUX1 | |
| Protein Name | Sodium-coupled neutral amino acid transporter 5 | |
| Gene Name | SLC38A5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 472 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium.. | |
| Protein Sequence | MELQDPKMNGALPSDAVGYRQEREGFLPSRGPAPGSKPVQFMDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCAGIAGIRAYEQLGQRAFGPAGKVVVATVICLHNVGAMSSYLFIIKSELPLVIGTFLYMDPEGDWFLKGNLLIIIVSVLIILPLALMKHLGYLGYTSGLSLTCMLFFLVSVIYKKFQLGCAIGHNETAMESEALVGLPSQGLNSSCEAQMFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCRPSKRRMQAVANVSIGAMFCMYGLTATFGYLTFYSSVKAEMLHMYSQKDPLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPGKAFSWPRHVAIALILLVLVNVLVICVPTIRDIFGVIGSTSAPSLIFILPSIFYLRIVPSEVEPFLSWPKIQALCFGVLGVLFMAVSLGFMFANWATGQSRMSGH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MELQDPKM -------CCCCCCCC | 11.93 | 22814378 | |
| 19 | Phosphorylation | LPSDAVGYRQEREGF CCCCCCCHHHHCCCC | 11.52 | 27259358 | |
| 29 | Phosphorylation | EREGFLPSRGPAPGS HCCCCCCCCCCCCCC | 52.60 | 26434776 | |
| 36 | Phosphorylation | SRGPAPGSKPVQFMD CCCCCCCCCCEEEEE | 32.50 | 25159151 | |
| 37 | Ubiquitination | RGPAPGSKPVQFMDF CCCCCCCCCEEEEEC | 55.94 | 21890473 | |
| 37 (in isoform 1) | Ubiquitination | - | 55.94 | 21890473 | |
| 226 | N-linked_Glycosylation | LGCAIGHNETAMESE CCCCCCCCCCHHHHH | 43.00 | UniProtKB CARBOHYD | |
| 318 (in isoform 2) | Ubiquitination | - | 25.19 | 21890473 | |
| 369 | Ubiquitination | QQLLFPGKAFSWPRH HHHHCCCCCCCCHHH | 46.63 | 21890473 | |
| 369 (in isoform 1) | Ubiquitination | - | 46.63 | 21890473 | |
| 372 | Phosphorylation | LFPGKAFSWPRHVAI HCCCCCCCCHHHHHH | 40.82 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of S38A5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of S38A5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of S38A5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of S38A5_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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