dbPTM

SPTB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPTB2_MOUSE
UniProt AC	Q62261
Protein Name	Spectrin beta chain, non-erythrocytic 1
Gene Name	Sptbn1
Organism	Mus musculus (Mouse).
Sequence Length	2363
Subcellular Localization	Cytoplasm, cytoskeleton . Endomembrane system . Cytoplasm, myofibril, sarcomere, M line . Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes. Isoform 2: Cytoplasm . Cell membrane Peripheral membrane protein C
Protein Description	Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane..
Protein Sequence	MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLLLSQDYGKHLLGVEDLLQKHALVEADIAIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSNDVGHDEYSTQSLVKKHKDVAEEITNYRPTIDTLHEQASALPQAHAESPDVKGRLAGIEERCKEMAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHNGHPSEKEIRAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNREAASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLSERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIITDSSSLNAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHKAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNNMADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACEGRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTACIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPDPNTKVSEEAESQQWDTSKGDQVSQNGLPAEQGSPRMAGTMETSEMVNGAAEQRTSSKESSPVPSPTLDRKAKSALPAQSAATLPARTLETPAAQMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKSAASGIPYHSEVPVSLKEAICEVALDYKKKKHVFKLRLSDGNEYLFQAKDDEEMNTWIQAISSAISSDKHDTSASTQSTPASSRAQTLPTSVVTITSESSPGKREKDKEKDKEKRFSLFGKKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTTTVATDY ------CCCEEECCC	42.34	-
2	Phosphorylation	------MTTTVATDY ------CCCEEECCC	42.34	25338131
6 (in isoform 2)	Phosphorylation	-	7.83	24704852
7	Phosphorylation	-MTTTVATDYDNIEI -CCCEEECCCCCCEE	30.65	30387612
7 (in isoform 2)	Phosphorylation	-	30.65	26745281
8 (in isoform 2)	Phosphorylation	-	38.77	24704852
9	Phosphorylation	TTTVATDYDNIEIQQ CCEEECCCCCCEEHH	13.41	25338131
10 (in isoform 2)	Phosphorylation	-	53.06	26745281
14 (in isoform 2)	Phosphorylation	-	3.87	23984901
17 (in isoform 2)	Phosphorylation	-	24.26	25266776
18 (in isoform 2)	Phosphorylation	-	11.51	26026062
23 (in isoform 2)	Phosphorylation	-	46.39	23140645
25 (in isoform 2)	Phosphorylation	-	16.47	23984901
35	Phosphorylation	DDWDNENSSARLFER CCCCCCCHHHHHHHH	21.13	23737553
36	Phosphorylation	DWDNENSSARLFERS CCCCCCHHHHHHHHH	29.05	23737553
57	Ubiquitination	DEREAVQKKTFTKWV HHHHHHHHHHHHHHH	47.37	22790023
62	Ubiquitination	VQKKTFTKWVNSHLA HHHHHHHHHHHHHHH	44.98	22790023
90	Acetylation	RDGRMLIKLLEVLSG CCCCHHHHHHHHHCC	42.95	-
90	Ubiquitination	RDGRMLIKLLEVLSG CCCCHHHHHHHHHCC	42.95	22790023
102	Ubiquitination	LSGERLPKPTKGRMR HCCCCCCCCCCCCCC	70.66	22790023
105	Ubiquitination	ERLPKPTKGRMRIHC CCCCCCCCCCCCHHH	53.71	22790023
118	Ubiquitination	HCLENVDKALQFLKE HHHCCHHHHHHHHHH	46.87	22790023
124	Ubiquitination	DKALQFLKEQRVHLE HHHHHHHHHCCCCCC	53.76	22790023
163	Phosphorylation	RFQIQDISVETEDNK HHHHCCCCCCCCCCC	23.38	25521595
170	Ubiquitination	SVETEDNKEKKSAKD CCCCCCCCCCCCHHH	81.09	22790023
228	Phosphorylation	DFDKLKKSNAHYNLQ CHHHHCCCCCCCCHH	37.35	19060867
257	Phosphorylation	LLDPEDISVDHPDEK CCCHHHCCCCCCCHH	33.54	25521595
274	Phosphorylation	ITYVVTYYHYFSKMK HHHHHHHHHHHHHHH	4.81	-
346	Phosphorylation	QQLQAFNTYRTVEKP HHHHHHHCCCCCCCC	14.13	22817900
349	Phosphorylation	QAFNTYRTVEKPPKF HHHHCCCCCCCCCCC	23.70	25521595
359	Ubiquitination	KPPKFTEKGNLEVLL CCCCCCCCCCEEEEE	50.47	22790023
390	Phosphorylation	PREGKLISDINKAWE CCCCCCHHHHHHHHH	42.76	22324799
430	Ubiquitination	LARRFDRKAAMRETW HHHHHHHHHHHHHHH	42.20	22790023
439	Phosphorylation	AMRETWLSENQRLVS HHHHHHHCHHHHHHC	26.51	-
446	Phosphorylation	SENQRLVSQDNFGFD CHHHHHHCCCCCCCC	36.09	29899451
558	Ubiquitination	LLSQDYGKHLLGVED HHCCCHHHHHCCHHH	25.50	22790023
558	Acetylation	LLSQDYGKHLLGVED HHCCCHHHHHCCHHH	25.50	22826441
593	Ubiquitination	GVNASAQKFATDGEG CCCCCCCCCCCCCCC	36.36	22790023
593	Acetylation	GVNASAQKFATDGEG CCCCCCCCCCCCCCC	36.36	22826441
602	Acetylation	ATDGEGYKPCDPQVI CCCCCCCCCCCHHHH	50.45	22826441
659	Ubiquitination	GWIREKEKILSSDDY CCHHHHHHHCCCCCC	61.08	22790023
668	Ubiquitination	LSSDDYGKDLTSVMR CCCCCCCCCHHHHHH	43.25	22790023
678	Phosphorylation	TSVMRLLSKHRAFED HHHHHHHHHCHHHCH	30.89	-
768	Phosphorylation	LDILKIVSSNDVGHD HHHHHHHCCCCCCCC	27.22	20415495
769	Phosphorylation	DILKIVSSNDVGHDE HHHHHHCCCCCCCCC	26.59	20415495
777	Phosphorylation	NDVGHDEYSTQSLVK CCCCCCCCCHHHHHH	24.07	22817900
778	Phosphorylation	DVGHDEYSTQSLVKK CCCCCCCCHHHHHHH	20.23	20415495
779	Phosphorylation	VGHDEYSTQSLVKKH CCCCCCCHHHHHHHC	22.67	20415495
781	Phosphorylation	HDEYSTQSLVKKHKD CCCCCHHHHHHHCHH	34.91	20415495
794	Phosphorylation	KDVAEEITNYRPTID HHHHHHHHCCCCCHH	29.49	23984901
796	Phosphorylation	VAEEITNYRPTIDTL HHHHHHCCCCCHHHH	14.87	23984901
799	Phosphorylation	EITNYRPTIDTLHEQ HHHCCCCCHHHHHHH	23.61	23984901
802	Phosphorylation	NYRPTIDTLHEQASA CCCCCHHHHHHHHHH	26.60	23984901
808	Phosphorylation	DTLHEQASALPQAHA HHHHHHHHHCCHHHH	29.99	23984901
817	Phosphorylation	LPQAHAESPDVKGRL CCHHHHCCCCHHHHH	27.47	26824392
842	Ubiquitination	AELTRLRKQALQDTL HHHHHHHHHHHHHHH	44.51	-
842	Malonylation	AELTRLRKQALQDTL HHHHHHHHHHHHHHH	44.51	26320211
893	Phosphorylation	VIQHRFESLEPEMNN HHHHHHHHCCHHHCC	35.01	28066266
903	Phosphorylation	PEMNNQASRVAVVNQ HHHCCHHHHHHHHHH	19.95	25521595
924	Ubiquitination	HNGHPSEKEIRAQQD HCCCCCHHHHHHHHH	63.88	22790023
938	Phosphorylation	DKLNTRWSQFRELVD HHHHHHHHHHHHHHH	19.02	29514104
956	Phosphorylation	DALLSALSIQNYHLE HHHHHHHHHHCHHHC	23.11	29899451
960	Phosphorylation	SALSIQNYHLECNET HHHHHHCHHHCCCCC	7.45	19060867
967	Phosphorylation	YHLECNETKSWIREK HHHCCCCCHHHHHHH	19.18	22807455
969	Phosphorylation	LECNETKSWIREKTK HCCCCCHHHHHHHHH	34.84	22324799
976	Ubiquitination	SWIREKTKVIESTQD HHHHHHHHHHHHCHH	52.89	22790023
999	Phosphorylation	MALQRKLTGMERDLV HHHHHHHHCCHHHHH	37.20	26643407
1011	Ubiquitination	DLVAIEAKLSDLQKE HHHHHHHHHHHHHHH	35.42	22790023
1013	Phosphorylation	VAIEAKLSDLQKEAE HHHHHHHHHHHHHHH	35.25	19367708
1017	Ubiquitination	AKLSDLQKEAEKLES HHHHHHHHHHHHHHH	67.21	22790023
1057	Phosphorylation	TLKNREASLGEASKL HHHHHHHHHHHHHHH	31.96	26824392
1063	Ubiquitination	ASLGEASKLQQFLRD HHHHHHHHHHHHHHC	58.31	22790023
1076	Phosphorylation	RDLDDFQSWLSRTQT HCHHHHHHHHHHHHH	29.94	22324799
1079	Phosphorylation	DDFQSWLSRTQTAIA HHHHHHHHHHHHHHH	27.33	19060867
1095	Phosphorylation	EDMPNTLTEAEKLLT CCCCCCHHHHHHHHH	30.98	25521595
1102	Phosphorylation	TEAEKLLTQHENIKN HHHHHHHHHHHHHHH	38.01	18779572
1108	Acetylation	LTQHENIKNEIDNYE HHHHHHHHHHHHCHH	61.17	22826441
1114	Phosphorylation	IKNEIDNYEEDYQKM HHHHHHCHHHHHHHH	19.56	22817900
1118	Phosphorylation	IDNYEEDYQKMRDMG HHCHHHHHHHHHHHH	17.20	22817900
1171	Phosphorylation	LLSQSHAYQQFLRDT HHHHHHHHHHHHHHH	9.45	17242355
1237	Phosphorylation	ETGRRLVSDGNINSD HCCCHHHHCCCCCHH	44.38	25521595
1252	Phosphorylation	RIQEKVDSIDDRHRK HHHHHHHHCHHHHHH	30.79	21183079
1265	Phosphorylation	RKNREAASELLMRLK HHHHHHHHHHHHHHH	35.51	21183079
1335	Ubiquitination	EWLDKIEKEGMQLIS HHHHHHHHHHHHHHC	64.14	22790023
1342	Phosphorylation	KEGMQLISEKPETEA HHHHHHHCCCCCCHH	48.43	-
1360	Ubiquitination	EKLTGLHKMWEVLES HHCHHHHHHHHHHHH	51.23	22790023
1381	Ubiquitination	QRLFDANKAELFTQS HHHHCCCHHHHHHHH	44.98	22790023
1386	Phosphorylation	ANKAELFTQSCADLD CCHHHHHHHHHHHHH	32.00	29899451
1388	Phosphorylation	KAELFTQSCADLDKW HHHHHHHHHHHHHHH	14.28	22324799
1389	S-nitrosocysteine	AELFTQSCADLDKWL HHHHHHHHHHHHHHH	2.16	-
1389	S-nitrosylation	AELFTQSCADLDKWL HHHHHHHHHHHHHHH	2.16	20925432
1420	Ubiquitination	TSVNILLKKQQMLEN HHHHHHHHHHHHHHH	45.12	22790023
1421	Ubiquitination	SVNILLKKQQMLENQ HHHHHHHHHHHHHHH	45.81	22790023
1447	Phosphorylation	QSQAQALSQEGKSTD HHHHHHHHHCCCCCH	29.24	25521595
1452	Phosphorylation	ALSQEGKSTDEVDSK HHHHCCCCCHHHHHH	52.53	29899451
1459	Acetylation	STDEVDSKRLTVQTK CCHHHHHHHHHHHHH	47.14	15612537
1462	Phosphorylation	EVDSKRLTVQTKFME HHHHHHHHHHHHHHH	18.01	18779572
1475	Phosphorylation	MELLEPLSERKHNLL HHHHHHHHHHHHHHH	46.18	28066266
1529	Phosphorylation	LLIKKNQTLQKEIQG HHHHHCHHHHHHHCC	40.32	30387612
1557	Phosphorylation	NIITDSSSLNAEAIR CCCCCCCCCCHHHHH	29.60	-
1622	Ubiquitination	MMSEEKAKDEQSAVS HHCHHHHCCHHHHHH	73.24	22790023
1629	Phosphorylation	KDEQSAVSMLKKHQI CCHHHHHHHHHHHHH	20.36	28059163
1633	Acetylation	SAVSMLKKHQILEQA HHHHHHHHHHHHHHH	36.46	22826441
1652	Phosphorylation	AETVHQLSKTSRALV HHHHHHHHHHHHHHH	27.58	29899451
1653	Acetylation	ETVHQLSKTSRALVA HHHHHHHHHHHHHHC	60.14	22826441
1662	Phosphorylation	SRALVADSHPESERI HHHHHCCCCCHHHHH	31.07	29899451
1678	Ubiquitination	MRQSKVDKLYAGLKD HCHHHHHHHHHHHHH	46.51	22790023
1680	Phosphorylation	QSKVDKLYAGLKDLA HHHHHHHHHHHHHHH	12.36	25263469
1684	Ubiquitination	DKLYAGLKDLAEERR HHHHHHHHHHHHHHC	50.18	22790023
1768	Phosphorylation	MADELINSGHSDAAT HHHHHHHCCCCCHHH	30.78	20415495
1771	Phosphorylation	ELINSGHSDAATIAE HHHHCCCCCHHHHHH	32.25	20415495
1775	Phosphorylation	SGHSDAATIAEWKDG CCCCCHHHHHHHHHH	23.57	22817900
1804	Phosphorylation	RTQILAASYELHKFY HHHHHHHHHHHHHHH	17.34	20415495
1805	Phosphorylation	TQILAASYELHKFYH HHHHHHHHHHHHHHH	20.13	22817900
1811	Phosphorylation	SYELHKFYHDAKEIF HHHHHHHHHHHHHHH	12.00	22817900
1815	Acetylation	HKFYHDAKEIFGRIQ HHHHHHHHHHHHHHH	58.35	23236377
1815	Ubiquitination	HKFYHDAKEIFGRIQ HHHHHHHHHHHHHHH	58.35	22790023
1847	Phosphorylation	ETLQRMHTTFEHDIQ HHHHHHHHHHHHHHH	24.68	22802335
1848	Phosphorylation	TLQRMHTTFEHDIQA HHHHHHHHHHHHHHH	16.61	22802335
1878	Acetylation	QAAYAGDKADDIQKR HHHHHCCCHHHHHHH	53.44	23806337
1913	Acetylation	RLVDTGDKFRFFSMV EEEECCCHHHHHHHH	39.52	22826441
1913	Malonylation	RLVDTGDKFRFFSMV EEEECCCHHHHHHHH	39.52	26320211
1918	Phosphorylation	GDKFRFFSMVRDLML CCHHHHHHHHHHHHH	17.41	15572359
1945	Phosphorylation	EKPRDVSSVELLMNN CCCCCCCHHHHHHHC	21.32	25521595
1976	Phosphorylation	ACIELGKSLLARKHY HHHHHHHHHHHHCCC	27.15	21183079
1989	Acetylation	HYASEEIKEKLLQLT CCCCHHHHHHHHHHH	52.67	-
2027	Phosphorylation	HQFSRDASVAEAWLL HHHCCCCCHHHHHHH	26.58	29899451
2039	Phosphorylation	WLLGQEPYLSSREIG HHHCCCCCCCHHHHC	20.61	29899451
2041	Phosphorylation	LGQEPYLSSREIGQS HCCCCCCCHHHHCCC	22.85	29899451
2048	Phosphorylation	SSREIGQSVDEVEKL CHHHHCCCHHHHHHH	26.73	22324799
2054	Ubiquitination	QSVDEVEKLIKRHEA CCHHHHHHHHHHHHH	61.77	22790023
2057	Acetylation	DEVEKLIKRHEAFEK HHHHHHHHHHHHHHH	59.13	8276469
2074	Phosphorylation	ATWDERFSALERLTT CCHHHHHHHHHHHHH	37.86	19060867
2081	Phosphorylation	SALERLTTLELLEVR HHHHHHHHHHHHHHH	23.87	29514104
2089 (in isoform 2)	Phosphorylation	-	47.94	20047950
2102	Phosphorylation	ERKRRPPSPDPNTKV HHHHCCCCCCCCCCC	44.62	27087446
2107	Phosphorylation	PPSPDPNTKVSEEAE CCCCCCCCCCCHHHH	37.91	24925903
2110	Phosphorylation	PDPNTKVSEEAESQQ CCCCCCCCHHHHHCC	31.13	25521595
2114 (in isoform 2)	Phosphorylation	-	52.97	25521595
2115	Phosphorylation	KVSEEAESQQWDTSK CCCHHHHHCCCCCCC	34.42	24925903
2120	Phosphorylation	AESQQWDTSKGDQVS HHHCCCCCCCCCCCC	29.40	24925903
2121	Phosphorylation	ESQQWDTSKGDQVSQ HHCCCCCCCCCCCCC	31.97	25521595
2124 (in isoform 2)	Phosphorylation	-	49.82	25521595
2127	Phosphorylation	TSKGDQVSQNGLPAE CCCCCCCCCCCCCCC	16.58	24925903
2129 (in isoform 2)	Phosphorylation	-	46.60	22802335
2131 (in isoform 2)	Phosphorylation	-	4.81	22802335
2133 (in isoform 2)	Phosphorylation	-	27.13	22802335
2134 (in isoform 2)	Phosphorylation	-	54.24	22802335
2137	Phosphorylation	GLPAEQGSPRMAGTM CCCCCCCCCCCCCCC	14.72	24925903
2137 (in isoform 2)	Phosphorylation	-	14.72	29514104
2138 (in isoform 2)	Ubiquitination	-	36.57	-
2143	Phosphorylation	GSPRMAGTMETSEMV CCCCCCCCCCHHHHH	11.42	22817900
2146	Phosphorylation	RMAGTMETSEMVNGA CCCCCCCHHHHHCCH	21.11	23737553
2147	Phosphorylation	MAGTMETSEMVNGAA CCCCCCHHHHHCCHH	15.47	23737553
2147 (in isoform 2)	Phosphorylation	-	15.47	25338131
2150 (in isoform 2)	Phosphorylation	-	5.40	29514104
2158	Phosphorylation	NGAAEQRTSSKESSP CCHHHHCCCCCCCCC	36.73	24925903
2159	Phosphorylation	GAAEQRTSSKESSPV CHHHHCCCCCCCCCC	41.42	25521595
2160	Phosphorylation	AAEQRTSSKESSPVP HHHHCCCCCCCCCCC	39.57	27087446
2163	Phosphorylation	QRTSSKESSPVPSPT HCCCCCCCCCCCCCC	43.61	24925903
2164	Phosphorylation	RTSSKESSPVPSPTL CCCCCCCCCCCCCCC	30.89	24925903
2168	Phosphorylation	KESSPVPSPTLDRKA CCCCCCCCCCCCHHH	30.65	24925903
2170	Phosphorylation	SSPVPSPTLDRKAKS CCCCCCCCCCHHHHH	45.70	25521595
2176	Ubiquitination	PTLDRKAKSALPAQS CCCCHHHHHCCCCCC	39.02	22790023
2177	Phosphorylation	TLDRKAKSALPAQSA CCCHHHHHCCCCCCC	39.64	25619855
2183	Phosphorylation	KSALPAQSAATLPAR HHCCCCCCCCCCCCC	23.21	25521595
2186	Phosphorylation	LPAQSAATLPARTLE CCCCCCCCCCCCCCC	32.75	25521595
2191	Phosphorylation	AATLPARTLETPAAQ CCCCCCCCCCCCHHH	30.93	24925903
2194	Phosphorylation	LPARTLETPAAQMEG CCCCCCCCCHHHHHH	22.72	25521595
2220	Phosphorylation	NKKASSRSWHNVYCV CCCCCCCCCCCEEEE	34.34	21082442
2225	Phosphorylation	SRSWHNVYCVINNQE CCCCCCEEEEECCCC	6.06	29899451
2240	Ubiquitination	MGFYKDAKSAASGIP CCEECCHHHHHCCCC	51.25	22790023
2248	Phosphorylation	SAASGIPYHSEVPVS HHHCCCCCCCCCCCC	18.96	29514104
2268	Acetylation	CEVALDYKKKKHVFK HHHHCCCCCCCCEEE	58.76	23806337
2275	Ubiquitination	KKKKHVFKLRLSDGN CCCCCEEEEECCCCC	31.44	-
2296	Phosphorylation	KDDEEMNTWIQAISS CCHHHHHHHHHHHHH	23.72	25293948
2302	Phosphorylation	NTWIQAISSAISSDK HHHHHHHHHHHHCCC	19.41	22324799
2303	Phosphorylation	TWIQAISSAISSDKH HHHHHHHHHHHCCCC	24.41	29899451
2306	Phosphorylation	QAISSAISSDKHDTS HHHHHHHHCCCCCCC	32.00	19060867
2307	Phosphorylation	AISSAISSDKHDTSA HHHHHHHCCCCCCCC	44.56	22324799
2312	Phosphorylation	ISSDKHDTSASTQST HHCCCCCCCCCCCCC	26.38	23684622
2313	Phosphorylation	SSDKHDTSASTQSTP HCCCCCCCCCCCCCC	26.69	23684622
2315	Phosphorylation	DKHDTSASTQSTPAS CCCCCCCCCCCCCCH	27.09	25521595
2316	Phosphorylation	KHDTSASTQSTPASS CCCCCCCCCCCCCHH	26.67	25521595
2318	Phosphorylation	DTSASTQSTPASSRA CCCCCCCCCCCHHHC	36.12	25521595
2319	Phosphorylation	TSASTQSTPASSRAQ CCCCCCCCCCHHHCC	17.04	25521595
2322	Phosphorylation	STQSTPASSRAQTLP CCCCCCCHHHCCCCC	22.89	23737553
2323	O-linked_Glycosylation	TQSTPASSRAQTLPT CCCCCCHHHCCCCCC	33.47	30059200
2323	Phosphorylation	TQSTPASSRAQTLPT CCCCCCHHHCCCCCC	33.47	23737553
2327	Phosphorylation	PASSRAQTLPTSVVT CCHHHCCCCCCEEEE	33.45	25521595
2330	Phosphorylation	SRAQTLPTSVVTITS HHCCCCCCEEEEEEC	36.95	25521595
2331	Phosphorylation	RAQTLPTSVVTITSE HCCCCCCEEEEEECC	16.79	24925903
2334	Phosphorylation	TLPTSVVTITSESSP CCCCEEEEEECCCCC	19.17	24925903
2336	Phosphorylation	PTSVVTITSESSPGK CCEEEEEECCCCCCC	19.64	24925903
2337	Phosphorylation	TSVVTITSESSPGKR CEEEEEECCCCCCCC	31.46	25521595
2339	Phosphorylation	VVTITSESSPGKREK EEEEECCCCCCCCCC	41.42	25521595
2340	Phosphorylation	VTITSESSPGKREKD EEEECCCCCCCCCCC	33.35	24925903
2343	Ubiquitination	TSESSPGKREKDKEK ECCCCCCCCCCCCHH	61.85	22790023
2357	Phosphorylation	KDKEKRFSLFGKKK- HHHHHHHHHCCCCC-	27.16	26824392
2361	Acetylation	KRFSLFGKKK----- HHHHHCCCCC-----	50.48	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
346	T	Phosphorylation	Kinase	PRKACA	P05132	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPTB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPTB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CPNE1_HUMAN	CPNE1	physical	12522145
CPNE4_HUMAN	CPNE4	physical	12522145

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPTB2_MOUSE

Related Literatures of Post-Translational Modification

O-linked Glycosylation
Reference	PubMed
"O-linked N-acetylglucosamine proteomics of postsynaptic densitypreparations using lectin weak affinity chromatography and massspectrometry."; Vosseller K., Trinidad J.C., Chalkley R.J., Specht C.G.,Thalhammer A., Lynn A.J., Snedecor J.O., Guan S., Medzihradszky K.F.,Maltby D.A., Schoepfer R., Burlingame A.L.; Mol. Cell. Proteomics 5:923-934(2006). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT SER-2323, AND MASSSPECTROMETRY.	16452088 [Abstract]
Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2164 AND SER-2168, ANDMASS SPECTROMETRY.	19131326 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-257; SER-2102; SER-2137;THR-2327 AND SER-2357, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2127; SER-2137 ANDTHR-2194, AND MASS SPECTROMETRY.	17114649 [Abstract]
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis."; Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.; J. Proteome Res. 7:3957-3967(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2102, AND MASSSPECTROMETRY.	18630941 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-999; SER-2102; SER-2164;SER-2168 AND THR-2194, AND MASS SPECTROMETRY.	16452087 [Abstract]
"Proteomic analysis of in vivo phosphorylated synaptic proteins."; Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I.,Blackstock W.P., Choudhary J.S., Grant S.G.; J. Biol. Chem. 280:5972-5982(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1918; SER-2115; SER-2137AND SER-2168, AND MASS SPECTROMETRY.	15572359 [Abstract]
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1805, AND MASSSPECTROMETRY.	18034455 [Abstract]