CPNE1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CPNE1_MOUSE
• UniProt AC: Q8C166
• Protein Name: Copine-1 {ECO:0000305}
• Gene Name: Cpne1 {ECO:0000312|MGI:MGI:2386621}
• Organism: Mus musculus (Mouse).
• Sequence Length: 536
• Subcellular Localization: Nucleus . Cytoplasm . Cell membrane . Translocates to the cell membrane in a calcium-dependent manner.
• Protein Description: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL..
• Protein Sequence: MAHCVTLVQLSVSCEHLIDKDIGSKSDPLCVLLQDVGGAWAELCRTERVRNCSSPEFSKTLQIEYHFETVQKLRFGIYDIDNKTPELGDDDFLGGAECSLGQIVSSQTLTLPLMLKPGKPAGRGTITVSAQELKDSRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGDGKWQLAYRTEVVKNNLNPTWKRFSVSLQHFCGGDLSTPIQVRCSDYDSDGSHDLIGTFHTTLAQLQAVPAEFECVHPEKQQRKKNYRNSGTVRVKTCRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDPSSPDSLHYLSPTGVNEYLTALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAQQRSASQYFVLLLLTDGAVTDVEATCKAVVDASKLPMSVIIVGVGGADFEVMEQLDADGGPLRTRSGEAAARDIVQFVPYRRFQNAPRETLAQTVLAEVPTQMVSYFRAQGWAPLKAPPTPGKGPAQAPQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Glutathionylation	RTERVRNCSSPEFSK HHHCCCCCCCCHHHC	2.74	24333276
53	Phosphorylation	TERVRNCSSPEFSKT HHCCCCCCCCHHHCC	53.10	26745281
54	Phosphorylation	ERVRNCSSPEFSKTL HCCCCCCCCHHHCCE	30.56	25521595
58	Phosphorylation	NCSSPEFSKTLQIEY CCCCCHHHCCEEEEE	24.06	21743459
156	Ubiquitination	DKKDFLGKSDPFLEF CCCHHCCCCCHHHHH	54.56	-
170	Acetylation	FFRQGDGKWQLAYRT HHHCCCCCEEEEEEE	36.18	23806337
187	Phosphorylation	VKNNLNPTWKRFSVS HHCCCCCCHHHEEEE	42.41	22817900
192	Phosphorylation	NPTWKRFSVSLQHFC CCCHHHEEEEHHHHC	18.15	26060331
194	Phosphorylation	TWKRFSVSLQHFCGG CHHHEEEEHHHHCCC	22.55	26060331
212	Phosphorylation	TPIQVRCSDYDSDGS CCEEEEEECCCCCCC	28.74	23984901
214	Phosphorylation	IQVRCSDYDSDGSHD EEEEEECCCCCCCCC	10.89	23984901
216	Phosphorylation	VRCSDYDSDGSHDLI EEEECCCCCCCCCCE	37.33	23984901
219	Phosphorylation	SDYDSDGSHDLIGTF ECCCCCCCCCCEEEH	20.86	23984901
225	Phosphorylation	GSHDLIGTFHTTLAQ CCCCCEEEHHHHHHH	12.78	23984901
228	Phosphorylation	DLIGTFHTTLAQLQA CCEEEHHHHHHHHHC	21.22	23984901
229	Phosphorylation	LIGTFHTTLAQLQAV CEEEHHHHHHHHHCC	16.13	23984901
257	Phosphorylation	RKKNYRNSGTVRVKT HHHHCCCCCCEEEEE	27.17	25338131
385	Phosphorylation	ALPQVRLYGPTNFAP HCCCCEECCCCCHHH	15.53	29514104
525	Phosphorylation	APLKAPPTPGKGPAQ CCCCCCCCCCCCCCC	43.55	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CPNE1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CPNE1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CPNE1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPNE1_HUMAN	CPNE1	physical	12522145
CPNE4_HUMAN	CPNE4	physical	12522145

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-525, AND MASSSPECTROMETRY.
PubMed: 17114649