AT2C1_HUMAN - dbPTM
AT2C1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AT2C1_HUMAN
UniProt AC P98194
Protein Name Calcium-transporting ATPase type 2C member 1
Gene Name ATP2C1
Organism Homo sapiens (Human).
Sequence Length 919
Subcellular Localization Golgi apparatus membrane
Multi-pass membrane protein .
Protein Description This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium..
Protein Sequence MKVARFQKIPNGENETMIPVLTSKKASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKKVERSREKIQKHVSSTSSSFLEV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8UbiquitinationMKVARFQKIPNGENE
CCEEEEEECCCCCCC		58.3721906983
8 (in isoform 7)Phosphorylation-58.3724247654
8 (in isoform 8)Phosphorylation-58.3724247654
8 (in isoform 2)Ubiquitination-58.3721890473
8 (in isoform 1)Ubiquitination-58.3721890473
8 (in isoform 5)Ubiquitination-58.3721890473
8 (in isoform 6)Ubiquitination-58.3721890473
16PhosphorylationIPNGENETMIPVLTS
CCCCCCCCEEEEECC		31.7923403867
17SulfoxidationPNGENETMIPVLTSK
CCCCCCCEEEEECCC		2.3821406390
22PhosphorylationETMIPVLTSKKASEL
CCEEEEECCCCCCCC		38.44-
23PhosphorylationTMIPVLTSKKASELP
CEEEEECCCCCCCCC		28.18-
25UbiquitinationIPVLTSKKASELPVS
EEEECCCCCCCCCHH		57.84-
25 (in isoform 2)Ubiquitination-57.84-
32PhosphorylationKASELPVSEVASILQ
CCCCCCHHHHHHHHH		25.1423403867
36PhosphorylationLPVSEVASILQADLQ
CCHHHHHHHHHHHHH		29.0723403867
70PhosphorylationFDISEDEPLWKKYIS
CCCCCCCHHHHHHHH		56.71-
70 (in isoform 8)Phosphorylation-56.71-
77PhosphorylationPLWKKYISQFKNPLI
HHHHHHHHHCCCHHH		26.8620068231
146UbiquitinationCHCVREGKLEHTLAR
CCEECCCCCCEECCC		46.05-
182PhosphorylationLFEAVDLSIDESSLT
HEEEEEEEECCCCCC		24.4324275569
206PhosphorylationTAPQPAATNGDLASR
CCCCCCCCCCCHHHH		41.6728555341
229UbiquitinationLVRCGKAKGVVIGTG
EEECCCCCEEEEECC		56.58-
229 (in isoform 2)Ubiquitination-56.58-
420PhosphorylationDAVIRNNTLMGKPTE
CCHHCCCCCCCCCCH		22.9820068231
424UbiquitinationRNNTLMGKPTEGALI
CCCCCCCCCCHHHHH		34.50-
426PhosphorylationNTLMGKPTEGALIAL
CCCCCCCCHHHHHHH		51.0020068231
449UbiquitinationLQQDYIRKAEYPFSS
HHHHHHHHCCCCCCH		35.69-
452PhosphorylationDYIRKAEYPFSSEQK
HHHHHCCCCCCHHHH		17.9030576142
455PhosphorylationRKAEYPFSSEQKWMA
HHCCCCCCHHHHEEE		28.5830576142
456PhosphorylationKAEYPFSSEQKWMAV
HCCCCCCHHHHEEEE		44.4124719451
480UbiquitinationRPEICFMKGAYEQVI
CCCEEEECCHHHHHH		21.8221890473
480AcetylationRPEICFMKGAYEQVI
CCCEEEECCHHHHHH		21.8226051181
480 (in isoform 3)Ubiquitination-21.8221890473
480 (in isoform 4)Ubiquitination-21.8221890473
488UbiquitinationGAYEQVIKYCTTYQS
CHHHHHHHHHHHHCC		35.10-
490 (in isoform 7)Phosphorylation-1.6224719451
492PhosphorylationQVIKYCTTYQSKGQT
HHHHHHHHHCCCCCE		18.9224247654
495PhosphorylationKYCTTYQSKGQTLTL
HHHHHHCCCCCEEEE		28.4824247654
496UbiquitinationYCTTYQSKGQTLTLT
HHHHHCCCCCEEEEE		39.2421890473
496 (in isoform 6)Ubiquitination-39.2421890473
496 (in isoform 2)Ubiquitination-39.2421890473
496 (in isoform 1)Ubiquitination-39.2421890473
496 (in isoform 5)Ubiquitination-39.2421890473
498 (in isoform 3)Ubiquitination-36.7521890473
498 (in isoform 4)Ubiquitination-36.7521890473
501PhosphorylationQSKGQTLTLTQQQRD
CCCCCEEEEEHHHHH		31.0224247654
514UbiquitinationRDVYQQEKARMGSAG
HHHHHHHHHHHCHHH		36.6321906983
514AcetylationRDVYQQEKARMGSAG
HHHHHHHHHHHCHHH		36.6326051181
514 (in isoform 1)Ubiquitination-36.6321890473
514 (in isoform 2)Ubiquitination-36.6321890473
514 (in isoform 5)Ubiquitination-36.6321890473
514 (in isoform 6)Ubiquitination-36.6321890473
519PhosphorylationQEKARMGSAGLRVLA
HHHHHHCHHHHHHHH		15.15-
530UbiquitinationRVLALASGPELGQLT
HHHHHHCCCCHHHEE		17.6921890473
557PhosphorylationTGVKEAVTTLIASGV
CCHHHHHHHHHHCCC		23.96-
558PhosphorylationGVKEAVTTLIASGVS
CHHHHHHHHHHCCCE		15.01-
570PhosphorylationGVSIKMITGDSQETA
CCEEEEEECCCHHHH		31.2924114839
573PhosphorylationIKMITGDSQETAVAI
EEEEECCCHHHHHHH		31.1224114839
573 (in isoform 3)Ubiquitination-31.1221890473
573 (in isoform 4)Ubiquitination-31.1221890473
576PhosphorylationITGDSQETAVAIASR
EECCCHHHHHHHHHH		20.8524114839
582PhosphorylationETAVAIASRLGLYSK
HHHHHHHHHHCCCCC		23.17-
589UbiquitinationSRLGLYSKTSQSVSG
HHHCCCCCCCCCCCC		38.3421906983
589 (in isoform 2)Ubiquitination-38.3421890473
589 (in isoform 1)Ubiquitination-38.3421890473
589 (in isoform 5)Ubiquitination-38.3421890473
589 (in isoform 6)Ubiquitination-38.3421890473
590PhosphorylationRLGLYSKTSQSVSGE
HHCCCCCCCCCCCCC		26.5129978859
591PhosphorylationLGLYSKTSQSVSGEE
HCCCCCCCCCCCCCC		24.9729978859
593PhosphorylationLYSKTSQSVSGEEID
CCCCCCCCCCCCCCC		20.3029978859
595PhosphorylationSKTSQSVSGEEIDAM
CCCCCCCCCCCCCCC		45.8129978859
608PhosphorylationAMDVQQLSQIVPKVA
CCCHHHHHHHCHHHH		17.3329978859
618PhosphorylationVPKVAVFYRASPRHK
CHHHHHEEECCHHHH		9.9318083107
621PhosphorylationVAVFYRASPRHKMKI
HHHEEECCHHHHHHH		17.3029214152
630UbiquitinationRHKMKIIKSLQKNGS
HHHHHHHHHHHHCCC		48.89-
634UbiquitinationKIIKSLQKNGSVVAM
HHHHHHHHCCCEEEE		69.44-
637PhosphorylationKSLQKNGSVVAMTGD
HHHHHCCCEEEEECC		23.86-
642PhosphorylationNGSVVAMTGDGVNDA
CCCEEEEECCCHHHH		23.5323879269
655 (in isoform 7)Phosphorylation-13.8424719451
664PhosphorylationIGVAMGQTGTDVCKE
HHCCCCCCCHHHHHH		36.0023879269
769PhosphorylationPPRNWKDSILTKNLI
CCCCCCCCHHCHHHH		18.7724719451
804PhosphorylationELRDNVITPRDTTMT
HHHCCCCCCCCCCCC		14.16-
808PhosphorylationNVITPRDTTMTFTCF
CCCCCCCCCCCCHHH		21.5330576142
813PhosphorylationRDTTMTFTCFVFFDM
CCCCCCCHHHHHHHH		8.8922798277
815 (in isoform 3)Ubiquitination-4.9521890473
815 (in isoform 4)Ubiquitination-4.9521890473
825PhosphorylationFDMFNALSSRSQTKS
HHHHHHHCCCCCCCC		22.6922798277
826PhosphorylationDMFNALSSRSQTKSV
HHHHHHCCCCCCCCH		36.48-
828PhosphorylationFNALSSRSQTKSVFE
HHHHCCCCCCCCHHH		44.1230576142
831UbiquitinationLSSRSQTKSVFEIGL
HCCCCCCCCHHHHEE		36.6621906983
831 (in isoform 1)Ubiquitination-36.6621890473
831 (in isoform 2)Ubiquitination-36.6621890473
831 (in isoform 5)Ubiquitination-36.6621890473
831 (in isoform 6)Ubiquitination-36.6621890473
839S-palmitoylationSVFEIGLCSNRMFCY
CHHHHEECCCHHHHH		2.6029575903
891UbiquitinationLTSSVCIVAEIIKKV
HHHHHHHHHHHHHHH		3.1021890473
891 (in isoform 4)Ubiquitination-3.1021890473
897AcetylationIVAEIIKKVERSREK
HHHHHHHHHHHHHHH		38.6319817999
901PhosphorylationIIKKVERSREKIQKH
HHHHHHHHHHHHHHH		31.1429496963
907UbiquitinationRSREKIQKHVSSTSS
HHHHHHHHHHHHCCC		49.822189047
907 (in isoform 6)Ubiquitination-49.8221890473
907 (in isoform 1)Ubiquitination-49.8221890473
909 (in isoform 8)Phosphorylation-6.6120068231
910PhosphorylationEKIQKHVSSTSSSFL
HHHHHHHHHCCCHHC		27.8423403867
911PhosphorylationKIQKHVSSTSSSFLE
HHHHHHHHCCCHHCC		31.0825159151
912PhosphorylationIQKHVSSTSSSFLEV
HHHHHHHCCCHHCCC		25.7325159151
913PhosphorylationQKHVSSTSSSFLEV-
HHHHHHCCCHHCCC-		26.4025159151
914PhosphorylationKHVSSTSSSFLEV--
HHHHHCCCHHCCC--		25.7925159151
914 (in isoform 9)Phosphorylation-25.7920068231
915PhosphorylationHVSSTSSSFLEV---
HHHHCCCHHCCC---		33.3525159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AT2C1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AT2C1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AT2C1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AT2C1_HUMAN !!
Drug and Disease Associations
Kegg Disease
H00844 Hailey-Hailey disease; Benign familial pemphigus
OMIM Disease
169600Hailey-Hailey disease (HHD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB01189Desflurane
DB00228Enflurane
DB01159Halothane
DB00753Isoflurane
DB01028Methoxyflurane
DB01236Sevoflurane
Regulatory Network of AT2C1_HUMAN

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Related Literatures of Post-Translational Modification

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