SGSM3_HUMAN - dbPTM
SGSM3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SGSM3_HUMAN
UniProt AC Q96HU1
Protein Name Small G protein signaling modulator 3
Gene Name SGSM3 {ECO:0000312|HGNC:HGNC:25228}
Organism Homo sapiens (Human).
Sequence Length 749
Subcellular Localization Cytoplasm .
Protein Description May play a cooperative role in NF2-mediated growth suppression of cells..
Protein Sequence MSGSHTPACGPFSALTPSIWPQEILAKYTQKEESAEQPEFYYDEFGFRVYKEEGDEPGSSLLANSPLMEDAPQRLRWQAHLEFTHNHDVGDLTWDKIAVSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDIPSQMEDAELLLGVAMRLAGSLTDVAVETQRRKHLAYLIADQGQLLGAGTLTNLSQVVRRRTQRRKSTITALLFGEDDLEALKAKNIKQTELVADLREAILRVARHFQCTDPKNCSVELTPDYSMESHQRDHENYVACSRSHRRRAKALLDFERHDDDELGFRKNDIITIVSQKDEHCWVGELNGLRGWFPAKFVEVLDERSKEYSIAGDDSVTEGVTDLVRGTLCPALKALFEHGLKKPSLLGGACHPWLFIEEAAGREVERDFASVYSRLVLCKTFRLDEDGKVLTPEELLYRAVQSVNVTHDAVHAQMDVKLRSLICVGLNEQVLHLWLEVLCSSLPTVEKWYQPWSFLRSPGWVQIKCELRVLCCFAFSLSQDWELPAKREAQQPLKEGVRDMLVKHHLFSWDVDG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSGSHTPAC
------CCCCCCCCC		49.3428348404
4Phosphorylation----MSGSHTPACGP
----CCCCCCCCCCC		19.5128348404
6Phosphorylation--MSGSHTPACGPFS
--CCCCCCCCCCCCC		17.8024719451
59PhosphorylationEEGDEPGSSLLANSP
CCCCCCCCCCCCCCC		28.6426657352
60PhosphorylationEGDEPGSSLLANSPL
CCCCCCCCCCCCCCC		33.0627251275
65PhosphorylationGSSLLANSPLMEDAP
CCCCCCCCCCCCCCC		17.5025159151
100PhosphorylationTWDKIAVSLPRSEKL
CHHEEEEECCCHHHH		24.5124719451
128PhosphorylationPQLWMRLSGALQKKR
HHHHHHHHHHHHHHH		16.20-
146UbiquitinationLSYREIVKNSSNDET
CCHHHHHHCCCCCHH		57.6921906983
146 (in isoform 1)Ubiquitination-57.6921906983
146 (in isoform 2)Ubiquitination-57.6921906983
157UbiquitinationNDETIAAKQIEKDLL
CCHHHHHHHHHHHHH		42.6721906983
157 (in isoform 1)Ubiquitination-42.6721906983
157 (in isoform 2)Ubiquitination-42.6721906983
161UbiquitinationIAAKQIEKDLLRTMP
HHHHHHHHHHHHHCC		56.13-
166PhosphorylationIEKDLLRTMPSNACF
HHHHHHHHCCCCCCH		33.1422210691
169PhosphorylationDLLRTMPSNACFASM
HHHHHCCCCCCHHHC		26.6622210691
360PhosphorylationVAMRLAGSLTDVAVE
HHHHHHHHHHHHHHH		23.6124719451
362PhosphorylationMRLAGSLTDVAVETQ
HHHHHHHHHHHHHHH		30.0828348404
405UbiquitinationRRRTQRRKSTITALL
HHHHHHCHHHHHHHH		54.89-
406PhosphorylationRRTQRRKSTITALLF
HHHHHCHHHHHHHHC		24.1926657352
407PhosphorylationRTQRRKSTITALLFG
HHHHCHHHHHHHHCC		25.9426657352
409PhosphorylationQRRKSTITALLFGED
HHCHHHHHHHHCCCC		16.0218669648
422 (in isoform 1)Ubiquitination-65.4521906983
422 (in isoform 2)Ubiquitination-65.4521906983
422UbiquitinationEDDLEALKAKNIKQT
CCHHHHHHHCCCCHH		65.4521906983
452 (in isoform 2)Ubiquitination-73.69-
452UbiquitinationHFQCTDPKNCSVELT
HCCCCCCCCCEEEEC		73.69-
455PhosphorylationCTDPKNCSVELTPDY
CCCCCCCEEEECCCC		28.2028842319
463PhosphorylationVELTPDYSMESHQRD
EEECCCCCCHHHCCC		24.37-
474PhosphorylationHQRDHENYVACSRSH
HCCCCCCCCCCCHHH		6.0927642862
486UbiquitinationRSHRRRAKALLDFER
HHHHHHHHHHHCHHC		37.44-
511PhosphorylationNDIITIVSQKDEHCW
CCEEEEEECCCCCEE		27.8821815630
532 (in isoform 1)Ubiquitination-50.6221906983
532UbiquitinationLRGWFPAKFVEVLDE
CCCCCCHHHHHHHHH		50.6221906983
542UbiquitinationEVLDERSKEYSIAGD
HHHHHHCCCEEECCC		67.8821906983
542 (in isoform 1)Ubiquitination-67.8821906983
560 (in isoform 2)Ubiquitination-6.2121906983
569UbiquitinationGTLCPALKALFEHGL
HCHHHHHHHHHHCCC		45.19-
570 (in isoform 2)Ubiquitination-20.5221906983
578UbiquitinationLFEHGLKKPSLLGGA
HHHCCCCCCHHCCCC		44.90-
606PhosphorylationEVERDFASVYSRLVL
CCHHHHHHHHHHHHH		22.91-
608PhosphorylationERDFASVYSRLVLCK
HHHHHHHHHHHHHHH		5.8827642862
609PhosphorylationRDFASVYSRLVLCKT
HHHHHHHHHHHHHHH		19.58-
615UbiquitinationYSRLVLCKTFRLDED
HHHHHHHHHEEECCC		46.68-
624 (in isoform 1)Ubiquitination-46.5221906983
624UbiquitinationFRLDEDGKVLTPEEL
EEECCCCCEECHHHH		46.5221906983
633PhosphorylationLTPEELLYRAVQSVN
ECHHHHHHHHHHHCC		14.78-
642PhosphorylationAVQSVNVTHDAVHAQ
HHHHCCCCCCHHHHH		14.61-
652 (in isoform 2)Ubiquitination-5.4421906983
730 (in isoform 1)Ubiquitination-60.1421906983
730UbiquitinationREAQQPLKEGVRDML
HHCCCCHHHHHHHHH		60.142190698
739UbiquitinationGVRDMLVKHHLFSWD
HHHHHHHHHHHHCCC		22.73-
758 (in isoform 2)Ubiquitination-21906983
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SGSM3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SGSM3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SGSM3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MERL_HUMANNF2physical
15541357
PDC6I_HUMANPDCD6IPphysical
12771190
NTRK1_HUMANNTRK1physical
17267689
RAB5A_HUMANRAB5Aphysical
16923123
RAB5B_HUMANRAB5Bphysical
16923123
RAB5C_HUMANRAB5Cphysical
16923123
RB39B_HUMANRAB39Bphysical
16923123
LEMD2_HUMANLEMD2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SGSM3_HUMAN

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Related Literatures of Post-Translational Modification

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