dbPTM

C2CD5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	C2CD5_HUMAN
UniProt AC	Q86YS7
Protein Name	C2 domain-containing protein 5
Gene Name	C2CD5
Organism	Homo sapiens (Human).
Sequence Length	1000
Subcellular Localization	Cytoplasmic vesicle membrane . Cytoplasm, cell cortex . Cell membrane . Cell projection, ruffle . Dynamically associated with GLUT4-containing glucose storage vesicles (GSV) and plasma membrane in response to insulin stimulation.
Protein Description	Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM..
Protein Sequence	MPGKLKVKIVAGRHLPVMDRASDLTDAFVEVKFGNTTFKTDVYLKSLNPQWNSEWFKFEVDDEDLQDEPLQITVLDHDTYSANDAIGKVYIDIDPLLYSEAATVISGWFPIYDTIHGIRGEINVVVKVDLFNDLNRFRQSSCGVKFFCTTSIPKCYRAVIIHGFVEELVVNEDPEYQWIDRIRTPRASNEARQRLISLMSGELQRKIGLKVLEMRGNAVVGYLQCFDLEGESGLVVRAIGTACTLDKLSSPAAFLPACNSPSKEMKEIPFNEDPNPNTHSSGPSTPLKNQTYSFSPSKSYSRQSSSSDTDLSLTPKTGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPPGFLVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLNPRFLQDGTVEGCLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQARLCRLKKKAQAEANATAISNLLPFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGSYEQHISHMQKKINDTIAKNKELYEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPPSGFYSCNTEIMPGINNWTSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQVTVTAVAITFDKNQALQTTKTPVEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKAMTVEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGNAVVSYIMKQCVFMENPNKNQAQCLINVSGDAVVFVRESDLEVVSSQQPTTNCQSSCTEGEVTT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
36	Phosphorylation	VEVKFGNTTFKTDVY EEEEECCCEEEEEEE	-
80	Phosphorylation	TVLDHDTYSANDAIG EEEECCCCCCCCCCC	-
151	Phosphorylation	VKFFCTTSIPKCYRA CEEEECCCCCHHHEE	24719451
176	Phosphorylation	VVNEDPEYQWIDRIR CCCCCCCCCEECCCC	-
197	Phosphorylation	EARQRLISLMSGELQ HHHHHHHHHHCHHHH	21907143
200	Phosphorylation	QRLISLMSGELQRKI HHHHHHHCHHHHHHH	21907143
241	Phosphorylation	LVVRAIGTACTLDKL EEEEEEEEEECHHHH	28464451
249	Phosphorylation	ACTLDKLSSPAAFLP EECHHHHCCCCCCCC	30266825
250	Phosphorylation	CTLDKLSSPAAFLPA ECHHHHCCCCCCCCC	30266825
260	Phosphorylation	AFLPACNSPSKEMKE CCCCCCCCCCHHHCC	19664994
262	Phosphorylation	LPACNSPSKEMKEIP CCCCCCCCHHHCCCC	29255136
278	Phosphorylation	NEDPNPNTHSSGPST CCCCCCCCCCCCCCC	30266825
280	Phosphorylation	DPNPNTHSSGPSTPL CCCCCCCCCCCCCCC	23401153
280 (in isoform 2)	Phosphorylation	-	27732954
280 (in isoform 4)	Phosphorylation	-	27732954
280 (in isoform 5)	Phosphorylation	-	27732954
281	Phosphorylation	PNPNTHSSGPSTPLK CCCCCCCCCCCCCCC	23401153
281 (in isoform 2)	Phosphorylation	-	27732954
281 (in isoform 4)	Phosphorylation	-	27732954
281 (in isoform 5)	Phosphorylation	-	27732954
284	Phosphorylation	NTHSSGPSTPLKNQT CCCCCCCCCCCCCCE	25463755
284 (in isoform 2)	Phosphorylation	-	27732954
284 (in isoform 4)	Phosphorylation	-	27732954
284 (in isoform 5)	Phosphorylation	-	27732954
285	Phosphorylation	THSSGPSTPLKNQTY CCCCCCCCCCCCCEE	26503892
288 (in isoform 2)	Phosphorylation	-	27732954
288 (in isoform 4)	Phosphorylation	-	27732954
288 (in isoform 5)	Phosphorylation	-	27732954
291	Phosphorylation	STPLKNQTYSFSPSK CCCCCCCEEEECCCC	22167270
292	Phosphorylation	TPLKNQTYSFSPSKS CCCCCCEEEECCCCC	22167270
293	Phosphorylation	PLKNQTYSFSPSKSY CCCCCEEEECCCCCC	19664994
295	Phosphorylation	KNQTYSFSPSKSYSR CCCEEEECCCCCCCC	29255136
295 (in isoform 2)	Phosphorylation	-	24905233
295 (in isoform 4)	Phosphorylation	-	24905233
295 (in isoform 5)	Phosphorylation	-	24905233
297	Phosphorylation	QTYSFSPSKSYSRQS CEEEECCCCCCCCCC	30266825
299	Phosphorylation	YSFSPSKSYSRQSSS EEECCCCCCCCCCCC	28450419
299 (in isoform 2)	Phosphorylation	-	24905233
299 (in isoform 4)	Phosphorylation	-	24905233
299 (in isoform 5)	Phosphorylation	-	24905233
300	Phosphorylation	SFSPSKSYSRQSSSS EECCCCCCCCCCCCC	28450419
301	Phosphorylation	FSPSKSYSRQSSSSD ECCCCCCCCCCCCCC	25159151
301 (in isoform 2)	Phosphorylation	-	24905233
301 (in isoform 4)	Phosphorylation	-	24905233
301 (in isoform 5)	Phosphorylation	-	24905233
304	Phosphorylation	SKSYSRQSSSSDTDL CCCCCCCCCCCCCCC	25159151
304 (in isoform 2)	Phosphorylation	-	24905233
304 (in isoform 4)	Phosphorylation	-	24905233
304 (in isoform 5)	Phosphorylation	-	24905233
305	Phosphorylation	KSYSRQSSSSDTDLS CCCCCCCCCCCCCCC	23401153
306	Phosphorylation	SYSRQSSSSDTDLSL CCCCCCCCCCCCCCC	30266825
307	Phosphorylation	YSRQSSSSDTDLSLT CCCCCCCCCCCCCCC	30266825
307 (in isoform 2)	Phosphorylation	-	24905233
307 (in isoform 4)	Phosphorylation	-	24905233
307 (in isoform 5)	Phosphorylation	-	24905233
308 (in isoform 2)	Phosphorylation	-	24905233
308 (in isoform 4)	Phosphorylation	-	24905233
308 (in isoform 5)	Phosphorylation	-	24905233
309	Phosphorylation	RQSSSSDTDLSLTPK CCCCCCCCCCCCCCC	30266825
312	Phosphorylation	SSSDTDLSLTPKTGM CCCCCCCCCCCCCCC	30266825
312 (in isoform 2)	Phosphorylation	-	24719451
312 (in isoform 4)	Phosphorylation	-	24719451
312 (in isoform 5)	Phosphorylation	-	24719451
314	Phosphorylation	SDTDLSLTPKTGMGS CCCCCCCCCCCCCCC	30266825
314 (in isoform 2)	Phosphorylation	-	24905233
314 (in isoform 4)	Phosphorylation	-	24905233
314 (in isoform 5)	Phosphorylation	-	24905233
317	Phosphorylation	DLSLTPKTGMGSGSA CCCCCCCCCCCCCCC	23927012
321	Phosphorylation	TPKTGMGSGSAGKEG CCCCCCCCCCCCCCC	23401153
323	Phosphorylation	KTGMGSGSAGKEGGP CCCCCCCCCCCCCCH	23927012
339	Phosphorylation	KALLRQQTQSALEQR HHHHHHHHHHHHHHC	21955146
341	Phosphorylation	LLRQQTQSALEQREF HHHHHHHHHHHHCCC	23090842
392 (in isoform 5)	Phosphorylation	-	24076635
395 (in isoform 5)	Phosphorylation	-	24076635
497	Phosphorylation	KVPDVLFTTIDLPTD CCCCEEEEEECCCCC	30387612
498	Phosphorylation	VPDVLFTTIDLPTDA CCCEEEEEECCCCCC	30387612
601	Phosphorylation	GIQIAGKTPNDGSYE CEEECEECCCCCCHH	21082442
606	Phosphorylation	GKTPNDGSYEQHISH EECCCCCCHHHHHHH	23911959
607	Phosphorylation	KTPNDGSYEQHISHM ECCCCCCHHHHHHHH	26657352
612	Phosphorylation	GSYEQHISHMQKKIN CCHHHHHHHHHHHHH	28796482
629	Phosphorylation	IAKNKELYEINPPEI HHHCHHHEECCCCHH	24732914
637	Phosphorylation	EINPPEISEEIIGSP ECCCCHHCHHHCCCC	25159151
643	Phosphorylation	ISEEIIGSPIPEPRQ HCHHHCCCCCCCHHH	25159151
643 (in isoform 2)	Phosphorylation	-	18669648
652	Phosphorylation	IPEPRQRSRLLRSQS CCCHHHHHHHHHCCC	26074081
657	Phosphorylation	QRSRLLRSQSESSDE HHHHHHHCCCCCCCC	29255136
659	Phosphorylation	SRLLRSQSESSDEVT HHHHHCCCCCCCCCC	29255136
661	Phosphorylation	LLRSQSESSDEVTEL HHHCCCCCCCCCCEE	22167270
662	Phosphorylation	LRSQSESSDEVTELD HHCCCCCCCCCCEEE	22167270
666	Phosphorylation	SESSDEVTELDLSHG CCCCCCCCEEECCCC	22167270
671	Phosphorylation	EVTELDLSHGKKDAF CCCEEECCCCCCCEE	23927012
804	Phosphorylation	DKNQALQTTKTPVEK CCCCCCCCCCCHHHH	21712546
805	Phosphorylation	KNQALQTTKTPVEKS CCCCCCCCCCHHHHH	23186163
806	Ubiquitination	NQALQTTKTPVEKSL CCCCCCCCCHHHHHH	-
807	Phosphorylation	QALQTTKTPVEKSLQ CCCCCCCCHHHHHHH	25159151
811	Ubiquitination	TTKTPVEKSLQRAST CCCCHHHHHHHHCCC	-
812	Phosphorylation	TKTPVEKSLQRASTD CCCHHHHHHHHCCCC	28450419
817	Phosphorylation	EKSLQRASTDNEELL HHHHHHCCCCCHHHH	30266825
818	Phosphorylation	KSLQRASTDNEELLQ HHHHHCCCCCHHHHH	30266825
832	Phosphorylation	QFPLELCSDSLPSHP HHHHHHCCCCCCCCC	26657352
834	Phosphorylation	PLELCSDSLPSHPFP HHHHCCCCCCCCCCC	29632367
837	Phosphorylation	LCSDSLPSHPFPPAK HCCCCCCCCCCCCCC	29632367
847	Phosphorylation	FPPAKAMTVEKASPV CCCCCCEEEEECCCC	24732914
850	Ubiquitination	AKAMTVEKASPVGDG CCCEEEEECCCCCCC	-
852	Phosphorylation	AMTVEKASPVGDGNF CEEEEECCCCCCCCC	29255136
854 (in isoform 2)	Phosphorylation	-	30266825
855 (in isoform 2)	Phosphorylation	-	30266825
858 (in isoform 2)	Phosphorylation	-	24117733
859 (in isoform 2)	Phosphorylation	-	30266825
860 (in isoform 2)	Phosphorylation	-	30266825
863	Phosphorylation	DGNFRNRSAPPCANS CCCCCCCCCCCCCCC	-
863 (in isoform 3)	Phosphorylation	-	30266825
864 (in isoform 3)	Phosphorylation	-	30266825
865 (in isoform 4)	Phosphorylation	-	30266825
866 (in isoform 4)	Phosphorylation	-	30266825
867 (in isoform 3)	Phosphorylation	-	24117733
868 (in isoform 3)	Phosphorylation	-	30266825
869 (in isoform 3)	Phosphorylation	-	30266825
869 (in isoform 4)	Phosphorylation	-	24117733
870 (in isoform 4)	Phosphorylation	-	30266825
871 (in isoform 4)	Phosphorylation	-	30266825
878	Phosphorylation	TVGVVKMTPLSFIPG CCEEEECCCCCCCCC	23403867
878 (in isoform 2)	Phosphorylation	-	29514088
883 (in isoform 2)	Phosphorylation	-	29514088
885	Ubiquitination	TPLSFIPGAKITKYL CCCCCCCCCHHHHHH	-
887 (in isoform 2)	Phosphorylation	-	22210691
887 (in isoform 3)	Phosphorylation	-	29514088
889 (in isoform 4)	Phosphorylation	-	29514088
890 (in isoform 5)	Phosphorylation	-	29514088
891	Phosphorylation	PGAKITKYLGIINMF CCCHHHHHHCEEEEE	-
892 (in isoform 3)	Phosphorylation	-	29514088
894 (in isoform 2)	Phosphorylation	-	29743597
894 (in isoform 4)	Phosphorylation	-	29514088
895 (in isoform 5)	Phosphorylation	-	29514088
896 (in isoform 3)	Phosphorylation	-	22210691
898 (in isoform 4)	Phosphorylation	-	22210691
899 (in isoform 5)	Phosphorylation	-	22210691
903 (in isoform 3)	Phosphorylation	-	29743597
905 (in isoform 4)	Phosphorylation	-	29743597
906 (in isoform 5)	Phosphorylation	-	29743597
965	Phosphorylation	AQCLINVSGDAVVFV EEEEEEECCCEEEEE	-
981	Phosphorylation	ESDLEVVSSQQPTTN HHHCEEEECCCCCCC	22468782
987	Phosphorylation	VSSQQPTTNCQSSCT EECCCCCCCCCCCCC	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
197	S	Phosphorylation	Kinase	AKT2	P31751	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
197	S	Myristoylation	21907143
Phosphorylated on Ser-197 by active myristoylated kinase AKT2; insulin-stimulated phosphorylation by AKT2 regulates SLC2A4/GLUT4 translocation into the plasma membrane.
197	S	Phosphorylation	21907143
Phosphorylated on Ser-197 by active myristoylated kinase AKT2; insulin-stimulated phosphorylation by AKT2 regulates SLC2A4/GLUT4 translocation into the plasma membrane.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of C2CD5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of C2CD5_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of C2CD5_HUMAN

Related Literatures of Post-Translational Modification

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