SKIL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SKIL_MOUSE
• UniProt AC: Q60665
• Protein Name: Ski-like protein
• Gene Name: Skil
• Organism: Mus musculus (Mouse).
• Sequence Length: 675
• Protein Description: May have regulatory role in cell division or differentiation in response to extracellular signals..
• Protein Sequence: MENLQSKFSLVQGSNKKLNGMEDDGSPPVKKMMTDIHANGKTLTKVKKEHLDDYGDASVEPDGEHAKRNRVSLPETLNLNPSLKHTLAQFHLSSQSSLGGPAAFSARYSQESMSPTVFLPLPSPQVLPGPLLIPSDSSTELTQTLLEGESISCFQVGGEKRLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSILPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRNGKRIQSKTDTPSGMELPSWYPVIKQEGDHVPQTHSFLHPSYYLYMCDKVVAPNVSLTSAASQSKEATKAETSKSTSKQSEKPHESSQHQKTVSYPDVSLEEQEKMDLKTSRELYSCLDSSISNNSTSRKKSESAVCSLVRGTSKRDSEDSSPLLVRDGEDDKGKIMEDVMRTYVRQQEKLNSILQRKQQLQMEVEMLSSSKAMKELTEEQQNLQKELESLQSEHAQRMEEFYIEQRDLEKKLEQVMQQKCTCDSTLEKDREAEYAAQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQIGKSSKPSKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	PPVKKMMTDIHANGK CCHHHHHHEECCCCC	28.44	26060331
42	Phosphorylation	DIHANGKTLTKVKKE EECCCCCEEEHHCHH	40.85	26060331
349	Ubiquitination	KIILEEMKEKFSMRN HHHHHHHHHHHCCCC	62.12	22790023
364	Phosphorylation	GKRIQSKTDTPSGME CCCCCCCCCCCCCCC	50.80	26643407
366	Phosphorylation	RIQSKTDTPSGMELP CCCCCCCCCCCCCCC	25.28	26643407
368	Phosphorylation	QSKTDTPSGMELPSW CCCCCCCCCCCCCCC	53.52	26643407
449	Phosphorylation	SQHQKTVSYPDVSLE CCCCCCCCCCCCCHH	35.86	-
487	Phosphorylation	NSTSRKKSESAVCSL CCCCCCCCHHHHHHH	39.56	27600695
489	Phosphorylation	TSRKKSESAVCSLVR CCCCCCHHHHHHHHC	32.85	25266776
503	Phosphorylation	RGTSKRDSEDSSPLL CCCCCCCCCCCCCCE	47.54	26643407
506	Phosphorylation	SKRDSEDSSPLLVRD CCCCCCCCCCCEEEC	29.78	26643407
507	Phosphorylation	KRDSEDSSPLLVRDG CCCCCCCCCCEEECC	31.71	26643407
538	Phosphorylation	RQQEKLNSILQRKQQ HHHHHHHHHHHHHHH	34.80	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Fzr1	Q9R1K5	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SKIL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SKIL_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPNE1_HUMAN	CPNE1	physical	12522145
CPNE4_HUMAN	CPNE4	physical	12522145
P53_MOUSE	Trp53	physical	22805162
PML_MOUSE	Pml	physical	22805162
FZR1_MOUSE	Fzr1	physical	17215516
M3K7_MOUSE	Map3k7	physical	17276978
PML_MOUSE	Pml	physical	19745809
P53_MOUSE	Trp53	physical	19745809

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.