| UniProt ID | LLR1_HUMAN | |
|---|---|---|
| UniProt AC | Q96L50 | |
| Protein Name | Leucine-rich repeat protein 1 | |
| Gene Name | LRR1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 414 | |
| Subcellular Localization | ||
| Protein Description | May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.. | |
| Protein Sequence | MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPPVRAFLLISTLKDKRGTRYELRENIEQFFTKFVDEGKATVRLKEPPVDICLSKAISSSLKGFLSAMRLAHRGCNVDTPVSTLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLFGNTFEQPKVLPVIKLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCGRFCLNSFIQGTTTMNLHSVAHTVVLVDNLGGTEAPIISYFCSLGCYVNSSDMLK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 31 | Phosphorylation | KGVRAVLSLCQQTSR HHHHHHHHHHHHCCC | 22.09 | 25278378 | |
| 53 | Ubiquitination | FLLISTLKDKRGTRY EEEHHHHHCCCCCHH | 62.38 | - | |
| 72 | Ubiquitination | NIEQFFTKFVDEGKA HHHHHHHHHHCCCCC | 37.93 | 21906983 | |
| 72 (in isoform 1) | Ubiquitination | - | 37.93 | 21906983 | |
| 72 (in isoform 2) | Ubiquitination | - | 37.93 | 21906983 | |
| 78 (in isoform 1) | Ubiquitination | - | 38.55 | 21906983 | |
| 78 (in isoform 2) | Ubiquitination | - | 38.55 | 21906983 | |
| 78 | Ubiquitination | TKFVDEGKATVRLKE HHHHCCCCCEEEECC | 38.55 | 2190698 | |
| 84 | Ubiquitination | GKATVRLKEPPVDIC CCCEEEECCCCCHHH | 58.57 | - | |
| 94 | Ubiquitination | PVDICLSKAISSSLK CCHHHHHHHHHHHHH | 36.47 | - | |
| 97 | Phosphorylation | ICLSKAISSSLKGFL HHHHHHHHHHHHHHH | 20.80 | 23403867 | |
| 98 | Phosphorylation | CLSKAISSSLKGFLS HHHHHHHHHHHHHHH | 33.31 | 23403867 | |
| 99 | Phosphorylation | LSKAISSSLKGFLSA HHHHHHHHHHHHHHH | 27.58 | 23403867 | |
| 101 | Ubiquitination | KAISSSLKGFLSAMR HHHHHHHHHHHHHHH | 49.95 | - | |
| 118 | Phosphorylation | HRGCNVDTPVSTLTP HCCCCCCCCCCCCCC | 22.70 | 29396449 | |
| 121 | Phosphorylation | CNVDTPVSTLTPVKT CCCCCCCCCCCCCCC | 20.92 | 29255136 | |
| 122 | Phosphorylation | NVDTPVSTLTPVKTS CCCCCCCCCCCCCCH | 34.58 | 29255136 | |
| 124 | Phosphorylation | DTPVSTLTPVKTSEF CCCCCCCCCCCCHHH | 26.56 | 29255136 | |
| 127 | Ubiquitination | VSTLTPVKTSEFENF CCCCCCCCCHHHCCC | 47.76 | - | |
| 128 | Phosphorylation | STLTPVKTSEFENFK CCCCCCCCHHHCCCC | 33.45 | - | |
| 129 | Phosphorylation | TLTPVKTSEFENFKT CCCCCCCHHHCCCCE | 34.27 | - | |
| 135 | Ubiquitination | TSEFENFKTKMVITS CHHHCCCCEEEEEEE | 59.84 | - | |
| 136 | Phosphorylation | SEFENFKTKMVITSK HHHCCCCEEEEEEEC | 21.89 | - | |
| 181 | Ubiquitination | LCLKSLRKLDLSHNH HHHHHHHHCCCCCHH | 52.20 | - | |
| 190 | Ubiquitination | DLSHNHIKKLPATIG CCCCHHHHHCCCCHH | 40.48 | - | |
| 227 | Phosphorylation | CHSTLQKSLRSLDLS HHHHHHHHHHCCCCC | 18.96 | 24719451 | |
| 235 | Ubiquitination | LRSLDLSKNKIKALP HHCCCCCCCCCCEEC | 70.34 | - | |
| 235 | Acetylation | LRSLDLSKNKIKALP HHCCCCCCCCCCEEC | 70.34 | 21690583 | |
| 239 | Ubiquitination | DLSKNKIKALPVQFC CCCCCCCCEECCCHH | 45.54 | - | |
| 252 | Ubiquitination | FCQLQELKNLKLDDN HHHHHHHCCCCCCCC | 60.52 | - | |
| 255 | Ubiquitination | LQELKNLKLDDNELI HHHHCCCCCCCCCEE | 60.30 | - | |
| 283 | Ubiquitination | FLSAARNKLPFLPSE HHHHHHHCCCCCCHH | 52.57 | - | |
| 316 | Ubiquitination | PKVLPVIKLQAPLTL CCCCCEEECCCCHHH | 34.48 | - | |
| 326 | Phosphorylation | APLTLLESSARTILH CCHHHHHHCHHHHHH | 29.30 | - | |
| 330 | Phosphorylation | LLESSARTILHNRIP HHHHCHHHHHHCCCC | 27.83 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LLR1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LLR1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LLR1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RFWD2_HUMAN | RFWD2 | physical | 19295130 | |
| CSN2_HUMAN | COPS2 | physical | 19295130 | |
| CSN3_HUMAN | COPS3 | physical | 19295130 | |
| CSN4_HUMAN | COPS4 | physical | 19295130 | |
| CSN5_HUMAN | COPS5 | physical | 19295130 | |
| CSN6_HUMAN | COPS6 | physical | 19295130 | |
| CSN7A_HUMAN | COPS7A | physical | 19295130 | |
| CSN7B_HUMAN | COPS7B | physical | 19295130 | |
| CSN8_HUMAN | COPS8 | physical | 19295130 | |
| RBX1_HUMAN | RBX1 | physical | 19295130 | |
| CUL2_HUMAN | CUL2 | physical | 19295130 | |
| ELOB_HUMAN | TCEB2 | physical | 19295130 | |
| ELOC_HUMAN | TCEB1 | physical | 19295130 | |
| CUL2_HUMAN | CUL2 | physical | 15601820 | |
| RBX1_HUMAN | RBX1 | physical | 15601820 | |
| ELOB_HUMAN | TCEB2 | physical | 15601820 | |
| ELOC_HUMAN | TCEB1 | physical | 15601820 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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