S35E1_HUMAN - dbPTM
S35E1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S35E1_HUMAN
UniProt AC Q96K37
Protein Name Solute carrier family 35 member E1
Gene Name SLC35E1
Organism Homo sapiens (Human).
Sequence Length 410
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Putative transporter..
Protein Sequence MAAAAVGAGHGAGGPGAASSSGGAREGARVAALCLLWYALSAGGNVVNKVILSAFPFPVTVSLCHILALCAGLPPLLRAWRVPPAPPVSGPGPSPHPSSGPLLPPRFYPRYVLPLAFGKYFASVSAHVSIWKVPVSYAHTVKATMPIWVVLLSRIIMKEKQSTKVYLSLIPIISGVLLATVTELSFDMWGLVSALAATLCFSLQNIFSKKVLRDSRIHHLRLLNILGCHAVFFMIPTWVLVDLSAFLVSSDLTYVYQWPWTLLLLAVSGFCNFAQNVIAFSILNLVSPLSYSVANATKRIMVITVSLIMLRNPVTSTNVLGMMTAILGVFLYNKTKYDANQQARKHLLPVTTADLSSKERHRSPLEKPHNGLLFPQHGDYQYGRNNILTDHFQYSRQSYPNSYSLNRYDV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20PhosphorylationGGPGAASSSGGAREG
CCCCCCCCCCHHHHH		28.42-
21PhosphorylationGPGAASSSGGAREGA
CCCCCCCCCHHHHHH		38.46-
45 (in isoform 2)Ubiquitination-33.3821890473
58 (in isoform 2)Ubiquitination-22.5521890473
67 (in isoform 2)Ubiquitination-1.0121890473
89PhosphorylationVPPAPPVSGPGPSPH
CCCCCCCCCCCCCCC		45.0723312004
94PhosphorylationPVSGPGPSPHPSSGP
CCCCCCCCCCCCCCC		41.5826425664
98PhosphorylationPGPSPHPSSGPLLPP
CCCCCCCCCCCCCCC		44.9123312004
99PhosphorylationGPSPHPSSGPLLPPR
CCCCCCCCCCCCCCC		49.2123312004
208PhosphorylationFSLQNIFSKKVLRDS
HHHHHHHCCHHHHCC		27.9824719451
219PhosphorylationLRDSRIHHLRLLNIL
HHCCCCHHHHHHHHH		15.4118669648
304PhosphorylationTKRIMVITVSLIMLR
CHHHEEEEEEHHHHH		7.8221406692
306PhosphorylationRIMVITVSLIMLRNP
HHEEEEEEHHHHHCC		11.9721406692
315PhosphorylationIMLRNPVTSTNVLGM
HHHHCCCCCHHHHHH		30.9624043423
316PhosphorylationMLRNPVTSTNVLGMM
HHHCCCCCHHHHHHH		20.4424043423
317PhosphorylationLRNPVTSTNVLGMMT
HHCCCCCHHHHHHHH		21.7124043423
324PhosphorylationTNVLGMMTAILGVFL
HHHHHHHHHHHHHHH		11.1424043423
332PhosphorylationAILGVFLYNKTKYDA
HHHHHHHHCCCCCCH		11.8024043423
336AcetylationVFLYNKTKYDANQQA
HHHHCCCCCCHHHHH		42.6226051181
345UbiquitinationDANQQARKHLLPVTT
CHHHHHHHHCCCCCH		41.4421890473
345 (in isoform 1)Ubiquitination-41.4421890473
351PhosphorylationRKHLLPVTTADLSSK
HHHCCCCCHHCCCCC		17.8328348404
352PhosphorylationKHLLPVTTADLSSKE
HHCCCCCHHCCCCCH		20.5730576142
356PhosphorylationPVTTADLSSKERHRS
CCCHHCCCCCHHHCC		39.6525159151
357PhosphorylationVTTADLSSKERHRSP
CCHHCCCCCHHHCCC		45.9225159151
358 (in isoform 1)Ubiquitination-56.2221890473
358UbiquitinationTTADLSSKERHRSPL
CHHCCCCCHHHCCCC		56.2221890473
363PhosphorylationSSKERHRSPLEKPHN
CCCHHHCCCCCCCCC		27.9322617229
367UbiquitinationRHRSPLEKPHNGLLF
HHCCCCCCCCCCCCC		60.3021890473
367 (in isoform 1)Ubiquitination-60.3021890473
380PhosphorylationLFPQHGDYQYGRNNI
CCCCCCCCCCCCCCC		14.2925884760
382PhosphorylationPQHGDYQYGRNNILT
CCCCCCCCCCCCCCC		16.3028796482
389PhosphorylationYGRNNILTDHFQYSR
CCCCCCCCCCHHHHC		24.51-
394PhosphorylationILTDHFQYSRQSYPN
CCCCCHHHHCCCCCC		12.6021945579
395PhosphorylationLTDHFQYSRQSYPNS
CCCCHHHHCCCCCCC		17.0421945579
398PhosphorylationHFQYSRQSYPNSYSL
CHHHHCCCCCCCCCC		41.2528857561
399PhosphorylationFQYSRQSYPNSYSLN
HHHHCCCCCCCCCCC		9.7024043423
402PhosphorylationSRQSYPNSYSLNRYD
HCCCCCCCCCCCCCC		16.1725884760
403PhosphorylationRQSYPNSYSLNRYDV
CCCCCCCCCCCCCCC		24.6628796482
404PhosphorylationQSYPNSYSLNRYDV-
CCCCCCCCCCCCCC-		20.9928796482
408PhosphorylationNSYSLNRYDV-----
CCCCCCCCCC-----		21.7124043423
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of S35E1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of S35E1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S35E1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IFT52_HUMANIFT52physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of S35E1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, AND MASSSPECTROMETRY.

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