BCOR_MOUSE - dbPTM
BCOR_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BCOR_MOUSE
UniProt AC Q8CGN4
Protein Name BCL-6 corepressor
Gene Name Bcor
Organism Mus musculus (Mouse).
Sequence Length 1759
Subcellular Localization Nucleus .
Protein Description Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2) (By similarity)..
Protein Sequence MLSATPLYGNVHSWMNSERVRMCGTSEDRKIPVNDGDASKARLELREETPLSHSVVDTSGAHRIDGLAALSMDRTGLIREGLRVPGNIVYSGLCGLGSEKGREATPSSLSGLGFSSERNPEMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAVATAESLGLDRPASDKQSPLNINGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQSYGLAQPLYSPVCTSGERFLYLPPPHYVNPHIPSSLASPMRLSTPSASAAIPPLVHCSDKSLPWKMGVNPGNPVDSHSYPHIQNSKQPRVTSAKAVNSGLPGDTALLLPPSPRPSARVHLPTQPAAETYSEFHKHYPRISTSPSVTLTKPYMTANSEFSTSRLSNGKYPKALDGGDCAQSMPGHTRKTTVQDRKDGGSPPLLEKQTVTKDVTDKPLDLSSKVVDADASKGDHMKKMAPTVLVHSRAASGLVLSGSEIPKETLSPPGNGCSIYRSEIISTAPSSWVVPGPSPNEENNGKSLSLKNKALDWAIPQQRSSSCPRMGGTDAVVTNVSGSVSSSGRPASASPAPNANANADGTKTSRSSVDTTPSVIQHVGQPSSTPAKHGGSTSSKGAKANPEPSFKASENGLPPTSIFLSPNEAFRSPAIPYPRSYLPYAAPEGIALSPLSLHGKGPVYPHPVLLPNGSLFPGHLAPKPGLPYGLHTSRPEFVTYQDALGLGMVHPMLIPHTPIEITKEEKPERRSRSHERARYEDPTLRSRFSEMLEASSTKLHPEVPTDKNLKPNSSWNQGKTGVKSDKLVYVDLLREEADTKTDAGAPKAGLVAENVGQDTEATKPSADPVIQQRREFISLREELGRITDFHESFTFKQASSQPVFSLGKDSGAAGTNKENLGVQVATPFLETALGSEGPAVTFGKTQEDPKPFCVGGAPPNMDVTPAYTKEGTDEAESNDGKVLKPKPSKLAKRIANSAGYVGDRFKCVTTELYADSSQLSREQRALQMEGLQEDSILCLPAAYCERAMMRFSELEMKEREGSHPATKDSEVCKFSPADWERLKGNQEKKPKSVTLEEAIADQNDSERCEYSTGNKHDLFEAPEDKDLPVEKYFLERPPVSEPPSDQGVVDTPHSPTLRLDRKRKLSGDSTHTETAVEELAEDPLKAKRRRISKDDWPEREMTNSSSNHLEDPHCNELTNLKVCIELTGLHPKKQRHLLHLRERWEQQVSAAESKPGRQSRKEVAQAVQPEVTSQGTNITEEKPGRKKAEAKGNRGWSEESLKSCDNEQGLPVLSGSPPMKSLSSTNASGKKQTQPSCTPASRLPAKQQKIKESQKTDVLCTGEDEDCQAASPLQKYTDNIEKPSGKRLCKTKHLIPQESRRSLQITGDYYVENTDTKMTVRRFRKRPEPSSDYDLSPPAKQEPKPFDRLQQLLPATQATQLPRSNSPQETTQSRPMPPEARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKVCDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRSEDDTSGAWEFYGSSVCEPDDESGYDVLANPPGPEDPDEEEDTYSDLFEFEFAESSLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRSNFPNLEIVTIAEAEFYRQVSTSLLFSCPKDLEAFNPESKELLDLVEFTNELQTLLGSSVEWLHPSDTGHENYW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MLSATPLYGN
-----CCCCCCCCCC		41.7925293948
5Phosphorylation---MLSATPLYGNVH
---CCCCCCCCCCHH		15.5125293948
8PhosphorylationMLSATPLYGNVHSWM
CCCCCCCCCCHHHHH		14.0925293948
13PhosphorylationPLYGNVHSWMNSERV
CCCCCHHHHHHCCCE		24.6025293948
17PhosphorylationNVHSWMNSERVRMCG
CHHHHHHCCCEEECC		15.6325293948
128PhosphorylationEMQFKPNTPETVEAS
CCCCCCCCCCCEEHH		30.9125777480
131PhosphorylationFKPNTPETVEASAVS
CCCCCCCCEEHHHHC		25.5025777480
135PhosphorylationTPETVEASAVSGKPP
CCCCEEHHHHCCCCC		18.7225777480
204PhosphorylationEGATPAIYPFLDSPN
CCCCCCHHHCCCCCC		7.0526643407
209PhosphorylationAIYPFLDSPNKYSLN
CHHHCCCCCCCCCCH		32.3026643407
317PhosphorylationSKQPRVTSAKAVNSG
CCCCCCCCHHHHHCC		25.5623140645
329PhosphorylationNSGLPGDTALLLPPS
HCCCCCCCEEECCCC		25.7226643407
336PhosphorylationTALLLPPSPRPSARV
CEEECCCCCCCCCCE		31.4428066266
340PhosphorylationLPPSPRPSARVHLPT
CCCCCCCCCCEECCC		29.9526643407
361PhosphorylationYSEFHKHYPRISTSP
HHHHHHHCCCCCCCC		10.06-
365PhosphorylationHKHYPRISTSPSVTL
HHHCCCCCCCCCEEE		24.90-
366PhosphorylationKHYPRISTSPSVTLT
HHCCCCCCCCCEEEC		42.1428066266
367PhosphorylationHYPRISTSPSVTLTK
HCCCCCCCCCEEECC		14.3725266776
369PhosphorylationPRISTSPSVTLTKPY
CCCCCCCCEEECCCE		27.7428066266
371PhosphorylationISTSPSVTLTKPYMT
CCCCCCEEECCCEEC		32.8026643407
373PhosphorylationTSPSVTLTKPYMTAN
CCCCEEECCCEECCC		22.17-
392AcetylationTSRLSNGKYPKALDG
CCHHCCCCCCCCCCC		63.73-
423PhosphorylationQDRKDGGSPPLLEKQ
CCCCCCCCCCCCCCE		28.9527087446
488PhosphorylationEIPKETLSPPGNGCS
CCCHHHCCCCCCCCC		36.1525266776
508PhosphorylationIISTAPSSWVVPGPS
EEECCCCCCCCCCCC		23.8822802335
515PhosphorylationSWVVPGPSPNEENNG
CCCCCCCCCCCCCCC		46.3922802335
524PhosphorylationNEENNGKSLSLKNKA
CCCCCCCCCCHHHHH		25.2924719451
526PhosphorylationENNGKSLSLKNKALD
CCCCCCCCHHHHHHH		44.3724719451
558PhosphorylationDAVVTNVSGSVSSSG
CEEEEECCCCCCCCC		27.6728285833
563PhosphorylationNVSGSVSSSGRPASA
ECCCCCCCCCCCCCC		34.3622802335
564PhosphorylationVSGSVSSSGRPASAS
CCCCCCCCCCCCCCC		31.1721454597
569PhosphorylationSSSGRPASASPAPNA
CCCCCCCCCCCCCCC		31.7829472430
571PhosphorylationSGRPASASPAPNANA
CCCCCCCCCCCCCCC		21.0629472430
583PhosphorylationANANADGTKTSRSSV
CCCCCCCCCCCHHHC		31.5324224561
836PhosphorylationAENVGQDTEATKPSA
EECCCCCCCCCCCCC		21.4522871156
842PhosphorylationDTEATKPSADPVIQQ
CCCCCCCCCCHHHHH		47.0322871156
869PhosphorylationRITDFHESFTFKQAS
HCCCHHHHCCCCCCC		22.4827600695
941PhosphorylationAPPNMDVTPAYTKEG
CCCCCCCCCCCCCCC		9.6526745281
977PhosphorylationRIANSAGYVGDRFKC
HHHHHCCCCCCCEEE		10.85-
1052PhosphorylationDSEVCKFSPADWERL
CCCCCCCCHHHHHHH		12.5029514104
1069PhosphorylationNQEKKPKSVTLEEAI
CCCCCCCCEEHHHHH		28.9421149613
1071PhosphorylationEKKPKSVTLEEAIAD
CCCCCCEEHHHHHHC		35.2321149613
1109PhosphorylationKDLPVEKYFLERPPV
CCCCHHHHCCCCCCC		10.4125777480
1117PhosphorylationFLERPPVSEPPSDQG
CCCCCCCCCCCCCCC		50.5925777480
1121PhosphorylationPPVSEPPSDQGVVDT
CCCCCCCCCCCCCCC		53.9725777480
1128PhosphorylationSDQGVVDTPHSPTLR
CCCCCCCCCCCCCCC		15.9925266776
1131PhosphorylationGVVDTPHSPTLRLDR
CCCCCCCCCCCCCCC		22.3026824392
1133PhosphorylationVDTPHSPTLRLDRKR
CCCCCCCCCCCCCCH		27.7626643407
1143PhosphorylationLDRKRKLSGDSTHTE
CCCCHHCCCCCCCHH		43.5226824392
1146PhosphorylationKRKLSGDSTHTETAV
CHHCCCCCCCHHHHH		26.1322802335
1147PhosphorylationRKLSGDSTHTETAVE
HHCCCCCCCHHHHHH		37.2425619855
1149PhosphorylationLSGDSTHTETAVEEL
CCCCCCCHHHHHHHH		34.8125619855
1151 (in isoform 4)Phosphorylation-36.8422942356
1151PhosphorylationGDSTHTETAVEELAE
CCCCCHHHHHHHHHH		36.8425619855
1169 (in isoform 3)Phosphorylation-28.3722942356
1169PhosphorylationKAKRRRISKDDWPER
HHHHHHCCCCCCCHH		28.3728066266
1280PhosphorylationWSEESLKSCDNEQGL
CCHHHHHCCCCCCCC		31.8125777480
1291PhosphorylationEQGLPVLSGSPPMKS
CCCCCCCCCCCCCCC		37.1426643407
1293PhosphorylationGLPVLSGSPPMKSLS
CCCCCCCCCCCCCCC		23.5827087446
1333PhosphorylationKIKESQKTDVLCTGE
HHHHHHCCCCEECCC		24.5725619855
1338PhosphorylationQKTDVLCTGEDEDCQ
HCCCCEECCCCHHHH		39.1725619855
1348PhosphorylationDEDCQAASPLQKYTD
CHHHHCCCCHHHHCC		29.2027087446
1379PhosphorylationIPQESRRSLQITGDY
CCHHHHHHCEEECCE		24.4230635358
1383PhosphorylationSRRSLQITGDYYVEN
HHHHCEEECCEEECC		15.8422802335
1407PhosphorylationFRKRPEPSSDYDLSP
HHHCCCCCCCCCCCC		33.8925266776
1408PhosphorylationRKRPEPSSDYDLSPP
HHCCCCCCCCCCCCC		51.4025266776
1412UbiquitinationEPSSDYDLSPPAKQE
CCCCCCCCCCCCCCC		7.2427667366
1413PhosphorylationPSSDYDLSPPAKQEP
CCCCCCCCCCCCCCC		26.4125266776
1430UbiquitinationFDRLQQLLPATQATQ
CHHHHHHCHHHHCCC		2.0527667366
1433PhosphorylationLQQLLPATQATQLPR
HHHHCHHHHCCCCCC		19.4524719451
1436PhosphorylationLLPATQATQLPRSNS
HCHHHHCCCCCCCCC		22.3324719451
1441PhosphorylationQATQLPRSNSPQETT
HCCCCCCCCCCCCCC		39.4525619855
1443PhosphorylationTQLPRSNSPQETTQS
CCCCCCCCCCCCCCC		29.2525619855
1446UbiquitinationPRSNSPQETTQSRPM
CCCCCCCCCCCCCCC		58.1527667366
1464UbiquitinationARRLIVNKNAGETLL
HHHHHEECCHHHHHH		36.9627667366
1671PhosphorylationPRNWLLLSDVLKKLK
CCCEEHHHHHHHHHH		26.1623737553
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BCOR_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BCOR_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BCOR_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CPNE1_HUMANCPNE1physical
12522145
CPNE4_HUMANCPNE4physical
12522145
ZBT7C_MOUSEZbtb7cphysical
22253232
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BCOR_MOUSE

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1146, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory